LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Origens, distribuicoes e ramificacoes das arterias linguais em suinos da linhagem rezende

    Roberto Bernardino Junior / Renato Souto Severino / Claudio Silva Teixeira

    Bioscience Journal, Vol 19, Iss

    2006  Volume 1

    Abstract: No contexto da medicina veterinária, a morfologia tem importante papel no incremento de informações para a emergente área da odontologia animal. Com o objetivo de se conhecer melhor a irrigação da língua, buscou-se estudar as origens, ramificações e ... ...

    Abstract No contexto da medicina veterinária, a morfologia tem importante papel no incremento de informações para a emergente área da odontologia animal. Com o objetivo de se conhecer melhor a irrigação da língua, buscou-se estudar as origens, ramificações e distribuições das artérias linguais direita e esquerda em suínos da linhagem Rezende. Constatou-se que as artérias linguais tiveram, em 100,0% dos animais estudados, suas origens rostralmente aos segmentos iniciais das artérias carótidas externas e que cada uma delas emitiu cerca de 9 (nove) colaterais que foram agrupados e nominados de acordo com suas áreas de distribuição, que se fizeram notar na região ventral da cavidade oral. Utilizando-se o teste t para observações pareadas, em proporções, viu-se que quando comparadas as artérias linguais direita e esquerda em 2 (dois) de seus colaterais encontrou-se diferenças estatisticamente significantes. UNITERMOS: Suíno, Artérias linguais, Origens, Ramificações, Distribuições.
    Keywords Suino ; Arterias linguais ; Origens ; Ramificacoes ; Distribuicoes ; Agriculture ; S ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2006-03-01T00:00:00Z
    Publisher Universidade Federal de Uberlândia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis

    Lázaro de Sousa Fideles / João Antônio Leal de Miranda / Conceição da Silva Martins / Maria Lucianny Lima Barbosa / Helder Bindá Pimenta / Paulo Vitor de Souza Pimentel / Claudio Silva Teixeira / Marina Alves Sampaio Scafuri / Samuel de Osterno Façanha / João Erivan Façanha Barreto / Poliana Moreira de Medeiros Carvalho / Ariel Gustavo Scafuri / Joabe Lima Araújo / Jefferson Almeida Rocha / Icaro Gusmão Pinto Vieira / Nágila Maria Pontes Silva Ricardo / Matheus da Silva Campelo / Maria Elenir Nobre Pinho Ribeiro / Gerly Anne de Castro Brito /
    Gilberto Santos Cerqueira

    Molecules, Vol 25, Iss 2786, p

    Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress

    2020  Volume 2786

    Abstract: Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from ... ...

    Abstract Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from Dimorphandra gardneriana , exhibits antioxidant, anti-inflammatory, cytoprotective, and gastroprotective properties. However, the effect of RUT on inflammatory processes in the intestine, especially on mucositis promoted by antineoplastic agents, has not yet been reported. In this study, we investigated the role of RUT on 5-FU-induced experimental intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, RUT-50, RUT-100, RUT-200, Celecoxib (CLX), and CLX + RUT-200 groups. The mice were weighed daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis); malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH) concentrations; mast and goblet cell counts; and cyclooxygenase-2 (COX-2) activity, as well as to perform immunohistochemical analyses. RUT treatment (200 mg/kg) prevented 5-FU-induced histopathological changes and reduced oxidative stress by decreasing MDA concentrations and increasing GSH concentrations. RUT attenuated the inflammatory response by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. These results suggest that the COX-2 pathway is one of the underlying protective mechanisms of RUT against 5-FU-induced intestinal mucositis.
    Keywords flavonoid ; inflammation ; antimetabolites ; intestine ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa

    João Antônio Leal de Miranda / Conceição da Silva Martins / Lázaro de Sousa Fideles / Maria Lucianny Lima Barbosa / João Erivan Façanha Barreto / Helder Bindá Pimenta / Francisco Orlando Rafael Freitas / Paulo Vitor de Souza Pimentel / Claudio Silva Teixeira / Ariel Gustavo Scafuri / Maria Claudia dos Santos Luciano / Joabe Lima Araújo / Jefferson Almeida Rocha / Icaro Gusmão Pinto Vieira / Nágila Maria Pontes Silva Ricardo / Matheus da Silva Campelo / Maria Elenir Nobre Pinho Ribeiro / Gerly Anne de Castro Brito / Gilberto Santos Cerqueira

    Pharmaceuticals, Vol 13, Iss 1, p

    Role of Cyclooxygenase-2 Pathway

    2020  Volume 10

    Abstract: Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), a semi-synthetic flavonoid extracted from Dimorphandra gardneriana , has been reported as a potent ... ...

    Abstract Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), a semi-synthetic flavonoid extracted from Dimorphandra gardneriana , has been reported as a potent antioxidant and anti-inflammatory agent. In the present study, we aimed to evaluate the effect of TRX on 5-FU-induced intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, TRX-50, TRX-100, TRX-150, Celecoxib (CLX), and CLX + TRX-100. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), mast and goblet cell counts, immunohistochemical analysis, and cyclooxygenase-2 (COX-2) activity. Compared to the saline treatment, the 5-FU treatment induced intense weight loss and reduction in villus height. TRX treatment (100 mg/kg) prevented the 5-FU-induced histopathological changes and decreased oxidative stress by decreasing the MDA levels and increasing GSH concentration. TRX attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. TRX also reversed the depletion of goblet cells. Our findings suggest that TRX at a concentration of 100 mg/kg had chemopreventive effects on 5-FU-induced intestinal mucositis via COX-2 pathway.
    Keywords chemoprevention ; inflammation ; flavonoid ; intestine ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Topografia dos forames mentonianos laterais em suinos das linhagens Agroceres e Seghers genetics do Brasil

    Aline Gomes de Moura / Roberto Bernardino Junior / Renato Souto Severino / Claudio Silva Teixeira

    Bioscience Journal, Vol 22, Iss

    2007  Volume 2

    Abstract: A odontologia animal é uma área emergente e de extrema importância da medicina veterinária. Objetivando ampliar os conhecimentos desta área, e que também serão de grande valor em testes comparativos com humanos, foram estudados topograficamente e ... ...

    Abstract A odontologia animal é uma área emergente e de extrema importância da medicina veterinária. Objetivando ampliar os conhecimentos desta área, e que também serão de grande valor em testes comparativos com humanos, foram estudados topograficamente e numericamente os forames mentonianos laterais em hemimandíbulas de suínos das linhagens Agroceres e Seghers Genetics do Brasil com idades variando de 150 a 170 dias. Usando como referência o terceiro pré-molar decíduo inferior, observou -se que o mais posterior dos forames mentonianos laterais, em 95,2% das hemimandíbulas estudadas está localizado no nível deste dente, sendo que os forames mentonianos laterais mais anteriores estão irregularmente dispostos rostralmente ao supracitado. Os forames mentonianos laterais são em número de três em 61,9% dos casos observados, sendo que no sentido ventro dorsal, todos observados estão localizados no terço médio do corpo da mandíbula. Com base nestas observações ter-se-á maior segurança na execução de uma intervenção operatória nesta região e de se anestesiar, caso necessário, o nervo mental que aí se faz presente.
    Keywords Suinos ; Forames mentonianos laterais ; Topografia ; Agriculture ; S ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2007-01-01T00:00:00Z
    Publisher Universidade Federal de Uberlândia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top