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  1. Article ; Online: Radioactive iodine treatment for Graves' hyperthyroidism: incidence of Graves orbitopathy.

    Quah, Nicole Q X / Sobti, Manvi M / Wren, Alison M / Scawn, Richard / Kalogianni, Eleni / Cleland, James / Maenhout, Annelies

    Nuclear medicine communications

    2023  Volume 45, Issue 2, Page(s) 103–107

    Abstract: Purpose: There are limited recent data on the effect of radioactive iodine (RAI) for Graves' disease on Graves' orbitopathy (GO) development or reactivation. This audit investigates the GO incidence in patients with Graves' disease after RAI treatment, ... ...

    Abstract Purpose: There are limited recent data on the effect of radioactive iodine (RAI) for Graves' disease on Graves' orbitopathy (GO) development or reactivation. This audit investigates the GO incidence in patients with Graves' disease after RAI treatment, and explores risk factors present, and steroid prophylaxis use.
    Methods: A retrospective audit of Graves' disease patients treated with RAI over a 5-year period. Data collected: smoking status, thyroid-stimulating hormone receptor antibody (TRAb) status, GO history, Graves' disease duration, eye features pre- and post-treatment, prophylactic corticosteroids, RAI dose given, post-RAI thyroid status, duration until hypothyroid.
    Results: One hundred one patients were included, with a median Graves' disease duration 36 months. 34/101 (33.7%) were active/ex-smokers, 86/101 (85.1%) were TRAb-positive, 11/101 (10.9%) had a GO history; 32 (31.7%) had eye features present. Median RAI dose given was 596MBq. 8/101 (7.9%) patients received prophylactic corticosteroid; 89/101 (88.1%) achieved hypothyroid state in the year after RAI. GO developed in 5/101 (5.0%), of which 4/5 (80%) were de novo in high-risk individuals who did not receive steroids. One was a GO reactivation despite steroids. Two required intravenous steroids with/without orbital radiotherapy, one completed oral steroid taper; the remainder were treated conservatively.
    Conclusion: Our cohort had a lower GO incidence in patients with Graves' disease receiving RAI, with majority arising de novo . It is essential that all patients are assessed for Graves orbitopathy risk factors and counselled adequately prior to RAI. The decision to initiate steroids should be undertaken in a multi-disciplinary setting involving endocrinologists and ophthalmologists.
    MeSH term(s) Humans ; Graves Ophthalmopathy/epidemiology ; Graves Ophthalmopathy/radiotherapy ; Graves Ophthalmopathy/etiology ; Iodine Radioisotopes/therapeutic use ; Retrospective Studies ; Incidence ; Thyroid Neoplasms/drug therapy ; Hyperthyroidism/radiotherapy ; Graves Disease/radiotherapy ; Graves Disease/complications ; Thyrotropin ; Steroids/therapeutic use
    Chemical Substances Iodine Radioisotopes ; Thyrotropin (9002-71-5) ; Steroids
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001791
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    Zs.A 1577: Show issues Location:
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  2. Book ; Online ; Thesis: An investigation into mechanisms of regeneration specificity in planarian flatworms.

    Cleland, James [Verfasser] / Dahmann, Christian [Gutachter] / Tanaka, Elly [Gutachter] / Rink, Jochen C. [Akademischer Betreuer]

    2023  

    Author's details James Cleland ; Gutachter: Christian Dahmann, Elly Tanaka ; Betreuer: Jochen C. Rink
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Technische Universität Dresden
    Publishing place Dresden
    Document type Book ; Online ; Thesis
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  3. Article ; Online: Neuronal intranuclear inclusion disease in New Zealand: A novel discovery.

    Zhang, Tony / Chancellor, Andrew / Liem, Bernard / Turner, Clinton / Hutchinson, David / Wong, Edward / Glamuzina, Emma / Hong, Jae Beom / Cleland, James / Child, Nicholas / Roxburgh, Richard H / Patel, Shilpan / Lee, Yi-Chung / Liao, Yi-Chu / Anderson, Neil E

    Journal of the neurological sciences

    2024  Volume 460, Page(s) 122987

    Abstract: Neuronal intranuclear inclusion disease, caused by a GGC repeat expansion in the 5'-untranslated region of NOTCH2NLC, is a rare neurodegenerative condition with highly variable clinical manifestations. In recent years, the number of reported cases have ... ...

    Abstract Neuronal intranuclear inclusion disease, caused by a GGC repeat expansion in the 5'-untranslated region of NOTCH2NLC, is a rare neurodegenerative condition with highly variable clinical manifestations. In recent years, the number of reported cases have increased dramatically in East Asia. We report the first four genetically confirmed cases of neuronal intranuclear inclusion disease in New Zealand, all having Polynesian ancestry (three New Zealand Māori and one Cook Island Māori). Phenotypically, they resemble cases reported from recent large East Asian cohorts.
    MeSH term(s) Humans ; New Zealand ; Intranuclear Inclusion Bodies/pathology ; Intranuclear Inclusion Bodies/genetics ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/pathology ; Male ; Female ; Middle Aged ; Aged ; Receptor, Notch2/genetics
    Chemical Substances Receptor, Notch2 ; NOTCH2 protein, human
    Language English
    Publishing date 2024-04-03
    Publishing country Netherlands
    Document type Journal Article ; Case Reports
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2024.122987
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    Zs.A 308: Show issues Location:
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  4. Article ; Online: CADASIL presenting with focal and generalised epilepsy due to a novel NOTCH3 mutation.

    Chen, Benson S / Cleland, James / King, Richard I / Anderson, Neil E

    Seizure

    2019  Volume 66, Page(s) 36–38

    MeSH term(s) Adult ; CADASIL/complications ; CADASIL/diagnosis ; CADASIL/genetics ; Epilepsies, Partial/diagnosis ; Epilepsies, Partial/etiology ; Epilepsies, Partial/genetics ; Epilepsy, Generalized/diagnosis ; Epilepsy, Generalized/etiology ; Epilepsy, Generalized/genetics ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Pedigree ; Receptor, Notch3/genetics
    Chemical Substances NOTCH3 protein, human ; Receptor, Notch3
    Language English
    Publishing date 2019-01-30
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2019.01.026
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    Zs.A 3573: Show issues Location:
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  5. Article ; Online: Post-exercise increment in compound muscle action potential amplitude in hyperkalemic periodic paralysis.

    Cleland, James C / Tawil, Rabi

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2014  Volume 125, Issue 10, Page(s) 2134–2135

    MeSH term(s) Action Potentials/physiology ; Adolescent ; Electrodiagnosis ; Electromyography ; Exercise/physiology ; Humans ; Male ; Muscle, Skeletal/physiopathology ; Paralysis, Hyperkalemic Periodic/genetics ; Paralysis, Hyperkalemic Periodic/physiopathology
    Language English
    Publishing date 2014-10
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2014.02.005
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  6. Article ; Online: Crescentic splinter haemorrhages reflect stroke pathophysiology in hypereosinophilic syndrome.

    Mulroy, Eoin / Cleland, James / Anderson, Neil E

    The Australasian journal of dermatology

    2017  Volume 59, Issue 3, Page(s) e211–e212

    MeSH term(s) Adult ; Female ; Hemorrhage/etiology ; Hemorrhage/physiopathology ; Humans ; Hypereosinophilic Syndrome/complications ; Hypereosinophilic Syndrome/diagnosis ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Nail Diseases/etiology ; Nail Diseases/physiopathology ; Predictive Value of Tests ; Sampling Studies ; Stroke/diagnostic imaging ; Stroke/etiology ; Stroke/physiopathology
    Language English
    Publishing date 2017-09-11
    Publishing country Australia
    Document type Letter
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.12717
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    Zs.A 236: Show issues Location:
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  7. Article ; Online: Evolutionary dynamics of whole-body regeneration across planarian flatworms.

    Vila-Farré, Miquel / Rozanski, Andrei / Ivanković, Mario / Cleland, James / Brand, Jeremias N / Thalen, Felix / Grohme, Markus A / von Kannen, Stephanie / Grosbusch, Alexandra L / Vu, Hanh T-K / Prieto, Carlos E / Carbayo, Fernando / Egger, Bernhard / Bleidorn, Christoph / Rasko, John E J / Rink, Jochen C

    Nature ecology & evolution

    2023  Volume 7, Issue 12, Page(s) 2108–2124

    Abstract: Regenerative abilities vary dramatically across animals. Even amongst planarian flatworms, well-known for complete regeneration from tiny body fragments, some species have restricted regeneration abilities while others are almost entirely regeneration ... ...

    Abstract Regenerative abilities vary dramatically across animals. Even amongst planarian flatworms, well-known for complete regeneration from tiny body fragments, some species have restricted regeneration abilities while others are almost entirely regeneration incompetent. Here, we assemble a diverse live collection of 40 planarian species to probe the evolution of head regeneration in the group. Combining quantification of species-specific head-regeneration abilities with a comprehensive transcriptome-based phylogeny reconstruction, we show multiple independent transitions between robust whole-body regeneration and restricted regeneration in freshwater species. RNA-mediated genetic interference inhibition of canonical Wnt signalling in RNA-mediated genetic interference-sensitive species bypassed all head-regeneration defects, suggesting that the Wnt pathway is linked to the emergence of planarian regeneration defects. Our finding that Wnt signalling has multiple roles in the reproductive system of the model species Schmidtea mediterranea raises the possibility that a trade-off between egg-laying, asexual reproduction by fission/regeneration and Wnt signalling drives regenerative trait evolution. Although quantitative comparisons of Wnt signalling levels, yolk content and reproductive strategy across our species collection remained inconclusive, they revealed divergent Wnt signalling roles in the reproductive system of planarians. Altogether, our study establishes planarians as a model taxon for comparative regeneration research and presents a framework for the mechanistic evolution of regenerative abilities.
    MeSH term(s) Animals ; Planarians/genetics ; Planarians/metabolism ; Transcriptome ; Phylogeny ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article
    ISSN 2397-334X
    ISSN (online) 2397-334X
    DOI 10.1038/s41559-023-02221-7
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  8. Article ; Online: A tough one to swallow.

    Mulroy, Eoin / Cleland, James / Child, Nicholas / Pereira, Jennifer / Anderson, Neil E

    Practical neurology

    2018  Volume 18, Issue 3, Page(s) 250–254

    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Antibodies/blood ; Deglutition Disorders/complications ; Deglutition Disorders/diagnosis ; Deglutition Disorders/drug therapy ; Female ; Humans ; Magnetic Resonance Imaging ; Methylprednisolone/therapeutic use ; Middle Aged ; Muscular Diseases/complications ; Prednisone/therapeutic use ; Small Ubiquitin-Related Modifier Proteins/immunology ; Tomography, X-Ray Computed
    Chemical Substances Anti-Inflammatory Agents ; Antibodies ; Small Ubiquitin-Related Modifier Proteins ; Prednisone (VB0R961HZT) ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2018-03-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/practneurol-2017-001860
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    Zs.A 6001: Show issues Location:
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  9. Article ; Online: Andersen-Tawil syndrome presenting as a fixed myopathy.

    Child, Nicholas D / Cleland, James C / Roxburgh, Richard

    Muscle & nerve

    2013  Volume 48, Issue 4, Page(s) 623

    MeSH term(s) Female ; Humans ; Male ; Paralysis/diagnosis
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.23872
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    Zs.A 1449: Show issues Location:
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    Zs.MO 551: Show issues

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  10. Article ; Online: Long Exercise Test in Periodic Paralysis: A Bayesian Analysis.

    Simmons, Daniel B / Lanning, Julie / Cleland, James C / Puwanant, Araya / Twydell, Paul T / Griggs, Robert C / Tawil, Rabi / Logigian, Eric L

    Muscle & nerve

    2018  Volume 59, Issue 1, Page(s) 47–54

    Abstract: Introduction: The long exercise test (LET) is used to assess the diagnosis of periodic paralysis (PP), but LET methodology and normal "cutoff" values vary.: Methods: To determine optimal LET methodology and cutoffs, we reviewed LET data (abductor ... ...

    Abstract Introduction: The long exercise test (LET) is used to assess the diagnosis of periodic paralysis (PP), but LET methodology and normal "cutoff" values vary.
    Methods: To determine optimal LET methodology and cutoffs, we reviewed LET data (abductor digiti minimi motor response amplitude, area) from 55 patients with PP (32 genetically definite) and 125 controls. Receiver operating characteristic curves were constructed, and area under the curve (AUC) was calculated to compare (1) peak-to-nadir versus baseline-to-nadir methodologies and (2) amplitude versus area decrements. Using bayesian principles, we calculated optimal cutoff decrements that achieved 95% posttest probability of PP for various pretest probabilities (PreTPs).
    Results: AUC was highest for peak-to-nadir methodology and equal for amplitude and area decrements. For PreTP ≤ 50%, optimal decrement cutoffs (peak-to-nadir) were > 40% (amplitude) or > 50% (area).
    Discussion: For confirmation of PP, our data endorse the diagnostic utility of peak-to-nadir LET methodology using 40% amplitude or 50% area decrement cutoffs for PreTP ≤50%. Muscle Nerve 59:47-54, 2019.
    MeSH term(s) Adult ; Bayes Theorem ; Cohort Studies ; Electromyography ; Evoked Potentials, Motor/physiology ; Exercise Test/methods ; Female ; Humans ; Male ; Muscle, Skeletal/physiopathology ; Paralyses, Familial Periodic/diagnosis ; Paralyses, Familial Periodic/physiopathology ; ROC Curve
    Language English
    Publishing date 2018-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.26157
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    Zs.MO 551: Show issues

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