Article ; Online: Non-invasive massive growing prostheses reduce infection in paediatric cancer patients.
Journal of orthopaedic surgery (Hong Kong)
2019 Volume 27, Issue 1, Page(s) 2309499019833403
Abstract: Purpose: In this study, we asked the question of whether non-invasive (NI) extendible bone tumour implants are as reliable and reduce infection when compared with patients who received a minimally invasive (MI) extendible implant.: Methods: Forty-two ...
Abstract | Purpose: In this study, we asked the question of whether non-invasive (NI) extendible bone tumour implants are as reliable and reduce infection when compared with patients who received a minimally invasive (MI) extendible implant. Methods: Forty-two NI extendible bone tumour implants were investigated at a mean follow-up of 22 months (range, 1-87 months) and 63 MI implants at a mean follow-up of 49 months (range, 1-156 months). Results: Kaplan-Meier analysis showed that the probability of MI implant survival was 58.8% compared with 78.6% in NI patients. No significant difference between these two patient groups was found. Infection was the main reason for failure in the MI implant group where nine (35%) implants were revised. However, only one (11%) NI implant was revised for infection ( p = 0.042). None of the NI implants failed due to aseptic loosening; however, six (23%) MI implants were revised for aseptic loosening of the intramedullary stem. Four (15%) of the failed MI implants were revised due to full extension and five (56%) of failed NI implants were replaced as the implant had been fully extended where the patient still required growth. Conclusion: Where possible, an NI massive prosthesis should be used in this patient group. Our results suggest that MI prostheses should be infrequently used due to the high incidence of infection. Lengthening of NI prostheses is painless, can be carried out in the clinic and is more cost-effective. However, further work is required to increase the amount of growth potential available in these implants. |
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MeSH term(s) | Adolescent ; Bone Neoplasms/surgery ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Prostheses and Implants/adverse effects ; Prosthesis Implantation/adverse effects ; Prosthesis Implantation/instrumentation ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/prevention & control ; Reconstructive Surgical Procedures/adverse effects ; Reconstructive Surgical Procedures/instrumentation ; Sarcoma/surgery ; Survival Analysis ; Treatment Outcome |
Language | English |
Publishing date | 2019-03-02 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1493368-8 |
ISSN | 2309-4990 ; 1022-5536 |
ISSN (online) | 2309-4990 |
ISSN | 1022-5536 |
DOI | 10.1177/2309499019833403 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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