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  1. Article ; Online: Resolving the Instructions for αβ T Cell Development.

    Cleveland, Sarah B / Huseby, Eric S

    Immunity

    2020  Volume 53, Issue 6, Page(s) 1126–1128

    Abstract: In this issue of Immunity, Chopp et. al. use single-cell transcriptomics and epigenomics in mice and human samples to delineate developmental trajectories of αβ T cell subsets and refine the kinetic selection model of ... ...

    Abstract In this issue of Immunity, Chopp et. al. use single-cell transcriptomics and epigenomics in mice and human samples to delineate developmental trajectories of αβ T cell subsets and refine the kinetic selection model of CD4
    MeSH term(s) Animals ; Cell Differentiation ; Epigenomics ; Humans ; Mice ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; T-Lymphocyte Subsets ; Transcriptome
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta ; Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2020.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: I-A

    Stadinski, Brian D / Cleveland, Sarah B / Brehm, Michael A / Greiner, Dale L / Huseby, Priya G / Huseby, Eric S

    Nature immunology

    2023  Volume 24, Issue 4, Page(s) 652–663

    Abstract: Genetic susceptibility to type 1 diabetes is associated with homozygous expression of major histocompatibility complex class II alleles that carry specific beta chain polymorphisms. Why heterozygous expression of these major histocompatibility complex ... ...

    Abstract Genetic susceptibility to type 1 diabetes is associated with homozygous expression of major histocompatibility complex class II alleles that carry specific beta chain polymorphisms. Why heterozygous expression of these major histocompatibility complex class II alleles does not confer a similar predisposition is unresolved. Using a nonobese diabetic mouse model, here we show that heterozygous expression of the type 1 diabetes-protective allele I-A
    MeSH term(s) Mice ; Animals ; Diabetes Mellitus, Type 1 ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Histocompatibility Antigens Class II ; Insulin/metabolism ; Mice, Inbred NOD
    Chemical Substances Histocompatibility Antigens Class II ; Insulin
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01441-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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