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  1. Book ; Online ; E-Book: Stem cells

    Mummery, Christine L. / van de Stolpe, Anja / Roelen, Bernard / Clevers, Hans

    scientific facts and fiction

    2021  

    Author's details Christine L. Mummery, Anja van de Stolpe, Bernard Roelen, Hans Clevers,
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (ix, 411 Seiten), Illustrationen, Diagramme
    Edition Third edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020892835
    ISBN 978-0-12-822677-3 ; 9780128203378 ; 0-12-822677-3 ; 0128203374
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Hallmarks of stemness in mammalian tissues.

    Beumer, Joep / Clevers, Hans

    Cell stem cell

    2024  Volume 31, Issue 1, Page(s) 7–24

    Abstract: All adult tissues experience wear and tear. Most tissues can compensate for cell loss through the activity of resident stem cells. Although the cellular maintenance strategies vary greatly between different adult (read: postnatal) tissues, the function ... ...

    Abstract All adult tissues experience wear and tear. Most tissues can compensate for cell loss through the activity of resident stem cells. Although the cellular maintenance strategies vary greatly between different adult (read: postnatal) tissues, the function of stem cells is best defined by their capacity to replace lost tissue through division. We discuss a set of six complementary hallmarks that are key enabling features of this basic function. These include longevity and self-renewal, multipotency, transplantability, plasticity, dependence on niche signals, and maintenance of genome integrity. We discuss these hallmarks in the context of some of the best-understood adult stem cell niches.
    MeSH term(s) Animals ; Mammals ; Stem Cell Niche ; Stem Cells
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Decoding endocrine cell differentiation: insights from high-throughput CRISPR screening in human gut organoids.

    Lin, Lin / Clevers, Hans

    Clinical and translational medicine

    2024  Volume 14, Issue 1, Page(s) e1526

    MeSH term(s) Humans ; Clustered Regularly Interspaced Short Palindromic Repeats ; Cell Differentiation/genetics ; High-Throughput Screening Assays ; Organoids
    Language English
    Publishing date 2024-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1526
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  4. Article ; Online: COVID-19: organoids go viral.

    Clevers, Hans

    Nature reviews. Molecular cell biology

    2020  Volume 21, Issue 7, Page(s) 355–356

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Norovirus ; Organoids ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Stem Cells
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-020-0258-4
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  5. Article ; Online: Expanding Impact of Stem Cell Science.

    Clevers, Hans

    Stem cell reports

    2018  Volume 10, Issue 5, Page(s) 1427–1428

    MeSH term(s) Awareness ; Congresses as Topic ; Humans ; Periodicals as Topic ; Policy ; Stem Cell Research ; Stem Cells/cytology
    Language English
    Publishing date 2018-05-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2018.04.017
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  6. Article ; Online: Organoids: Avatars for Personalized Medicine.

    Clevers, Hans C

    The Keio journal of medicine

    2019  Volume 68, Issue 4, Page(s) 95

    Abstract: Stem cells are the foundation of all mammalian life. Stem cells build and maintain our bodies throughout life. Two types of stem cells are discerned.1) Embryonic stem cells (ES cells) are briefly present in the early human or mouse embryo, a few days ... ...

    Abstract Stem cells are the foundation of all mammalian life. Stem cells build and maintain our bodies throughout life. Two types of stem cells are discerned.1) Embryonic stem cells (ES cells) are briefly present in the early human or mouse embryo, a few days after fertilization. These ES cells can be grown indefinitely in the lab and have the potential to build each and every tissue in our body. Because of this 'pluripotency', ES cells hold great promise for therapeutic application in the field of regenerative medicine. It is also possible to take skin cells (or other cells) from adults and convert these in the lab into cells with ES properties, so called iPS cells. Many of the hurdles that ES cell technology have faced, do not exist for iPS cells.2) Adult stem cells. Every organ in our body is believed to harbor its own dedicated stem cells. These adult stem cells replace tissue that is lost due to wear and tear, trauma and disease. Adult stem cells are highly specialized and can only produce the tissue in which they reside; they are 'multipotent'. Examples are bone marrow stem cells that make all blood cells, skin stem cells and gut stem cells. Even the brain is now known to harbor its specialized stem cells. The adult stem cells allow us to live 80-90 years, but this comes at a cost: they are the cells that most easily transform into cancer cells.Both types of stem cells can be used to establish 'organoids', 3D structures established in a dish, that recapitulate many aspects of the organ they represent. Pluripotent stem cells can be taken through the developmental steps that establish organs during embryogenesis. This has worked particularly well for parts of the the central nervous system, the kidney and GI organs. We have shown that adult epithelial stem cells carrying the generic Lgr5 marker can be cultured under tissue-repair conditions and generate epithelial organoids directly from healthy and diseased organs such as the gut, the liver, the lung and the pancreas. Organoid technology opens a range of avenues for the study of development, physiology and disease, for drug development and for personalized medicine. In the long run, cultured mini-organs may replace transplant organs from donors and hold promise in gene therapy.
    MeSH term(s) Adult Stem Cells/cytology ; Adult Stem Cells/metabolism ; Animals ; Biomarkers/metabolism ; Cell Differentiation ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/metabolism ; Gene Expression ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Organ Specificity ; Organoids/cytology ; Organoids/metabolism ; Organoids/transplantation ; Precision Medicine/methods ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Regenerative Medicine/methods
    Chemical Substances Biomarkers ; LGR5 protein, human ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2019-12-25
    Publishing country Japan
    Document type Lecture
    ZDB-ID 390981-5
    ISSN 1880-1293 ; 0022-9717
    ISSN (online) 1880-1293
    ISSN 0022-9717
    DOI 10.2302/kjm.68-006-ABST
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19

    Clevers, Hans

    Nature Reviews Molecular Cell Biology

    organoids go viral

    2020  Volume 21, Issue 7, Page(s) 355–356

    Keywords Cell Biology ; Molecular Biology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-020-0258-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures.

    Balážová, Katarína / Clevers, Hans / Dost, Antonella F M

    eLife

    2023  Volume 12

    Abstract: Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. Traditional therapeutic approaches such as chemotherapy or radiotherapy have provided only a marginal improvement in the treatment of lung carcinomas. Inhibitors targeting specific ...

    Abstract Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. Traditional therapeutic approaches such as chemotherapy or radiotherapy have provided only a marginal improvement in the treatment of lung carcinomas. Inhibitors targeting specific genetic aberrations present in non-small cell lung cancer (NSCLC), the most common subtype (85%), have improved the prognostic outlook, but due to the complexity of the LC mutational spectrum, only a fraction of patients benefit from these targeted molecular therapies. More recently, the realization that the immune infiltrate surrounding solid tumors can foster tumor-promoting inflammation has led to the development and implementation of anticancer immunotherapies in the clinic. In NSCLC, one of the most abundant leukocyte infiltrates is macrophages. These highly plastic phagocytes, which are part of the cellular repertoire of the innate immunity, can have a pivotal role in early NSCLC establishment, malignant progression, and tumor invasion. Emerging macrophage-targeting therapies have been focused on the re-differentiation of the macrophages toward an antitumorigenic phenotype, depletion of tumor-promoting macrophage subtypes, or combination therapies combining traditional cytotoxic treatments with immunotherapeutic agents. The most extensively used models employed for the exploration of NSCLC biology and therapy have been 2D cell lines and murine models. However, studying cancer immunology requires appropriately complex models. 3D platforms, including organoid models, are quickly advancing powerful tools to study immune cell-epithelial cell interactions within the tumor microenvironment. Co-cultures of immune cells along with NSCLC organoids allow for an in vitro observation of the tumor microenvironment dynamics closely resembling in vivo settings. Ultimately, the implementation of 3D organoid technology into tumor microenvironment-modeling platforms might facilitate the exploration of macrophage-targeted therapies in NSCLC immunotherapeutic research, thus establishing a new frontier in NSCLC treatment.
    MeSH term(s) Animals ; Mice ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Coculture Techniques ; Macrophages ; Antineoplastic Agents/pharmacology ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.82998
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  10. Article ; Online: Modeling Development and Disease with Organoids.

    Clevers, Hans

    Cell

    2016  Volume 165, Issue 7, Page(s) 1586–1597

    Abstract: Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, ... ...

    Abstract Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish." Additionally, patient-derived organoids hold promise to predict drug response in a personalized fashion. Organoids open up new avenues for regenerative medicine and, in combination with editing technology, for gene therapy. The many potential applications of this technology are only beginning to be explored.
    MeSH term(s) Animals ; Humans ; Models, Biological ; Organ Specificity ; Organoids/cytology ; Sequence Analysis, RNA ; Single-Cell Analysis ; Stem Cells/cytology
    Language English
    Publishing date 2016-06-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2016.05.082
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