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  1. AU="Clark, Sarah Elizabeth"
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  1. Artikel: Contextual assessment of the breadth and level of investments made by prevention initiatives to improve nutrition and prevent obesity in Los Angeles County, 2010-2015.

    Sutton, Katherine / Clark, Sarah Elizabeth / Thompson, Jack / Craypo, Lisa / Schwarte, Liz / Kuo, Tony

    Preventive medicine reports

    2019  Band 15, Seite(n) 100901

    Abstract: To better characterize and understand local investments made by prevention initiatives to address poor nutrition and obesity during 2010-2015, the Los Angeles County Department of Public Health partnered with an evaluation firm in 2014 to conduct a ... ...

    Abstract To better characterize and understand local investments made by prevention initiatives to address poor nutrition and obesity during 2010-2015, the Los Angeles County Department of Public Health partnered with an evaluation firm in 2014 to conduct a context scan of nutrition education programs (NEs) and policy, systems, and environmental change interventions (PSEs) in Los Angeles County (LAC). Using fiscal year 2012-2013 (FY12-13) as a midpoint for a before/after comparison based in part on the timeline of the last USDA Supplemental Nutrition Assistance Program Education (SNAP-Ed) funding cycle, the scan included both SNAP-Ed and non-SNAP-Ed initiatives. Systematic searches of peer-reviewed and grey literature, relevant organizations' websites and materials, and results from 51 key stakeholder interviews, were completed to help develop a context scan database for LAC. Thematic and content analyses of the context scan and interview data generated a "snapshot" of NE and PSE investments in the region. During the sampled period, at least $210 million was invested countywide to combat poor nutrition and obesity. Before FY12-13, 29 NEs and 33 PSEs were implemented. The PSEs included active transportation policies, healthy retail store conversions, and physical activity programming. NEs and PSEs increased to 50 and 98, respectively, after FY12-13. The context scan described the breadth and content of past and ongoing NEs and PSEs implemented by several prevention initiatives in LAC to improve nutrition and prevent obesity. Results suggest opportunities where SNAP-Ed can further tailor NE/PSE resources to address the needs of its target population.
    Sprache Englisch
    Erscheinungsdatum 2019-05-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2019.100901
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.

    Takahashi, Mariko / Chong, Harrison B / Zhang, Siwen / Yang, Tzu-Yi / Lazarov, Matthew J / Harry, Stefan / Maynard, Michelle / Hilbert, Brendan / White, Ryan D / Murrey, Heather E / Tsou, Chih-Chiang / Vordermark, Kira / Assaad, Jonathan / Gohar, Magdy / Dürr, Benedikt R / Richter, Marianne / Patel, Himani / Kryukov, Gregory / Brooijmans, Natasja /
    Alghali, Aliyu Sidi Omar / Rubio, Karla / Villanueva, Antonio / Zhang, Junbing / Ge, Maolin / Makram, Farah / Griesshaber, Hanna / Harrison, Drew / Koglin, Ann-Sophie / Ojeda, Samuel / Karakyriakou, Barbara / Healy, Alexander / Popoola, George / Rachmin, Inbal / Khandelwal, Neha / Neil, Jason R / Tien, Pei-Chieh / Chen, Nicholas / Hosp, Tobias / van den Ouweland, Sanne / Hara, Toshiro / Bussema, Lillian / Dong, Rui / Shi, Lei / Rasmussen, Martin Q / Domingues, Ana Carolina / Lawless, Aleigha / Fang, Jacy / Yoda, Satoshi / Nguyen, Linh Phuong / Reeves, Sarah Marie / Wakefield, Farrah Nicole / Acker, Adam / Clark, Sarah Elizabeth / Dubash, Taronish / Kastanos, John / Oh, Eugene / Fisher, David E / Maheswaran, Shyamala / Haber, Daniel A / Boland, Genevieve M / Sade-Feldman, Moshe / Jenkins, Russell W / Hata, Aaron N / Bardeesy, Nabeel M / Suvà, Mario L / Martin, Brent R / Liau, Brian B / Ott, Christopher J / Rivera, Miguel N / Lawrence, Michael S / Bar-Peled, Liron

    Cell

    2024  Band 187, Heft 10, Seite(n) 2536–2556.e30

    Abstract: Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this ... ...

    Abstract Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed "DrugMap," an atlas of cysteine ligandability compiled across 416 cancer cell lines. We unexpectedly find that cysteine ligandability varies across cancer cell lines, and we attribute this to differences in cellular redox states, protein conformational changes, and genetic mutations. Leveraging these findings, we identify actionable cysteines in NF-κB1 and SOX10 and develop corresponding covalent ligands that block the activity of these transcription factors. We demonstrate that the NF-κB1 probe blocks DNA binding, whereas the SOX10 ligand increases SOX10-SOX10 interactions and disrupts melanoma transcriptional signaling. Our findings reveal heterogeneity in cysteine ligandability across cancers, pinpoint cell-intrinsic features driving cysteine targeting, and illustrate the use of covalent probes to disrupt oncogenic transcription-factor activity.
    Mesh-Begriff(e) Animals ; Humans ; Mice ; Cell Line, Tumor ; Cysteine/metabolism ; Cysteine/chemistry ; Ligands ; Melanoma/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; NF-kappa B/chemistry ; NF-kappa B/metabolism ; Oxidation-Reduction ; Signal Transduction ; SOXE Transcription Factors/chemistry ; SOXE Transcription Factors/metabolism
    Chemische Substanzen Cysteine (K848JZ4886) ; Ligands ; NF-kappa B ; SOX10 protein, human ; SOXE Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2024-04-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.03.027
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.

    Takahashi, Mariko / Chong, Harrison B / Zhang, Siwen / Lazarov, Matthew J / Harry, Stefan / Maynard, Michelle / White, Ryan / Murrey, Heather E / Hilbert, Brendan / Neil, Jason R / Gohar, Magdy / Ge, Maolin / Zhang, Junbing / Durr, Benedikt R / Kryukov, Gregory / Tsou, Chih-Chiang / Brooijmans, Natasja / Alghali, Aliyu Sidi Omar / Rubio, Karla /
    Vilanueva, Antonio / Harrison, Drew / Koglin, Ann-Sophie / Ojeda, Samuel / Karakyriakou, Barbara / Healy, Alexander / Assaad, Jonathan / Makram, Farah / Rachman, Inbal / Khandelwal, Neha / Tien, Pei-Chieh / Popoola, George / Chen, Nicholas / Vordermark, Kira / Richter, Marianne / Patel, Himani / Yang, Tzu-Yi / Griesshaber, Hanna / Hosp, Tobias / van den Ouweland, Sanne / Hara, Toshiro / Bussema, Lily / Dong, Rui / Shi, Lei / Rasmussen, Martin Q / Domingues, Ana Carolina / Lawless, Aleigha / Fang, Jacy / Yoda, Satoshi / Nguyen, Linh Phuong / Reeves, Sarah Marie / Wakefield, Farrah Nicole / Acker, Adam / Clark, Sarah Elizabeth / Dubash, Taronish / Fisher, David E / Maheswaran, Shyamala / Haber, Daniel A / Boland, Genevieve / Sade-Feldman, Moshe / Jenkins, Russel / Hata, Aaron / Bardeesy, Nabeel / Suva, Mario L / Martin, Brent / Liau, Brian / Ott, Christopher / Rivera, Miguel N / Lawrence, Michael S / Bar-Peled, Liron

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this ... ...

    Abstract Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed
    Sprache Englisch
    Erscheinungsdatum 2023-10-23
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.20.563287
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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