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  1. Article ; Online: Introducing the Office of Autoimmune Disease Research.

    Shanmugam, Victoria K / Clayton, Janine A

    Arthritis & rheumatology (Hoboken, N.J.)

    2024  

    Language English
    Publishing date 2024-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42837
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    Zs.A 24: Show issues Location:
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  2. Article ; Online: Addressing the Public Health Crisis of Maternal Mortality: A National Research Agenda.

    Bianchi, Diana W / Clayton, Janine A / Zenk, Shannon N

    JAMA

    2023  Volume 330, Issue 18, Page(s) 1729–1730

    MeSH term(s) Female ; Humans ; Pregnancy ; Maternal Health/statistics & numerical data ; Maternal Health Services/statistics & numerical data ; Maternal Mortality ; Public Health/statistics & numerical data ; United States/epidemiology
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.21294
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    Ua VI Zs.88: Show issues Location:
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  3. Article ; Online: Dry Eye.

    Clayton, Janine A

    The New England journal of medicine

    2018  Volume 378, Issue 23, Page(s) 2212–2223

    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Dry Eye Syndromes/diagnosis ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/therapy ; Eye/anatomy & histology ; Female ; Humans ; Lubricant Eye Drops/therapeutic use ; Male ; Ocular Physiological Phenomena ; Ophthalmic Solutions/therapeutic use ; Risk Factors ; Tears/physiology
    Chemical Substances Anti-Inflammatory Agents ; Lubricant Eye Drops ; Ophthalmic Solutions
    Language English
    Publishing date 2018-07-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1407936
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    Ua VI Zs.34: Show issues Location:
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  4. Article ; Online: Dry Eye.

    Clayton, Janine A

    The New England journal of medicine

    2018  Volume 379, Issue 11, Page(s) e19

    MeSH term(s) Dry Eye Syndromes ; Humans
    Language English
    Publishing date 2018-09-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1808906
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  5. Article ; Online: ORWH, NIH, SCORE Career Enhancement Core Programs Are Shaping the Future of Women's Health and Sex and Gender Research Training.

    Agarwal, Rajeev K / Macioce, Nikeya / Hunter, Chyren / Clayton, Janine A

    Journal of women's health (2002)

    2023  Volume 32, Issue 8, Page(s) 838–839

    MeSH term(s) Female ; Humans ; Women's Health
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2023.0216
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    Zs.A 3584: Show issues Location:
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  6. Article ; Online: The role of gynecologists in screening older women for ocular surface disease symptoms.

    Clayton, Janine A / Stratton, Pamela

    Menopause (New York, N.Y.)

    2020  Volume 27, Issue 9, Page(s) 969–971

    MeSH term(s) Aged ; Female ; Gynecology ; Humans ; Mass Screening ; Postmenopause ; Prevalence
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 1205262-0
    ISSN 1530-0374 ; 1072-3714
    ISSN (online) 1530-0374
    ISSN 1072-3714
    DOI 10.1097/GME.0000000000001627
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    Zs.A 4111: Show issues Location:
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  7. Article ; Online: Integrating the Influence of Sex and Gender in Research: Keeping Women Veterans in Focus.

    Bevans, Margaret / Clayton, Janine A

    Women's health issues : official publication of the Jacobs Institute of Women's Health

    2019  Volume 29 Suppl 1, Page(s) S9–S11

    Language English
    Publishing date 2019-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085396-0
    ISSN 1878-4321 ; 1049-3867
    ISSN (online) 1878-4321
    ISSN 1049-3867
    DOI 10.1016/j.whi.2019.05.001
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    Zs.A 3298: Show issues Location:
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  8. Article ; Online: Chronic conditions in women: the development of a National Institutes of health framework.

    Temkin, Sarah M / Barr, Elizabeth / Moore, Holly / Caviston, Juliane P / Regensteiner, Judith G / Clayton, Janine A

    BMC women's health

    2023  Volume 23, Issue 1, Page(s) 162

    Abstract: Rising rates of chronic conditions were cited as one of the key public health concerns in the Fiscal Year (FY) 2021 U.S. Senate and House of Representatives appropriations bills, where a review of current National Institutes of Health (NIH) portfolios ... ...

    Abstract Rising rates of chronic conditions were cited as one of the key public health concerns in the Fiscal Year (FY) 2021 U.S. Senate and House of Representatives appropriations bills, where a review of current National Institutes of Health (NIH) portfolios relevant to research on women's health was requested. Chronic conditions were last defined by the US Department of Health and Human Services (HHS) in 2010. However, existing definitions of chronic conditions do not incorporate sex or gender considerations. Sex and gender influence health, yet significant knowledge gaps exist in the evidence-base for prevention, diagnosis, and treatment of chronic diseases amongst women. The presentation, prevalence, and long-term effects of chronic conditions and multimorbidity differs in women from men. A clinical framework was developed to adequately assess the NIH investment in research related to chronic conditions in women. The public health needs and NIH investment related to conditions included in the framework were measured. By available measures, research within the NIH has not mapped to the burden of chronic conditions among women. Clinical research questions and endpoints centered around women can be developed and implemented; clinical trials networks with expanded or extended eligibility criteria can be created; and data science could be used to extrapolate the effects of overlapping or multiple morbidities on the health of women. Aligning NIH research priorities to address the specific needs of women with chronic diseases is critical to addressing women's health needs from a life course perspective.
    MeSH term(s) Male ; United States ; Female ; Humans ; National Institutes of Health (U.S.) ; Women's Health ; Public Health ; Chronic Disease
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2050444-5
    ISSN 1472-6874 ; 1472-6874
    ISSN (online) 1472-6874
    ISSN 1472-6874
    DOI 10.1186/s12905-023-02319-x
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  9. Article ; Online: Taking cardiology clinical trials to the next level: A call to action.

    Clayton, Janine A / Arnegard, Matthew E

    Clinical cardiology

    2018  Volume 41, Issue 2, Page(s) 179–184

    Abstract: Physicians previously perceived heart disease to be a man's disease; yet, since 1984, more women have died of ischemic heart disease. Because women who develop obstructive coronary heart disease and heart failure tend to do so 10 years later than men, ... ...

    Abstract Physicians previously perceived heart disease to be a man's disease; yet, since 1984, more women have died of ischemic heart disease. Because women who develop obstructive coronary heart disease and heart failure tend to do so 10 years later than men, cardiology clinical trials that use arbitrary age cutoffs or exclusion criteria based on comorbidities and polypharmacy often limit the pool of potential participants to a greater extent for women. Issues related to trial design and insufficient accounting for female-predominant disease patterns have contributed to low rates of enrollment of women in certain domains of cardiology research. Accordingly, women do not benefit from as rich an evidence base for cardiology as men. Here, we review major sex differences in heart disease and discuss areas of cardiology research in which women have been underrepresented. Considering the widespread sex differences in cardiovascular structure and function, it is important to include balanced numbers of women and men in cardiovascular clinical trials. Beyond inclusion, sex-specific reporting is also essential. Moreover, with ongoing developments of clinical-trial methodology, it is imperative to seek innovative ways to learn as much as possible about how interventions behave in women and men. Adaptive trials are specifically identified as promising opportunities to consider sex-based analyses at interim stages, allowing sex-specific flexibility as these trials unfold. Finally, we emphasize the importance of factoring sex as a biological variable into the design, analysis, and reporting of preclinical research, because this research critically informs the design and execution of clinical trials.
    MeSH term(s) Cardiology/methods ; Clinical Trials as Topic/methods ; Heart Diseases/therapy ; Humans ; Risk Assessment
    Language English
    Publishing date 2018-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391935-3
    ISSN 1932-8737 ; 0160-9289
    ISSN (online) 1932-8737
    ISSN 0160-9289
    DOI 10.1002/clc.22907
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    Zs.A 1423: Show issues Location:
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  10. Article ; Online: Community voices: NIH working toward inclusive excellence by promoting and supporting women in science.

    Ten Hagen, Kelly G / Wolinetz, Carrie / Clayton, Janine A / Bernard, Marie A

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1682

    MeSH term(s) Female ; Humans ; National Institutes of Health (U.S.) ; Science ; United States ; Women
    Language English
    Publishing date 2022-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28665-2
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