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  1. Article ; Online: Radioactive and stable isotopes reveal variations in nearshore submarine groundwater discharge composition and magnitude across low inflow northwestern Gulf of Mexico estuaries.

    Murgulet, Dorina / Lopez, Cody V / Douglas, Audrey R

    The Science of the total environment

    2022  Volume 823, Page(s) 153814

    Abstract: To determine how submarine groundwater discharge (SGD) magnitudes and composition (fresh or saline/recirculated) vary in nearshore low inflow estuaries across ⁓125 km of a semiarid coastline, this study assessed three south Texas estuaries, using radon [ ...

    Abstract To determine how submarine groundwater discharge (SGD) magnitudes and composition (fresh or saline/recirculated) vary in nearshore low inflow estuaries across ⁓125 km of a semiarid coastline, this study assessed three south Texas estuaries, using radon [
    MeSH term(s) Environmental Monitoring ; Estuaries ; Groundwater ; Gulf of Mexico ; Radium/analysis ; Seawater
    Chemical Substances Radium (W90AYD6R3Q)
    Language English
    Publishing date 2022-02-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.153814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Radioactive and stable isotopes reveal variations in nearshore submarine groundwater discharge composition and magnitude across low inflow northwestern Gulf of Mexico estuaries

    Murgulet, Dorina / Lopez, Cody V. / Douglas, Audrey R.

    Science of the total environment. 2022 June 01, v. 823

    2022  

    Abstract: To determine how submarine groundwater discharge (SGD) magnitudes and composition (fresh or saline/recirculated) vary in nearshore low inflow estuaries across ⁓125 km of a semiarid coastline, this study assessed three south Texas estuaries, using radon [² ...

    Abstract To determine how submarine groundwater discharge (SGD) magnitudes and composition (fresh or saline/recirculated) vary in nearshore low inflow estuaries across ⁓125 km of a semiarid coastline, this study assessed three south Texas estuaries, using radon [²²²Rn], radium [²²⁶Ra and ²²⁴Ra], and water isotopes [δ¹⁸O and δD]. Mass balance models of time-series ²²²Rn, found to be representative of total SGD in this study, revealed much higher SGD inputs to the Nueces Estuary (average [x̅] Nueces, Corpus Christi and Oso Bays: 120, 83, and 44 cm·d⁻¹, respectively), attributed to anthropogenically-disturbed substrates and potentially surfacing growth-faults. The lowest ²²²Rn-derived SGD occurred in the Upper Laguna Madre Estuary (x̅: Upper Laguna Madre and Baffin Bay: 21 and 18 cm·d⁻¹, respectively), explained by the drier climate, lower anthropogenic disturbance, and neighboring groundwater cone of depression. Aransas Bay in the Mission Aransas Estuary received greater average annual precipitation but exhibited low total SGD rates (x̅: 23 cm·d⁻¹). Seasonally, average ²²²Rn-derived SGD rates increased following Hurricane Harvey (43 cm·d⁻¹ in spring to 64 cm·d⁻¹ in summer). In the Nueces Estuary, the overall ²²²Rn-derived SGDs were substantially higher than SGDs from ²²⁴Ra and ²²⁶Ra. The closer agreement between ²²⁴Ra and ²²²Rn-derived SGD and larger ²²⁴Ra rates in the Upper Laguna Madre Estuary, Aransas Bay and Oso Bay indicate that saline/recirculated SGD contributions were significant. Values of δ¹⁸O and δD confirm these types of inputs, with effects of evaporation/salinization more pronounced where recirculation was predominant and the opposite where terrestrial/²²²Rn-derived SGD inputs dominate. ²²⁶Ra-derived SGDs were lower than the ²²⁴Ra due to different behavior of the two isotopes while released into water following transport through saline and fine-grained estuarine sediments or due to wind-driven disturbances.
    Keywords anthropogenic activities ; atmospheric precipitation ; climate ; coasts ; environment ; estuaries ; evaporation ; groundwater ; hurricanes ; radium ; radon ; spring ; summer ; time series analysis ; Gulf of Mexico ; Texas
    Language English
    Dates of publication 2022-0601
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.153814
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Efficacy of Demineralized Bone Matrix for Revision Alveolar Bone Grafting in Patients Previously Treated with Bone Morphogenetic Protein 2 (BMP-2).

    Francoisse, Caitlin A / Sescleifer, Anne M / Okeke, Raymond I / Tyson, Cody V / Plikaitis, Christina

    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

    2023  , Page(s) 10556656231159259

    Abstract: Objective: This study investigates the effectiveness of demineralized bone matrix (DBX) to close alveolar clefts in patients previously treated with bone morphogenic protein-2 (BMP-2) who remained with bone nonunion.: Design: This is an IRB-approved ... ...

    Abstract Objective: This study investigates the effectiveness of demineralized bone matrix (DBX) to close alveolar clefts in patients previously treated with bone morphogenic protein-2 (BMP-2) who remained with bone nonunion.
    Design: This is an IRB-approved retrospective, single-center study.
    Setting: This study was conducted at a tertiary academic center.
    Patients/participants: We searched for all surgical encounters with the Current Procedural Terminology (CPT) code 42210 from the years 2013-2019. Included patients were diagnosed with cleft alveolus, previous BMP-2 exposure and required revision bone grafting during mixed dentition for persistent alveolar defects.
    Interventions: 17 patients underwent revision alveolar bone grafting (ABG) with either DBX (n = 10) or autograft (n = 7) to repair persistent bony cleft.
    Main outcome measure(s): The primary study outcome measured was alveolar bone graft revision failure described as continued alveolar nonunion.
    Results: The median age at revision ABG was 13.1 ± 3.3 years, with a mean follow-up time of 4.9 years (1.1-9.2 years). Patients were 53% male, 47% had a unilateral cleft lip and alveolus. 58.8% of patients were treated with DBX in the cleft, 41.2% treated with autograft from iliac crest. Overall, 11.8% (n = 2) of all revisions failed, requiring a second revision. The average time to reoperation was 2.06 years, and both were re-grafted with autograft. There was no statistically significant difference between the type of bone graft source used and the failure rate obtained (
    Conclusions: DBX and autologous iliac crest bone grafts achieve similar alveolar union rates during revision ABG in patients treated with previous BMP-2 to the alveolar cleft.
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1069409-2
    ISSN 1545-1569 ; 0009-8701 ; 1055-6656
    ISSN (online) 1545-1569
    ISSN 0009-8701 ; 1055-6656
    DOI 10.1177/10556656231159259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: High-sensitivity low-energy ion scattering studies of calcium aluminosilicate glass fracture surfaces

    Ryan Thorpe / Nicholas J. Smith / Cody V. Cushman / Gabriel P. Agnello / Joy Banerjee / Andrew C. Antony / Robert G. Manley

    Journal of Non-Crystalline Solids: X, Vol 17, Iss , Pp 100156- (2023)

    2023  

    Abstract: Glass surfaces play a critical role in several modern applications, and open questions remain as to how the bulk composition of a multicomponent glass informs its surface composition—particularly at the outermost monolayer. This has important ... ...

    Abstract Glass surfaces play a critical role in several modern applications, and open questions remain as to how the bulk composition of a multicomponent glass informs its surface composition—particularly at the outermost monolayer. This has important implications for properties such as electrostatic charging, wetting, and adhesion. Here, we apply high-sensitivity low-energy ion scattering (HS-LEIS) to examine a systematic series of ternary CaO-Al2O3-SiO2 glass compositions. Analyzed are fresh fracture surfaces created under high-vacuum conditions, giving rigorous attention to peak quantification details. Results indicate that the measured surface compositions are, within uncertainty, very close to analyzed bulk compositions. This finding runs contrary to many studies showing disagreement between surface and bulk composition in glass, and possible reasons are discussed. By providing an experimental foundation from relatively ideal fracture surfaces, these results pave the way for further studies on the outermost composition of realistic glass surfaces of commercial importance.
    Keywords Glass ; Surface ; Low energy ion scattering ; Monolayer ; Aluminosilicate ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Radioactive and stable isotope measurements reveal saline submarine groundwater discharge in a semiarid estuary

    Lopez, Cody V / Murgulet, Dorina / Santos, Isaac R

    Journal of hydrology. 2020 Nov., v. 590

    2020  

    Abstract: There is little information on submarine groundwater discharge (SGD) in hypersaline estuaries in semi-arid climates where SGD may be the dominant nutrient source. Here, we assess the spatial and temporal variability of SGD in the hypersaline Baffin Bay ( ... ...

    Abstract There is little information on submarine groundwater discharge (SGD) in hypersaline estuaries in semi-arid climates where SGD may be the dominant nutrient source. Here, we assess the spatial and temporal variability of SGD in the hypersaline Baffin Bay (Texas) using radon [²²²Rn], radium [²²⁶Ra, ²²⁴Ra, and ²²³Ra], and water isotopes [δ¹⁸O and δD]. Continuous electrical resistivity surveys revealed potential SGD at nearshore serpulid reefs. High spatial and temporal resolution radon measurements revealed slightly higher SGD inputs at the shoreline near course-grained sediments and relic serpulid reefs. Mass balance models of ²²²Rn and ²²⁶Ra produced equal SGD estimates within the range of uncertainty, while ²²³Ra yielded substantially higher SGD rates. Baywide SGD rates from ²²⁶Ra, ²²³Ra, and ²²²Rn ranged from 1.6 ± 0.2 to 41.3 ± 4.1. Larger SGD rates obtained from short-lived isotopes imply higher recirculated/saline SGD rates over short time scales. Radiogenic and stable isotopes as well as resistivity indicate that saline rather than freshwater accounts for most SGD in this hypersaline estuary. Because saline porewater exchange can play a significant role in coastal biogeochemical budgets, SGD inputs should be considered in management strategies in semi-arid areas where surface inflows are almost absent.
    Keywords electrical resistance ; estuaries ; freshwater ; groundwater ; hypersalinity ; radium ; radon ; shorelines ; stable isotopes ; temporal variation ; uncertainty ; Texas
    Language English
    Dates of publication 2020-11
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1473173-3
    ISSN 1879-2707 ; 0022-1694
    ISSN (online) 1879-2707
    ISSN 0022-1694
    DOI 10.1016/j.jhydrol.2020.125395
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Three-Dimensional Modeling of Thyroid Hormone Metabolites Binding to the Cancer-Relevant αvβ3 Integrin:

    Tobi, Dror / Krashin, Eilon / Davis, Paul J / Cody, Vivian / Ellis, Martin / Ashur-Fabian, Osnat

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 895240

    Abstract: Background: Thyroid hormones (TH), T4 and T3, mediate pro-mitogenic effects in cancer cells through binding the membrane receptor αvβ3 integrin. The deaminated analogue tetrac effectively blocks TH binding to this receptor and prevents their action. ... ...

    Abstract Background: Thyroid hormones (TH), T4 and T3, mediate pro-mitogenic effects in cancer cells through binding the membrane receptor αvβ3 integrin. The deaminated analogue tetrac effectively blocks TH binding to this receptor and prevents their action. While computational data on TH binding to the αvβ3 integrin was published, a comprehensive analysis of additional TH metabolites is lacking.
    Methods: In-silico
    Results: All TH molecules demonstrated negative free energy, suggesting affinity to the αvβ3 integrin. Notably, based on both Grid and Amber scores sulfated forms of 3,3' T2 (3,3' T2S) and T4 (T4S) demonstrated the highest binding affinity to the integrin, compared to both cyclic RGD and an array of examined TH metabolites. The major thyroid hormones, T3 and T4, showed high affinity to the integrin, which was superior to that of linear RGD. For all hormone metabolites, decarboxylation led to decreased affinity. This corresponds with the observation that the carboxylic group mediates binding to the integrin pocket
    Summary: Three-dimensional docking of various TH metabolites uncovered a structural basis for a differential computational free energy to the αvβ3 integrin. These findings may suggest that naturally occurring endogenous TH metabolites may impact integrin-mediate intracellular pathways in physiology and cancer.
    MeSH term(s) Amber ; Humans ; Integrin alphaVbeta3/metabolism ; Neoplasms/metabolism ; Oligopeptides/metabolism ; Thyroid Hormones/metabolism
    Chemical Substances Amber ; Integrin alphaVbeta3 ; Oligopeptides ; Thyroid Hormones
    Language English
    Publishing date 2022-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.895240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Practice Trends in the Management of Asymptomatic Breast Reconstruction Patients with Textured Implants: A Survey Analysis.

    Roider, Laura A / Nguyen, David C / Pusapadi Ramkumar, Shreya / Tyson, Cody V / Lund, Herluf G / Plikaitis, Christina M

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 7, Page(s) e5139

    Abstract: Despite the increasing prevalence of breast implant associated anaplastic large cell lymphoma, there remains a paucity of literature guiding management of asymptomatic patients with textured breast implants. This risk can be anxiety provoking in breast ... ...

    Abstract Despite the increasing prevalence of breast implant associated anaplastic large cell lymphoma, there remains a paucity of literature guiding management of asymptomatic patients with textured breast implants. This risk can be anxiety provoking in breast reconstruction patients given their history of cancer or increased future risk. The purpose of this study is to evaluate current practice trends when managing the concerned asymptomatic patient following textured implant-based breast reconstruction.
    Methods: An electronic survey was distributed to members of the American Society of Plastic Surgeons, regarding management of asymptomatic breast reconstruction patients with textured devices. Anonymous responses were collected, and statistical analysis was performed.
    Results: A total of 304 responses were received. Of respondents, 237 (92%) have managed asymptomatic patients with textured devices. Historically, the overwhelming majority (89%) used textured devices; however, only 25% report current use. Regarding management of asymptomatic breast reconstruction patients, 87% recommend conservative management, while 13% recommend surgical management. When surgery is performed, 16.3% of respondents elected for implant exchange, 33.8% recommended implant exchange with partial capsulectomy, and 49.8% elected for implant exchange with total capsulectomy. Evaluation of practice patterns based on demographics demonstrated statistically significant differences in current use of textured devices and management of acellular dermal matrix.
    Conclusions: Despite decreased current use, there is a significant population of asymptomatic breast reconstruction patients with a history of textured devices concerned for risk of breast implant associated anaplastic large cell lymphoma. This survey demonstrates ongoing variability in surgeon recommendations regarding conservative and surgical management of these patients and the need for continued development of evidence-based guidelines.
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Structural Analysis of the Complex of Human Transthyretin with 3',5'-Dichlorophenylanthranilic Acid at 1.5 Å Resolution.

    Cody, Vivian / Truong, Jia Q / Holdsworth, Bruce A / Holien, Jessica K / Richardson, Samantha J / Chalmers, David K / Craik, David J

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 21

    Abstract: Human transthyretin (hTTR) can form amyloid deposits that accumulate in nerves and organs, disrupting cellular function. Molecules such as tafamidis that bind to and stabilize the TTR tetramer can reduce such amyloid formation. Here, we studied the ... ...

    Abstract Human transthyretin (hTTR) can form amyloid deposits that accumulate in nerves and organs, disrupting cellular function. Molecules such as tafamidis that bind to and stabilize the TTR tetramer can reduce such amyloid formation. Here, we studied the interaction of VCP-6 (2-((3,5-dichlorophenyl)amino)benzoic acid) with hTTR. VCP-6 binds to hTTR with 5 times the affinity of the cognate ligand, thyroxine (T
    MeSH term(s) Humans ; Prealbumin/metabolism ; Protein Conformation ; Models, Molecular ; Binding Sites ; Crystallography, X-Ray ; Amyloid ; Amyloidogenic Proteins ; Amyloidosis ; Halogens
    Chemical Substances Prealbumin ; Amyloid ; Amyloidogenic Proteins ; Halogens
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27217206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Emergency Medical Services resource capacity and competency amid COVID-19 in the United States: Preliminary findings from a national survey

    Gibson, Cody V. / Venture, Christian A. / Collier, Ceorge D.

    Cell Press

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #133307
    Database COVID19

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  10. Article ; Online: Emergency Medical Services resource capacity and competency amid COVID-19 in the United States: Preliminary findings from a national survey

    Ventura, Christian / Gibson, Cody V / Collier, George Donald

    Abstract: This study aimed to investigate available resources, Personal Protective Equipment (PPE) availability, sanitation practices, institutional policies, and opinions among EMS professionals in the United States amid the COVID-19 pandemic using a self-report ... ...

    Abstract This study aimed to investigate available resources, Personal Protective Equipment (PPE) availability, sanitation practices, institutional policies, and opinions among EMS professionals in the United States amid the COVID-19 pandemic using a self-report survey questionnaire. METHODS An online 42-question multiple choice survey was randomly distributed between April 1, 2020, and April 12, 2020 to various active Emergency Medical Services (EMS) paid personnel in all 50 U.S. states including the District of Columbia (n=165). We approximate a 95% confidence interval (+/- 0.0755). RESULTS An overwhelming number of EMS providers report having limited access to N95 respirators, receiving little or no benefits from COVID-19 related work, and report no institutional policy on social distancing practices despite CDC recommendations. For providers who do have access to N95 respirators, 31% report having to use the same mask for 1 week or longer. Approximately [1/3] of the surveyed participants were unsure of when a COVID-19 patient is infectious. The data suggests regular decontamination of EMS equipment after each patient contact is not a regular practice. DISCUSSION Current practices to educate EMS providers on appropriate response to the novel coronavirus may not be sufficient, and future patients may benefit from a nationally established COVID-19 EMS response protocol. Further investigation on whether current EMS practices are contributing to the spread of infection is warranted. The data reveals concerning deficits in COVID-19 related education and administrative protocols which pose as a serious public health concern that should be urgently addressed.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20073296
    DOI 10.1101/2020.04.24.20073296
    Database COVID19

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