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  1. Article ; Online: Experiences and perceptions of everyday decision-making in the lives of adults with intellectual disabilities, their care partners and direct care support workers.

    Casey, Hannah / Trayer, Áine / Desmond, Deirdre / Coffey, Laura

    Journal of intellectual disabilities : JOID

    2023  , Page(s) 17446295231189020

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2071898-6
    ISSN 1744-6309 ; 1469-0047 ; 1744-6295
    ISSN (online) 1744-6309
    ISSN 1469-0047 ; 1744-6295
    DOI 10.1177/17446295231189020
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  2. Article ; Online: "You either sink or you swim, and you're better off swimming": A qualitative study exploring the self-management experiences of soft tissue sarcoma survivors.

    Beghean, Rahela / Coffey, Laura

    European journal of oncology nursing : the official journal of European Oncology Nursing Society

    2021  Volume 55, Page(s) 102062

    Abstract: Purpose: To qualitatively explore the consequences of soft tissue sarcoma and its treatment experienced by survivors, the self-management strategies they use to deal with these consequences, and any factors that may act as barriers or facilitators to ... ...

    Abstract Purpose: To qualitatively explore the consequences of soft tissue sarcoma and its treatment experienced by survivors, the self-management strategies they use to deal with these consequences, and any factors that may act as barriers or facilitators to their self-management.
    Methods: Semi-structured interviews were conducted with seven soft tissue sarcoma survivors who had completed their primary treatment. Interviews were audio-recorded, transcribed and thematically analysed.
    Results: Physical, psychological and social consequences of soft tissue sarcoma and its treatment were identified, with side-effects, physical restrictions, body image issues, fear of recurrence, feeling depressed, familial relationships and sexual activity being the most frequently reported. Nine different types of self-management strategy encompassing eighteen specific strategies were identified, including cognitive strategies, lifestyle changes and utilisation of resources. Personal, social and environmental facilitators of self-management were identified; being in a relationship, being at an appropriate life stage, and having support from family, friends and medical staff were most commonly reported. Finally, personal and environmental barriers to self-management included the adaptation period, ongoing complications, rareness of sarcoma and poor patient-healthcare provider communication.
    Conclusions: The findings of this study suggest that soft tissue sarcoma survivors, especially those who are younger and experience physical limitations, may find the immediate post-treatment period particularly challenging and may benefit from nurse-led self-management support.
    MeSH term(s) Humans ; Qualitative Research ; Sarcoma/therapy ; Self-Management ; Survivors ; Swimming
    Language English
    Publishing date 2021-11-09
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2017117-1
    ISSN 1532-2122 ; 1462-3889
    ISSN (online) 1532-2122
    ISSN 1462-3889
    DOI 10.1016/j.ejon.2021.102062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Book ; Online: Small Business Cybersecurity 2020-2021 Checklist

    coffey, L (via Mendeley Data)

    2020  

    Abstract: Cyber attacks are a growing concern for small businesses during COVID-19 . Be Protected While You Work. Upgrade Your Small Business's Virus Protection Today! Before going for a Cyber security solutions for small to mid-sized businesses deliver enterprise- ...

    Abstract Cyber attacks are a growing concern for small businesses during COVID-19 . Be Protected While You Work. Upgrade Your Small Business's Virus Protection Today! Before going for a Cyber security solutions for small to mid-sized businesses deliver enterprise-level protection. Download this (Checklist for a Small Firm's Cybersecurity Program 2020-2021) data set to deploy secure functioning of various aspects of your small business including, employee data, website and more.This checklist is provided to assist small member firms with limited resources to establish a cybersecurity program to identify and assess cybersecurity threats, protect assets from cyber intrusions, detect when their systems and assets have been compromised, plan for the response when a compromise occurs and implement a plan to recover lost, stolen or unavailable assets. Train employees in security principles. Protect information, computers, and networks from malware attacks. Provide firewall security for your Internet connection. Create a mobile device action plan. Make backup copies of important business data and information. Learn about the threats and how to protect your website. Protect Your Small Business site. Learn the basics for protecting your business web sites from cyber attacks at WP Hacked Help Blog Created With Inputs From Security Experts at WP Hacked Help - Pioneer In WordPress Malware Removal & Security
    Keywords Interdisciplinary sciences ; covid19
    Publishing date 2020-09-12T00:48:20.808Z
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Using deep learning to detect digitally encoded DNA trigger for Trojan malware in Bio-Cyber attacks.

    Islam, M S / Ivanov, S / Awan, H / Drohan, J / Balasubramaniam, S / Coffey, L / Kidambi, S / Sri-Saan, W

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 9631

    Abstract: This article uses Deep Learning technologies to safeguard DNA sequencing against Bio-Cyber attacks. We consider a hybrid attack scenario where the payload is encoded into a DNA sequence to activate a Trojan malware implanted in a software tool used in ... ...

    Abstract This article uses Deep Learning technologies to safeguard DNA sequencing against Bio-Cyber attacks. We consider a hybrid attack scenario where the payload is encoded into a DNA sequence to activate a Trojan malware implanted in a software tool used in the sequencing pipeline in order to allow the perpetrators to gain control over the resources used in that pipeline during sequence analysis. The scenario considered in the paper is based on perpetrators submitting synthetically engineered DNA samples that contain digitally encoded IP address and port number of the perpetrator's machine in the DNA. Genetic analysis of the sample's DNA will decode the address that is used by the software Trojan malware to activate and trigger a remote connection. This approach can open up to multiple perpetrators to create connections to hijack the DNA sequencing pipeline. As a way of hiding the data, the perpetrators can avoid detection by encoding the address to maximise similarity with genuine DNAs, which we showed previously. However, in this paper we show how Deep Learning can be used to successfully detect and identify the trigger encoded data, in order to protect a DNA sequencing pipeline from Trojan attacks. The result shows nearly up to 100% accuracy in detection in such a novel Trojan attack scenario even after applying fragmentation encryption and steganography on the encoded trigger data. In addition, feasibility of designing and synthesizing encoded DNA for such Trojan payloads is validated by a wet lab experiment.
    MeSH term(s) Computer Security ; DNA/genetics ; Deep Learning ; Sequence Analysis, DNA ; Software
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-06-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-13700-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Immune System, Inflammation and Autoantigens in Wet Age-Related Macular Degeneration: Pathological Significance and Therapeutic Importance.

    Manikandan, Sreeraj Kuruppilakath / Logan, Ann / Cerrada-Gimenez, Marc / Fitzhenry, Laurence / Coffey, Lee / Kaja, Simon / Rani, Sweta

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: Wet age-related macular degeneration (wAMD) is a chronic inflammation-associated neurodegenerative disease affecting the posterior part of the eye in the aging population. Aging results in the reduced functionality of cells and tissues, including the ... ...

    Abstract Wet age-related macular degeneration (wAMD) is a chronic inflammation-associated neurodegenerative disease affecting the posterior part of the eye in the aging population. Aging results in the reduced functionality of cells and tissues, including the cells of the retina. Initiators of a chronic inflammatory and pathologic state in wAMD may be a result of the accumulation of inevitable metabolic injuries associated with the maintenance of tissue homeostasis from a young age to over 50. Apart from this, risk factors like smoking, genetic predisposition, and failure to repair the injuries that occur, alongside attempts to rescue the hypoxic outer retina may also contribute to the pathogenesis. Aging of the immune system (immunosenescence) and a compromised outer blood retinal barrier (BRB) result in the exposure of the privileged milieu of the retina to the systemic immune system, further increasing the severity of the disease. When immune-privileged sites like the retina are under pathological stress, certain age- and disease-related conditions may necessitate assistance from cells distant from the resident ones to help restore the functionality of the tissue. As a necessary part of tissue repair, inflammation is a major response to disease and recruits immune cells to the site of damage. We suspect that the specific reparative inflammatory responses are controlled by an autoantigen-T cell-mediated mechanism, a process that may be hindered in wAMD.
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13122236
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  6. Article ; Online: The role of expectations and future-oriented cognitions in quality of life of people with multiple sclerosis: A systematic review.

    Maguire, Rebecca / McKeague, Beth / Kóka, Nathalie / Coffey, Laura / Maguire, Phil / Desmond, Deirdre

    Multiple sclerosis and related disorders

    2021  Volume 56, Page(s) 103293

    Abstract: Purpose: Multiple Sclerosis (MS) is a highly variable condition characterised by uncertainty of disease course which can make formation of expectations about the future difficult. This systematic review aimed to examine associations between expectations, ...

    Abstract Purpose: Multiple Sclerosis (MS) is a highly variable condition characterised by uncertainty of disease course which can make formation of expectations about the future difficult. This systematic review aimed to examine associations between expectations, or Future Oriented Cognitions (FOCs), and Quality of Life (QOL) in people with MS (PwMS).
    Methods: Following PRISMA guidelines, literature up to October 2019 was searched using Medline, EMBASE, PsycINFO and Web of Science. Quantitative studies that investigated relationships between FOCs and QOL in PwMS (assessed using a standardised QOL assessment) were considered for inclusion. After data extraction, results were analysed using narrative synthesis, focusing on the valence of FOCs (positive, negative, unvalenced). Quality appraisal was conducted using the Mixed Methods Appraisal Tool (MMAT). All stages of the review were patient-led by a person with MS.
    Results: A total of 13 studies met the review inclusion criteria, with a combined sample size of 4,179. Of these studies, 11 involved measures of positive FOCs, most commonly self-efficacy, one measured a negative FOC, with one FOC unclassified. Nine studies found significant associations between QOL and self-efficacy. Although other positively valenced constructs were less frequently reported, significant associations with higher QOL were also evidenced.
    Conclusions: Identifying ways to foster positive FOCs, particularly self-efficacy, may have beneficial effects on QOL. More research is needed to understand the impacts of negative FOCs on QOL to determine whether these processes could be meaningfully targeted in interventions.
    MeSH term(s) Cognition ; Humans ; Motivation ; Multiple Sclerosis ; Quality of Life ; Self Efficacy
    Language English
    Publishing date 2021-10-01
    Publishing country Netherlands
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2021.103293
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  7. Article: Enhancing Educator Knowledge of Sheep and Goat Production

    Coffey, L

    Sustainable Agriculture Research and Education (SARE) research projects. Southern Region. 2005, PROJECT ES02-060

    2005  

    Keywords sheep ; goats ; sustainable agriculture ; ruminants ; agricultural education ; farm planning ; Arkansas ; Georgia ; Kentucky ; North Carolina
    Language English
    Size 1 portfolio.
    Document type Article
    Note SARE Project Number: ES02-060. ; Contains final report (2005), annual reports (2002, 2003, 2004), cover letter, project profile, 3 publications, 4 sets of program materials, 1 newsletter, 1 communications printout and 1 minor product list.
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Perceptions and experiences of diabetic foot ulceration and foot care in people with diabetes: A qualitative meta-synthesis.

    Coffey, Laura / Mahon, Conor / Gallagher, Pamela

    International wound journal

    2018  Volume 16, Issue 1, Page(s) 183–210

    Abstract: Diabetic foot ulceration (DFU) is a common and debilitating complication of diabetes that is preventable through active engagement in appropriate foot-related behaviours, yet many individuals with diabetes do not adhere to foot care recommendations. The ... ...

    Abstract Diabetic foot ulceration (DFU) is a common and debilitating complication of diabetes that is preventable through active engagement in appropriate foot-related behaviours, yet many individuals with diabetes do not adhere to foot care recommendations. The aim of this paper was to synthesise the findings of qualitative papers exploring diabetic people's perceptions and experiences of DFU in order to identify how they could be better supported to prevent ulceration or manage its impact. Five databases (MEDLINE, PsycINFO, CINAHL, EMBASE, Web of Science) were searched in May 2016 to identify eligible articles. Findings were synthesised using a meta-ethnographic approach. Forty-two articles were eligible for inclusion. Synthesis resulted in the development of five overarching themes: personal understandings of diabetic foot ulceration; preventing diabetic foot ulceration: knowledge, attitudes, and behaviours; views on health care experiences; development of diabetic foot ulceration and actions taken; and wide-ranging impacts of diabetic foot ulceration. The findings highlight various barriers and facilitators of foot care experienced by people with diabetes and demonstrate the significant consequences of ulcers for their physical, social, and psychological well-being. The insights provided could inform the development of interventions to promote foot care effectively and provide appropriate support to those living with ulceration.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Diabetic Foot/physiopathology ; Diabetic Foot/psychology ; Diabetic Foot/therapy ; Female ; Guideline Adherence ; Humans ; Male ; Middle Aged ; Patients/psychology ; Qualitative Research ; Self Care/psychology
    Language English
    Publishing date 2018-11-04
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.13010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6006: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Preventing strokes.

    Coffey, L

    Healthplan

    1997  Volume 38, Issue 1, Page(s) 67–70

    MeSH term(s) Aged ; Cerebrovascular Disorders/epidemiology ; Cerebrovascular Disorders/prevention & control ; Colorado ; Humans ; Incidence ; Independent Practice Associations/organization & administration ; Life Style ; Medicare ; Patient Compliance ; Preventive Health Services/organization & administration ; Risk Factors ; Surveys and Questionnaires ; United States/epidemiology
    Language English
    Publishing date 1997-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2056897-6
    ISSN 1087-3678
    ISSN 1087-3678
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5655: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article: Chitosan-Coated PLGA Nanoparticles Encapsulating Triamcinolone Acetonide as a Potential Candidate for Sustained Ocular Drug Delivery.

    Dandamudi, Madhuri / McLoughlin, Peter / Behl, Gautam / Rani, Sweta / Coffey, Lee / Chauhan, Anuj / Kent, David / Fitzhenry, Laurence

    Pharmaceutics

    2021  Volume 13, Issue 10

    Abstract: The current treatment for the acquired retinal vasculopathies involves lifelong repeated intravitreal injections of either anti-vascular endothelial growth factor (VEGF) therapy or modulation of inflammation with steroids. Consequently, any treatment ... ...

    Abstract The current treatment for the acquired retinal vasculopathies involves lifelong repeated intravitreal injections of either anti-vascular endothelial growth factor (VEGF) therapy or modulation of inflammation with steroids. Consequently, any treatment modification that decreases this treatment burden for patients and doctors alike would be a welcome intervention. To that end, this research aims to develop a topically applied nanoparticulate system encapsulating a corticosteroid for extended drug release. Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) supports the controlled release of the encapsulated drug, while surface modification of these NPs with chitosan might prolong the mucoadhesion ability leading to improved bioavailability of the drug. Triamcinolone acetonide (TA)-loaded chitosan-coated PLGA NPs were fabricated using the oil-in-water emulsion technique. The optimized surface-modified NPs obtained using Box-Behnken response surface statistical design were reproducible with a particle diameter of 334 ± 67.95 to 386 ± 15.14 nm and PDI between 0.09 and 0.15. These NPs encapsulated 55-57% of TA and displayed a controlled release of the drug reaching a plateau in 27 h. Fourier-transform infrared spectroscopic (FTIR) analysis demonstrated characteristic peaks for chitosan (C-H, CONH2 and C-O at 2935, 1631 and 1087 cm
    Language English
    Publishing date 2021-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13101590
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