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  1. AU="Cohen, Sidney R"
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  1. Article ; Online: Trivalent Dopant Size Influences Electrostrictive Strain in Ceria Solid Solutions.

    Varenik, Maxim / Nino, Juan Claudio / Wachtel, Ellen / Kim, Sangtae / Cohen, Sidney R / Lubomirsky, Igor

    ACS applied materials & interfaces

    2021  Volume 13, Issue 17, Page(s) 20269–20276

    Abstract: The technologically important frequency range for the application of electrostrictors and piezoelectrics is tens of Hz to tens of kHz. ... ...

    Abstract The technologically important frequency range for the application of electrostrictors and piezoelectrics is tens of Hz to tens of kHz. Sm
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c20810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The role of convolutional neural networks in scanning probe microscopy: a review.

    Azuri, Ido / Rosenhek-Goldian, Irit / Regev-Rudzki, Neta / Fantner, Georg / Cohen, Sidney R

    Beilstein journal of nanotechnology

    2021  Volume 12, Page(s) 878–901

    Abstract: Progress in computing capabilities has enhanced science in many ways. In recent years, various branches of machine learning have been the key facilitators in forging new paths, ranging from categorizing big data to instrumental control, from materials ... ...

    Abstract Progress in computing capabilities has enhanced science in many ways. In recent years, various branches of machine learning have been the key facilitators in forging new paths, ranging from categorizing big data to instrumental control, from materials design through image analysis. Deep learning has the ability to identify abstract characteristics embedded within a data set, subsequently using that association to categorize, identify, and isolate subsets of the data. Scanning probe microscopy measures multimodal surface properties, combining morphology with electronic, mechanical, and other characteristics. In this review, we focus on a subset of deep learning algorithms, that is, convolutional neural networks, and how it is transforming the acquisition and analysis of scanning probe data.
    Language English
    Publishing date 2021-08-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2583584-1
    ISSN 2190-4286
    ISSN 2190-4286
    DOI 10.3762/bjnano.12.66
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The exoskeleton of scorpions' pincers: Structure and micro-mechanical properties.

    Kellersztein, Israel / Cohen, Sidney R / Bar-On, Benny / Wagner, H Daniel

    Acta biomaterialia

    2019  Volume 94, Page(s) 565–573

    Abstract: Since scorpions exist almost all over the world, some expected body differences exist among the species: undoubtedly, the most evident is the shape and size of their pincers or chelae. The scorpion chela is a multifunctional body component (e.g. attack/ ... ...

    Abstract Since scorpions exist almost all over the world, some expected body differences exist among the species: undoubtedly, the most evident is the shape and size of their pincers or chelae. The scorpion chela is a multifunctional body component (e.g. attack/defense, mating and protection from the environment) that leads to the development of different stresses in the cuticle. How such stresses in the cuticle are accommodated by different chelae shape and size is largely unknown. Here we provide new comparative data on the hierarchical structure and mechanical properties of the chela cuticle in two scorpion species: Scorpio Maurus Palmatus (SP) that has a large chela and Buthus Occitanus Israelis (BO), with a slender chela. We found that the SP exocuticle is composed of four different sublayers whereas the BO exocuticle displays only two sublayers. These structures are different from the exocuticle morphologies in crustaceans, where the Bouligand morphology is present throughout the entire layer. Moreover, the scorpion chela cuticle presents an exclusive structural layer made of unidirectional fibers arranged vertically towards the normal direction of the cuticle. Nanoindentation measurements were performed under dry conditions on transversal and longitudinal planes to evaluate the stiffness and hardness of the different chela cuticle layers in both scorpions. The chela cuticle structure is a key factor towards the decision of the scorpion whether to choose to sting or use the chela for other mechanical functions. STATEMENT OF SIGNIFICANCE: Many arthropods such as lobsters, crabs, stomatopods, isopods, and spiders have been the subject of research in recent years, and their hierarchical structure and mechanical properties extensively investigated. Yet, except for a limited number of pre-1980 publications, comparatively little work has been devoted to the terrestrial scorpion. The scorpion chela is a multifunctional part of the body (e.g. attack/defense, mating and protection from the environment) that involves the development of various stresses in the cuticle. How these stresses in the chela cuticle are managed by different chelae shape and size is still unknown. The lack of a single study that integrates morphological characterization of the entire hierarchical structure of the scorpion chela cuticle, and local mechanical properties, significantly affects the scientific knowledge regarding important structural approaches that can be used by nature to maximize functionality.
    MeSH term(s) Animal Shells/chemistry ; Animals ; Scorpions/chemistry
    Language English
    Publishing date 2019-06-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2019.06.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Laboratory Insights into the Diel Cycle of Optical and Chemical Transformations of Biomass Burning Brown Carbon Aerosols

    Li, Chunlin / He, Quanfu / Fang, Zheng / Brown, Steven S / Laskin, Alexander / Cohen, Sidney R / Rudich, Yinon

    Environmental science & technology. 2020 Sept. 01, v. 54, no. 19

    2020  

    Abstract: Transformations of biomass burning brown carbon aerosols (BB-BrC) over their diurnal lifecycle are currently not well studied. In this study, the aging of BB tar proxy aerosols processed by NO₃• under dark conditions followed by the photochemical OH• ... ...

    Abstract Transformations of biomass burning brown carbon aerosols (BB-BrC) over their diurnal lifecycle are currently not well studied. In this study, the aging of BB tar proxy aerosols processed by NO₃• under dark conditions followed by the photochemical OH• reaction and photolysis were investigated in tandem flow reactors. The results show that O₃ oxidation in the dark diminishes light absorption of wood tar aerosols, resulting in higher particle single-scattering albedo (SSA). NO₃• reactions augment the mass absorption coefficient (MAC) of the aerosols by a factor of 2–3 by forming secondary chromophores, such as nitroaromatic compounds (NACs) and organonitrates. Subsequent OH• oxidation and direct photolysis both decompose the organic nitrates (ONs, representing bulk functionalities of NACs and organonitrates) in the NO₃•-aged wood tar aerosols, thus decreasing particle absorption. Moreover, NACs degrade faster than organonitrates by photochemical aging. The NO₃•-aged wood tar aerosols are more susceptible to photolysis than to OH• reactions. The photolysis lifetimes for the ONs and for the absorbance of the NO₃•-aged aerosols are on the order of hours under typical solar irradiation, while the absorption and ON lifetimes toward OH• oxidation are substantially longer. Overall, nighttime aging via NO₃• reactions increases the light absorption of wood tar aerosols and shortens their absorption lifetime under daytime conditions.
    Keywords absorbance ; absorption ; biomass ; carbon ; environmental science ; oxidation ; photolysis ; solar radiation ; technology ; wood
    Language English
    Dates of publication 2020-0901
    Size p. 11827-11837.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1520-5851
    DOI 10.1021/acs.est.0c04310
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Protein nanofibril design via manipulation of hydrogen bonds.

    Aggarwal, Nidhi / Eliaz, Dror / Cohen, Hagai / Rosenhek-Goldian, Irit / Cohen, Sidney R / Kozell, Anna / Mason, Thomas O / Shimanovich, Ulyana

    Communications chemistry

    2021  Volume 4, Issue 1, Page(s) 62

    Abstract: The process of amyloid nanofibril formation has broad implications including the generation of the strongest natural materials, namely silk fibers, and their major contribution to the progression of many degenerative diseases. The key question that ... ...

    Abstract The process of amyloid nanofibril formation has broad implications including the generation of the strongest natural materials, namely silk fibers, and their major contribution to the progression of many degenerative diseases. The key question that remains unanswered is whether the amyloidogenic nature, which includes the characteristic H-bonded β-sheet structure and physical characteristics of protein assemblies, can be modified via controlled intervention of the molecular interactions. Here we show that tailored changes in molecular interactions, specifically in the H-bonded network, do not affect the nature of amyloidogenic fibrillation, and even have minimal effect on the initial nucleation events of self-assembly. However, they do trigger changes in networks at a higher hierarchical level, namely enhanced 2D packaging which is rationalized by the 3D hierarchy of β-sheet assembly, leading to variations in fibril morphology, structural composition and, remarkably, nanomechanical properties. These results pave the way to a better understanding of the role of molecular interactions in sculpting the structural and physical properties of protein supramolecular constructs.
    Language English
    Publishing date 2021-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929562-2
    ISSN 2399-3669 ; 2399-3669
    ISSN (online) 2399-3669
    ISSN 2399-3669
    DOI 10.1038/s42004-021-00494-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Control over size, shape, and photonics of self-assembled organic nanocrystals.

    Shahar, Chen / Tidhar, Yaron / Jung, Yunmin / Weissman, Haim / Cohen, Sidney R / Bitton, Ronit / Pinkas, Iddo / Haran, Gilad / Rybtchinski, Boris

    Beilstein journal of organic chemistry

    2021  Volume 17, Page(s) 42–51

    Abstract: The facile fabrication of free-floating organic nanocrystals (ONCs) was achieved via the kinetically controlled self-assembly of simple perylene diimide building blocks in aqueous medium. The ONCs have a thin rectangular shape, with an aspect ratio that ... ...

    Abstract The facile fabrication of free-floating organic nanocrystals (ONCs) was achieved via the kinetically controlled self-assembly of simple perylene diimide building blocks in aqueous medium. The ONCs have a thin rectangular shape, with an aspect ratio that is controlled by the content of the organic cosolvent (THF). The nanocrystals were characterized in solution by cryogenic transmission electron microscopy (cryo-TEM) and small-angle X-ray scattering. The ONCs retain their structure upon drying, as was evidenced by TEM and atom force microscopy. Photophysical studies, including femtosecond transient absorption spectroscopy, revealed a distinct influence of the ONC morphology on their photonic properties (excitation energy transfer was observed only in the high-aspect ONCs). Convenient control over the structure and function of organic nanocrystals can enhance their utility in new and developed technologies.
    Language English
    Publishing date 2021-01-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.17.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unusual Surface Texture, Dimensions and Morphology Variations of Chiral and Single Crystals*.

    Singh, Vivek / Houben, Lothar / Shimon, Linda J W / Cohen, Sidney R / Golani, Ofra / Feldman, Yishay / Lahav, Michal / van der Boom, Milko E

    Angewandte Chemie (International ed. in English)

    2021  Volume 60, Issue 33, Page(s) 18256–18264

    Abstract: We demonstrate here a unique metallo-organic material where the appearance and the internal crystal structure are in contradiction. The egg-shaped (ovoid) crystals have a brain-like texture. Although these micro-sized crystals are monodispersed; like ... ...

    Abstract We demonstrate here a unique metallo-organic material where the appearance and the internal crystal structure are in contradiction. The egg-shaped (ovoid) crystals have a brain-like texture. Although these micro-sized crystals are monodispersed; like fingerprints their grainy surfaces are never exactly alike. Remarkably, our X-ray and electron diffraction studies unexpectedly revealed that these structures are single-crystals comprising a continuous coordination network of two differently shaped homochiral channels. By using the same building blocks under different reaction conditions, a rare series of crystals have been obtained that are uniquely rounded in their shape. In stark contrast to the brain-like crystals, these isostructural and monodispersed crystals have a comparatively smooth appearance. The sizes of these crystals vary by several orders of magnitude.
    Language English
    Publishing date 2021-07-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202105772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways.

    Kshirsagar, Aditya / Doroshev, Svetlana Maslov / Gorelik, Anna / Olender, Tsviya / Sapir, Tamar / Tsuboi, Daisuke / Rosenhek-Goldian, Irit / Malitsky, Sergey / Itkin, Maxim / Argoetti, Amir / Mandel-Gutfreund, Yael / Cohen, Sidney R / Hanna, Jacob H / Ulitsky, Igor / Kaibuchi, Kozo / Reiner, Orly

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3293

    Abstract: Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 is essential for the viability of mouse embryonic stem cells (mESCs), and it governs ... ...

    Abstract Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 is essential for the viability of mouse embryonic stem cells (mESCs), and it governs the physical properties of these cells. LIS1 dosage substantially affects gene expression, and we uncovered an unexpected interaction of LIS1 with RNA and RNA-binding proteins, most prominently the Argonaute complex. We demonstrate that LIS1 overexpression partially rescued the extracellular matrix (ECM) expression and mechanosensitive genes conferring stiffness to Argonaute null mESCs. Collectively, our data transforms the current perspective on the roles of LIS1 in post-transcriptional regulation underlying development and mechanosensitive processes.
    MeSH term(s) Animals ; Mice ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism ; Blastocyst/cytology ; Blastocyst/metabolism ; Cell Survival ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/metabolism ; Microtubule-Associated Proteins/metabolism ; Pluripotent Stem Cells ; Protein Interaction Maps ; Argonaute Proteins/metabolism
    Chemical Substances 1-Alkyl-2-acetylglycerophosphocholine Esterase (EC 3.1.1.47) ; Microtubule-Associated Proteins ; Pafah1b1 protein, mouse (EC 3.1.1.47) ; Ago2 protein, mouse ; Argonaute Proteins
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38797-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: C

    Cohen, Asaf / Cohen, Hagai / Cohen, Sidney R / Khodorov, Sergey / Feldman, Yishay / Kossoy, Anna / Kaplan-Ashiri, Ifat / Frenkel, Anatoly / Wachtel, Ellen / Lubomirsky, Igor / Ehre, David

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 18

    Abstract: A protocol for successfully depositing [001] textured, 2−3 µm thick films of Al0.75Sc0.25N, is proposed. The procedure relies on the fact that sputtered Ti is [001]-textured α-phase (hcp). Diffusion of nitrogen ions into the α-Ti film during reactive ... ...

    Abstract A protocol for successfully depositing [001] textured, 2−3 µm thick films of Al0.75Sc0.25N, is proposed. The procedure relies on the fact that sputtered Ti is [001]-textured α-phase (hcp). Diffusion of nitrogen ions into the α-Ti film during reactive sputtering of Al0.75,Sc0.25N likely forms a [111]-oriented TiN intermediate layer. The lattice mismatch of this very thin film with Al0.75Sc0.25N is ~3.7%, providing excellent conditions for epitaxial growth. In contrast to earlier reports, the Al0.75Sc0.25N films prepared in the current study are Al-terminated. Low growth stress (<100 MPa) allows films up to 3 µm thick to be deposited without loss of orientation or decrease in piezoelectric coefficient. An advantage of the proposed technique is that it is compatible with a variety of substrates commonly used for actuators or MEMS, as demonstrated here for both Si wafers and D263 borosilicate glass. Additionally, thicker films can potentially lead to increased piezoelectric stress/strain by supporting application of higher voltage, but without increase in the magnitude of the electric field.
    Language English
    Publishing date 2022-09-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22187041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Self-assembly at solid surfaces.

    Cohen, Sidney R / Sagiv, Jacob

    Beilstein journal of nanotechnology

    2011  Volume 2, Page(s) 824–825

    Language English
    Publishing date 2011-12-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2583584-1
    ISSN 2190-4286 ; 2190-4286
    ISSN (online) 2190-4286
    ISSN 2190-4286
    DOI 10.3762/bjnano.2.91
    Database MEDical Literature Analysis and Retrieval System OnLINE

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