Article ; Online: Assessing the Cervicovaginal Microbiota in the Context of hrHPV Infections: Temporal Dynamics and Therapeutic Strategies.
2022 Volume 13, Issue 5, Page(s) e0161922
Abstract: Cervical cancer is the third leading cause of female cancers globally, resulting in more than 300,000 deaths every year. The majority of all cervical cancers are caused by persistent infections with high-risk human papillomaviruses (hrHPV) that can ... ...
| Abstract | Cervical cancer is the third leading cause of female cancers globally, resulting in more than 300,000 deaths every year. The majority of all cervical cancers are caused by persistent infections with high-risk human papillomaviruses (hrHPV) that can progress to cancer via a series of premalignant lesions. Most women, however, clear this infection within a year, concomitant with disease regression. Both hrHPV clearance and disease regression have been associated with the composition of the cervicovaginal microenvironment, which is defined by the host immune system and the cervicovaginal microbiome (CVM). A healthy microbiome is generally characterized by a high abundance of |
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| MeSH term(s) | Female ; Humans ; Papillomavirus Infections/complications ; Vagina/microbiology ; Microbiota ; Uterine Cervical Neoplasms ; Lactobacillus ; Papillomaviridae ; Tumor Microenvironment |
| Language | English |
| Publishing date | 2022-08-18 |
| Publishing country | United States |
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2557172-2 |
| ISSN | 2150-7511 ; 2161-2129 |
| ISSN (online) | 2150-7511 |
| ISSN | 2161-2129 |
| DOI | 10.1128/mbio.01619-22 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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