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  1. Article ; Online: Limited seizures, but a broader impact.

    Coan, Ana Carolina

    Arquivos de neuro-psiquiatria

    2021  Volume 79, Issue 12, Page(s) 1068–1069

    MeSH term(s) Humans ; Seizures
    Language English
    Publishing date 2021-12-17
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1590/0004-282X-ANP-2021-e012
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  2. Article ; Online: Beyond Nature Versus Nurture: the Emergence of Emotion.

    Wood, Adrienne / Coan, James A

    Affective science

    2023  Volume 4, Issue 3, Page(s) 443–452

    Abstract: Affective science is stuck in a version of the nature-versus-nurture debate, with theorists arguing whether emotions are evolved adaptations or psychological constructions. We do not see these as mutually exclusive options. Many adaptive behaviors that ... ...

    Abstract Affective science is stuck in a version of the nature-versus-nurture debate, with theorists arguing whether emotions are evolved adaptations or psychological constructions. We do not see these as mutually exclusive options. Many adaptive behaviors that humans have evolved to be good at, such as walking, emerge during development - not according to a genetically dictated program, but through interactions between the affordances of the body, brain, and environment. We suggest emotions are the same. As developing humans acquire increasingly complex goals and learn optimal strategies for pursuing those goals, they are inevitably pulled to particular brain-body-behavior states that maximize outcomes and self-reinforce via positive feedback loops. We call these recurring, self-organized states
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2978299-5
    ISSN 2662-205X ; 2662-2041
    ISSN (online) 2662-205X
    ISSN 2662-2041
    DOI 10.1007/s42761-023-00212-2
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  3. Article ; Online: Laboratory diagnosis of measles infection using molecular and serology during 2019-2020 outbreak in Brazil.

    Coan, Etienne Wessler / Tuon, Felipe Francisco

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2023  Volume 170, Page(s) 105623

    Abstract: Introduction: Laboratory diagnosis of measles can be challenging, and the reintroduction of the measles virus in Brazil has brought about new issues. The aim of this study was to analyze the qPCR results of swab and urine samples and compare them with ... ...

    Abstract Introduction: Laboratory diagnosis of measles can be challenging, and the reintroduction of the measles virus in Brazil has brought about new issues. The aim of this study was to analyze the qPCR results of swab and urine samples and compare them with those of immunological methods for the diagnosis of measles.
    Methods: This was a cross-sectional study based on a retrospective analysis of 3,451 suspected cases using laboratory test surveillance databases for qPCR (respiratory swabs and urine) and serologic tests for IgM and paired IgG. Sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and agreement through kappa and adjusted kappa coefficients (PABAK) were calculated using different diagnostic strategies.
    Results: The swab and urine samples obtained using real-time qPCR were equivalent. Samples collected simultaneously and the combined samples showed moderate agreement between IgM ELISA and real-time qPCR; however, 48.9 % of the IgM ELISA analyses did not demonstrate detectable qPCR concentrations during simultaneous collections and 43.9 % of combined collections. The paired analysis of IgG showed an accuracy of 67.5 % for IgM and 90.7 % for real-time qPCR.
    Conclusions: Diagnosis based on IgM presents detection delimitation in samples collected early (1-5 days), suggesting that these individuals satisfy at least two criteria. In addition to qPCR, paired analysis of IgG using ELISA can be used to increase the sensitivity and specificity of laboratory diagnoses.
    MeSH term(s) Humans ; Brazil/epidemiology ; Retrospective Studies ; Cross-Sectional Studies ; Antibodies, Viral ; Measles/diagnosis ; Measles/epidemiology ; Clinical Laboratory Techniques ; Enzyme-Linked Immunosorbent Assay/methods ; Sensitivity and Specificity ; Disease Outbreaks ; Immunoglobulin M ; Immunoglobulin G
    Chemical Substances Antibodies, Viral ; Immunoglobulin M ; Immunoglobulin G
    Language English
    Publishing date 2023-11-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2023.105623
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  4. Article ; Online: Targeting and engineering long non-coding RNAs for cancer therapy.

    Coan, Michela / Haefliger, Simon / Ounzain, Samir / Johnson, Rory

    Nature reviews. Genetics

    2024  

    Abstract: RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or employing RNA molecules for therapeutic purposes. Amongst the most promising targets are long non-coding RNAs (lncRNAs), which regulate oncogenic molecular networks in a ... ...

    Abstract RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or employing RNA molecules for therapeutic purposes. Amongst the most promising targets are long non-coding RNAs (lncRNAs), which regulate oncogenic molecular networks in a cell type-restricted manner. lncRNAs are distinct from protein-coding genes in important ways that increase their therapeutic potential yet also present hurdles to conventional clinical development. Advances in genome editing, oligonucleotide chemistry, multi-omics and RNA engineering are paving the way for efficient and cost-effective lncRNA-focused drug discovery pipelines. In this Review, we present the emerging field of lncRNA therapeutics for oncology, with emphasis on the unique strengths and challenges of lncRNAs within the broader RNATx framework. We outline the necessary steps for lncRNA therapeutics to deliver effective, durable, tolerable and personalized treatments for cancer.
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2035157-4
    ISSN 1471-0064 ; 1471-0056
    ISSN (online) 1471-0064
    ISSN 1471-0056
    DOI 10.1038/s41576-024-00693-2
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  5. Article ; Online: Brain morphological abnormalities in genetic generalized epilepsies: The starting point?

    Coan, Ana Carolina

    Epilepsia

    2019  Volume 60, Issue 7, Page(s) 1279–1280

    MeSH term(s) Brain ; Brain Diseases ; Epilepsies, Partial ; Epilepsy, Generalized ; Humans
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.16101
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  6. Article ; Online: King Solomon’s Mines on film

    Stephen COAN

    E-REA, Vol 18, Iss

    modernity in reverse?

    2020  Volume 1

    Abstract: There have been four feature films made under the title King Solomon’s Mines, each of them crediting H. Rider Haggard’s Victorian adventure novel published in 1885 as their source. Several films, under different titles, have also claimed either this ... ...

    Abstract There have been four feature films made under the title King Solomon’s Mines, each of them crediting H. Rider Haggard’s Victorian adventure novel published in 1885 as their source. Several films, under different titles, have also claimed either this novel or its sequel Allan Quatermain, as their source material. While close adherence to an original text should not be the criterion for the merits, or otherwise, of a film, it is worth noting that only the first film version of King Solomon’s Mines shot in South Africa in 1918, retained the inter-racial romance found in Haggard’s novel. Later versions substituted an invented white female character as the romantic interest for either the book’s hero, Allan Quatermain, or his fellow adventurer, Sir Henry Curtis. This includes the most recent version released in 2004 starring Patrick Swayze and Alison Doody. That Haggard’s novel (and the first film of his book made thirty-three years later) featured a love story between a white man and a black woman would perhaps seem counterintuitive given the perceived racial mores of the time. Equally, such a love story should seem less problematic given the passage of time. That this is not the case, even in the first decade of the 21st century, this novel presents us with an intriguing example of modernity in reverse. This paper explores the strange trajectory of cinema’s iterations of Haggard’s King Solomon’s Mines.
    Keywords film ; cinema ; South Africa ; modernity ; English language ; PE1-3729 ; Social sciences (General) ; H1-99
    Subject code 820
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Laboratoire d’Etudes et de Recherches sur le Monde Anglophone (LERMA)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Limited seizures, but a broader impact

    Coan, Ana Carolina

    Arquivos de Neuro-Psiquiatria

    2021  Volume 79, Issue 12, Page(s) 1068–1069

    Language English
    Publishing date 2021-12-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1590/0004-282X-ANP-2021-e012
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  8. Article ; Online: Dental and primary care professionals learning and collaborating to improve oral health.

    Phillips, Lori / Coan, Lorinda / Wijesuriya, Uditha

    Journal of dental education

    2023  Volume 87 Suppl 3, Page(s) 1819–1821

    MeSH term(s) Humans ; Oral Health ; Learning ; Dentists ; Primary Health Care
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410579-5
    ISSN 1930-7837 ; 0022-0337
    ISSN (online) 1930-7837
    ISSN 0022-0337
    DOI 10.1002/jdd.13205
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  9. Article ; Online: Multiplicidades, Narrativas de Vida e Memória Coletiva da Docência na História em Quadrinhos Fessora!

    Nara Bretas Lage / Samanta Coan

    Revista Lusófona de Estudos Culturais, Vol 10, Iss

    2023  Volume 2

    Abstract: O artigo apresenta o quadrinho Fessora!, desenhado e escrito pela brasileira Aline Lemos, publicado de modo independente e por financiamento coletivo em 2021. A história narrada tem como enfoque a experiência pessoal da autora quando foi docente de ... ...

    Abstract O artigo apresenta o quadrinho Fessora!, desenhado e escrito pela brasileira Aline Lemos, publicado de modo independente e por financiamento coletivo em 2021. A história narrada tem como enfoque a experiência pessoal da autora quando foi docente de história no ensino público por um semestre. A autora nos apresenta um conjunto de 15 histórias que abordam suas memórias pessoais com colegas de trabalho, corpo discente e pais. Neste texto, foram selecionadas seis bandas desenhadas, a fim de compreender, a partir das memórias e dos fragmentos de vida narrados, as tensões e confluências entre as vivências de trabalho acionadas pela artista. Retratam sua experiência pessoal como professora, revelando o cotidiano de professores da educação pública no Brasil. Para esta análise, usamos a ótica da narrativa de vida da linguista argentina Leonor Arfuch (2002/2003, 2013), quanto à relação entre narrativas de vida contemporâneas e o espaço biográfico; e a noção de memória coletiva (Halbwachs, 1950/1999; Bosi, 2009) para compreender a multiplicidade de experiências a partir da memória individual. Conclui-se que Aline Lemos apresenta uma obra que evidencia os desafios da educação sobre a valorização do docente e as desigualdades sociais em sala de aula.
    Keywords educação ; memória coletiva ; docência ; história em quadrinho ; narrativa de vida ; General Works ; A ; Ethnology. Social and cultural anthropology ; GN301-674 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Universidade do Minho
    Document type Article ; Online
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  10. Article ; Online: Groups as organisms: Implications for therapy and training.

    Wilson, David Sloan / Coan, James A

    Clinical psychology review

    2021  Volume 85, Page(s) 101987

    Abstract: The intellectual tradition of individualism treats the individual person as the fundamental unit of analysis and reduces all things social to the motives and actions of individuals. Most methods in clinical psychology are influenced by individualism and ... ...

    Abstract The intellectual tradition of individualism treats the individual person as the fundamental unit of analysis and reduces all things social to the motives and actions of individuals. Most methods in clinical psychology are influenced by individualism and therefore treat the individual as the primary object of therapy/training, even when recognizing the importance of nurturing social relationships for individual wellbeing. Multilevel selection theory offers an alternative to individualism in which individuals become part of something larger than themselves that qualifies as an organism in its own right. Seeing individuals as parts of social organisms provides a new perspective with numerous implications for improving wellbeing at all scales, from individuals to the planet.
    MeSH term(s) Humans ; Individuality ; Interpersonal Relations ; Motivation
    Language English
    Publishing date 2021-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604577-7
    ISSN 1873-7811 ; 0272-7358
    ISSN (online) 1873-7811
    ISSN 0272-7358
    DOI 10.1016/j.cpr.2021.101987
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