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Article ; Online: Clinicians should remain vigilant for biliary atresia as early diagnosis and surgery are vital.

Clemente, Maria Grazia / Garzi, Alfredo / Vajro, Pietro

Acta paediatrica (Oslo, Norway : 1992)

2019 Volume 108, Issue 12, Page(s) 2129–2131

MeSH term(s)	Biliary Atresia ; Early Diagnosis ; Humans ; Incidence ; Republic of Korea ; Rotavirus ; Vaccination
Language	English
Publishing date	2019-10-01
Publishing country	Norway
Document type	Editorial ; Comment
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.14986
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Article ; Online: Vitamin D Status in an Italian Pediatric Cohort: Is There a Role for Tobacco Smoking Exposure?

Clemente, Maria Grazia / Argiolas, Dario / Bassu, Stefania / Bitti, Angela / Locci, Cristian / Argiolas, Mauro / Argiolas, Lino / Saderi, Laura / Puci, Mariangela V / Sotgiu, Giovanni / Blue, Mary E / Antonucci, Roberto

Journal of clinical research in pediatric endocrinology

2024

Abstract: Introduction: Vitamin D deficiency is a common public health issue worldwide. The purpose of this study was to investigate the vitamin D status and its potential determinants in children residing in Sardinia (40°N), Italy.: Methods: A total of 182 ... ...

Abstract	Introduction: Vitamin D deficiency is a common public health issue worldwide. The purpose of this study was to investigate the vitamin D status and its potential determinants in children residing in Sardinia (40°N), Italy. Methods: A total of 182 children (males: 51.7%; median age: 9 years) were enrolled over a 12-month period. Serum 25(OH)D was measured by an immune-chemiluminescence assay. A questionnaire was used to gather information on other variables, including passive smoke exposure. Results: Mean (SD) serum 25(OH)D was 25.2 (8.3) ng/mL for the whole group. The majority (n=123, 67.6%) of children had vitamin D sufficient values >20 ng/mL, while about 1/3 had vitamin D insufficient/deficient values (≤20 ng/mL (n=59, 32.4%). Among the variables investigated, passive smoke exposure was significantly associated with insufficient 25(OH)D levels (p<0.0001). Conclusion: Our results further prove that hypovitaminosis D is common in the Italian children and documented that passive smoke exposure is a significant risk factor for hypovitaminosis D.
Language	English
Publishing date	2024-03-25
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2641608-6
ISSN	1308-5735 ; 1308-5727
ISSN (online)	1308-5735
ISSN	1308-5727
DOI	10.4274/jcrpe.galenos.2024.2023-11-16
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Article ; Online: Unplanned pregnancy in women with beta-thalassaemia treated with luspatercept.

Zaccheddu, Eleonora / Zappu, Antonietta / Barella, Susanna / Clemente, Maria Grazia / Orecchia, Valeria / Pilia, Maria Paola / Piras, Simona / Pitturru, Carla / Scarano, Manuel / Origa, Raffaella

British journal of haematology

2024

Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Letter
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.19480
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Article ; Online: An update on the strategies used for the treatment of chronic hepatitis B in children.

Clemente, Maria Grazia / Vajro, Pietro

Expert review of gastroenterology & hepatology

2016 Volume 10, Issue 5, Page(s) 649–658

Abstract: Chronic hepatitis B (CHB) in children shows a variety of clinical presentations, which influence its natural course and treatment options. This report provides an overview of the ongoing strategies in pediatric CHB management. Interferon-α represents the ...

Abstract	Chronic hepatitis B (CHB) in children shows a variety of clinical presentations, which influence its natural course and treatment options. This report provides an overview of the ongoing strategies in pediatric CHB management. Interferon-α represents the first choice of treatment in children showing HBV replication and hepatic inflammation (immune active CHB), while the recommendation is to monitor inactive/immune-tolerant children (normal transaminases and low/absent viral replication). When circumstances preclude the use of Interferon-α and in cases of compensated/decompensated cirrhosis, entecavir for children above 2 years of age or tenofovir for children above 12 years of age are the nucleos(t)ide analogues recommended by the most recent guidelines.
MeSH term(s)	Adolescent ; Age Factors ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Child ; Child, Preschool ; Drug Therapy, Combination ; Hepatitis B virus/drug effects ; Hepatitis B virus/immunology ; Hepatitis B virus/pathogenicity ; Hepatitis B, Chronic/diagnosis ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/immunology ; Humans ; Infant ; Patient Selection ; Risk Factors ; Treatment Outcome
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2481021-6
ISSN	1747-4132 ; 1747-4124
ISSN (online)	1747-4132
ISSN	1747-4124
DOI	10.1586/17474124.2016.1139450
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Zs.A 6978: Show issues

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Article ; Online: Infant botulism: an underestimated threat.

Antonucci, Luca / Locci, Cristian / Schettini, Livia / Clemente, Maria Grazia / Antonucci, Roberto

Infectious diseases (London, England)

2021 Volume 53, Issue 9, Page(s) 647–660

Abstract: Infant botulism (IB) is defined as a potentially life-threatening neuroparalytic disorder affecting children younger than 12 months. It is caused by ingestion of food or dust contaminated ... ...

Abstract	Infant botulism (IB) is defined as a potentially life-threatening neuroparalytic disorder affecting children younger than 12 months. It is caused by ingestion of food or dust contaminated by
MeSH term(s)	Botulism/diagnosis ; Botulism/epidemiology ; Botulism/therapy ; Child ; Clostridium botulinum ; Humans ; Infant
Language	English
Publishing date	2021-05-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2839775-7
ISSN	2374-4243 ; 2374-4235
ISSN (online)	2374-4243
ISSN	2374-4235
DOI	10.1080/23744235.2021.1919753
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Article ; Online: Multiple glycolytic enzymes are antigens also in biliary atresia.

Clemente, Maria Grazia / Schwarz, Kathleen B / Antonucci, Roberto

Immunology letters

2018 Volume 196, Page(s) 124–125

MeSH term(s)	Adolescent ; Adult ; Animals ; Autoantibodies/blood ; Autoantibodies/immunology ; Autoantigens/immunology ; Biliary Atresia/blood ; Biliary Atresia/immunology ; Child ; Child, Preschool ; Humans ; Immunoblotting ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; Infant ; Phosphopyruvate Hydratase/immunology ; Pyruvate Kinase/immunology ; Rabbits
Chemical Substances	Autoantibodies ; Autoantigens ; Immunoglobulin G ; Immunoglobulin M ; Pyruvate Kinase (EC 2.7.1.40) ; Phosphopyruvate Hydratase (EC 4.2.1.11)
Language	English
Publishing date	2018-02-09
Publishing country	Netherlands
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	445150-8
ISSN	1879-0542 ; 0165-2478
ISSN (online)	1879-0542
ISSN	0165-2478
DOI	10.1016/j.imlet.2018.02.003
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Zs.A 1512: Show issues

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Article ; Online: Present and future management of viral hepatitis B and C in children.

Clemente, Maria Grazia / Antonucci, Roberto / Sotgiu, Giovanni / Dettori, Marco / Piana, Andrea / Vajro, Pietro

Clinics and research in hepatology and gastroenterology

2020 Volume 44, Issue 6, Page(s) 801–809

Abstract: Having a hepatitis B virus (HBV) or hepatitis C virus (HCV) infection places a child at higher risk for subsequent chronic hepatitis B (CHB) or chronic hepatitis C (CHC) infection. The risk of mother-to-child transmission is higher for HBV (20% to 90%) ... ...

Abstract	Having a hepatitis B virus (HBV) or hepatitis C virus (HCV) infection places a child at higher risk for subsequent chronic hepatitis B (CHB) or chronic hepatitis C (CHC) infection. The risk of mother-to-child transmission is higher for HBV (20% to 90%) than for HCV (<5%). Perinatal HBV infection generally causes CHB infection while perinatal HCV infection has a certain rate of spontaneous viral clearance (around 20% to 30%). Of the two, only HBV infection can benefit from passive/active perinatal immunoprophylaxis. The risk of CHB in children with HBV horizontal transmission decreases with age, whereas HCV transmission among teenagers commonly results into a long-life infection and CHC infection. Children with CHB or CHC should be carefully assessed for the need for antiviral treatment. When treatment cannot be deferred, pediatric CHB infection has different first-line treatment options: standard interferon (for children aged≥1 year), pegylated interferon (for children aged≥3 years), and the oral nucleotide analogues entecavir (for children aged≥2 years) and tenofovir (for children aged≥12 years). The choice of treatment depends on the child's age, virus genotypes, previous treatment failure and presence of contraindications. Expected responsiveness rate is 25% of hepatitis B e-antigen clearance, with both standard interferon and nucleotide analogues. Direct antiviral agents are first-line treatment for CHC infection in children aged 3 years or older. Hepatitis C virus sustained virus response is as high as 97%. Therefore, if direct antiviral agents can be proven to be safe and well tolerated in very young children, HCV eradication could be planned after the first screening.
MeSH term(s)	Algorithms ; Antiviral Agents/therapeutic use ; Child ; Drug Therapy, Combination ; Female ; Hepatitis B/drug therapy ; Hepatitis B/transmission ; Hepatitis B Antigens/blood ; Hepatitis B Vaccines ; Hepatitis C/drug therapy ; Hepatitis C/transmission ; Humans ; Infectious Disease Transmission, Vertical ; Pregnancy
Chemical Substances	Antiviral Agents ; Hepatitis B Antigens ; Hepatitis B Vaccines
Language	English
Publishing date	2020-03-12
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2020.02.010
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Article ; Online: Ceftriaxone-associated biliary pseudolithiasis in children: do we know enough?

Cuzzolin, Laura / Oggiano, Anna Maria / Clemente, Maria Grazia / Locci, Cristian / Antonucci, Luca / Antonucci, Roberto

Fundamental & clinical pharmacology

2020 Volume 35, Issue 1, Page(s) 40–52

Abstract: Ceftriaxone is an antibiotic agent frequently used in paediatric hospital practice for the treatment of severe bacterial infections. The use of this agent can result in cholelithiasis and/or biliary sludge, more commonly in children than in adults. This ... ...

Abstract	Ceftriaxone is an antibiotic agent frequently used in paediatric hospital practice for the treatment of severe bacterial infections. The use of this agent can result in cholelithiasis and/or biliary sludge, more commonly in children than in adults. This systematic review was aimed at analysing available literature concerning ceftriaxone-associated biliary pseudolithiasis in paediatric patients, with a special emphasis on the clinical aspects. A literature analysis was performed using Medline and Embase electronic databases (articles published in English up to December 2019), with the search terms and combinations as follows:'ceftriaxone', 'cholelithiasis', 'biliary sludge' 'gallstones' 'neonates' 'children' 'clinical aspects' 'management'. Several case reports, case series and prospective/retrospective studies have documented a relationship between ceftriaxone treatment and biliary pseudolithiasis in the paediatric population, even though literature data regarding neonates and infants are scarce. Ceftriaxone-associated biliary pseudolithiasis is dose-dependent and usually asymptomatic but, sometimes, it may present with abdominal pain, nausea and emesis. Abdominal ultrasonography should be performed when this complication is suspected. Generally, ceftriaxone-associated cholelithiasis resolves over a variable period of time (days to months) after cessation of therapy. Therefore, a conservative approach to this condition is advocated, but a prolonged follow-up may be necessary. A personalized assessment of factors predisposing to ceftriaxone-associated biliary pseudolithiasis before prescribing the drug can allow to minimize the risk of developing it, with significant advantages in terms of human and economic costs.
MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Ceftriaxone/adverse effects ; Child ; Cholelithiasis/chemically induced ; Cholelithiasis/therapy ; Humans
Chemical Substances	Anti-Bacterial Agents ; Ceftriaxone (75J73V1629)
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/fcp.12577
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Article: Safety and Efficacy of the New Combination Iron Chelation Regimens in Patients with Transfusion-Dependent Thalassemia and Severe Iron Overload.

Origa, Raffaella / Cinus, Monia / Pilia, Maria Paola / Gianesin, Barbara / Zappu, Antonietta / Orecchia, Valeria / Clemente, Maria Grazia / Pitturru, Carla / Denotti, Anna Rita / Corongiu, Francesco / Piras, Simona / Barella, Susanna

Journal of clinical medicine

2022 Volume 11, Issue 7

Abstract: The aim of this study is the evaluation of the safety and the efficacy of long-term combination therapy deferasirox plus desferrioxamine and deferasirox plus deferiprone in a large group of transfusion-dependent thalassemia patients with high values of ... ...

Abstract	The aim of this study is the evaluation of the safety and the efficacy of long-term combination therapy deferasirox plus desferrioxamine and deferasirox plus deferiprone in a large group of transfusion-dependent thalassemia patients with high values of serum ferritin and/or magnetic resonance, indicative of severe liver and cardiac iron accumulation. Sixteen adults with transfusion-dependent thalassemia were treated simultaneously with deferasirox plus desferrioxamine, while another 42 patients (seven children) were treated with deferasirox plus deferiprone. The hepatic and cardiac iron overload was assessed prior to treatment and then annually with magnetic resonance imaging, and the serum ferritin was measured monthly. Adverse events were checked at each transfusion visit. The safety of both the combinations was consistent with established monotherapies. Both treatments were able to decrease the serum ferritin and liver iron concentration over time, depending on the level of compliance with therapy. Cardiac iron measured as R2* did not significantly change in patients treated with deferasirox plus desferrioxamine. Most patients with MRI indicative of myocardial siderosis at the beginning of treatment reached normal values of cardiac iron at the last determination if treated with deferasirox plus desferrioxamine. The greatest limitation of these therapies was low patient adherence to the two drugs, which is not surprising considering that the need for an intensive chelation is generally linked to previous issues of compliance.
Language	English
Publishing date	2022-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11072010
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Article ; Online: Impact of the SARS-CoV-2 pandemic and associated restrictions on Pediatric Emergency Department utilization in Sardinia: a retrospective bicentric observational study.

Antonucci, Roberto / Clemente, Maria Grazia / Antonucci, Luca / Canetto, Alessandro / Mastromattei, Stefania / Chiapello, Noemi / Vacca, Nadia / Saderi, Laura / Sotgiu, Giovanni / Locci, Cristian

Italian journal of pediatrics

2022 Volume 48, Issue 1, Page(s) 37

Abstract: Background: The COVID-19 pandemic and associated public health measures have had a profound impact on health systems worldwide. The aim of this study was to assess quantitative and qualitative changes in Pediatric Emergency Department (PED) visits in ... ...

Abstract	Background: The COVID-19 pandemic and associated public health measures have had a profound impact on health systems worldwide. The aim of this study was to assess quantitative and qualitative changes in Pediatric Emergency Department (PED) visits in Sardinia, Italy, during the early period of the COVID-19 pandemic. Methods: We retrospectively investigated the number and characteristics of visits to two major Sardinian PEDs, in the periods January-June 2020 and January-June 2019. Results: From January to June 2020, 8399 PED visits with 1160 hospital admissions (13.8% of PED visits) were registered, compared with 15,692 PED visits (Δ = -46.5%) and 1819 hospital admissions (11.6% of PED visits) occurring from January to June 2019. Comparing January-June 2020 with January-June 2019, we found differences in the percentage of visits for age groups, and significant changes in the proportion of triage codes, with a decrease in green codes (72.1% vs 74.2%, respectively) and an increase in white codes (19.0% vs 16.5%, respectively). Moreover, in the period January-June 2020, the frequency of skin disorders and acute respiratory disease significantly decreased, while the frequency of trauma, acute surgical disease, intoxication, and neuropsychiatric disease significantly increased. Conclusions: After the beginning of the Italian lockdown, we observed a marked drop in the number of PED visits, an increase in hospital admission rate, and radical changes in the reason for visit.
MeSH term(s)	COVID-19/epidemiology ; Child ; Communicable Disease Control ; Emergency Service, Hospital ; Humans ; Italy/epidemiology ; Pandemics ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2022-03-03
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-022-01225-6
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