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  1. Article ; Online: Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy

    Hilal Kalkan / Ester Pagano / Debora Paris / Elisabetta Panza / Mariarosaria Cuozzo / Claudia Moriello / Fabiana Piscitelli / Armita Abolghasemi / Elisabetta Gazzerro / Cristoforo Silvestri / Raffaele Capasso / Andrea Motta / Roberto Russo / Vincenzo Di Marzo / Fabio Arturo Iannotti

    EMBO Molecular Medicine, Vol 15, Iss 3, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Nothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal microbiota composition along with circulating levels of short‐chain fatty acids (SCFAs) and related metabolites ...

    Abstract Abstract Nothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal microbiota composition along with circulating levels of short‐chain fatty acids (SCFAs) and related metabolites are altered in the mdx mouse model of Duchenne muscular dystrophy (DMD) compared with healthy controls. Supplementation with sodium butyrate (NaB) in mdx mice rescued muscle strength and autophagy, and prevented inflammation associated with excessive endocannabinoid signaling at CB1 receptors to the same extent as deflazacort (DFZ), the standard palliative care for DMD. In LPS‐stimulated C2C12 myoblasts, NaB reduces inflammation, promotes autophagy, and prevents dysregulation of microRNAs targeting the endocannabinoid CB1 receptor gene, in a manner depending on the activation of GPR109A and PPARγ receptors. In sum, we propose a novel disease‐modifying approach in DMD that may have benefits also in other muscular dystrophies.
    Keywords autophagy ; duchenne muscular dystrophy ; endocannabinoid system ; gut microbiota ; short‐chain fatty acids ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Subject code 571
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Molecular Alterations in Spermatozoa of a Family Case Living in the Land of Fires. A First Look at Possible Transgenerational Effects of Pollutants

    Gennaro Lettieri / Federica Marra / Claudia Moriello / Marina Prisco / Tiziana Notari / Marco Trifuoggi / Antonella Giarra / Liana Bosco / Luigi Montano / Marina Piscopo

    International Journal of Molecular Sciences, Vol 21, Iss 6710, p

    2020  Volume 6710

    Abstract: In our previous work, we reported alterations in protamines/histones ratio, in DNA binding of these proteins and their involvement in DNA oxidative damage in 84% of the young men living in the Land of Fires. In the present work, we extended our findings, ...

    Abstract In our previous work, we reported alterations in protamines/histones ratio, in DNA binding of these proteins and their involvement in DNA oxidative damage in 84% of the young men living in the Land of Fires. In the present work, we extended our findings, evaluating any alterations in spermatozoa of a family case, a father and son, living in this area, to also give a first look at the possibility of transgenerational inherited effects of environmental contaminants on the molecular alterations of sperm nuclear basic proteins (SNBP), DNA and semen parameters. In the father and son, we found a diverse excess of copper and chromium in the semen, different alterations in SNBP content and low DNA binding affinity of these proteins. In addition, DNA damage, in the presence of CuCl 2 and H 2 O 2 , increased by adding both the father and son SNBP. Interestingly, son SNBP, unlike his father, showed an unstable DNA binding and were able to produce DNA damage even without external addition of CuCl 2 , in line with a lower seminal antioxidant activity than the father. The peculiarity of some characteristics of son semen could be a basis for possible future studies on transgenerational effects of pollutants on fertility.
    Keywords human spermatozoa ; human protamines ; Land of Fires ; DNA oxidative damage ; protein-DNA binding ; heavy metals ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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