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  1. Article ; Online: Blood pressure and cardiovascular disease: are diastolic values 80-89 mmHg enough to define hypertension?

    Coca, Antonio

    European heart journal

    2021  Volume 42, Issue 21, Page(s) 2130–2132

    MeSH term(s) Blood Pressure ; Cardiovascular Diseases ; Diastole ; Heart Murmurs ; Humans ; Hypertension
    Language English
    Publishing date 2021-03-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  2. Article ; Online: A Further Step to Classical Semiology: The Subtle Expression of Structural and Functional Cerebral Changes in Hypertension.

    Coca, Antonio / Camafort, Miguel

    American journal of hypertension

    2022  Volume 35, Issue 7, Page(s) 593–595

    MeSH term(s) Blood Pressure ; Humans ; Hypertension/physiopathology ; Middle Aged
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpac050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2329: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Ionic transport in hypertension

    Coca, Antonio

    new perspectives

    1994  

    Author's details ed. by Antonio Coca
    Keywords Hypertension / metabolism ; Ion Transport / physiology ; Hypertonie ; Ionentransport
    Subject Ionentranslokation ; Ionenstrom ; Arterielle Hypertonie ; Arterieller Hochdruck ; Bluthochdruck ; Hochdruck ; Hypertension ; Hypertonus
    Language English
    Size 323 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006316244
    ISBN 0-8493-5474-9 ; 978-0-8493-5474-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 2662 order for loan Magazin

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  4. Article: Editorial: Hypertension in the Elderly.

    Coca, Antonio / Burnier, Michel

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 645580

    Language English
    Publishing date 2021-02-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.645580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Hypertension and brain damage

    Coca, Antonio

    (Updates in hypertension and cardiovascular protection,)

    2016  

    Institution European Society of Hypertension,
    Author's details Antonio Coca, editor
    Series title Updates in hypertension and cardiovascular protection,
    MeSH term(s) Hypertension/complications ; Brain Damage, Chronic/etiology ; Stroke/etiology ; Brain Damage, Chronic/diagnosis
    Language English
    Size xii, 211 pages :, illustrations.
    Document type Book
    ISBN 9783319320724 ; 9783319320748 ; 3319320726 ; 3319320742
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article ; Online: The Rationale for Using Fixed-Dose Combination Therapy in the Management of Hypertension in Colombia: A Narrative Review.

    Molina de Salazar, Dora Inés / Coca, Antonio / Alcocer, Luis / Piskorz, Daniel

    American journal of cardiovascular drugs : drugs, devices, and other interventions

    2024  Volume 24, Issue 2, Page(s) 197–209

    Abstract: Hypertension is a major risk factor for cardiovascular disease and the leading cause of death in Colombia. While the rate of hypertension awareness in Colombia is generally high, rates of treatment initiation, adherence, and blood pressure (BP) control ... ...

    Abstract Hypertension is a major risk factor for cardiovascular disease and the leading cause of death in Colombia. While the rate of hypertension awareness in Colombia is generally high, rates of treatment initiation, adherence, and blood pressure (BP) control are suboptimal. Major international hypertension guidelines recommend starting treatment with a combination of antihypertensive agents, and the use of a single-pill combination (SPC) to maximize adherence. In contrast, Colombian hypertension guidelines recommend starting treatment with diuretic monotherapy in most patients, and only initiating combination therapy in those with BP > 160/100 mmHg. Therefore, the aim of the current narrative review is to examine the rationale for using SPCs to treat hypertension in Colombia, in the context of the major issues for BP control there. There is evidence of widespread therapeutic inertia in hypertension management, particularly in primary care, in Colombia. Moreover, combination therapy, angiotensin-converting enzyme inhibitors, and long-acting calcium channel blockers, which are internationally recommended as first-line drug therapies, are underutilized there. Adherence to antihypertensive therapy is low in Colombia and may be enhanced by use of SPCs as well as better patient education and follow-up. While there are promising national initiatives to improve BP management, more needs to be done by individual physicians. Antihypertensive SPCs are available on the national essential medicines list and may help to overcome some of the problems with suboptimal adherence, therapeutic inertia, and low rates of BP control that contribute to the high cardiovascular death rate in Colombia.
    MeSH term(s) Humans ; Antihypertensive Agents/therapeutic use ; Colombia ; Hypertension/drug therapy ; Calcium Channel Blockers ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Blood Pressure ; Drug Therapy, Combination ; Drug Combinations
    Chemical Substances Antihypertensive Agents ; Calcium Channel Blockers ; Angiotensin-Converting Enzyme Inhibitors ; Drug Combinations
    Language English
    Publishing date 2024-03-15
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2052547-3
    ISSN 1179-187X ; 1175-3277
    ISSN (online) 1179-187X
    ISSN 1175-3277
    DOI 10.1007/s40256-024-00634-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5487: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Correction: The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease - expert panel meeting report.

    Grigorian-Shamagian, Lilian / Coca, Antonio / Morais, Joao / Perez-Martinez, Pablo

    BMC proceedings

    2023  Volume 17, Issue 1, Page(s) 27

    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2411867-9
    ISSN 1753-6561
    ISSN 1753-6561
    DOI 10.1186/s12919-023-00279-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The use of the CNIC-Polypill in real-life clinical practice: opportunities and challenges in patients at very high risk of atherosclerotic cardiovascular disease - expert panel meeting report.

    Grigorian-Shamagian, Lilian / Coca, Antonio / Morais, Joao / Perez-Martinez, Pablo

    BMC proceedings

    2023  Volume 17, Issue Suppl 8, Page(s) 20

    Abstract: Although the cardiovascular (CV) polypill concept is not new and several guidelines state that a CV polypill should be considered an integral part of a comprehensive CV disease (CVD) prevention strategy, there are still some barriers to its ... ...

    Abstract Although the cardiovascular (CV) polypill concept is not new and several guidelines state that a CV polypill should be considered an integral part of a comprehensive CV disease (CVD) prevention strategy, there are still some barriers to its implementation in the real-world setting, mainly in secondary CV prevention. As the CNIC-polypill is the only one approved for secondary CV prevention in patients with atherosclerotic CVD in 27 countries worldwide, a panel of four discussants and 30 participants from 18 countries conveyed in a virtual meeting on April 21, 2022, to discuss key clinical questions regarding the practical use of the CNIC-Polypill and barriers to its implementation.Data presented showed that, although the use of the CV polypill is not explicitly mentioned in the current 2021 European Society of Cardiology guidelines on CVD prevention, it may be used in any patient for secondary CVD prevention tolerating all their components to improve outcomes through different aspects. The favourable results of the Secondary Prevention of Cardiovascular Disease in the Elderly (SECURE) trial now reinforce this recommendation. The panellists presented algorithms on how to switch from any baseline regimen when starting treatment with the CNIC-polypill in different situations, including patients with hypertension, dyslipidaemia, and a previous CV event; at discharge after a cardiovascular event; in chronic ischemic conditions; and in cases of polypharmacy. The panellists and expert discussants did agree that available studies conducted so far with the CNIC-polypill demonstrate that it is as efficacious as the monocomponents, equipotent drugs, or other therapies; reduces the risk of experiencing recurrent major CV events; improves medication adherence; reduces health care costs and resources compared to patients treated with loose drugs; and the patients prefer it over the multipill strategy.In conclusion, the data presented by the participants provided the evidence behind the use of the CNIC-polypill to help fulfil the goal of encouraging its adoption by physicians.
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2411867-9
    ISSN 1753-6561
    ISSN 1753-6561
    DOI 10.1186/s12919-023-00268-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Polypill in cardiovascular disease prevention: recent advances.

    Coca, Antonio / Castellano, José M / Camafort, Miguel / Fuster, Valentín

    Polish archives of internal medicine

    2023  Volume 133, Issue 3

    Abstract: Triple therapy with lipid‑lowering, antihypertensive, and antiplatelet agents reduces the risk of recurrent cardiovascular fatal and nonfatal events, cardiovascular mortality, and total mortality in secondary prevention. In real life, however, effective ... ...

    Abstract Triple therapy with lipid‑lowering, antihypertensive, and antiplatelet agents reduces the risk of recurrent cardiovascular fatal and nonfatal events, cardiovascular mortality, and total mortality in secondary prevention. In real life, however, effective implementation of these optimal treatments both in primary and secondary prevention is low, and thus their contribution to cardiovascular prevention is much lower than it could be, based on research data. One of the main barriers to the adequate implementation of these strategies is low adherence to the elevated number of pills, as adherence is adversely affected by the complexity of the prescribed treatment regimen, and can be considerably improved by treatment simplification. This review updates the findings provided by recent epidemiological and clinical studies favoring a polypill‑based approach to cardiovascular prevention. The increased prevalence of patients with multiple cardiovascular risk factors and comorbidities provides the rationale for a therapeutic strategy based on a combination of drugs against different risk factors in a single pill. Pharmacologic studies have demonstrated that different cardiovascular drugs can be combined in a single pill with no loss of their individual efficacy, and this favors adherence to and persistence of treatment, as well as multiple risk factor control. Recently, a randomized clinical trial SECURE (Secondary Prevention of Cardiovascular Disease in the Elderly) has shown a significant, 30% reduction in cardiovascular events, and a 33% reduction in cardiovascular death in patients after myocardial infarction treated with a polypill, as compared with usual care, thus supporting the polypill use as an integral part of any cardiovascular prevention strategy.
    MeSH term(s) Humans ; Aged ; Cardiovascular Diseases/etiology ; Drug Combinations ; Antihypertensive Agents/therapeutic use ; Platelet Aggregation Inhibitors/therapeutic use ; Myocardial Infarction/chemically induced ; Randomized Controlled Trials as Topic
    Chemical Substances Drug Combinations ; Antihypertensive Agents ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2023-03-13
    Publishing country Poland
    Document type Review ; Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: How to implement the recommendations of the 2018 ESC/ESH Hypertension Guidelines in a given patient: a step by step approach.

    Coca, Antonio / Doménech, Monica

    European heart journal. Cardiovascular pharmacotherapy

    2019  Volume 5, Issue 3, Page(s) 164–170

    Abstract: All clinical guidelines release general recommendations based on the best available evidence on the issue, usually obtained from epidemiological studies, randomized clinical trials, or meta-analyses. However, the final data of these studies are averages ... ...

    Abstract All clinical guidelines release general recommendations based on the best available evidence on the issue, usually obtained from epidemiological studies, randomized clinical trials, or meta-analyses. However, the final data of these studies are averages of a given parameter from groups of patients whose clinical characteristics are not necessarily similar to those of a specific patient seen in daily practice. As the guidelines recommendations have to be implemented in patients, not in group of patients, the final decisions concerning an individual patient must be made by the attending physician, in consultation with the patient and caregiver, as appropriate. In this article, a clinical case of a patient with hypertension and other associated cardiovascular risk factors is discussed and managed following the recommendations of the 2018 ESC/ESH Hypertension Guidelines implemented in this specific patient.
    MeSH term(s) Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Blood Pressure Determination/standards ; Clinical Decision-Making ; Guideline Adherence/standards ; Healthy Lifestyle ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Practice Guidelines as Topic/standards ; Practice Patterns, Physicians'/standards ; Risk Assessment ; Risk Factors ; Risk Reduction Behavior ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2019-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvz011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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