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  1. Article ; Online: Applications of Omics Technologies for Three-Dimensional

    Pieters, Vera M / Co, Ileana L / Wu, Nila C / McGuigan, Alison P

    Tissue engineering. Part C, Methods

    2021  Volume 27, Issue 3, Page(s) 183–199

    Abstract: Omics technologies, such as genomics, epigenomics, transcriptomics, proteomics, metabolomics, lipidomics, multiomics, and integrated modalities, have greatly contributed to our understanding of various diseases by enabling researchers to probe the ... ...

    Abstract Omics technologies, such as genomics, epigenomics, transcriptomics, proteomics, metabolomics, lipidomics, multiomics, and integrated modalities, have greatly contributed to our understanding of various diseases by enabling researchers to probe the molecular wiring of cellular systems in a high-throughput and precise manner. With the development of tissue-engineered three-dimensional (3D)
    MeSH term(s) Epigenomics ; Genomics ; Humans ; Metabolomics ; Neoplasms ; Proteomics
    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2420585-0
    ISSN 1937-3392 ; 1937-3384
    ISSN (online) 1937-3392
    ISSN 1937-3384
    DOI 10.1089/ten.TEC.2020.0300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5500/C: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Article ; Online: An Engineered Paper-Based 3D Coculture Model of Pancreatic Cancer to Study the Impact of Tissue Architecture and Microenvironmental Gradients on Cell Phenotype.

    Cadavid, Jose L / Latour, Simon / Nowlan, Ferris / Co, Ileana L / Landon-Brace, Natalie / Wouters, Bradly G / Grünwald, Barbara T / Nitz, Mark / Jackson, Hartland Warren / McGuigan, Alison P

    Advanced healthcare materials

    2022  Volume 12, Issue 14, Page(s) e2201846

    Abstract: The spatial configuration of cells in the tumor microenvironment (TME) affects both cancer and fibroblast cell phenotypes contributing to the clinical challenge of tumor heterogeneity and therapeutic resistance. This is a particular challenge in stroma- ... ...

    Abstract The spatial configuration of cells in the tumor microenvironment (TME) affects both cancer and fibroblast cell phenotypes contributing to the clinical challenge of tumor heterogeneity and therapeutic resistance. This is a particular challenge in stroma-rich pancreatic ductal adenocarcinoma (PDAC). Here, a versatile system is described to study the impact of tissue architecture on cell phenotype using PDAC as a model system. This fully human system encompassing both primary pancreatic stellate cells and primary organoid cells using the TRACER platform to allow the creation of user-defined TME architectures that have been inferred from clinical PDAC samples and are analyzed by CyTOF to characterize cells extracted from the system. High dimensional characterization using CyTOF demonstrates that tissue architecture leads to distinct hypoxia and proliferation gradients. Furthermore, phenotypic markers for both cell types are also graded in ways that cannot be explained by either hypoxia or coculture alone. This demonstrates the importance of using complex models encompassing cancer cells, stromal cells, and allowing control over architecture to explore the impact of tissue architecture on cell phenotype. It is anticipated that this model will help decipher how tissue architecture and cell interactions regulate cell phenotype and hence cellular and tissue heterogeneity.
    MeSH term(s) Humans ; Coculture Techniques ; Pancreatic Neoplasms/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Phenotype ; Tumor Microenvironment ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-11-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202201846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6966: Show issues Location:
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  3. Article: Brain Organoids: A New, Transformative Investigational Tool for Neuroscience Research.

    Vaez Ghaemi, Roza / Co, Ileana L / McFee, Matthew C / Yadav, Vikramaditya G

    Advanced biosystems

    2018  Volume 3, Issue 1, Page(s) e1800174

    Abstract: Brain organoids are self-assembled, three-dimensionally structured tissues that are typically derived from pluripotent stem cells. They are multicellular aggregates that more accurately recapitulate the tissue microenvironment compared to the other cell ... ...

    Abstract Brain organoids are self-assembled, three-dimensionally structured tissues that are typically derived from pluripotent stem cells. They are multicellular aggregates that more accurately recapitulate the tissue microenvironment compared to the other cell culture systems and can also reproduce organ function. They are promising models for evaluating drug leads, particularly those that target neurodegeneration, since they are genetically and phenotypically stable over prolonged durations of culturing and they reasonably reproduce critical physiological phenomena such as biochemical gradients and responses by the native tissue to stimuli. Beyond drug discovery, the use of brain organoids could also be extended to investigating early brain development and identifying the mechanisms that elicit neurodegeneration. Herein, the current state of the fabrication and use of brain organoids in drug development and medical research is summarized. Although the use of brain organoids represents a quantum leap over existing investigational tools used by the pharmaceutical industry, they are nonetheless imperfect systems that could be greatly improved through bioengineering. To this end, some key scientific challenges that would need to be addressed in order to enhance the relevance of brain organoids as model tissue are listed. Potential solutions to these challenges, including the use of bioprinting, are highlighted thereafter.
    Language English
    Publishing date 2018-10-08
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2366-7478
    ISSN 2366-7478
    DOI 10.1002/adbi.201800174
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  4. Article ; Online: Discovery

    Callaghan, Neal I / Khaira, Sukhmani / Ouyang, Angelina / Cadavid, Jose L / Chang, Huntley H / Co, Ileana L / Diep, Patrick / Ivanov, Nicolas / Li, Guijin / Li, Nancy T / Tran-Nguyen, Nhien / Smith, Corinna / Davenport Huyer, Locke / Kilkenny, Dawn M

    Biomedical engineering education

    2020  Volume 1, Issue 1, Page(s) 87–94

    Language English
    Publishing date 2020-08-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 3040682-1
    ISSN 2730-5945 ; 2730-5937
    ISSN (online) 2730-5945
    ISSN 2730-5937
    DOI 10.1007/s43683-020-00014-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.

    Hezaveh, Kebria / Shinde, Rahul S / Klötgen, Andreas / Halaby, Marie Jo / Lamorte, Sara / Ciudad, M Teresa / Quevedo, Rene / Neufeld, Luke / Liu, Zhe Qi / Jin, Robbie / Grünwald, Barbara T / Foerster, Elisabeth G / Chaharlangi, Danica / Guo, Mengdi / Makhijani, Priya / Zhang, Xin / Pugh, Trevor J / Pinto, Devanand M / Co, Ileana L /
    McGuigan, Alison P / Jang, Gun Ho / Khokha, Rama / Ohashi, Pamela S / O'Kane, Grainne M / Gallinger, Steven / Navarre, William W / Maughan, Heather / Philpott, Dana J / Brooks, David G / McGaha, Tracy L

    Immunity

    2022  Volume 55, Issue 2, Page(s) 324–340.e8

    Abstract: The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated macrophage (TAM) function in pancreatic ductal adenocarcinoma (PDAC). TAMs ... ...

    Abstract The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated macrophage (TAM) function in pancreatic ductal adenocarcinoma (PDAC). TAMs exhibited high AhR activity and Ahr-deficient macrophages developed an inflammatory phenotype. Deletion of Ahr in myeloid cells or pharmacologic inhibition of AhR reduced PDAC growth, improved efficacy of immune checkpoint blockade, and increased intra-tumoral frequencies of IFNγ
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Pancreatic Ductal/immunology ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/mortality ; Carcinoma, Pancreatic Ductal/pathology ; Humans ; Immune Tolerance/immunology ; Indoles/immunology ; Indoles/metabolism ; Lymphocytes, Tumor-Infiltrating/immunology ; Mice ; Microbiota/immunology ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Prognosis ; Receptors, Aryl Hydrocarbon/antagonists & inhibitors ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/immunology ; Receptors, Aryl Hydrocarbon/metabolism ; Tryptophan/immunology ; Tryptophan/metabolism ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/metabolism
    Chemical Substances Indoles ; Receptors, Aryl Hydrocarbon ; Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Discovery

    Callaghan, Neal I. / Khaira, Sukhmani / Ouyang, Angelina / Cadavid, Jose L. / Chang, Huntley H. / Co, Ileana L. / Diep, Patrick / Ivanov, Nicolas / Li, Guijin / Li, Nancy T. / Tran-Nguyen, Nhien / Smith, Corinna / Davenport Huyer, Locke / Kilkenny, Dawn M.

    Biomedical Engineering Education ; ISSN 2730-5937 2730-5945

    Virtual Implementation of Inquiry-Based Remote Learning for Secondary STEM Students During the COVID-19 Pandemic

    2020  

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s43683-020-00014-z
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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