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  1. Article ; Online: The β2

    Meneghini, Simone / Modena, Debora / Colombo, Giulia / Coatti, Aurora / Milani, Niccolò / Madaschi, Laura / Amadeo, Alida / Becchetti, Andrea

    Progress in neurobiology

    2022  Volume 214, Page(s) 102279

    Abstract: Mutant subunits of the neuronal nicotinic ACh receptor (nAChR) can cause Autosomal Dominant Sleep-related Hypermotor Epilepsy (ADSHE), characterized by frontal seizures during non-rapid eye movement (NREM) sleep. We studied the cellular bases of the ... ...

    Abstract Mutant subunits of the neuronal nicotinic ACh receptor (nAChR) can cause Autosomal Dominant Sleep-related Hypermotor Epilepsy (ADSHE), characterized by frontal seizures during non-rapid eye movement (NREM) sleep. We studied the cellular bases of the pathogenesis in brain slices from mice conditionally expressing the ADSHE-linked β2
    MeSH term(s) Acetylcholine/pharmacology ; Animals ; Epilepsy ; Humans ; Mice ; Mice, Transgenic ; Neurons/physiology ; Nicotine/pharmacology ; Prefrontal Cortex/metabolism ; Receptors, Nicotinic/metabolism ; Seizures ; Sleep/physiology ; Somatostatin
    Chemical Substances Receptors, Nicotinic ; Somatostatin (51110-01-1) ; Nicotine (6M3C89ZY6R) ; Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2022.102279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: α4β2

    Aracri, Patrizia / Meneghini, Simone / Coatti, Aurora / Amadeo, Alida / Becchetti, Andrea

    Neuroscience

    2016  Volume 340, Page(s) 48–61

    Abstract: Nicotinic acetylcholine receptors (nAChRs) produce widespread and complex effects on neocortex excitability. We studied how heteromeric nAChRs regulate inhibitory post-synaptic currents (IPSCs), in fast-spiking (FS) layer V neurons of the mouse frontal ... ...

    Abstract Nicotinic acetylcholine receptors (nAChRs) produce widespread and complex effects on neocortex excitability. We studied how heteromeric nAChRs regulate inhibitory post-synaptic currents (IPSCs), in fast-spiking (FS) layer V neurons of the mouse frontal area 2 (Fr2). In the presence of blockers of ionotropic glutamate receptors, tonic application of 10μM nicotine augmented the spontaneous IPSC frequency, with minor alterations of amplitudes and kinetics. These effects were studied since the 3rd postnatal week, and persisted throughout the first two months of postnatal life. The action of nicotine was blocked by 1μM dihydro-β-erythroidine (DHβE; specific for α4
    MeSH term(s) Aging/drug effects ; Aging/metabolism ; Animals ; Female ; Immunohistochemistry ; Inhibitory Postsynaptic Potentials/drug effects ; Inhibitory Postsynaptic Potentials/physiology ; Male ; Mice ; Microscopy, Confocal ; Miniature Postsynaptic Potentials/drug effects ; Miniature Postsynaptic Potentials/physiology ; Neurons/drug effects ; Neurons/metabolism ; Neurotransmitter Agents/pharmacology ; Parvalbumins/metabolism ; Patch-Clamp Techniques ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Receptors, Nicotinic/metabolism ; Somatostatin/metabolism ; Tissue Culture Techniques ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Neurotransmitter Agents ; Parvalbumins ; Receptors, Nicotinic ; nicotinic receptor alpha4beta2 ; Somatostatin (51110-01-1) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2016-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2016.10.045
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    Zs.A 1215: Show issues Location:
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  3. Article ; Online: Postnatal Changes in K

    Amadeo, Alida / Coatti, Aurora / Aracri, Patrizia / Ascagni, Miriam / Iannantuoni, Davide / Modena, Debora / Carraresi, Laura / Brusco, Simone / Meneghini, Simone / Arcangeli, Annarosa / Pasini, Maria Enrica / Becchetti, Andrea

    Neuroscience

    2018  Volume 386, Page(s) 91–107

    Abstract: ... The ... ...

    Abstract The Na
    MeSH term(s) Animals ; Animals, Newborn ; Epilepsy/genetics ; Epilepsy/metabolism ; Female ; Gene Expression ; Male ; Mice ; Mice, Transgenic ; Mutation/physiology ; Neocortex/metabolism ; Prosencephalon/metabolism ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Receptors, Nicotinic/genetics ; Receptors, Nicotinic/metabolism ; Sleep/physiology ; Solute Carrier Family 12, Member 2/biosynthesis ; Solute Carrier Family 12, Member 2/genetics ; Symporters/biosynthesis ; Symporters/genetics ; Thalamus/metabolism ; K Cl- Cotransporters
    Chemical Substances Protein Subunits ; Receptors, Nicotinic ; Slc12a2 protein, mouse ; Solute Carrier Family 12, Member 2 ; Symporters
    Language English
    Publishing date 2018-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2018.06.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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