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Article: Les 14es Journées scientifiques de l’Afipp.

Bressollette-Bodin, Céline / Touzé, Antoine / Jung, Alain / Herfs, Michael / Lepiller, Quentin / Bravo, Ignacio / Péré, Hélène / Clavel, Christine

Virologie (Montrouge, France)

2024 Volume 28, Issue 1, Page(s) 44–54

Title translation	The 14th Afipp scientific days.
Language	French
Publishing date	2024-02-21
Publishing country	France
Document type	Journal Article
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/vir.2024.1037
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Article ; Online: Immunotherapy in non-small-cell lung cancer: from targeted molecules to resistance patterns.

Brassart-Pasco, Sylvie / Dalstein, Véronique / Brassart, Bertrand / Dewolf, Maxime / Clavel, Christine / Oudart, Jean-Baptiste

Pharmacogenomics

2020 Volume 21, Issue 10, Page(s) 705–720

Abstract: Immunotherapies are now considered as a pillar of non-small-cell lung cancer treatment. The main targets of immune-checkpoint inhibitors (ICI) are programmed cell death 1/programmed cell death ligand 1 and cytotoxic T-lymphocyte antigen 4, aiming at ... ...

Abstract	Immunotherapies are now considered as a pillar of non-small-cell lung cancer treatment. The main targets of immune-checkpoint inhibitors (ICI) are programmed cell death 1/programmed cell death ligand 1 and cytotoxic T-lymphocyte antigen 4, aiming at restoring antitumor immunity. Despite durable responses observed in some patients, all patients do not benefit from the treatment and almost all responders ultimately relapse after some time. In this review, we discuss the biomarkers that could be used to predict response to ICI, the current indications of ICI in non-small-cell lung cancer, the mechanisms inducing tumor-cell intrinsic or extrinsic resistance to ICI and finally, the potential treatment response monitoring.
MeSH term(s)	Biomarkers, Tumor/immunology ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/therapy ; Humans ; Immune Checkpoint Inhibitors/immunology ; Immune System/immunology ; Immunotherapy/methods ; Lung Neoplasms/immunology ; Lung Neoplasms/therapy ; Signal Transduction/immunology
Chemical Substances	Biomarkers, Tumor ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/pgs-2020-0021
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Zs.A 5247: Show issues

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Article ; Online: No association of endothelial lipase and aldose reductase polymorphisms with proliferative diabetic retinopathy: Results of the French prospective multicenter REDIAGEN study.

Diabetes & metabolism

2024 Volume 50, Issue 3, Page(s) 101533

MeSH term(s)	Humans ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/epidemiology ; Aldehyde Reductase/genetics ; Lipase/genetics ; Male ; Prospective Studies ; Female ; France/epidemiology ; Middle Aged ; Aged ; Polymorphism, Single Nucleotide
Chemical Substances	LIPG protein, human
Language	English
Publishing date	2024-04-01
Publishing country	France
Document type	Letter ; Multicenter Study
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2024.101533
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Zs.A 1267: Show issues

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Article ; Online: High levels of HPV16-L1 antibody but not HPV16 DNA load or integration predict oropharyngeal patient outcome: The Papillophar study.

Prétet, Jean-Luc / Dalstein, Véronique / Touzé, Antoine / Beby-Defaux, Agnès / Soussan, Patrick / Jacquin, Élise / Birembaut, Philippe / Clavel, Christine / Mougin, Christiane / Rousseau, Alexandra / Lacau Saint Guily, Jean

Clinical and experimental medicine

2022 Volume 23, Issue 1, Page(s) 87–96

Abstract: The incidence of oropharyngeal cancers (OPC) is increasing in the world. Among OPC, those induced by human papillomaviruses have a better prognosis than non-HPV-associated OPC. The objective of this study was to highlight the relevance of HPV16 load, ... ...

Abstract	The incidence of oropharyngeal cancers (OPC) is increasing in the world. Among OPC, those induced by human papillomaviruses have a better prognosis than non-HPV-associated OPC. The objective of this study was to highlight the relevance of HPV16 load, HPV16 DNA integration and HPV16-L1 serology on progression-free survival and overall survival of OPC patients. The PAPILLOPHAR cohort consists of 362 patients with oropharyngeal squamous cell carcinomas prospectively followed up for 5 years after treatment. Tumor biopsies and sera were collected at inclusion to investigate tumor HPV DNA/RNA characteristics and HPV16 L1 serology, respectively. Twenty-seven percent of tumor biopsies were HPV DNA- and RNA-positive and HPV16 represented 93% of HPV-positive cases. Among them, neither HPV16 viral load nor HPV16 DNA integration was associated with overall survival (OS) or progression-free survival (PFS). In contrast, high anti-HPV16 L1 antibody titers were significantly associated with a better OS and PFS. This study reveals that HPV16 load and integration are not relevant prognosis biomarkers in OPC patients.Clinical Relevance: High levels of HPV16 L1 antibodies may be useful to predict OPC patient outcome following treatment.ClinicalTrials.gov Identifier: NCT00918710, May 2017.
MeSH term(s)	Humans ; Human papillomavirus 16/genetics ; Antibodies, Viral ; Oropharyngeal Neoplasms/pathology ; Prognosis ; DNA, Viral/genetics
Chemical Substances	Antibodies, Viral ; DNA, Viral
Language	English
Publishing date	2022-02-23
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-022-00796-2
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Zs.A 5481: Show issues

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Article ; Online: Development and interlaboratory agreement of real-time PCR for HPV16 quantification in liquid-based cervical samples.

Guenat, David / Dalstein, Véronique / Mauny, Frédéric / Saunier, Maëlle / Briolat, Jenny / Clavel, Christine / Riethmuller, Didier / Mougin, Christiane / Prétet, Jean-Luc

Papillomavirus research (Amsterdam, Netherlands)

2018 Volume 6, Page(s) 27–32

Abstract: High risk HPV infection is the necessary cause for the development of precancerous and cancerous lesions of the cervix. Among HPV, HPV16 represents the most carcinogenic type. Since the determination of HPV16 DNA load could be clinically useful, we ... ...

Abstract	High risk HPV infection is the necessary cause for the development of precancerous and cancerous lesions of the cervix. Among HPV, HPV16 represents the most carcinogenic type. Since the determination of HPV16 DNA load could be clinically useful, we assessed quantitative real-time PCR targeting E6HPV16 and albumin genes on two different platforms. Series of SiHa cells diluted in PreservCyt were used to assess repeatability and reproducibility of two in-house real-time PCR techniques run in two different laboratories to determine HPV16 load. Furthermore, 97 HPV16 positive cervical samples were evaluated to estimate inter-center variability using Bland-Alman plots. As a whole, both techniques presented coefficients of variation for HPV16 load measurement similar to those established for other virus quantification with commercial kits. Moreover, the two real-time PCR techniques showed a very good agreement for HPV16 load calculation. Finally, we emphasize that robust HPV16 DNA quantification requires normalization of viral load by the cell number.
MeSH term(s)	Cervix Uteri/virology ; Female ; Human papillomavirus 16/genetics ; Human papillomavirus 16/isolation & purification ; Humans ; Oncogene Proteins, Viral/genetics ; Papillomavirus Infections/virology ; Real-Time Polymerase Chain Reaction/methods ; Repressor Proteins/genetics ; Reproducibility of Results ; Viral Load/methods
Chemical Substances	E6 protein, Human papillomavirus type 16 ; Oncogene Proteins, Viral ; Repressor Proteins
Language	English
Publishing date	2018-10-18
Publishing country	Netherlands
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2837553-1
ISSN	2405-8521 ; 2405-8521
ISSN (online)	2405-8521
ISSN	2405-8521
DOI	10.1016/j.pvr.2018.10.003
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Article ; Online: Prevalence of human papillomavirus in tonsil brushings and gargles in cancer-free patients: The SPLIT study.

Combes, Jean-Damien / Dalstein, Véronique / Gheit, Tarik / Clifford, Gary M / Tommasino, Massimo / Clavel, Christine / Lacau St Guily, Jean / Franceschi, Silvia

Oral oncology

2017 Volume 66, Page(s) 52–57

Abstract: Objective: To evaluate human papillomavirus (HPV) prevalence in the tonsil using extensive ex vivo brushing and gargling in a large age-stratified sample of cancer-free patients.: Materials and methods: From 2012 to 2016, consecutive patients ... ...

Abstract	Objective: To evaluate human papillomavirus (HPV) prevalence in the tonsil using extensive ex vivo brushing and gargling in a large age-stratified sample of cancer-free patients. Materials and methods: From 2012 to 2016, consecutive patients undergoing tonsillectomy for benign indications in 19 French University Hospitals were invited to participate in the SPLIT study. Immediately after resection, half-tonsils were extensively brushed at the pathology laboratories on the surface epithelium and in tonsil crypts to collect exfoliated cells. In 11 centers, patients aged 15 and over (adults) were also asked to provide gargle samples before surgery. HPV-DNA detection used a very sensitive Luminex technology to evaluate 21 HPV types. Results: Tonsil brushings from 692 patients aged 1-70 years and gargles from 268 adults were tested for HPV. Among adults, overall HPV prevalence was 3.6% in tonsil brushings and 13.1% in gargles and HPV16 prevalence was 2.2% and 4.1%, respectively. Among 139 children, tonsil brushings were positive in two girls (1.4%). Percent agreement in HPV detection in paired tonsil brushings and gargles in adults was 85.8% and positive agreement 9.5%. HPV prevalence in gargles significantly varied by sex (prevalence ratio in men vs women=2.1; 95% confidence interval; 1.1-4.1) and tonsillectomy indication (non-infectious vs. infectious=4.9; 1.4-17.0). Conclusion: HPV infection is infrequent in tonsil brushings of cancer-free children and adults. In contrast, HPV infection in gargles in adults is rather common. Low agreement in paired tonsil brushings and gargles suggests that gargle is not representative of HPV prevalence in the tonsil.
MeSH term(s)	Adolescent ; Adult ; Aged ; Alphapapillomavirus/isolation & purification ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Middle Aged ; Palatine Tonsil/virology ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/virology ; Saliva/virology ; Tumor Virus Infections/diagnosis ; Tumor Virus Infections/virology ; Young Adult
Language	English
Publishing date	2017-01-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2017.01.001
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article: DNA demethylation agent 5azadC downregulates HPV16 E6 expression in cervical cancer cell lines independently of TBX2 expression.

Perrard, Jerome / Morel, Adrien / Meznad, Koceila / Paget-Bailly, Philippe / Dalstein, Veronique / Guenat, David / Mourareau, Celine / Clavel, Christine / Fauconnet, Sylvie / Baguet, Aurelie / Mougin, Christiane / Pretet, Jean-Luc

Oncology letters

2019 Volume 19, Issue 1, Page(s) 1074–1081

Abstract: HPV16 is the most carcinogenic human papillomavirus and causes >50% of cervical cancers, the majority of anal cancers and 30% of oropharyngeal squamous cell carcinomas. HPV carcinogenesis relies on the continuous expression of the two main viral ... ...

Abstract	HPV16 is the most carcinogenic human papillomavirus and causes >50% of cervical cancers, the majority of anal cancers and 30% of oropharyngeal squamous cell carcinomas. HPV carcinogenesis relies on the continuous expression of the two main viral oncoproteins E6 and E7 that target >150 cellular proteins. Among them, epigenetic modifiers, including DNA Methyl Transferases (DNMT), are dysregulated, promoting an aberrant methylation pattern in HPV-positive cancer cells. It has been previously reported that the treatment of HPV-positive cervical cancer cells with DNMT inhibitor 5-aza-2'-deoxycytidine (5azadC) caused the downregulation of E6 expression due to mRNA destabilization that was mediated by miR-375. Recently, the T-box transcription factor 2 (TBX2) has been demonstrated to repress HPV LCR activity. In the current study, the role of TBX2 in E6 repression was investigated in HPV16 cervical cancer cell lines following 5azadC treatment. A decrease of E6 expression was accompanied by p53 and p21 restoration. While TBX2 mRNA was upregulated in 5azadC-treated SiHa and Ca Ski cells, TBX2 protein was not detectable. Furthermore, the overexpression of TBX2 protein in cervical cancer cells did not allow the repression of E6 expression. The TBX2 transcription factor is therefore unlikely to be associated with the repression of E6 following 5azadC treatment of SiHa and Ca Ski cells.
Language	English
Publishing date	2019-11-28
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2019.11158
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Article ; Online: Prevalence and risk factors of human polyomavirus infections in non-malignant tonsils and gargles: the SPLIT study.

Kourieh, Aboud / Combes, Jean-Damien / Tommasino, Massimo / Dalstein, Véronique / Clifford, Gary M / Lacau St Guily, Jean / Clavel, Christine / Franceschi, Silvia / Gheit, Tarik / For The Split Study Group

The Journal of general virology

2018 Volume 99, Issue 12, Page(s) 1686–1698

Abstract: The prevalence of 13 polyomaviruses (PyVs) in the tonsil brushings and gargles of immunocompetent children and adults was assessed. Patients undergoing tonsillectomy for benign indications were recruited in 19 centres in France. After resection, the ... ...

Abstract	The prevalence of 13 polyomaviruses (PyVs) in the tonsil brushings and gargles of immunocompetent children and adults was assessed. Patients undergoing tonsillectomy for benign indications were recruited in 19 centres in France. After resection, the entire outer surface of the right and left halves of the tonsils was brushed extensively. Gargles were also collected prior to surgery in selected adults. A species-specific multiplex assay was used to detect the DNA of 13 PyVs. In tonsil brushings (n=689), human PyV 6 (HPyV6) and Merkel cell PyV (MCPyV) were the most prevalent (≈15 %), followed by trichodysplasia spinulosa-associated PyV (TSPyV), BKPyV, Washington University PyV (WUPyV) and human PyV 9 (HPyV9) (1 to 5 %), and human PyV 7 (HPyV7), John Cunningham PyV (JCPyV) and Simian virus 40 (SV40) (<1 %), while no Karolinska Institute PyV (KIPyV), Malawi PyV (MWPyV), human PyV 12 (HPyV12) or Lyon IARC PyV (LIPyV) were detected. The prevalence of TSPyV and BKPyV was significantly higher in children versus adults, whereas for HPyV6 the opposite was found. HPyV6 and WUPyV were significantly more prevalent in men versus women. In gargles (n=139), MCPyV was the most prevalent (≈40 %), followed by HPyV6, HPyV9 and LIPyV (2 to 4 %), and then BKPyV (≈1 %), while other PyVs were not detected. MCPyV and LIPyV were significantly more prevalent in gargles compared to tonsil brushings, in contrast to HPyV6. We described differing patterns of individual PyV infections in tonsils and gargles in a large age-stratified population. Comparison of the spectrum of PyVs in paired tonsil samples and gargles adds to the current knowledge on PyV epidemiology, contributing towards a better understanding of PyV acquisition and transmission and its potential role in head and neck diseases.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; DNA, Viral/analysis ; DNA, Viral/genetics ; Female ; France/epidemiology ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction ; Palatine Tonsil/virology ; Pharynx/virology ; Polyomavirus/classification ; Polyomavirus/isolation & purification ; Polyomavirus Infections/epidemiology ; Polyomavirus Infections/virology ; Prevalence ; Risk Factors ; Therapeutic Irrigation ; Young Adult
Chemical Substances	DNA, Viral
Language	English
Publishing date	2018-11-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219316-4
ISSN	1465-2099 ; 0022-1317
ISSN (online)	1465-2099
ISSN	0022-1317
DOI	10.1099/jgv.0.001156
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Zs.A 610: Show issues

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Article ; Online: Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study.

Kourieh, Aboud / Gheit, Tarik / Tommasino, Massimo / Dalstein, Véronique / Clifford, Gary M / Lacau St Guily, Jean / Clavel, Christine / Franceschi, Silvia / Combes, Jean-Damien

Journal of medical virology

2018 Volume 91, Issue 4, Page(s) 687–697

Abstract: Objective: To assess the prevalence of all known human herpesviruses (HHV) in tonsils of an age-stratified large sample of immunocompetent children and adults.: Methods: Patients undergoing tonsillectomy for benign indications were recruited in 19 ... ...

Abstract	Objective: To assess the prevalence of all known human herpesviruses (HHV) in tonsils of an age-stratified large sample of immunocompetent children and adults. Methods: Patients undergoing tonsillectomy for benign indications were recruited in 19 French hospitals. After resection, the entire outer surfaces of right and left half tonsils were extensively brushed. A highly sensitive species-specific multiplex assay was used to detect herpes simplex virus 1 (HSV1), HSV2, Epstein-Barr virus (EBV; types 1 and 2), and human cytomegalovirus (CMV) DNA in 688, as well as varicella zoster virus (VZV), HHV6A, HHV6B, HHV7, and Kaposi's sarcoma-associated herpesvirus (KSHV) DNA in a subset of 440 tonsil brushings. Results: Overall 85% of tonsil brushing samples were infected with at least one HHV species. HHV7 and EBV were the most prevalent (≈70%), followed by HHV6B (≈50%), HSV1, CMV, VZV (≈2%), and KSHV and HSV2 (<1%), while HHV6A was not detected. EBV prevalence was significantly higher in adults than in children, whereas it was opposite for HHV6B and VZV. No difference in HHV prevalence was observed by sex. In multivariate analysis, EBV detection was associated with age greater than or equal to 15 years (prevalence ratio [PR] = 1.8; 95% confidence interval [CI]: 1.5-2.3) and marginally with tobacco smoking (PR = 1.2; 95% CI: 1.1-1.3). Conclusion: Differing patterns of HHV infection in tonsils in a large age-stratified population were described. This study is by far the largest available and shows that EBV, HHV6B, and HHV7 are commonly detected in the tonsils in both men and women, in contrast to other HHVs.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Epidemiologic Studies ; Female ; France/epidemiology ; Herpesviridae/classification ; Herpesviridae/isolation & purification ; Herpesviridae Infections/epidemiology ; Herpesviridae Infections/virology ; Humans ; Infant ; Male ; Middle Aged ; Palatine Tonsil/virology ; Prevalence ; Young Adult
Language	English
Publishing date	2018-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.25338
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Article ; Online: Human papillomavirus type 16 E6 variants in France and risk of viral persistence

Cornet Iris / Gheit Tarik / Clifford Gary M / Combes Jean-Damien / Dalstein Véronique / Franceschi Silvia / Tommasino Massimo / Clavel Christine

Infectious Agents and Cancer, Vol 8, Iss 1, p

2013 Volume 4

Abstract: Abstract Background Only a small portion of HPV 16 infections persist and can lead to cervical intraepithelial lesions and cancer. Factors that favour HPV persistence versus clearance are still poorly understood, but several studies have suggested that ... ...

Abstract	Abstract Background Only a small portion of HPV 16 infections persist and can lead to cervical intraepithelial lesions and cancer. Factors that favour HPV persistence versus clearance are still poorly understood, but several studies have suggested that HPV intra-type variants may influence persistence and clinical outcome. The aim of this study was to assess the possible association between HPV 16 variants and the risk for viral persistence in the general population of France. Methods One hundred and forty two women infected with HPV 16 with normal cytology, without previous treatment for cervical lesions, and with a valid second follow-up visit 4 to 16 months later, were selected from patients participating in routine cervical cancer screening in the Reims HPV Primary Screening Cohort Study. HPV intra-type variants were determined by sequencing the HPV 16 E6 open reading frame, and were compared for viral persistence at the second visit using odds ratios (OR) to estimate relative risk. Results Although no statistically significant differences in risk for persistence were observed by the HPV 16 variant lineage, European variants containing the polymorphism 350 T (EUR-350 T) appeared to persist more often than those containing 350 G (EUR-350 G) (OR = 1.6, 95% CI = 0.8-3.4). Conclusions No strong differences were observed in the risk of viral persistence for the HPV 16 variants that predominate in France.
Keywords	Cervical cancer screening ; Cohort ; Polymorphism ; HPV ; Variants ; Persistence ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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