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Book ; Conference proceedings: Milk and milk products in human nutrition

Clemens, Roger A.

[67th Nestlé Nutrition Institute Workshop, Pediatric Program, Marrakech, March 16 - 20, 2010]

(Nestlé Nutrition Institute Workshop Series : Pediatric Program ; 67)

2011

Author's details	ed.: Roger A. Clemens
Series title	Nestlé Nutrition Institute Workshop Series : Pediatric Program ; 67 Nestlé Nutrition Institute workshop series Nestlé Nutrition Institute Workshop Series ; Pediatric Program
Collection	Nestlé Nutrition Institute workshop series Nestlé Nutrition Institute Workshop Series ; Pediatric Program
Keywords	Muttermilch ; Milch ; Milchprodukt ; Ernährungsphysiologie
Subject	Nahrungsphysiologie ; Milcherzeugnis ; Molkereiprodukt ; Konsummilch ; Kuhmilch ; Trinkmilch ; Frauenmilch ; Humanmilch
Language	English
Size	XIII, 219 S. : Ill., graph. Darst.
Publisher	Karger
Publishing place	Basel u.a.
Publishing country	Germany
Document type	Book ; Conference proceedings
HBZ-ID	HT016570818
ISBN	978-3-8055-9586-5 ; 9783805595872 ; 3-8055-9586-7 ; 3805595875
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
118/136	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: SARS-CoV-2 Infection Dysregulates Host Iron (Fe)-Redox Homeostasis (Fe-R-H): Role of Fe-Redox Regulators, Ferroptosis Inhibitors, Anticoagulants, and Iron-Chelators in COVID-19 Control.

Naidu, Sreus A G / Clemens, Roger A / Naidu, A Satyanarayan

Journal of dietary supplements

2022 Volume 20, Issue 2, Page(s) 312–371

Abstract: Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in every symptomatic (mild, moderate to severe) clinical phase of COVID-19. ...

Abstract	Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in every symptomatic (mild, moderate to severe) clinical phase of COVID-19.
MeSH term(s)	Humans ; Iron/metabolism ; Ferroptosis/physiology ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; COVID-19 ; SARS-CoV-2/metabolism ; Oxidation-Reduction ; Iron Chelating Agents ; Iron Overload/drug therapy ; Homeostasis ; Cytokines/metabolism
Chemical Substances	Iron (E1UOL152H7) ; Anticoagulants ; Iron Chelating Agents ; Cytokines
Language	English
Publishing date	2022-05-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2022.2075072
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Article ; Online: The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage.

Hayes, A Wallace / Clemens, Roger A / Pressman, Peter

Toxicology mechanisms and methods

2022 Volume 32, Issue 5, Page(s) 385–394

Abstract: Aloe products are increasingly valued as ingredients in food supplements and as flavoring agents. The ... ...

Abstract	Aloe products are increasingly valued as ingredients in food supplements and as flavoring agents. The global
MeSH term(s)	Aloe/toxicity ; Beverages ; DNA Damage ; Emodin/analogs & derivatives ; Emodin/analysis ; Emodin/toxicity ; Plant Extracts/toxicity
Chemical Substances	Plant Extracts ; Emodin (KA46RNI6HN) ; alloin (W41H6S09F4)
Language	English
Publishing date	2022-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2081252-8
ISSN	1537-6524 ; 1537-6516 ; 1051-7235
ISSN (online)	1537-6524
ISSN	1537-6516 ; 1051-7235
DOI	10.1080/15376516.2021.2023828
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Article ; Online: SARS-CoV-2 Infection Dysregulates Host Iron (Fe)-Redox Homeostasis (Fe-R-H): Role of Fe-Redox Regulators, Ferroptosis Inhibitors, Anticoagulants, and Iron-Chelators in COVID-19 Control

Naidu, Sreus A.G. / Clemens, Roger A. / Naidu, A. Satyanarayan

Journal of Dietary Supplements. 2023 Mar. 4, v. 20, no. 2 p.312-371

2023

Abstract: Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in every symptomatic (mild, moderate to severe) clinical phase of COVID-19. Phase-I – Hypoxia correlates with reduced O₂ transport by erythrocytes, overexpression of HIF- ... ...

Abstract	Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in every symptomatic (mild, moderate to severe) clinical phase of COVID-19. Phase-I – Hypoxia correlates with reduced O₂ transport by erythrocytes, overexpression of HIF-1α, altered mitochondrial bioenergetics with host metabolic reprogramming (HMR). Phase-II – Hyperferritinemia results from an increased iron overload, which triggers a fulminant proinflammatory response – the acute cytokine release syndrome (CRS). Elevated cytokine levels (i.e. IL6, TNFα and CRP) strongly correlates with altered ferritin/TF ratios in COVID-19 patients. Phase-III – Thromboembolism is consequential to erythrocyte dysfunction with heme release, increased prothrombin time and elevated D-dimers, cumulatively linked to severe coagulopathies with life-threatening outcomes such as ARDS, and multi-organ failure. Taken together, Fe-R-H dysregulation is implicated in every symptomatic phase of COVID-19. Fe-R-H regulators such as lactoferrin (LF), hemoxygenase-1 (HO-1), erythropoietin (EPO) and hepcidin modulators are innate bio-replenishments that sequester iron, neutralize iron-mediated free radicals, reduce oxidative stress, and improve host defense by optimizing iron metabolism. Due to its pivotal role in ‘cytokine storm’, ferroptosis is a potential intervention target. Ferroptosis inhibitors such as ferrostatin-1, liproxstatin-1, quercetin, and melatonin could prevent mitochondrial lipid peroxidation, up-regulate antioxidant/GSH levels and abrogate iron overload-induced apoptosis through activation of Nrf2 and HO-1 signaling pathways. Iron chelators such as heparin, deferoxamine, caffeic acid, curcumin, α-lipoic acid, and phytic acid could protect against ferroptosis and restore mitochondrial function, iron-redox potential, and rebalance Fe-R-H status. Therefore, Fe-R-H restoration is a host biomarker-driven potential combat strategy for an effective clinical and post-recovery management of COVID-19.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antioxidants ; apoptosis ; caffeic acid ; curcumin ; deferoxamine ; energy metabolism ; erythrocytes ; erythropoietin ; ferritin ; ferroptosis ; heme ; heparin ; hepcidin ; homeostasis ; hypoxia ; inflammation ; interleukin-6 ; iron ; iron absorption ; iron overload ; lactoferrin ; lipid peroxidation ; melatonin ; mitochondria ; oxidative stress ; phytic acid ; prothrombin ; quercetin ; COVID-19 ; ferroptosis inhibitors ; Fe-R-H regulators ; host metabolic reprogramming (HMR) ; iron chelators ; iron-redox homeostasis (Fe-R-H)
Language	English
Dates of publication	2023-0304
Size	p. 312-371.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2022.2075072
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against RNA-Dependent RNA Polymerase Complex (nsp7/nsp8/nsp12) of SARS-CoV-2

Naidu, Sreus A. G. / Mustafa, Ghulam / Clemens, Roger A. / Naidu, A. Satyanarayan

Journal of Dietary Supplements. 2023 Mar. 4, v. 20, no. 2 p.254-283

2023

Abstract: The emergence of fast-spreading SARS-CoV-2 mutants has sparked a new phase of COVID-19 pandemic. There is a dire necessity for antivirals targeting highly conserved genomic domains on SARS-CoV-2 that are less prone to mutation. The nsp12, also known as ... ...

Abstract	The emergence of fast-spreading SARS-CoV-2 mutants has sparked a new phase of COVID-19 pandemic. There is a dire necessity for antivirals targeting highly conserved genomic domains on SARS-CoV-2 that are less prone to mutation. The nsp12, also known as the RNA-dependent RNA-polymerase (RdRp), the core component of ‘SARS-CoV-2 replication-transcription complex’, is a potential well-conserved druggable antiviral target. Several FDA-approved RdRp ‘nucleotide analog inhibitors (NAIs)’ such as remdesivir, have been repurposed to treat COVID-19 infections. The NAIs target RdRp protein translation and competitively block the nucleotide insertion into the RNA chain, resulting in the inhibition of viral replication. However, the replication proofreading function of nsp14-ExoN could provide resistance to SARS-CoV-2 against many NAIs. Conversely, the ‘non-nucleoside analog inhibitors (NNAIs)’ bind to allosteric sites on viral polymerase surface, change the redox state; thereby, exert antiviral activity by altering interactions between the enzyme substrate and active core catalytic site of the RdRp. NNAIs neither require metabolic activation (unlike NAIs) nor compete with intracellular pool of nucleotide triphosphates (NTPs) for anti-RdRp activity. The NNAIs from phytonutrient origin are potential antiviral candidates compared to their synthetic counterparts. Several in-silico studies reported the antiviral spectrum of natural phytonutrient-NNAIs such as Suramin, Silibinin (flavonolignan), Theaflavin (tea polyphenol), Baicalein (5,6,7-trihydroxyflavone), Corilagin (gallotannin), Hesperidin (citrus bioflavonoid), Lycorine (pyrrolidine alkaloid), with superior redox characteristics (free binding energy, hydrogen-bonds, etc.) than antiviral drugs (i.e. remdesivir, favipiravir). These phytonutrient-NNAIs also exert anti-inflammatory, antioxidant, immunomodulatory and cardioprotective functions, with multifunctional therapeutic benefits in the clinical management of COVID-19.
Keywords	COVID-19 infection ; Citrus ; RNA ; RNA-directed RNA polymerase ; Severe acute respiratory syndrome coronavirus 2 ; active sites ; antioxidants ; antiviral agents ; antiviral properties ; computer simulation ; energy ; enzyme substrates ; genomics ; hesperidin ; hydrogen bonding ; lycorine ; mutation ; phytonutrients ; suramin ; tea ; theaflavins ; therapeutics ; virus replication ; Antiviral ; COVID-19 ; Non-nucleoside analog inhibitors (NNAIs) ; nsp14-ExoN ; Redox ; Remdesivir ; RNA-dependent RNA polymerase (RdRp) ; SARS-CoV-2
Language	English
Dates of publication	2023-0304
Size	p. 254-283.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2021.2006387
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Call for Perspective and Precision in Research Design and Conclusions Drawn From Preclinical Data.

Pressman, Peter / Clemens, Roger A / Hayes, Andrew W

American journal of clinical oncology

2021 Volume 45, Issue 3, Page(s) 134–135

MeSH term(s)	Humans ; Research Design
Language	English
Publishing date	2021-10-18
Publishing country	United States
Document type	Letter
ZDB-ID	604536-4
ISSN	1537-453X ; 0277-3732
ISSN (online)	1537-453X
ISSN	0277-3732
DOI	10.1097/COC.0000000000000889
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Article: Neurodevelopment and Exposure to Cannabis

Pressman, Peter / Clemens, Roger A

Nutrition today. 2019 , v. 54, no. 3

2019

Abstract: This article discusses human brain development and what is known about the effects of exposure to cannabis to it. It summarizes the differences between traditional uses of cannabis and more recent uses as a drug rather than in a social context and their ... ...

Abstract	This article discusses human brain development and what is known about the effects of exposure to cannabis to it. It summarizes the differences between traditional uses of cannabis and more recent uses as a drug rather than in a social context and their possible health implications. It discusses the Farm Bill’s provisions on hemp. The next article in the series will discuss the risk in the use of cannabis in food.
Keywords	Cannabis ; Farm Bill ; brain ; drugs ; hemp ; human nutrition ; humans ; neurodevelopment ; nutrition risk assessment
Language	English
Dates of publication	2019-05
Size	p. 116-120.
Publishing place	Wolters Kluwer Health
Document type	Article
Note	Affiliations: Peter Pressman, MD, PhD, is vice president, Medical Operations, Polyscience Consulting, Los Angeles, California, and a fellow of the American College of Nutrition. He can be reached at drpressvm2@gmail.com. Roger A. Clemens, DrPH, is an expert in nutrition, food toxicology, and food regulations. He is an adjunct professor of pharmacology and pharmaceutical sciences, as well as quality and regulatory science at the University of Southern California School of Pharmacy. He is former president of the Institute of Food Technologists and was a member of the Dietary Guidelines Advisory Committee in 2010. He can be reached at clemens@usc.edu.
ZDB-ID	960337-2
ISSN	0029-666X
ISSN	0029-666X
DOI	10.1097/NT.0000000000000341
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Phytonutrient Inhibitors of SARS-CoV-2/NSP5-Encoded Main Protease (Mᵖʳᵒ) Autocleavage Enzyme Critical for COVID-19 Pathogenesis

Naidu, Sreus A. G. / Tripathi, Yamini B. / Shree, Priya / Clemens, Roger A. / Naidu, A. Satyanarayan

Journal of Dietary Supplements. 2023 Mar. 4, v. 20, no. 2 p.284-311

2023

Abstract: The genomic reshuffling, mutagenicity, and high transmission rate of the SARS-CoV-2 pathogen highlights an urgent need for effective antiviral interventions for COVID-19 control. Targeting the highly conserved viral genes and/or gene-encoded viral ... ...

Abstract	The genomic reshuffling, mutagenicity, and high transmission rate of the SARS-CoV-2 pathogen highlights an urgent need for effective antiviral interventions for COVID-19 control. Targeting the highly conserved viral genes and/or gene-encoded viral proteins such as main proteinase (Mᵖʳᵒ), RNA-dependent RNA polymerase (RdRp) and helicases are plausible antiviral approaches to prevent replication and propagation of the SARS-CoV-2 infection. Coronaviruses (CoVs) are prone to extensive mutagenesis; however, any genetic alteration to its highly conserved Mᵖʳᵒ enzyme is often detrimental to the viral pathogen. Therefore, inhibitors that target the Mᵖʳᵒ enzyme could reduce the risk of mutation-mediated drug resistance and provide effective antiviral protection. Several existing antiviral drugs and dietary bioactives are currently repurposed to treat COVID-19. Dietary bioactives from three ayurvedic medicinal herbs, 18 β-glycyrrhetinic acid (ΔG = 8.86 kcal/mol), Solanocapsine (ΔG = 8.59 kcal/mol), and Vasicoline (ΔG = 7.34 kcal/mol), showed high-affinity binding to Mᵖʳᵒ enzyme than the native N3 inhibitor (ΔG = 5.41 kcal/mol). Flavonoids strongly inhibited SARS-CoV-2 Mᵖʳᵒ with comparable or higher potency than the antiviral drug, remdesivir. Several tannin hydrolysates avidly bound to the receptor-binding domain and catalytic dyad (His₄₁ and Cys₁₄₅) of SARS‐CoV‐2 Mᵖʳᵒ through H-bonding forces. Quercetin binding to Mᵖʳᵒ altered the thermostability of the viral protein through redox-based mechanism and inhibited the viral enzymatic activity. Interaction of quercetin-derivatives with the Mᵖʳᵒ seem to be influenced by the 7-OH group and the acetoxylation of sugar moiety on the ligand molecule. Based on pharmacokinetic and ADMET profiles, several phytonutrients could serve as a promising redox nutraceutical for COVID-19 management.
Keywords	COVID-19 infection ; RNA-directed RNA polymerase ; Severe acute respiratory syndrome coronavirus 2 ; antiviral agents ; dietary supplements ; drug resistance ; enzyme activity ; genomics ; hydrogen bonding ; ligands ; moieties ; mutagenesis ; mutagenicity ; pathogenesis ; pathogens ; pharmacokinetics ; phytonutrients ; proteinases ; quercetin ; risk reduction ; sugars ; thermal stability ; Antiviral ; Ayurvedic Medicine ; COVID-19 ; Mpro ; Redox nutraceutical ; SARS-CoV-2
Language	English
Dates of publication	2023-0304
Size	p. 284-311.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2021.2006388
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against

Naidu, Sreus A G / Mustafa, Ghulam / Clemens, Roger A / Naidu, A Satyanarayan

Journal of dietary supplements

2021 Volume 20, Issue 2, Page(s) 254–283

Abstract	The emergence of fast-spreading SARS-CoV-2 mutants has sparked a new phase of COVID-19 pandemic. There is a dire necessity for antivirals targeting highly conserved genomic domains on SARS-CoV-2 that are less prone to mutation. The
MeSH term(s)	Humans ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/genetics ; RNA-Dependent RNA Polymerase/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Pandemics ; COVID-19 ; RNA ; Nucleotides ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Antiviral Agents/chemistry
Chemical Substances	RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; RNA (63231-63-0) ; Nucleotides ; Antiviral Agents
Language	English
Publishing date	2021-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2460305-3
ISSN	1939-022X ; 1939-0211
ISSN (online)	1939-022X
ISSN	1939-0211
DOI	10.1080/19390211.2021.2006387
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID.

Naidu, A Satyanarayan / Wang, Chin-Kun / Rao, Pingfan / Mancini, Fabrizio / Clemens, Roger A / Wirakartakusumah, Aman / Chiu, Hui-Fang / Yen, Chi-Hua / Porretta, Sebastiano / Mathai, Issac / Naidu, Sreus A G

NPJ science of food

2024 Volume 8, Issue 1, Page(s) 19

Abstract: SARS-CoV-2, the etiological agent of COVID-19, is devoid of any metabolic capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic machinery for its replication and propagation. This single-stranded RNA virus with a 29. ...

Abstract	SARS-CoV-2, the etiological agent of COVID-19, is devoid of any metabolic capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic machinery for its replication and propagation. This single-stranded RNA virus with a 29.9 kb genome encodes 14 open reading frames (ORFs) and initiates a plethora of virus-host protein-protein interactions in the human body. These extensive viral protein interactions with host-specific cellular targets could trigger severe human metabolic reprogramming/dysregulation (HMRD), a rewiring of sugar-, amino acid-, lipid-, and nucleotide-metabolism(s), as well as altered or impaired bioenergetics, immune dysfunction, and redox imbalance in the body. In the infectious process, the viral pathogen hijacks two major human receptors, angiotensin-converting enzyme (ACE)-2 and/or neuropilin (NRP)-1, for initial adhesion to cell surface; then utilizes two major host proteases, TMPRSS2 and/or furin, to gain cellular entry; and finally employs an endosomal enzyme, cathepsin L (CTSL) for fusogenic release of its viral genome. The virus-induced HMRD results in 5 possible infectious outcomes: asymptomatic, mild, moderate, severe to fatal episodes; while the symptomatic acute COVID-19 condition could manifest into 3 clinical phases: (i) hypoxia and hypoxemia (Warburg effect), (ii) hyperferritinemia ('cytokine storm'), and (iii) thrombocytosis (coagulopathy). The mean incubation period for COVID-19 onset was estimated to be 5.1 days, and most cases develop symptoms after 14 days. The mean viral clearance times were 24, 30, and 39 days for acute, severe, and ICU-admitted COVID-19 patients, respectively. However, about 25-70% of virus-free COVID-19 survivors continue to sustain virus-induced HMRD and exhibit a wide range of symptoms that are persistent, exacerbated, or new 'onset' clinical incidents, collectively termed as post-acute sequelae of COVID-19 (PASC) or long COVID. PASC patients experience several debilitating clinical condition(s) with >200 different and overlapping symptoms that may last for weeks to months. Chronic PASC is a cumulative outcome of at least 10 different HMRD-related pathophysiological mechanisms involving both virus-derived virulence factors and a multitude of innate host responses. Based on HMRD and virus-free clinical impairments of different human organs/systems, PASC patients can be categorized into 4 different clusters or sub-phenotypes: sub-phenotype-1 (33.8%) with cardiac and renal manifestations; sub-phenotype-2 (32.8%) with respiratory, sleep and anxiety disorders; sub-phenotype-3 (23.4%) with skeleto-muscular and nervous disorders; and sub-phenotype-4 (10.1%) with digestive and pulmonary dysfunctions. This narrative review elucidates the effects of viral hijack on host cellular machinery during SARS-CoV-2 infection, ensuing detrimental effect(s) of virus-induced HMRD on human metabolism, consequential symptomatic clinical implications, and damage to multiple organ systems; as well as chronic pathophysiological sequelae in virus-free PASC patients. We have also provided a few evidence-based, human randomized controlled trial (RCT)-tested, precision nutrients to reset HMRD for health recovery of PASC patients.
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article ; Review
ISSN	2396-8370
ISSN (online)	2396-8370
DOI	10.1038/s41538-024-00261-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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