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  1. Article ; Online: Blood and Its Components.

    Cohn, Claudia S / Shaz, Beth H

    JAMA

    2023  Volume 330, Issue 19, Page(s) 1903–1904

    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.22133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Platelet transfusion refractoriness: how do I diagnose and manage?

    Cohn, Claudia S

    Hematology. American Society of Hematology. Education Program

    2020  Volume 2020, Issue 1, Page(s) 527–532

    Abstract: Platelet refractoriness continues to be a problem for thrombocytopenic patients because the risk of a major spontaneous or life-threatening bleed significantly increases when platelet counts drop below 10 × 109/L. The majority of patients have nonimmune ... ...

    Abstract Platelet refractoriness continues to be a problem for thrombocytopenic patients because the risk of a major spontaneous or life-threatening bleed significantly increases when platelet counts drop below 10 × 109/L. The majority of patients have nonimmune causes driving the refractoriness, such as bleeding, medications, or diffuse intravascular coagulation; however, this article is dedicated to the diagnosis and support of patients with immune-based platelet refractoriness. Antibodies to class I HLA molecules (A and B alleles) are responsible for most immune-based refractory cases, with antibodies to platelet antigens seen much less frequently. Patients may be supported with either crossmatch-compatible or HLA-matched/compatible platelet units. When trying to select HLA units it can be difficult to find a perfect "4 of 4" match for the patient's class IA and IB alleles. In these cases, it is better to use the antibody specificity prediction method, which identifies compatible units that lack antigens recognized by the patient's anti-HLA antibodies. For an algorithmic approach to the patient with platelet refractoriness, see Visual Abstract.
    MeSH term(s) Female ; HLA-A Antigens/blood ; HLA-B Antigens/blood ; Histocompatibility ; Histocompatibility Testing ; Humans ; Middle Aged ; Platelet Transfusion/adverse effects ; Thrombocytopenia/blood ; Thrombocytopenia/therapy ; Transfusion Reaction/blood ; Transfusion Reaction/diagnosis ; Transfusion Reaction/prevention & control
    Chemical Substances HLA-A Antigens ; HLA-B Antigens
    Language English
    Publishing date 2020-12-04
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2020000137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Time to be proactive about passive D: Distinguishing anti-D alloimmunisation from RhIG.

    Adkins, Brian D / Cohn, Claudia S

    Transfusion medicine (Oxford, England)

    2021  Volume 31, Issue 1, Page(s) 3–4

    MeSH term(s) Anemia, Hemolytic, Autoimmune ; Humans ; Rh Isoimmunization ; Rho(D) Immune Globulin
    Chemical Substances RHO(D) antibody ; Rho(D) Immune Globulin
    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Editorial
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12744
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    Zs.A 3177: Show issues Location:
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  4. Article ; Online: Ensuring a Reliable Platelet Supply in the United States.

    Riley, William / Cohn, Claudia S / Love, Kailey / McCullough, Jeffrey

    The New England journal of medicine

    2023  Volume 388, Issue 22, Page(s) 2017–2019

    MeSH term(s) Humans ; Blood Platelets ; United States ; Blood Safety
    Language English
    Publishing date 2023-05-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp2302523
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  5. Article ; Online: Warming Up to Cold-stored Platelets.

    Cohn, Claudia S / Shaz, Beth H

    Anesthesiology

    2020  Volume 133, Issue 6, Page(s) 1161–1163

    MeSH term(s) Blood Platelets ; Blood Preservation ; Cold Temperature ; Pilot Projects ; Platelet Transfusion ; Temperature
    Language English
    Publishing date 2020-09-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000003560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 199: Show issues

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  6. Article ; Online: Catch those antibodies before they fall.

    Shaz, Beth H / Cohn, Claudia S

    Blood

    2020  Volume 136, Issue 22, Page(s) 2489–2490

    MeSH term(s) COVID-19/therapy ; Humans ; Immunization, Passive ; Pandemics ; Plasma ; SARS-CoV-2 ; COVID-19 Serotherapy
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020008768
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    Zs.MO 364: Show issues

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  7. Article ; Online: Transfusion support issues in hematopoietic stem cell transplantation.

    Cohn, Claudia S

    Cancer control : journal of the Moffitt Cancer Center

    2015  Volume 22, Issue 1, Page(s) 52–59

    Abstract: Background: Patients receiving hematopoietic stem cell transplantation require extensive transfusion support until red blood cell and platelet engraftment occurs. Rare but predictable complications may arise when the transplanted stem cells are ... ...

    Abstract Background: Patients receiving hematopoietic stem cell transplantation require extensive transfusion support until red blood cell and platelet engraftment occurs. Rare but predictable complications may arise when the transplanted stem cells are incompatible with the native ABO type of the patient. Immediate and delayed hemolysis is often seen.
    Methods: A literature review was performed and the results from peer-reviewed papers that contained reproducible findings were integrated.
    Results: A strong body of clinical evidence has developed around the common complications experienced with ABO-incompatible hematopoietic stem cell transplantation. These complications are discussed and the underlying pathophysiology is explained. General treatment options and guidelines are enumerated.
    Conclusions: ABO-incompatible hematopoietic stem cell transplantations are frequently performed. Immune-related hemolysis is a commonly encountered complication; therefore, health care professionals must recognize the signs of immune-mediated hemolysis and understand the various etiologies that may drive the process.
    MeSH term(s) ABO Blood-Group System/immunology ; Blood Group Incompatibility/immunology ; Cytomegalovirus Infections/prevention & control ; Erythrocyte Transfusion ; Graft vs Host Disease/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Hemolysis ; Histocompatibility/immunology ; Humans ; Platelet Transfusion
    Chemical Substances ABO Blood-Group System
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1328503-8
    ISSN 1526-2359 ; 1073-2748
    ISSN (online) 1526-2359
    ISSN 1073-2748
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    Zs.A 4467: Show issues Location:
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  8. Article ; Online: COVID-19 convalescent plasma.

    Tobian, Aaron A R / Cohn, Claudia S / Shaz, Beth H

    Blood

    2021  Volume 140, Issue 3, Page(s) 196–207

    Abstract: As the coronavirus disease (COVID-19) pandemic led to a global health crisis, there were limited treatment options and no prophylactic therapies for those exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma is ... ...

    Abstract As the coronavirus disease (COVID-19) pandemic led to a global health crisis, there were limited treatment options and no prophylactic therapies for those exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma is quick to implement, potentially provides benefits, and has a good safety profile. The therapeutic potential of COVID-19 convalescent plasma (CCP) is likely mediated by antibodies through direct viral neutralization and Fc-dependent functions such as a phagocytosis, complement activation, and antibody-dependent cellular cytotoxicity. In the United States, CCP became one of the most common treatments with more than a half million units transfused despite limited efficacy data. More than a dozen randomized trials now demonstrate that CCP does not provide benefit for those hospitalized with moderate to severe disease. However, similar to other passive antibody therapies, CCP is beneficial for early disease when provided to elderly outpatients within 72 hours after symptom onset. Only high-titer CCP should be transfused. CCP should also be considered for immunosuppressed patients with COVID-19. CCP collected in proximity, by time and location, to the patient may be more beneficial because of SARS-CoV-2 variants. Additional randomized trial data are still accruing and should be incorporated with other trial data to optimize CCP indications.
    MeSH term(s) Aged ; Antibodies, Viral ; Betacoronavirus ; COVID-19/therapy ; Coronavirus ; Coronavirus Infections/therapy ; Humans ; Immunization, Passive ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; United States
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021012248
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  9. Article ; Online: Cryopreserved platelets: the thaw begins … (Article, p. 2794).

    Cohn, Claudia S / Williams, Shelly

    Transfusion

    2019  Volume 59, Issue 9, Page(s) 2759–2762

    MeSH term(s) Blood Loss, Surgical ; Blood Platelets ; Blood Preservation ; Cryopreservation ; Humans
    Language English
    Publishing date 2019-09-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.15465
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    Zs.A 284: Show issues Location:
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  10. Article ; Online: Comparison of prenatal anti-D titration testing by gel and tube methods: A review of the literature.

    Lieberman, Lani / Andrews, Jennifer / Evans, Michael D / Cohn, Claudia S

    Transfusion

    2021  Volume 61, Issue 6, Page(s) 1749–1756

    Abstract: Background: Antenatal titration testing is traditionally performed using a manual tube test. Tube testing has limitations; it is a manual, time-consuming method with wide interobserver variability. Gel-based testing is an attractive alternative because ... ...

    Abstract Background: Antenatal titration testing is traditionally performed using a manual tube test. Tube testing has limitations; it is a manual, time-consuming method with wide interobserver variability. Gel-based testing is an attractive alternative because it is more precise and can be automated. This study's objective was to summarize the published literature that assessed the relationship between titrations performed by tube and gel for anti-D alloimmunized pregnancies.
    Study design and methods: A comprehensive literature search was performed. Articles were selected if research was original and compared at least five pairs of anti-D titration tests performed by gel and tube. Differences in the number of dilutions between gel and tube methods were compared overall by study and cell type using linear models.
    Results: A total of 512 articles were identified; eight were included, and titer data from 384 tube and gel pairs were abstracted. The median anti-D titer in tube was 8 (range 0-2048) and by gel was 64 (range 0-4096). Anti-D gel titration results were 2.1 (95% CI; 1-3.3) additional dilutions greater than in tube. Most studies utilized double-dose reagent cells for testing. At a tube titer of 16, the sensitivity and specificity of gel titrations is maximal (91% and 94% respectively) at a gel titer of 64.
    Conclusion: Overall, titrations performed by gel were two dilutions higher than the corresponding tube titer. For titrations, double-dose reagent cells should be considered to standardize practice. A rigorous prospective study is needed to compare tube titrations with gel titrations using a standardized process.
    MeSH term(s) Erythroblastosis, Fetal/diagnosis ; Female ; Humans ; Immunoassay/methods ; Isoantibodies/analysis ; Pregnancy ; Prenatal Diagnosis/methods ; Rho(D) Immune Globulin/analysis ; Titrimetry/methods
    Chemical Substances Isoantibodies ; RHO(D) antibody ; Rho(D) Immune Globulin
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16388
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