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Book: Creatine and creatine phosphate

Conway, Michael A. / Clark, Joseph F.

scientific and clinical perspectives

1996

Author's details	Michael A. Conway and Joseph F. Clark
Keywords	Creatine ; Phosphocreatine ; Kreatinkinase ; Herzmuskel ; Muskelstoffwechsel ; Biochemie ; Kreatin
Subject	Biologische Chemie ; Creatin ; CAS 57-00-1 ; Kreatinphosphatkinase ; CPK ; Creatinkinase ; CK ; Muskel ; Herzmuskeln ; Herzmuskulatur ; Myokard ; Myocard ; Myocardium ; Herzmuskelgewebe
Language	English
Size	XII, 242 S. : graph. Darst.
Publisher	Academic Press
Publishing place	San Diego u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT007450199
ISBN	0-12-186340-9 ; 978-0-12-186340-1
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Effects of Prolonged Sitting with or without Elastic Garments on Limb Volume, Arterial Blood Flow, and Muscle Oxygenation.

Kurosawa, Yuko / Nirengi, Shinsuke / Tabata, Izumi / Isaka, Tadao / Clark, Joseph F / Hamaoka, Takafumi

Medicine and science in sports and exercise

2021 Volume 54, Issue 3, Page(s) 399–407

Abstract: Purpose: The physiological response induced by acute prolonged sitting is not fully understood. Therefore, we examined the effects of 8-h constant sitting on microcirculation and associated factors in the lower extremity among healthy males. We also ... ...

Abstract	Purpose: The physiological response induced by acute prolonged sitting is not fully understood. Therefore, we examined the effects of 8-h constant sitting on microcirculation and associated factors in the lower extremity among healthy males. We also evaluated the protective effects of lower-pressure thigh-length elastic compression garments on these parameters. Methods: Nine healthy males (age, 22.6 ± 1.4 yr; body mass index, 22.4 ± 1.8 kg·m-2) completed the 8-h constant sitting experiment. Following baseline measurements, each subject was randomized to wear a lower-pressure elastic garment on the right or left leg from the inguinal region to the ankle joint, with the noncompressed contralateral leg as a control. Circumferences of the calf and malleolus, extracellular water contents, blood flow and shear rate of the dorsal metatarsal artery, and oxygen dynamics in the gastrocnemius muscles were measured in both extremities before and during 8-h constant sitting. Results: Compared with baseline values, 8-h constant sitting caused enlargement of circumferences (calf, 2.4% ± 0.7%; malleolus, 2.7% ± 1.4%), retention of extracellular water in lower extremity muscles (10.1% ± 1.78%), deterioration of the blood flow (61.4% ± 16.2% of baseline) and shear rate of the dorsal metatarsal artery, and decrease in oxygenated hemoglobin and total hemoglobin levels in the gastrocnemius muscle (P < 0.05, respectively). When subjects wore the lower-pressure thigh-length compression garment, a significant reduction of these effects was observed (P < 0.05, for all). Conclusions: Prolonged sitting for 8 h induced edema, as well as deterioration of the arterial blood flow, shear rate, and microcirculation in lower limb muscles. Conversely, application of the lower-pressure elastic garment successfully prevented the pathophysiological deterioration associated with prolonged sitting.
MeSH term(s)	Humans ; Lower Extremity/blood supply ; Lower Extremity/physiology ; Male ; Muscle, Skeletal/blood supply ; Muscle, Skeletal/physiology ; Regional Blood Flow/physiology ; Sitting Position ; Stockings, Compression ; Young Adult
Language	English
Publishing date	2021-10-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603994-7
ISSN	1530-0315 ; 0195-9131 ; 0025-7990
ISSN (online)	1530-0315
ISSN	0195-9131 ; 0025-7990
DOI	10.1249/MSS.0000000000002822
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Zs.A 869: Show issues

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Article ; Online: Diagnostic methods and recommendations for the cerebral creatine deficiency syndromes.

Clark, Joseph F / Cecil, Kim M

Pediatric research

2014 Volume 77, Issue 3, Page(s) 398–405

Abstract: Primary care pediatricians and a variety of specialist physicians strive to define an accurate diagnosis for children presenting with impairment of expressive speech and delay in achieving developmental milestones. Within the past two decades, a group of ...

Abstract	Primary care pediatricians and a variety of specialist physicians strive to define an accurate diagnosis for children presenting with impairment of expressive speech and delay in achieving developmental milestones. Within the past two decades, a group of disorders featuring this presentation have been identified as cerebral creatine deficiency syndromes (CCDS). Patients with these disorders were initially discerned using proton magnetic resonance spectroscopy of the brain within a magnetic resonance imaging (MRI) examination. The objective of this review is to provide the clinician with an overview of the current information available on identifying and treating these conditions. We explain the salient features of creatine metabolism, synthesis, and transport required for normal development. We propose diagnostic approaches for confirming a CCDS diagnosis. Finally, we describe treatment approaches for managing patients with these conditions.
MeSH term(s)	Amidinotransferases/deficiency ; Amidinotransferases/genetics ; Amino Acid Metabolism, Inborn Errors/diagnosis ; Amino Acid Metabolism, Inborn Errors/drug therapy ; Amino Acid Metabolism, Inborn Errors/epidemiology ; Amino Acid Metabolism, Inborn Errors/genetics ; Amino Acid Metabolism, Inborn Errors/pathology ; Brain Diseases, Metabolic, Inborn/diagnosis ; Brain Diseases, Metabolic, Inborn/drug therapy ; Brain Diseases, Metabolic, Inborn/epidemiology ; Brain Diseases, Metabolic, Inborn/genetics ; Brain Diseases, Metabolic, Inborn/pathology ; Creatine/biosynthesis ; Creatine/blood ; Creatine/deficiency ; Creatine/genetics ; Creatine/physiology ; Creatine/urine ; Developmental Disabilities/diagnosis ; Developmental Disabilities/drug therapy ; Developmental Disabilities/epidemiology ; Developmental Disabilities/genetics ; Developmental Disabilities/pathology ; Female ; Guanidinoacetate N-Methyltransferase/deficiency ; Guanidinoacetate N-Methyltransferase/genetics ; Humans ; Incidence ; Infant ; Intellectual Disability/diagnosis ; Intellectual Disability/drug therapy ; Intellectual Disability/epidemiology ; Intellectual Disability/genetics ; Intellectual Disability/pathology ; Language Development Disorders/diagnosis ; Language Development Disorders/drug therapy ; Language Development Disorders/epidemiology ; Language Development Disorders/etiology ; Language Development Disorders/genetics ; Language Development Disorders/pathology ; Magnetic Resonance Spectroscopy/methods ; Male ; Mental Retardation, X-Linked/diagnosis ; Mental Retardation, X-Linked/drug therapy ; Mental Retardation, X-Linked/epidemiology ; Mental Retardation, X-Linked/genetics ; Mental Retardation, X-Linked/pathology ; Movement Disorders/congenital ; Movement Disorders/diagnosis ; Movement Disorders/drug therapy ; Movement Disorders/epidemiology ; Movement Disorders/genetics ; Movement Disorders/pathology ; Plasma Membrane Neurotransmitter Transport Proteins/deficiency ; Plasma Membrane Neurotransmitter Transport Proteins/genetics ; Sex Factors ; Speech Disorders/diagnosis ; Speech Disorders/drug therapy ; Speech Disorders/epidemiology ; Speech Disorders/genetics ; Speech Disorders/pathology ; Utah/epidemiology
Chemical Substances	Plasma Membrane Neurotransmitter Transport Proteins ; Guanidinoacetate N-Methyltransferase (EC 2.1.1.2) ; Amidinotransferases (EC 2.1.4.-) ; Creatine (MU72812GK0)
Language	English
Publishing date	2014-12-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/pr.2014.203
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: In Response to: Does Visual Performance Influence Head Impact Severity Among High School Football Athletes?

Clark, Joseph F / Mangine, Robert E / Divine, Jon G

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

2016 Volume 27, Issue 3, Page(s) e32

MeSH term(s)	Athletes ; Brain Concussion ; Football ; Humans ; Schools ; Soccer
Language	English
Publishing date	2016-06-28
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1062530-6
ISSN	1536-3724 ; 1050-642X
ISSN (online)	1536-3724
ISSN	1050-642X
DOI	10.1097/JSM.0000000000000335
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Zs.A 3120: Show issues

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Book: My ambulance education

Clark, Joseph F

life and death on the streets of New York

2009

Author's details	Joseph F. Clark
MeSH term(s)	Emergency Medical Technicians ; Emergency Medical Services
Keywords	New York City
Language	English
Size	254 p. :, ill., ports.
Publisher	Firefly Books
Publishing place	Richmond Hill, Ont ; Buffalo, N.Y
Document type	Book
Note	Includes index.
ISBN	9781554074648 ; 1554074649 ; 9781554074471 ; 1554074479
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: The influence of sport goggles on visual target detection in female intercollegiate athletes.

Kauffman, Danielle C / Clark, Joseph F / Smith, J Carson

Journal of sports sciences

2015 Volume 33, Issue 11, Page(s) 1117–1123

Abstract: The aim of this study was to examine the effects of sport goggles on visual target detection in female intercollegiate athletes. Participants were randomly divided into three groups that varied in goggle use (G) or no goggle use (NG) over a total of ... ...

Abstract	The aim of this study was to examine the effects of sport goggles on visual target detection in female intercollegiate athletes. Participants were randomly divided into three groups that varied in goggle use (G) or no goggle use (NG) over a total of three 1-min trials during a visual target detection task. The NG-NG-NG group did not wear goggles for any of the trials, whereas the NG-G-NG group wore goggles for the second trial only, and the G-NG-G group wore goggles for the first and third trials. The task consisted of illuminated targets arranged in five concentric rings from central to peripheral visual angles. The effects of sport goggles on response time to detect targets were most evident in the peripheral rings. Those who did not wear sport goggles showed improved performance from the first to second trials. This improvement was impaired, however, in those who wore sport goggles. Moreover, there was a reversal of the performance improvements achieved without goggles in those who wore goggles on the third trial. Together, these findings suggest the sport goggles not only impaired the expected initial performance but also impaired visual target detection after performance improvements were seen. These findings suggest sport goggles may impair detection of peripheral visual stimuli in athletes.
MeSH term(s)	Adolescent ; Athletic Performance/physiology ; Cross-Over Studies ; Eye Protective Devices/adverse effects ; Female ; Hockey/injuries ; Hockey/physiology ; Humans ; Reaction Time ; Risk Factors ; Sports Equipment/adverse effects ; Visual Fields ; Young Adult
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	995528-8
ISSN	1466-447X ; 0264-0414
ISSN (online)	1466-447X
ISSN	0264-0414
DOI	10.1080/02640414.2014.987156
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Zs.A 2388: Show issues

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Book: Guanidino compounds in biology and medicine

Clark, Joseph F

(Developments in molecular and cellular biochemistry ; v. 40)

2003

Author's details	edited by Joseph F. Clark
Series title	Developments in molecular and cellular biochemistry ; v. 40
MeSH term(s)	Guanidines
Language	English
Size	190 p. :, ill. ;, 29 cm.
Publisher	Kluwer Academic
Publishing place	Dordrecht ; Boston
Document type	Book
Note	Originally published in: Molecular and cellular biochemistry, v. 244, nos. 1 & 2, Feb. 2003.
ISBN	9781402072970 ; 140207297X
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Physiological Monitoring Detected Changes During Women's Soccer Anterior Cruciate Ligament Injury.

Detherage, John P / Divine, Jon G / Donaworth, Michael A / Palmer, Thomas G / Hagen, Joshua A / Hasselfeld, Kimberly A / Eifert-Mangine, Marsha / Mangine, Robert E / Clark, Joseph F / Grawe, Brian M

Cureus

2021 Volume 13, Issue 5, Page(s) e14838

Abstract: A growing number of studies utilizing wearable technologies are examining the influence of the autonomic nervous system (ANS) on intense training, recovery, and injury risk. Exercise biometric (EB) data were collected on collegiate, female soccer players ...

Abstract	A growing number of studies utilizing wearable technologies are examining the influence of the autonomic nervous system (ANS) on intense training, recovery, and injury risk. Exercise biometric (EB) data were collected on collegiate, female soccer players during a preseason camp. One player sustained an anterior cruciate ligament (ACL) injury. Baseline anthropometric and EB data were compared to non-injured, position-matched teammates. All players had similar baseline testing. The injured athlete had a higher body mass index (BMI) and slower vision reaction time (RT). On the day of her injury (DOI), relative percentage heart rate recovery (tHRR) between intense training sets was calculated. Relative percentage tHRR was much lower for the injured athlete, indicating reduced recovery between training sets immediately prior to the injury. Also on DOI, the injured athlete had a lower glomerular filtration rate (GFR). In addition to BMI and RT differences, the lower relative percentage tHRR and GFR on the DOI observed for the injured athlete may reflect an imbalanced ANS recovery, and potentially to risk factors leading to her ACL injury.
Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.14838
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of Central and Peripheral Vision Reaction Times in Patients With Postconcussion Visual Dysfunction.

Clark, Joseph F / Ellis, James K / Burns, Timothy M / Childress, John M / Divine, Jon G

Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine

2017 Volume 27, Issue 5, Page(s) 457–461

Abstract: Objective: To determine whether central and peripheral vision reaction times (PVRTs) are prolonged in patients with visual dysfunction after sustaining a concussion.: Design: Comparison of Dynavision D2 central and PVRTs in patients with ... ...

Abstract	Objective: To determine whether central and peripheral vision reaction times (PVRTs) are prolonged in patients with visual dysfunction after sustaining a concussion. Design: Comparison of Dynavision D2 central and PVRTs in patients with postconcussion visual dysfunction were compared with control data from a normative patient database. Concussion patients without visual dysfunction were not included in this study. Setting: National Collegiate Athletic Association Division 1 college training room and university based, academic health center. Participants: Patients were selected for inclusion based on diagnosis of new visual dysfunction as indicated either by physical examination of the team physician or by patient self-report of symptoms. Patients included college athletes, college students, and concussion patient's presenting to a university based, academic health center. Intervention: Measurement of central and PVRTs using a Dynavision D2 reaction time program were used as the dependent variables. Evaluations were conducted from 3 days to 11 months postconcussion, depending on the temporal development of visual symptoms after the concussion. No intervention was used. Main outcome measures: Average central and PVRTs for patients with postconcussion visual symptoms were compared with an asymptomatic control group with no history of concussion. Results: Both central and PVRTs were significantly prolonged in patients with postconcussion visual symptoms compared with patients with no history of concussion. Conclusions: Central and PVRTs are both prolonged in patients with postconcussion visual dysfunction with PVRT being disproportionately prolonged. The percent change from central to PVRT was also increased in patients with postconcussion visual dysfunction.
MeSH term(s)	Adolescent ; Adult ; Athletic Injuries/complications ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Post-Concussion Syndrome/complications ; Reaction Time ; Vision Disorders/diagnosis ; Vision Disorders/etiology ; Young Adult
Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062530-6
ISSN	1536-3724 ; 1050-642X
ISSN (online)	1536-3724
ISSN	1050-642X
DOI	10.1097/JSM.0000000000000381
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Zs.A 3120: Show issues

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Article ; Online: The effect of the creatine analogue beta-guanidinopropionic acid on energy metabolism: a systematic review.

Oudman, Inge / Clark, Joseph F / Brewster, Lizzy M

PloS one

2013 Volume 8, Issue 1, Page(s) e52879

Abstract: Background: Creatine kinase plays a key role in cellular energy transport. The enzyme transfers high-energy phosphoryl groups from mitochondria to subcellular sites of ATP hydrolysis, where it buffers ADP concentration by catalyzing the reversible ... ...

Abstract	Background: Creatine kinase plays a key role in cellular energy transport. The enzyme transfers high-energy phosphoryl groups from mitochondria to subcellular sites of ATP hydrolysis, where it buffers ADP concentration by catalyzing the reversible transfer of the high-energy phosphate moiety (P) between creatine and ADP. Cellular creatine uptake is competitively inhibited by beta-guanidinopropionic acid. This substance is marked as safe for human use, but the effects are unclear. Therefore, we systematically reviewed the effect of beta-guanidinopropionic acid on energy metabolism and function of tissues with high energy demands. Methods: We performed a systematic review and searched the electronic databases Pubmed, EMBASE, the Cochrane Library, and LILACS from their inception through March 2011. Furthermore, we searched the internet and explored references from textbooks and reviews. Results: After applying the inclusion criteria, we retrieved 131 publications, mainly considering the effect of chronic oral administration of beta-guanidinopropionic acid (0.5 to 3.5%) on skeletal muscle, the cardiovascular system, and brain tissue in animals. Beta-guanidinopropionic acid decreased intracellular creatine and phosphocreatine in all tissues studied. In skeletal muscle, this effect induced a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake and increased fatigue tolerance. In heart tissue this shift to mitochondrial metabolism was less pronounced. Myocardial contractility was modestly reduced, including a decreased ventricular developed pressure, albeit with unchanged cardiac output. In brain tissue adaptations in energy metabolism resulted in enhanced ATP stability and survival during hypoxia. Conclusion: Chronic beta-guanidinopropionic acid increases fatigue tolerance of skeletal muscle and survival during ischaemia in animal studies, with modestly reduced myocardial contractility. Because it is marked as safe for human use, there is a need for human data.
MeSH term(s)	Administration, Oral ; Animals ; Brain/drug effects ; Brain/metabolism ; Cardiovascular System/drug effects ; Cardiovascular System/metabolism ; Creatine Kinase/metabolism ; Energy Metabolism/drug effects ; Guanidines/administration & dosage ; Guanidines/pharmacology ; Humans ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Propionates/administration & dosage ; Propionates/pharmacology
Chemical Substances	Guanidines ; Propionates ; Creatine Kinase (EC 2.7.3.2) ; guanidinopropionic acid (UL1984YRKA)
Language	English
Publishing date	2013-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0052879
Database	MEDical Literature Analysis and Retrieval System OnLINE

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