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  1. Article ; Online: GLP-1 receptor agonists: European drug regulator asks makers for evidence of self-harm.

    Cohen, Deborah

    BMJ (Clinical research ed.)

    2023  Volume 383, Page(s) 2906

    MeSH term(s) Humans ; Glucagon-Like Peptide-1 Receptor Agonists ; Hypoglycemic Agents ; Diabetes Mellitus, Type 2 ; Self-Injurious Behavior ; Glucagon-Like Peptide-1 Receptor
    Chemical Substances Glucagon-Like Peptide-1 Receptor Agonists ; Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p2906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Money being paid for prescribing Wegovy in pilot studies is "over the top," say critics.

    Cohen, Deborah

    BMJ (Clinical research ed.)

    2023  Volume 383, Page(s) 2918

    MeSH term(s) Humans ; Pilot Projects ; Salaries and Fringe Benefits ; Glucagon-Like Peptides
    Chemical Substances semaglutide (53AXN4NNHX) ; Glucagon-Like Peptides (62340-29-8)
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p2918
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  3. Article ; Online: L’exposition des enfants à la pornographie est préoccupante.

    Cohen, David

    La Revue du praticien

    2023  Volume 73, Issue 4, Page(s) 351

    Title translation Children's exposure to pornography is a concern.
    MeSH term(s) Humans ; Child ; Erotica ; Sexual Behavior ; Child Abuse, Sexual
    Language French
    Publishing date 2023-06-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  4. Article ; Online: Family Constellation therapy: A nascent approach for working with non-local consciousness in a therapeutic container.

    Cohen, Dan

    Progress in biophysics and molecular biology

    2023  Volume 186, Page(s) 33–38

    Abstract: Family Constellations are an emerging therapeutic approach for working with local and non-local consciousness. First developed by German psychoanalyst Bert Hellinger, and now practiced by thousands of licensed and un-licensed facilitators globally, ... ...

    Abstract Family Constellations are an emerging therapeutic approach for working with local and non-local consciousness. First developed by German psychoanalyst Bert Hellinger, and now practiced by thousands of licensed and un-licensed facilitators globally, Family Constellations are a transpersonal and systemically oriented therapeutic process. Their aim is to address a focus client's emotional, behavioral, relational, or somatic issues by uncovering and resolving transgenerational entanglements within their family system. The author expands on the proposal of symbiogenesis as a mediator of local and non-local consciousness to query whether applying the Observer Effect to inherited trauma may influence epigenetic marks. An expanded perspective on consciousness, life, death, and quantum fields may provide a more comprehensive framework to address therapeutic interventions for common emotional and behavioral disorders. Innovative features of Family Constellations are its phenomenological orientation, reference to family system entanglements, and potential for symptom relief through cellular mediation of ancestral memory. Family Constellations utilize techniques called representative perception and tuning-in to identify and release ancestral traumas. These are akin to remote viewing and mediumship. While the scientific basis for Family Constellations is speculative, the text references research on the quantum theory of consciousness, mediumship and remote viewing as potential supporting evidence. Four case studies are presented.
    MeSH term(s) Humans ; Consciousness ; Family Relations ; Psychotherapy/methods
    Language English
    Publishing date 2023-12-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 209302-9
    ISSN 1873-1732 ; 0079-6107
    ISSN (online) 1873-1732
    ISSN 0079-6107
    DOI 10.1016/j.pbiomolbio.2023.11.008
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  5. Article: Appréhender le COVID-19 au fil de l’eau en tant que psychiatre d’enfant et d’adolescent.

    Cohen, D

    L'Encephale

    2020  Volume 46, Issue 3S, Page(s) S99–S106

    Abstract: COVID-19 is a multi-organ disease due to an infection with the SARS-CoV2 virus. It has become a pandemic in early 2020. The disease appears less devastating in children and adolescents. However, stress, quarantine and eventually mourning have major ... ...

    Title translation Appreciating COVID-19 as a child and adolescent psychiatrist on the move.
    Abstract COVID-19 is a multi-organ disease due to an infection with the SARS-CoV2 virus. It has become a pandemic in early 2020. The disease appears less devastating in children and adolescents. However, stress, quarantine and eventually mourning have major impacts on development. It is difficult to describe what this pandemic implies for a child psychiatrist, other than by giving a first-hand account. I propose to go through the main ethical questions that have arisen; to describe how my hospital team has reorganized itself to meet the new demands and questions, in particular by opening a unit dedicated to people with autism and challenging behaviors affected by COVID-19; and to address, in a context of national discussion, how the discipline has sought to understand the conditions of a certain well-being during quarantine. Finally, I will try to conclude with more speculative reflections on re-opening.
    MeSH term(s) Adolescent ; Adolescent Behavior ; Adolescent Psychiatry/ethics ; Attitude of Health Personnel ; Autistic Disorder/complications ; Autistic Disorder/psychology ; Autistic Disorder/therapy ; Betacoronavirus ; COVID-19 ; Child ; Child Behavior ; Child Psychiatry/ethics ; Communicable Disease Control/methods ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/psychology ; Coronavirus Infections/transmission ; Cross Infection/complications ; Cross Infection/psychology ; Cross Infection/therapy ; Environmental Exposure ; France ; Health Services Accessibility ; Hospital Restructuring ; Hospital Units/organization & administration ; Humans ; Infection Control/methods ; Mental Health Services/ethics ; Mental Health Services/organization & administration ; Olfaction Disorders/etiology ; Olfaction Disorders/psychology ; Pandemics/prevention & control ; Patient Acceptance of Health Care ; Patient Care Team ; Patient Isolation/psychology ; Play Therapy ; Pneumonia, Viral/complications ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/psychology ; Pneumonia, Viral/transmission ; Professional Practice/ethics ; Protective Devices ; Psychiatry ; Risk Factors ; SARS-CoV-2 ; Stress, Psychological/etiology
    Keywords covid19
    Language French
    Publishing date 2020-05-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 214431-1
    ISSN 0013-7006
    ISSN 0013-7006
    DOI 10.1016/j.encep.2020.05.005
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  6. Article: Preventie en behandeling van gewichts-toename bij antipsychotica.

    Veerman, S R T / Cohen, D

    Tijdschrift voor psychiatrie

    2023  Volume 65, Issue 4, Page(s) 259–265

    Abstract: Background: Metformin is the most investigated pharmacological treatment of antipsychotics-induced weight gain (AIWG). Based on a systematic literature review, the first guideline for the treatment of AIWG with metformin was recently published.: Aim: ...

    Title translation Prevention and treatment of antipsychotic induced weight gain.
    Abstract Background: Metformin is the most investigated pharmacological treatment of antipsychotics-induced weight gain (AIWG). Based on a systematic literature review, the first guideline for the treatment of AIWG with metformin was recently published.
    Aim: To present a step-by-step plan, based on recent literature and clinical experience to monitor, prevent, and treat AIWG.
    Method: Literature search to give specific advice on the choice of antipsychotic medication, stop, dose reduction or switch of antipsychotic, screening, non-pharmacological and pharmacological interventions to prevent and treat AIWG.
    Results: Especially in the first year of antipsychotic treatment timely detection of AIWG through regular monitoring is pivotal. The best way to treat AIWG is to prevent its emergence by choosing an antipsychotic with a favourable metabolic profile. Secondly, by titration of antipsychotic medication to the lowest dose possible. Achieving a healthy lifestyle shows a limited beneficial effect on AIWG. Drug-induced weight loss can be attained by the addition of metformin, topiramate, or aripiprazole. Topiramate and aripiprazole can improve positive and negative residual symptoms of schizophrenia. The evidence on liraglutide is scarce. All augmentation strategies may cause side effects. Besides, in case of nonresponse augmentation therapy should be stopped to prevent unnecessary polypharmacy.
    Conclusion: In the revision of the Dutch multidisciplinary guideline for schizophrenia, the detection, prevention, and treatment of AIWG deserves more attention.
    MeSH term(s) Humans ; Antipsychotic Agents/adverse effects ; Aripiprazole ; Topiramate ; Weight Gain ; Metformin/therapeutic use
    Chemical Substances Antipsychotic Agents ; Aripiprazole (82VFR53I78) ; Topiramate (0H73WJJ391) ; Metformin (9100L32L2N)
    Language Dutch
    Publishing date 2023-06-19
    Publishing country Netherlands
    Document type Systematic Review ; English Abstract ; Journal Article
    ZDB-ID 604662-9
    ISSN 0303-7339
    ISSN 0303-7339
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  7. Article ; Online: General Designs Reveal Distinct Codes in Protein-Coding and Non-Coding Human DNA.

    Cohen, Dana

    Genes

    2022  Volume 13, Issue 11

    Abstract: This study seeks to investigate distinct signatures and codes within different genomic sequence locations of the human genome. The promoter and other non-coding regions contain sites for the binding of biological particles, for processes such as ... ...

    Abstract This study seeks to investigate distinct signatures and codes within different genomic sequence locations of the human genome. The promoter and other non-coding regions contain sites for the binding of biological particles, for processes such as transcription regulation. The specific rules and sequence codes that govern this remain poorly understood. To derive these (codes), the general designs of sequence are investigated. Genomic signatures are a powerful tool for assessing the general designs of sequence, and cross-comparing different genomic regions for their distinct sequence properties. Through these genomic signatures, the relative non-random properties of sequences are also assessed. Furthermore, a binary components analysis is carried out making use of information theory ideas, to study the RY (purine/pyrimidine), WS (weak/strong) and KM (keto/amino) signatures in the sequences. From this comparison, it is possible to identify the relative importance of these properties within the various protein-coding and non-coding genomic locations. The results show that coding DNA has a strongly non-random WS signature, which reflects the genetic code, and the hydrogen-bond base pairing of codon-anti-codon interactions. In contrast, non-coding locations, such as the promoter, contain a distinct genomic signature. A prominent feature throughout non-coding DNA is a highly non-random RY signature, which is very different in nature to coding DNA, and suggests a structural-based RY code. This marks progress towards deciphering the unknown code(s) in non-protein-coding DNA, and a further understanding of the coding DNA. Additionally, it unravels how DNA carries information. These findings have implications for the most fundamental principles of biology, including knowledge of gene regulation, development and disease.
    MeSH term(s) Humans ; DNA/genetics ; Genetic Code ; Codon ; Genome, Human ; Promoter Regions, Genetic
    Chemical Substances DNA (9007-49-2) ; Codon
    Language English
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13111970
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  8. Article: Any Time, Any Place, Any Way, Any Pace: Markets, EdTech, and the spaces of schooling.

    Cohen, Dan

    Environment & planning A

    2022  Volume 56, Issue 1, Page(s) 270–287

    Abstract: For decades investors have sought to find ways of profiting off the billions of public dollars spent annually on systems of public schooling across the world. This interest has coincided with the growing marketization of systems of public schooling, ... ...

    Abstract For decades investors have sought to find ways of profiting off the billions of public dollars spent annually on systems of public schooling across the world. This interest has coincided with the growing marketization of systems of public schooling, especially in the United States, as well as the increased use of educational technologies (or EdTech). This study examines the implications of the growing use of profit-driven educational technologies for the politics and spatial practices of schooling. Specifically, it examines past experiences with market-oriented EdTech systems in Oregon and Michigan to highlight how the combination of market systems of governance and profit-driven EdTech practices depend on the deconstruction of links between schools, communities, and students in order to roll out aspatial and apolitical educational practices that maximize profits. The placeless vision for education embedded in profit-driven EdTech helps promote the reproduction of dominant orders and stifles place-based struggles over educational justice.
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 0308-518X
    ISSN 0308-518X
    DOI 10.1177/0308518X221084708
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  9. Article ; Online: Current issues in venous thromboembolism.

    Cohen, David

    Postgraduate medicine

    2021  Volume 133, Issue sup1, Page(s) 1–2

    MeSH term(s) Humans ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/therapy
    Language English
    Publishing date 2021-07-28
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.1080/00325481.2021.1955541
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  10. Article ; Online: Inclisiran: Government's strategy to promote cholesterol lowering drug after Brexit was "spectacular failure," says insider.

    Cohen, Deborah / McCartney, Margaret

    BMJ (Clinical research ed.)

    2024  Volume 384, Page(s) q90

    MeSH term(s) Humans ; European Union ; United Kingdom ; Anticholesteremic Agents/therapeutic use ; RNA, Small Interfering ; Cholesterol ; Government ; Proprotein Convertase 9
    Chemical Substances ALN-PCS ; Anticholesteremic Agents ; RNA, Small Interfering ; Cholesterol (97C5T2UQ7J) ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.q90
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