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  1. Article ; Online: Nature and Magnitude of the Benefits of Dapagliflozin and Empagliflozin for Heart Failure.

    Cleland, John G F

    Circulation

    2024  Volume 149, Issue 11, Page(s) 839–842

    MeSH term(s) Humans ; Randomized Controlled Trials as Topic ; Benzhydryl Compounds/therapeutic use ; Heart Failure/drug therapy ; Glucosides
    Chemical Substances empagliflozin (HDC1R2M35U) ; dapagliflozin (1ULL0QJ8UC) ; Benzhydryl Compounds ; Glucosides
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.068089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Defining iron deficiency in patients with heart failure.

    Cleland, John G F

    Nature reviews. Cardiology

    2023  Volume 21, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Iron Deficiencies ; Heart Failure/diagnosis ; Anemia, Iron-Deficiency/diagnosis
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-023-00951-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Atrial myopathy and heart failure with preserved ejection fraction: When a label does more harm than good?

    Pellicori, Pierpaolo / Cleland, John G F

    European journal of heart failure

    2024  Volume 26, Issue 2, Page(s) 299–301

    MeSH term(s) Humans ; Heart Failure ; Stroke Volume ; Heart Atria/diagnostic imaging ; Muscular Diseases ; Atrial Fibrillation
    Language English
    Publishing date 2024-01-28
    Publishing country England
    Document type Editorial
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3148
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  4. Article ; Online: Maintaining Public Trust in Medical Advice-Could Less Be More?

    Cleland, John G F

    JAMA network open

    2022  Volume 5, Issue 5, Page(s) e2211113

    MeSH term(s) Counseling ; Humans ; Trust
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.11113
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  5. Article ; Online: Aspirin for Primary and Secondary Prevention of Cardiovascular Disease: Time to Stop?

    Cleland, John G F

    Thrombosis and haemostasis

    2022  Volume 122, Issue 3, Page(s) 311–314

    MeSH term(s) Aspirin/therapeutic use ; Cardiovascular Diseases/prevention & control ; Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Primary Prevention ; Secondary Prevention
    Chemical Substances Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2022-01-20
    Publishing country Germany
    Document type Editorial
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0041-1740639
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  6. Article ; Online: Iron deficiency and supplementation in heart failure.

    Lakhal-Littleton, Samira / Cleland, John G F

    Nature reviews. Cardiology

    2024  

    Abstract: Non-anaemic iron deficiency (NAID) is a strategic target in cardiovascular medicine because of its association with a range of adverse effects in various conditions. Endeavours to tackle NAID in heart failure have yielded mixed results, exposing ... ...

    Abstract Non-anaemic iron deficiency (NAID) is a strategic target in cardiovascular medicine because of its association with a range of adverse effects in various conditions. Endeavours to tackle NAID in heart failure have yielded mixed results, exposing knowledge gaps in how best to define 'iron deficiency' and the handling of iron therapies by the body. To address these gaps, we harness the latest understanding of the mechanisms of iron homeostasis outside the erythron and integrate clinical and preclinical lines of evidence. The emerging picture is that current definitions of iron deficiency do not assimilate the multiple influences at play in patients with heart failure and, consequently, fail to identify those with a truly unmet need for iron. Additionally, current iron supplementation therapies benefit only certain patients with heart failure, reflecting differences in the nature of the unmet need for iron and the modifying effects of anaemia and inflammation on the handling of iron therapies by the body. Building on these insights, we identify untapped opportunities in the management of NAID, including the refinement of current approaches and the development of novel strategies. Lessons learned from NAID in cardiovascular disease could ultimately translate into benefits for patients with other chronic conditions such as chronic kidney disease, chronic obstructive pulmonary disease and cancer.
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-024-00988-1
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  7. Article ; Online: Low Serum Ferritin Might Predict Incident Heart Failure: But Why and Is It Clinically Useful?

    Cleland, John G F / Pellicori, Pierpaolo / Lakhal-Littleton, Samira

    JACC. Heart failure

    2024  Volume 12, Issue 3, Page(s) 549–551

    MeSH term(s) Humans ; Heart Failure/epidemiology ; Iron ; Ferritins
    Chemical Substances Iron (E1UOL152H7) ; Ferritins (9007-73-2)
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.12.012
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  8. Article ; Online: Reply to 'Vasodilators in congestive heart failure: The perfect weapon aiming just off the target?'

    Pellicori, Pierpaolo / Felker, G Michael / Cleland, John G F

    European journal of heart failure

    2024  Volume 26, Issue 2, Page(s) 528

    MeSH term(s) Humans ; Vasodilator Agents ; Heart Failure/drug therapy
    Chemical Substances Vasodilator Agents
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Letter
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3159
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  9. Article ; Online: Combining Iron Supplements With SGLT2 Inhibitor-Stimulated Erythropoiesis in Heart Failure: Should We Be Worried About Thromboembolic Events?

    Packer, Milton / Cleland, John G F

    Journal of cardiac failure

    2022  Volume 29, Issue 3, Page(s) 403–406

    MeSH term(s) Humans ; Iron ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Heart Failure/drug therapy ; Erythropoiesis ; Diabetes Mellitus, Type 2
    Chemical Substances Iron (E1UOL152H7) ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2022-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2022.12.007
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  10. Article ; Online: Heart failure: age is no excuse for complacency.

    Pellicori, Pierpaolo / Cleland, John G F

    European journal of heart failure

    2022  Volume 24, Issue 6, Page(s) 1063–1065

    MeSH term(s) Heart Failure ; Humans
    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2517
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