Article: Patterns of fos expression in the rostral medulla and caudal pons evoked by noxious craniovascular stimulation and periaqueductal gray stimulation in the cat.
2005 Volume 1045, Issue 1-2, Page(s) 1–11
Abstract: Functional imaging studies and clinical evidence suggest that structures in the brainstem contribute to migraine pathophysiology with a strong association between the brainstem areas, such as periaqueductal gray (PAG), and the headache phase of migraine. ...
| Abstract | Functional imaging studies and clinical evidence suggest that structures in the brainstem contribute to migraine pathophysiology with a strong association between the brainstem areas, such as periaqueductal gray (PAG), and the headache phase of migraine. Stimulation of the superior sagittal sinus (SSS) in humans evokes head pain. Second-order neurons in the trigeminal nucleus that are activated by SSS stimulation can be inhibited by PAG stimulation. The present study was undertaken to identify pontine and medullary structures that respond to noxious stimulation of the superior sagittal sinus or to ventrolateral PAG stimulation. The distribution of neurons expressing the protein product (fos) of the c-fos immediate early gene were examined in the rostral medulla and caudal pons of the cat after (i) sham, (ii) stimulation of the superior sagittal sinus, (iii) stimulation of the superior sagittal sinus with PAG stimulation, or (iv) stimulation of the PAG alone. The structures examined for fos were the trigeminal nucleus, infratrigeminal nucleus, reticular nuclei, nucleus raphe magnus, pontine blink premotor area, and superior salivatory nucleus. Compared with all other interventions, fos expression was significantly greater in the trigeminal nucleus and superior salivatory nucleus after SSS stimulation. After PAG with SSS stimulation, on the side ipsilateral to the site of PAG stimulation, fos was significantly greater in the nucleus raphe magnus. These structures are likely to be involved in the neurobiology of migraine. |
|---|---|
| MeSH term(s) | Afferent Pathways/anatomy & histology ; Afferent Pathways/physiology ; Animals ; Brain Mapping ; Cats ; Cerebrovascular Circulation ; Cranial Sinuses/innervation ; Cranial Sinuses/physiopathology ; Disease Models, Animal ; Immunohistochemistry ; Medulla Oblongata/anatomy & histology ; Medulla Oblongata/physiology ; Migraine Disorders/physiopathology ; Nociceptors/physiology ; Parasympathetic Nervous System/anatomy & histology ; Parasympathetic Nervous System/physiology ; Periaqueductal Gray/anatomy & histology ; Periaqueductal Gray/physiology ; Pons/anatomy & histology ; Pons/physiology ; Proto-Oncogene Proteins c-fos/metabolism ; Raphe Nuclei/anatomy & histology ; Raphe Nuclei/physiology ; Reticular Formation/anatomy & histology ; Reticular Formation/physiology ; Trigeminal Nuclei/anatomy & histology ; Trigeminal Nuclei/physiology |
| Chemical Substances | Proto-Oncogene Proteins c-fos |
| Language | English |
| Publishing date | 2005-05-31 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1200-2 |
| ISSN | 1872-6240 ; 0006-8993 |
| ISSN (online) | 1872-6240 |
| ISSN | 0006-8993 |
| DOI | 10.1016/j.brainres.2005.01.091 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 161: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.