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  1. Article ; Online: IL-9 exerts biological function on antigen-experienced murine T cells and exacerbates colitis induced by adoptive transfer.

    de Heusch, Magali / Steenwinckel, Valérie / Cochez, Perrine M / Louahed, Jamila / Warnier, Guy / Lemaire, Muriel M / Renauld, Jean-Christophe / Dumoutier, Laure

    European journal of immunology

    2020  Volume 50, Issue 7, Page(s) 1034–1043

    Abstract: IL-9 is involved in various T cell-dependent inflammatory models including colitis, encepahlitis, and asthma. However, the regulation and specificity of IL-9 responsiveness by T cells during immune responses remains poorly understood. Here, we addressed ... ...

    Abstract IL-9 is involved in various T cell-dependent inflammatory models including colitis, encepahlitis, and asthma. However, the regulation and specificity of IL-9 responsiveness by T cells during immune responses remains poorly understood. Here, we addressed this question using two different models: experimental colitis induced by transfer of naive CD4
    MeSH term(s) Adoptive Transfer/adverse effects ; Animals ; Colitis/etiology ; Colitis/genetics ; Colitis/immunology ; Colitis/pathology ; Disease Models, Animal ; Hyaluronan Receptors/genetics ; Hyaluronan Receptors/immunology ; Interleukin-2/genetics ; Interleukin-2/immunology ; Interleukin-9/genetics ; Interleukin-9/immunology ; Mice ; Mice, Knockout ; Mice, SCID ; Receptors, Interleukin-9/genetics ; Receptors, Interleukin-9/immunology ; Th17 Cells/immunology ; Th17 Cells/pathology ; Th17 Cells/transplantation ; Th2 Cells/immunology ; Th2 Cells/pathology ; Th2 Cells/transplantation
    Chemical Substances Cd44 protein, mouse ; Hyaluronan Receptors ; Il9r protein, mouse ; Interleukin-2 ; Interleukin-9 ; Receptors, Interleukin-9
    Language English
    Publishing date 2020-03-18
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201948430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 489: Show issues Location:
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  2. Article ; Online: The TLR7 ligand R848 prevents mouse graft-

    Gaignage, Mélanie / Marillier, Reece G / Cochez, Perrine M / Dumoutier, Laure / Uyttenhove, Catherine / Coutelier, Jean-Paul / Van Snick, Jacques

    Haematologica

    2018  Volume 104, Issue 2, Page(s) 392–402

    Abstract: In spite of considerable therapeutic progress, acute graft- ...

    Abstract In spite of considerable therapeutic progress, acute graft-
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Cytokines/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Graft vs Host Disease/etiology ; Graft vs Host Disease/mortality ; Graft vs Host Disease/prevention & control ; Imidazoles/pharmacology ; Immunomodulation/drug effects ; Interleukin-27/antagonists & inhibitors ; Ligands ; Melanoma, Experimental ; Mice ; Neoplasm Transplantation ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Toll-Like Receptor 7/metabolism
    Chemical Substances Antibodies, Monoclonal ; Cytokines ; Imidazoles ; Interleukin-27 ; Ligands ; Toll-Like Receptor 7 ; resiquimod (V3DMU7PVXF)
    Language English
    Publishing date 2018-09-13
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2018.195628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Increased expression of interleukin-9 in patients with allergic contact dermatitis caused by p-phenylenediamine.

    Baeck, Marie / Herman, Anne / de Montjoye, Laurence / Hendrickx, Emilie / Chéou, Paméla / Cochez, Perrine M / Dumoutier, Laure

    Contact dermatitis

    2018  Volume 79, Issue 6, Page(s) 346–355

    Abstract: Background: Allergic contact dermatitis has been described as a type IV reaction caused by antigen-specific T cells. Central roles for CD8: Objective: To determine the types of T cells and cytokines expressed in patients allergic to p- ... ...

    Abstract Background: Allergic contact dermatitis has been described as a type IV reaction caused by antigen-specific T cells. Central roles for CD8
    Objective: To determine the types of T cells and cytokines expressed in patients allergic to p-phenylenediamine (PPD).
    Methods: Serial skin biopsies of areas with positive patch test reactions in 29 PPD-sensitized patients were collected. T cell markers and cytokine expression were analysed by flow cytometry and quantitative reverse transcription polymerase chain reaction in both skin and peripheral blood mononuclear cells (PBMCs) of sensitized patients.
    Results: We observed increased expression of T cell markers and Th2/Th9-associated cytokines in both skin and stimulated PBMCs of PPD-allergic patients. Moreover, interleukin (IL)-9 was mainly produced by Th9 cells, in both skin and PBMCs. Further investigations showed that Il9r-deficient mice were more affected in a PPD contact hypersensitivity model than wild-type mice.
    Conclusion: We did not confirm the preclinical presence of CD8
    MeSH term(s) Dermatitis, Allergic Contact/genetics ; Dermatitis, Allergic Contact/immunology ; Female ; Gene Expression/drug effects ; Gene Expression/immunology ; Humans ; Interleukin-9/metabolism ; Male ; Phenylenediamines/adverse effects ; Phenylenediamines/immunology
    Chemical Substances IL9 protein, human ; Interleukin-9 ; Phenylenediamines
    Language English
    Publishing date 2018-09-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.13123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1116: Show issues Location:
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  4. Article ; Online: Ccr6 Is Dispensable for the Development of Skin Lesions Induced by Imiquimod despite its Effect on Epidermal Homing of IL-22-Producing Cells.

    Cochez, Perrine M / Michiels, Camille / Hendrickx, Emilie / Dauguet, Nicolas / Warnier, Guy / Renauld, Jean-Christophe / Dumoutier, Laure

    The Journal of investigative dermatology

    2017  Volume 137, Issue 5, Page(s) 1094–1103

    Abstract: Expression of the chemokine receptor Ccr6 is shared by most IL-22-producing cells, and Ccr6-deficient mice showed decreased IL-22 production and skin inflammation upon IL-23 intradermal injections. To determine whether this observation might be extended ... ...

    Abstract Expression of the chemokine receptor Ccr6 is shared by most IL-22-producing cells, and Ccr6-deficient mice showed decreased IL-22 production and skin inflammation upon IL-23 intradermal injections. To determine whether this observation might be extended to another psoriasis model, we applied imiquimod on Ccr6-deficient mice. Although epidermal IL-22 production was decreased because of a deficient recruitment of γδ T cells in these mice, they were not protected against psoriatic lesions. When primary epidermis or dermis tissue culture cells from nontreated mice were stimulated ex vivo with IL-1α/IL-2/IL-23, we observed that Ccr6 is crucial for Il22 expression from epidermal but not dermal cultures. Taking advantage of Ccr6-LacZ-knock-in mice, we showed that Ccr6 is necessary for the homing of Ccr6-positive cells, probably a γδ T-cell subset, which represents the main potential IL-22 source in the epidermis. Similar results were observed in Rag1
    MeSH term(s) Aminoquinolines/toxicity ; Animals ; Cells, Cultured ; Disease Models, Animal ; Epidermis/drug effects ; Epidermis/immunology ; Epidermis/pathology ; Gene Knock-In Techniques ; Homeodomain Proteins/genetics ; Imiquimod ; Interleukins/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Psoriasis/chemically induced ; Psoriasis/immunology ; Psoriasis/pathology ; Receptors, CCR6/genetics ; T-Lymphocyte Subsets/immunology ; beta-Galactosidase/genetics ; Interleukin-22
    Chemical Substances Aminoquinolines ; CCR6 protein, mouse ; Homeodomain Proteins ; Interleukins ; Receptors, CCR6 ; RAG-1 protein (128559-51-3) ; beta-Galactosidase (EC 3.2.1.23) ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2017-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2016.12.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.124: Show issues Location:
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  5. Article ; Online: IL-24 contributes to skin inflammation in Para-Phenylenediamine-induced contact hypersensitivity.

    Van Belle, Astrid B / Cochez, Perrine M / de Heusch, Magali / Pointner, Lisa / Opsomer, Remi / Raynaud, Peggy / Achouri, Younes / Hendrickx, Emilie / Cheou, Pamela / Warnier, Guy / Renauld, Jean-Christophe / Baeck, Marie / Dumoutier, Laure

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 1852

    Abstract: Para-Phenylenediamine (PPD) is an aromatic amine used in hair dyes and in temporary black henna tattoos, which is a frequent cause of allergic contact dermatitis (ACD). ACD is a skin inflammatory reaction characterized by modifications such as spongiosis, ...

    Abstract Para-Phenylenediamine (PPD) is an aromatic amine used in hair dyes and in temporary black henna tattoos, which is a frequent cause of allergic contact dermatitis (ACD). ACD is a skin inflammatory reaction characterized by modifications such as spongiosis, exocytosis and acanthosis. The aim of this study is to characterize the expression and the role of IL-20-related cytokines, including IL-19, IL-20, IL-22 and IL-24, in ACD. The expression of IL19, IL20, IL22 and IL24 is increased in affected skin from PPD allergic patients compared with uninvolved skin. In addition, the expression of these cytokines positively correlates with clinical symptoms. To assess their role in ACD, we set up a mouse model of PPD-induced allergic contact dermatitis and we showed that, in contrast to Il22-deficient mice, Il22ra1-, Il20rb- and Il24-deficient mice are partially protected against development of PPD-induced contact hypersensitivity. These mice have decreased ear thickening and less acanthosis compared with WT mice after PPD treatment. In addition, the absence of IL-22R, IL-20R2 or IL-24 affects the recruitment of neutrophils into the skin but not the total IgE production. Taken together, these results demonstrate the implication of IL-24 via the IL-20R type II receptor in the inflammatory process of ACD.
    MeSH term(s) Adult ; Aged ; Animals ; Biopsy ; Coloring Agents ; Cytokines/metabolism ; Dermatitis, Allergic Contact/metabolism ; Disease Models, Animal ; Humans ; Immunoglobulin E/metabolism ; Inflammation/chemically induced ; Inflammation/metabolism ; Interleukins/metabolism ; Leukocyte Common Antigens/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Middle Aged ; Phenylenediamines ; Receptors, Interleukin/metabolism ; Skin/drug effects ; Skin/metabolism ; Interleukin-22
    Chemical Substances Coloring Agents ; Cytokines ; Il24 protein, mouse ; Interleukins ; Phenylenediamines ; Receptors, Interleukin ; interleukin-20 receptor ; interleukin-22 receptor ; interleukin-24 ; Immunoglobulin E (37341-29-0) ; Leukocyte Common Antigens (EC 3.1.3.48) ; 4-phenylenediamine (U770QIT64J) ; interleukin 20 (U91R7IMG8U)
    Language English
    Publishing date 2019-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-38156-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model.

    Cochez, Perrine M / Michiels, Camille / Hendrickx, Emilie / Van Belle, Astrid B / Lemaire, Muriel M / Dauguet, Nicolas / Warnier, Guy / de Heusch, Magali / Togbe, Dieudonnée / Ryffel, Bernhard / Coulie, Pierre G / Renauld, Jean-Christophe / Dumoutier, Laure

    European journal of immunology

    2016  Volume 46, Issue 6, Page(s) 1449–1459

    Abstract: IL-22 has a detrimental role in skin inflammatory processes, for example in psoriasis. As transcription factor, AhR controls the IL-22 production by several cell types (i.e. Th17 cells). Here, we analyzed the role of Ahr in IL-22 production by immune ... ...

    Abstract IL-22 has a detrimental role in skin inflammatory processes, for example in psoriasis. As transcription factor, AhR controls the IL-22 production by several cell types (i.e. Th17 cells). Here, we analyzed the role of Ahr in IL-22 production by immune cells in the inflamed skin, using an imiquimod-induced psoriasis mouse model. Our results indicate that IL-22 is expressed in the ear of imiquimod-treated Ahr(-/-) mice but less than in wild-type mice. We then studied the role of AhR on three cell populations known to produce IL-22 in the skin: γδ T cells, Th17 cells, and ILC3, and a novel IL-22-producing cell type identified in this setting: CD4(-) CD8(-) TCRβ(+) T cells. We showed that AhR is required for IL-22 production by Th17, but not by the three other cell types, in the imiquimod-treated ears. Moreover, AhR has a role in the recruitment of γδ T cells, ILC3, and CD4(-) CD8(-) TCRβ(+) T cells into the inflamed skin or in their local proliferation. Taken together, AhR has a direct role in IL-22 production by Th17 cells in the mouse ear skin, but not by γδ T cells, CD4(-) CD8(-) TCRβ(+) T cells and ILCs.
    MeSH term(s) Aminoquinolines/adverse effects ; Animals ; Cell Proliferation ; Chemotaxis/genetics ; Chemotaxis/immunology ; Disease Models, Animal ; Imiquimod ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Interleukins/biosynthesis ; Interleukins/genetics ; Mice ; Mice, Knockout ; Psoriasis/etiology ; Psoriasis/metabolism ; Psoriasis/pathology ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Receptors, Aryl Hydrocarbon/deficiency ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Interleukin-22
    Chemical Substances Aminoquinolines ; Interleukins ; Receptors, Antigen, T-Cell, alpha-beta ; Receptors, Antigen, T-Cell, gamma-delta ; Receptors, Aryl Hydrocarbon ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2016-03-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201546070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 489: Show issues Location:
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