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  1. Article ; Online: Clonal Hematopoiesis: The Emergent CVD Risk Factor.

    Cochran, Jesse D / Walsh, Kenneth

    Arteriosclerosis, thrombosis, and vascular biology

    2024  Volume 44, Issue 4, Page(s) 768–771

    MeSH term(s) Humans ; Clonal Hematopoiesis/genetics ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/genetics ; Mutation ; Hematopoiesis/genetics
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.319562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Clonal Hematopoiesis: Getting to the Heart of the Problem With Clone Size.

    Walsh, Kenneth / Cochran, Jesse D / Evans, Megan A

    JACC. Heart failure

    2024  Volume 12, Issue 5, Page(s) 915–917

    MeSH term(s) Humans ; Clonal Hematopoiesis/genetics ; Heart Failure/physiopathology ; Mutation
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Therapy-Related Clonal Hematopoiesis: A New Link Between Cancer and Cardiovascular Disease.

    Yura, Yoshimitsu / Cochran, Jesse D / Walsh, Kenneth

    Heart failure clinics

    2022  Volume 18, Issue 3, Page(s) 349–359

    Abstract: Clonal hematopoiesis is a precancerous state that is recognized as a new causal risk factor for cardiovascular disease. Therapy-related clonal hematopoiesis is a condition that is often found in cancer survivors. These clonal expansions are caused by ... ...

    Abstract Clonal hematopoiesis is a precancerous state that is recognized as a new causal risk factor for cardiovascular disease. Therapy-related clonal hematopoiesis is a condition that is often found in cancer survivors. These clonal expansions are caused by mutations in DNA damage-response pathway genes that allow hematopoietic stem cells to undergo positive selection in response to the genotoxic stress. These mutant cells increasingly give rise to progeny leukocytes that display enhanced proinflammatory properties. Recent experimental studies suggest that therapy-related clonal hematopoiesis may contribute to the medium- to long-term risk of genotoxic therapies on the cardiovascular system.
    MeSH term(s) Cardiovascular Diseases/etiology ; Clonal Hematopoiesis/genetics ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/metabolism ; Humans ; Neoplasms/complications
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2022.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6554: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Cell cycle specific, differentially tagged ribosomal proteins to measure phase specific transcriptomes from asynchronously cycling cells.

    Cochran, Jesse D / Leathers, Tess A / Maldosevic, Emir / Siejda, Klara W / Vitello, Julian / Lee, Haesol / Bradley, Leigh A / Young, Alex / Jomaa, Ahmad / Wolf, Matthew J

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1623

    Abstract: Asynchronously cycling cells pose a challenge to the accurate characterization of phase-specific gene expression. Current strategies, including RNAseq, survey the steady state gene expression across the cell cycle and are inherently limited by their ... ...

    Abstract Asynchronously cycling cells pose a challenge to the accurate characterization of phase-specific gene expression. Current strategies, including RNAseq, survey the steady state gene expression across the cell cycle and are inherently limited by their inability to resolve dynamic gene regulatory networks. Single cell RNAseq (scRNAseq) can identify different cell cycle transcriptomes if enough cycling cells are present, however some cells are not amenable to scRNAseq. Therefore, we merged two powerful strategies, the CDT1 and GMNN degrons used in Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) cell cycle sensors and the ribosomal protein epitope tagging used in RiboTrap/Tag technologies to isolate cell cycle phase-specific mRNA for sequencing. The resulting cell cycle dependent, tagged ribosomal proteins (ccTaggedRP) were differentially expressed during the cell cycle, had similar subcellular locations as endogenous ribosomal proteins, incorporated into ribosomes and polysomes, and facilitated the recovery of cell cycle phase-specific RNA for sequencing. ccTaggedRP has broad applications to investigate phase-specific gene expression in complex cell populations.
    MeSH term(s) Cell Cycle Proteins/genetics ; Transcriptome ; Cell Cycle/genetics ; Ribosomal Proteins/genetics ; Ribosomes/genetics
    Chemical Substances Cell Cycle Proteins ; Ribosomal Proteins
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52085-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction.

    Cochran, Jesse D / Yura, Yoshimitsu / Thel, Mark C / Doviak, Heather / Polizio, Ariel H / Arai, Yuka / Arai, Yohei / Horitani, Keita / Park, Eunbee / Chavkin, Nicholas W / Kour, Anupreet / Sano, Soichi / Mahajan, Nitin / Evans, Megan / Huba, Mahalia / Naya, Nadia Martinez / Sun, Hanna / Ban, Young Ho / Hirschi, Karen K /
    Toldo, Stefano / Abbate, Antonio / Druley, Todd E / Ruberg, Frederick L / Maurer, Mathew S / Ezekowitz, Justin A / Dyck, Jason R B / Walsh, Kenneth

    Circulation

    2023  Volume 148, Issue 15, Page(s) 1165–1178

    Abstract: Background: Clonal hematopoiesis (CH), which results from an array of nonmalignant driver gene mutations, can lead to altered immune cell function and chronic disease, and has been associated with worse outcomes in patients with heart failure (HF) with ... ...

    Abstract Background: Clonal hematopoiesis (CH), which results from an array of nonmalignant driver gene mutations, can lead to altered immune cell function and chronic disease, and has been associated with worse outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the role of CH in the prognosis of HF with preserved ejection fraction (HFpEF) has been understudied. This study aimed to characterize CH in patients with HFpEF and elucidate its causal role in a murine model.
    Methods: Using a panel of 20 candidate CH driver genes and a variant allele fraction cutoff of 0.5%, ultradeep error-corrected sequencing identified CH in a cohort of 81 patients with HFpEF (mean age, 71±6 years; ejection fraction, 63±5%) and 36 controls without a diagnosis of HFpEF (mean age, 74±7 years; ejection fraction, 61.5±8%). CH was also evaluated in a replication cohort of 59 individuals with HFpEF.
    Results: Compared with controls, there was an enrichment of
    Conclusions: CH is associated with worse heart function and prognosis in patients with HFpEF, and a murine experimental model of
    MeSH term(s) Humans ; Mice ; Animals ; Aged ; Aged, 80 and over ; Heart Failure/diagnosis ; Heart Failure/genetics ; Heart Failure/drug therapy ; Stroke Volume ; Ventricular Function, Left ; Clonal Hematopoiesis/genetics ; Ventricular Dysfunction, Left/genetics
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.064170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Mitochondrial pyruvate carriers are required for myocardial stress adaptation.

    Zhang, Yuan / Taufalele, Paul V / Cochran, Jesse D / Robillard-Frayne, Isabelle / Marx, Jonas Maximilian / Soto, Jamie / Rauckhorst, Adam J / Tayyari, Fariba / Pewa, Alvin D / Gray, Lawrence R / Teesch, Lynn M / Puchalska, Patrycja / Funari, Trevor R / McGlauflin, Rose / Zimmerman, Kathy / Kutschke, William J / Cassier, Thomas / Hitchcock, Shannon / Lin, Kevin /
    Kato, Kevin M / Stueve, Jennifer L / Haff, Lauren / Weiss, Robert M / Cox, James E / Rutter, Jared / Taylor, Eric B / Crawford, Peter A / Lewandowski, E Douglas / Des Rosiers, Christine / Abel, E Dale

    Nature metabolism

    2020  Volume 2, Issue 11, Page(s) 1248–1264

    Abstract: In addition to fatty acids, glucose and lactate are important myocardial substrates under physiologic and stress conditions. They are metabolized to pyruvate, which enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycle ... ...

    Abstract In addition to fatty acids, glucose and lactate are important myocardial substrates under physiologic and stress conditions. They are metabolized to pyruvate, which enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycle metabolism. In the present study, we show that MPC-mediated mitochondrial pyruvate utilization is essential for the partitioning of glucose-derived cytosolic metabolic intermediates, which modulate myocardial stress adaptation. Mice with cardiomyocyte-restricted deletion of subunit 1 of MPC (cMPC1
    MeSH term(s) Adaptation, Physiological/genetics ; Adaptation, Physiological/physiology ; Animals ; Anion Transport Proteins/genetics ; Anion Transport Proteins/metabolism ; Cardiomegaly/diagnostic imaging ; Cardiomegaly/genetics ; Cardiomegaly/metabolism ; Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/metabolism ; Constriction, Pathologic ; Cytosol/metabolism ; Diet, High-Fat ; Diet, Ketogenic ; Echocardiography ; In Vitro Techniques ; Mice ; Mice, Knockout ; Mitochondria, Heart/metabolism ; Mitochondrial Membrane Transport Proteins/genetics ; Mitochondrial Membrane Transport Proteins/metabolism ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Pyruvic Acid/metabolism ; Stress, Physiological/genetics ; Stress, Physiological/physiology
    Chemical Substances Anion Transport Proteins ; MPC2 pyruvate carrier protein, mouse ; Mitochondrial Membrane Transport Proteins ; Pyruvic Acid (8558G7RUTR)
    Language English
    Publishing date 2020-10-26
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-020-00288-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation.

    Zhang, Yuan / Taufalele, Paul V / Cochran, Jesse D / Robillard-Frayne, Isabelle / Marx, Jonas Maximilian / Soto, Jamie / Rauckhorst, Adam J / Tayyari, Fariba / Pewa, Alvin D / Gray, Lawrence R / Teesch, Lynn M / Puchalska, Patrycja / Funari, Trevor R / McGlauflin, Rose / Zimmerman, Kathy / Kutschke, William J / Cassier, Thomas / Hitchcock, Shannon / Lin, Kevin /
    Kato, Kevin M / Stueve, Jennifer L / Haff, Lauren / Weiss, Robert M / Cox, James E / Rutter, Jared / Taylor, Eric B / Crawford, Peter A / Lewandowski, E Douglas / Des Rosiers, Christine / Abel, E Dale

    Nature metabolism

    2020  Volume 2, Issue 12, Page(s) 1498

    Language English
    Publishing date 2020-11-18
    Publishing country Germany
    Document type Published Erratum
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-020-00322-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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