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  1. Article ; Online: Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review.

    Cocco, Pierluigi

    International journal of environmental research and public health

    2022  Volume 19, Issue 5

    Abstract: Background: In January 2021, the European Union ended the license of Mancozeb, the bestselling ethylenedithiocarbamate (EBDC) fungicide, because of some properties typical of human carcinogens. This decision contrasts the IARC classification of EBDC ... ...

    Abstract Background: In January 2021, the European Union ended the license of Mancozeb, the bestselling ethylenedithiocarbamate (EBDC) fungicide, because of some properties typical of human carcinogens. This decision contrasts the IARC classification of EBDC fungicides (Group 3, not classifiable as to human carcinogenicity). A systematic review of the scientific literature was conducted to explore the current evidence.
    Methods: Human and experimental studies of cancer and exposure to EBDC fungicides (Mancozeb, Maneb, Zineb, and others) and ethylene thiourea (ETU), their major metabolite, published in English as of December 2021, were retrieved using PubMed, the list of references of the relevant reports, and grey literature.
    Results: The epidemiological evidence of EBDC carcinogenicity is inadequate, with two studies each suggesting an association with melanoma and brain cancer and inconsistent findings for thyroid cancer. Experimental animal studies point at thyroid cancer in rats and liver cancer in mice, while multiple organs were affected following the long-term oral administration of Mancozeb. The mechanism of thyroid carcinogenesis in rats has also been shown to occur in humans. Genotoxic effects have been reported.
    Conclusions: The results of this systematic review suggest inadequate evidence for the carcinogenicity of EBDC fungicides from human studies and sufficient evidence from animal studies, with positive results on three out of ten key characteristics of carcinogens applying to humans as well. An IARC re-evaluation of the human carcinogenicity of EBDC fungicides is warranted.
    MeSH term(s) Animals ; Carcinogens/toxicity ; Fungicides, Industrial/toxicity ; Humans ; Maneb/toxicity ; Mice ; Rats ; Thyroid Neoplasms
    Chemical Substances Carcinogens ; Fungicides, Industrial ; Maneb (12427-38-2)
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19052632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cancer incidence among the NATO peacekeeping forces in Bosnia and Kosovo: a systematic review and metanalysis.

    Cocco, Pierluigi

    La Medicina del lavoro

    2022  Volume 113, Issue 1, Page(s) e2022011

    Abstract: Background: A few cohort studies of the NATO peacekeepers in the Bosnia and Kosovo war reported inconclusive results on cancer risk. A systematic review and metanalysis of such studies might help to resolve the interpretative limitations.: Methods: ... ...

    Abstract Background: A few cohort studies of the NATO peacekeepers in the Bosnia and Kosovo war reported inconclusive results on cancer risk. A systematic review and metanalysis of such studies might help to resolve the interpretative limitations.
    Methods: Relevant publications were retrieved through a PubMed search and from the list of references of the selected reports. Five epidemiological studies, one each from Denmark, Italy, the Netherlands, Norway, and Sweden, satisfied the selection criteria. Random and fixed effect estimators were calculated. Heterogeneity across studies was formally tested for all cancer outcomes.
    Results: Incidence of all cancers was below the expectation, as was the case for lung cancer and cancer at most other organs. The incidence of Hodgkin's lymphoma exceeded expectation in the first years after deployment in the Italian cohort but not in the subsequent years of follow-up. The risk of colorectal cancer and bone cancer was increased in the Danish cohort, and so was the risk of leukaemia in the Swedish cohort. Bladder cancer cases were non significantly more than expected in the three Scandinavian studies. The Cochrane's Q-test was indicative of significant heterogeneity across studies for total cancer, colorectal cancer, melanoma, and leukaemia. The meta-estimate of risk of bladder cancer was increased two-fold (fixed effect summary [FES] = 2.16 (95% CI 1.35 - 2.97), based on three studies.
    Discussion: Exposure to depleted uranium, metals, and ultrafine particles has been claimed as responsible for the cancer cases observed among peacekeepers. None of these would account for the excess of bladder cancer. The hypothesis of viral epidemics around the deployment area of the Italian military as contributing to the temporary excess of Hodgkin's Lymphoma cases would be worth exploring.
    MeSH term(s) Bosnia and Herzegovina ; Humans ; Incidence ; Kosovo ; Military Personnel ; Neoplasms/epidemiology ; Neoplasms/etiology
    Language English
    Publishing date 2022-02-22
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 123678-7
    ISSN 0025-7818
    ISSN 0025-7818
    DOI 10.23749/mdl.v113i1.12600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.265: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 395: Show issues

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  3. Book ; Conference proceedings: Abstracts / Sixteenth International Symposium on Epidemiology in Occupational Health ; Jack Pepys Symposium on Prevention of Occupational Asthma ; Third International Conference on Women's Health: Occupation, Cancer and Reproduction

    Cocco, Pierluigi

    [11 - 14 September 2002, Barcelona, Spain]

    (La medicina del lavoro ; 93,5)

    2002  

    Institution International Symposium on Epidemiology in Occupational Health
    Event/congress Jack Pepys Symposium on Prevention of Occupational Asthma (2002, Barcelona) ; International Conference on Women's Health: Occupation, Cancer and Reproduction (3, 2002, Barcelona)
    Author's details Guest eds.: Pierluigi Cocco
    Series title La medicina del lavoro ; 93,5
    Collection
    Language English
    Size S. 367 - 494
    Publisher Casa Editrice Mattioli
    Publishing place Fidenza
    Publishing country Italy
    Document type Book ; Conference proceedings
    HBZ-ID HT013458232
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Un I Zs 265 -93- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Hazardous Effects of Pesticides on Human Health.

    Ádám, Balázs / Cocco, Pierluigi / Godderis, Lode

    Toxics

    2024  Volume 12, Issue 3

    Abstract: Pesticides, a major group of biocides, are designed to control harmful and/or unwanted organisms [ ... ]. ...

    Abstract Pesticides, a major group of biocides, are designed to control harmful and/or unwanted organisms [...].
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics12030186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The determinants of the changing speed of spread of COVID-19 across Italy.

    Cocco, Pierluigi / De Matteis, Sara

    Epidemiology and infection

    2022  , Page(s) 1–26

    Language English
    Publishing date 2022-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S095026882200084X
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    Un I Zs.271: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Article: COVID-19 incidence in a cohort of public transport workers.

    De Matteis, Sara / Cencedda, Valerio / Pilia, Ilaria / Cocco, Pierluigi

    La Medicina del lavoro

    2022  Volume 113, Issue 4, Page(s) e2022039

    Abstract: Background: Previous research has shown an excess risk of COVID-19 among several occupations, but data on public transport workers are scarce. To investigate the occupational risk posed by contact with the public, we followed up the incidence of COVID- ... ...

    Abstract Background: Previous research has shown an excess risk of COVID-19 among several occupations, but data on public transport workers are scarce. To investigate the occupational risk posed by contact with the public, we followed up the incidence of COVID-19 in a cohort of public transport workers.
    Methods: We identified the incident cases of COVID-19 between 1 September 2020 - 6 May 2021 in a cohort of 2,052 employees of a public transport agency in Sardinia, Italy. The diagnosis of COVID-19 was based on a positive molecular test. To calculate the expected events, we applied the age- and gender-specific incidence rates of the regional population in the same time period to the correspondent strata of the study cohort. We estimated the relative risk (RR) of COVID-19 as the ratio between the observed and the expected events and its 95% confidence interval (95% C.I.) among the total cohort and in two sub-cohorts: bus drivers, and the rest of the personnel (administrative staff, train and metro drivers, workers in the mechanical shop, and in the railroad maintenance, and security).
    Results: Bus drivers run an elevated risk of COVID-19 (RR = 1.4, 95% C.I. 1.07 - 1.79). There was no excess risk among the sub-cohort including the rest of the personnel.
    Conclusions: Our study suggests an excess risk of COVID-19 among bus drivers even in a relatively low incidence area, which could imply inadequacy of the preventive measures in place. Further, larger size studies with detailed information on personal and lifestyle characteristics are warranted.
    MeSH term(s) COVID-19/epidemiology ; Cohort Studies ; Humans ; Incidence ; Occupations ; Risk Factors
    Language English
    Publishing date 2022-08-25
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123678-7
    ISSN 0025-7818
    ISSN 0025-7818
    DOI 10.23749/mdl.v113i4.13478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.265: Show issues Location:
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    Zs.MO 395: Show issues

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  7. Article ; Online: COVID-19 and non-Hodgkin's lymphoma: A common susceptibility pattern?

    Sara, De Matteis / Minelli, Cosetta / Broccia, Giorgio / Vineis, Paolo / Cocco, Pierluigi

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0277588

    Abstract: Objective: To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence.: Design: Ecological study design.: Setting: Sardinia, Italy.: Participants: We used official reports on the total cases of COVID-19 in 2020, ...

    Abstract Objective: To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence.
    Design: Ecological study design.
    Setting: Sardinia, Italy.
    Participants: We used official reports on the total cases of COVID-19 in 2020, published data on NHL incidence, and socio-economic indicators by administrative unit, covering the whole regional population.
    Main outcomes and measures: We used multivariable regression analysis to explore the association between the natural logarithm (ln) of the 2020 cumulative incidence of COVID-19 and the ln-transformed NHL incidence in 1974-2003, weighing by population size and adjusting by socioeconomic deprivation and other covariates.
    Results: The cumulative incidence of COVID-19 increased in relation to past incidence of NHL (p < 0.001), socioeconomic deprivation (p = 0.006), and proportion of elderly residents (p < 0.001) and decreased with urban residency (p = 0.001). Several sensitivity analyses confirmed the finding of an association between COVID-19 and NHL.
    Conclusion: This ecological study found an ecological association between NHL and COVID-19. If further investigation would confirm our findings, shared susceptibility factors should be investigated among the plausible underlying mechanisms.
    MeSH term(s) Humans ; Aged ; COVID-19/epidemiology ; Lymphoma, Non-Hodgkin/epidemiology ; Incidence ; Italy/epidemiology
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Epidemiology of Chronic Lymphocytic Leukemia in Sardinia, Italy (1974-2003).

    Broccia, Giorgio / Carter, Jonathan / Ozsin-Ozler, Cansu / De Matteis, Sara / Cocco, Pierluigi

    Experimental hematology

    2023  Volume 125-126, Page(s) 37–44

    Abstract: Several reports have described a worldwide increasing incidence of chronic lymphocytic leukemia (CLL) dating back seven to eight decades. Although genetic susceptibility would be an implausible explanation, the determinants of this upward trend and its ... ...

    Abstract Several reports have described a worldwide increasing incidence of chronic lymphocytic leukemia (CLL) dating back seven to eight decades. Although genetic susceptibility would be an implausible explanation, the determinants of this upward trend and its spatial coordinates are poorly understood. We explored CLL incidence in Sardinia, Italy, using a validated database including the 1700 CLL cases diagnosed during 1974-2003. We applied Bayesian methods to map the CLL probability by administrative unit and Poisson regression analysis to investigate socioeconomic and environmental determinants adjusting by possible confounders. The standardized (Standard European population) incidence rate for the Sardinian population over the study period was 5.1 per 100,000 (95% confidence interval [CI] 4.9-5.3), increased annually by 5.8% (95% CI 5.7-6.0) consistently by sex and age, and was more noticeable in urban areas. Five administrative units exceeded the 95% posterior probability of an elevated CLL incidence: these were rural areas spread over the regional territory, not suggestive of spatial clustering. The Poisson regression analysis showed that the risk was elevated in urban areas (RR = 1.11, 95% CI 1.05-1.17), among residents ≥ 30 km from the nearest hospital (RR = 1.09, 95% CI 1.06-1.12), and with the local prevalence of cork harvesting (RR = 1.62, 95% CI 1.12-2.34). Our results suggest that better access to health care facilities and improvements in diagnostic efficacy might have generated the observed upward trend in CLL incidence, along with contributing environmental factors.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Bayes Theorem ; Incidence ; Prevalence ; Italy/epidemiology
    Language English
    Publishing date 2023-08-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0531-5573 ; 0301-472X
    ISSN (online) 1873-2399
    ISSN 0531-5573 ; 0301-472X
    DOI 10.1016/j.exphem.2023.08.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Incidence and Bayesian Mapping of Myeloid Hematologic Malignancies in Sardinia, Italy.

    Broccia, Giorgio / Carter, Jonathan / Ozsin-Ozler, Cansu / De Matteis, Sara / Cocco, Pierluigi

    Cancer control : journal of the Moffitt Cancer Center

    2023  Volume 30, Page(s) 10732748231202906

    Abstract: Background: The epidemiology of myeloid hematologic malignancies in Italy has been poorly investigated.: Methods: We used a validated database of 1974-2003 incident cases of hematologic malignancies among the resident population (all ages) of ... ...

    Abstract Background: The epidemiology of myeloid hematologic malignancies in Italy has been poorly investigated.
    Methods: We used a validated database of 1974-2003 incident cases of hematologic malignancies among the resident population (all ages) of Sardinia, Italy, to describe the incidence of myeloid malignancies overall (N = 4389 cases) and by subtype. We investigated the time trend of acute myeloid leukemia (N = 1227 cases), chronic myeloid leukemia (N = 613 cases), and myelodysplastic syndrome (N = 1296 cases), and used Bayesian methods to explore their geographic spread, and Poisson regression analysis to estimate their association with environmental and socio-economic factors.
    Results: The annual standardized (world population) incidence rate (IR) of myeloid malignancies over the study period was 6.5 per 100,000 (95% CI 6.2-6.7). Myelodysplastic syndromes were the most prevalent subgroup (IR = 1.7, 95% CI 1.5-1.8). Incidence of all myeloid malignancies combined increased sharply during the study period with an annual percent change (APC) of 10.06% (95% CI 9.51-10.61), 19.77% for myelodysplastic syndromes (95% CI 19.63-19.91), and 3.18% (95% CI 2.99-3.37) for acute myeloid leukemia. Chronic myeloid leukemia did not show an upward trend. Apart from sporadic excesses in small rural communities and the major urban area, there was no evidence of spatial clustering. The risk of myeloid malignancies increased with increasing prevalence of sheep breeding.
    Conclusions: Our results might prompt further research on the local genetic and environmental determinants of myeloid hematologic malignancies.
    MeSH term(s) Humans ; Animals ; Sheep ; Incidence ; Bayes Theorem ; Hematologic Neoplasms/epidemiology ; Myelodysplastic Syndromes/epidemiology ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/genetics ; Myeloproliferative Disorders/epidemiology ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1328503-8
    ISSN 1526-2359 ; 1073-2748
    ISSN (online) 1526-2359
    ISSN 1073-2748
    DOI 10.1177/10732748231202906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4467: Show issues Location:
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  10. Article: Lezioni dalla "sindrome di Quirra" Epidemiologia? No, grazie.

    Cocco, Pierluigi

    Epidemiologia e prevenzione

    2012  Volume 36, Issue 1, Page(s) 41–44

    Abstract: Since January 2011, media reports have been reviving claims about a presumed excess of haemolymphopoietic cancer in south-eastern Sardinia, Italy, that started 10 years before.The almost daily sequence of articles created alarm in the local population, ... ...

    Title translation Lessons learned from the "Quirra syndrome" epidemiology? No, thanks.
    Abstract Since January 2011, media reports have been reviving claims about a presumed excess of haemolymphopoietic cancer in south-eastern Sardinia, Italy, that started 10 years before.The almost daily sequence of articles created alarm in the local population, and a judicial investigation was initiated. The present commentary discusses possible reasons for the perception of an excess of haemolymphopoietic cancer, which was not confirmed by four independent epidemiological investigations. The update 2003 of the spatial analysis of haemolymphopoietic cancer incidence in southern Sardinia, on the other hand, commissioned by the local health authorities, has suggested an elevated risk of leukaemia among males residing in areas far from those reported at risk.No action followed. It is unclear why the regional authorities do not use the epidemiological investigations commissioned by themselves, whatever the results are either negative or positive for possible environmental health problems.
    MeSH term(s) Humans ; Italy/epidemiology ; Leukemia/epidemiology ; Lymphoma/epidemiology ; Syndrome
    Language Italian
    Publishing date 2012-01
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 1038112-0
    ISSN 1120-9763
    ISSN 1120-9763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 265: Show issues

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