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  1. Book: METABOLIC DISEASE

    Cohn, Robert M.

    A GUIDE TO EARLY RECOGNITION

    1983  

    Author's details ROBERT M. COHN
    Keywords METABOLIC DISEASES / DIAGNOSIS ; METABOLISM, INBORN ERRORS / DIAGNOSIS
    Size XII, 442 S.
    Publisher SAUNDERS
    Publishing place PHILADELPHIA (U.A.)
    Document type Book
    HBZ-ID HT002704199
    ISBN 0-7216-2652-1 ; 978-0-7216-2652-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1984 A 3254 order for loan Magazin

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  2. Book: Biochemistry and disease

    Cohn, Robert M. / Roth, Karl S.

    bridging basic science and clinical practice

    1996  

    Author's details Robert M. Cohn ; Karl S. Roth
    Keywords Medicine ; Biochemistry ; Metabolic Diseases
    Language English
    Size XIV, 587 S. : graph. Darst.
    Publisher Williams & Wilkins
    Publishing place Baltimore u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007558033
    ISBN 0-683-02049-8 ; 978-0-683-02049-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 4717 order for loan Magazin

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  3. Article: Hyperammonemia, bane of the brain.

    Cohn, Robert M / Roth, Karl S

    Clinical pediatrics

    2004  Volume 43, Issue 8, Page(s) 683–689

    Abstract: Ammonia, normally produced from catabolism of amino acids, is a deadly neurotoxin. As such, the concentration of free ammonia in the blood is very tightly regulated and is exceeded by two orders of magnitude by its physiologic derivative, urea. The ... ...

    Abstract Ammonia, normally produced from catabolism of amino acids, is a deadly neurotoxin. As such, the concentration of free ammonia in the blood is very tightly regulated and is exceeded by two orders of magnitude by its physiologic derivative, urea. The normal capacity for urea production far exceeds the rate of free ammonia production by protein catabolism under normal circumstances, such that any increase in free blood ammonia concentration is a reflection of either biochemical or pharmacologic impairment of urea cycle function or fairly extensive hepatic damage. Clinical signs of hyperammonemia occur at concentrations > 60 micromol/L and include anorexia, irritability, lethargy, vomiting, somnolence, disorientation, asterixis, cerebral edema, coma, and death; appearance of these findings is generally proportional to free ammonia concentration, is progressive, and is independent of the primary etiology. Causes of hyperammonemia include genetic defects in the urea cycle ("primary") or organic acidemias ("secondary"), as well as genetic or acquired disorders resulting in significant hepatic dysfunction. Thus, because of the neurotoxic implications of hyperammonemia and the typical absence of other specific laboratory abnormalities, appearance of the clinical signs should trigger an emergent search for elevated blood ammonia concentration.
    MeSH term(s) Brain Diseases, Metabolic/diagnosis ; Brain Diseases, Metabolic/etiology ; Brain Diseases, Metabolic/physiopathology ; Brain Diseases, Metabolic/therapy ; Humans ; Hyperammonemia/diagnosis ; Hyperammonemia/etiology ; Hyperammonemia/physiopathology ; Hyperammonemia/therapy
    Language English
    Publishing date 2004-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/000992280404300801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 454: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Biochemistry and disease

    Cohn, Robert M / Roth, Karl S

    bridging basic science and clinical practice

    1996  

    Author's details Robert M. Cohn, Karl S. Roth
    MeSH term(s) Medicine ; Biochemistry ; Metabolic Diseases
    Language English
    Size xiv, 587 p. :, ill.
    Publisher Williams & Wilkins
    Publishing place Baltimore
    Document type Book
    ISBN 9780683020496 ; 0683020498
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book: Metabolic disease, a guide to early recognition

    Cohn, Robert M / Roth, Karl S

    1983  

    Author's details Robert M. Cohn, Karl S. Roth
    MeSH term(s) Metabolic Diseases/diagnosis ; Metabolism, Inborn Errors/diagnosis
    Language English
    Size xii, 442 p. :, ill.
    Publisher Saunders
    Publishing place Philadelphia
    Document type Book
    ISBN 9780721626529 ; 0721626521
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Book: Principles of metabolic control in mammalian systems

    Herman, Robert H / Cohn, Robert M / McNamara, Pamela D

    1980  

    Abstract: Abstract: Basic biochemical principles of the regulation of metabolism are presented. Mechanisms that govern intracellular reactions in mammals which have evolved for metabolic control and fundamental theorems of theoretical biology and nonequilibrium ... ...

    Author's details edited by Robert H. Herman, Robert M. Cohn, and Pamela D. McNamara. --
    Abstract Abstract: Basic biochemical principles of the regulation of metabolism are presented. Mechanisms that govern intracellular reactions in mammals which have evolved for metabolic control and fundamental theorems of theoretical biology and nonequilibrium thermodynamics are reviewed. Regulatory mechanisms of noncovalent forces, interactions with water, enzyme activity and degradation, coenzymes, protein biosynthesis, DNA replication, phospholipid-protein interactions, membrane structure, membrane-bound enzymes, transport systems, secretion and hormones are discussed. The role of compartmentation in metabolic regulation is also described. A final chapter examines the biochemical basis of disease.
    Keywords Metabolism/Regulation. ; Mammals/Physiology.
    Language English
    Size xix, 669 p. :, ill.
    Publisher Plenum Press
    Publishing place New York
    Document type Book
    ISBN 0306402610 ; 9780306402616
    Database NAL-Catalogue (AGRICOLA)

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  7. Book: Principles of metabolic control in mammalian systems

    Herman, Robert H / Cohn, Robert M / McNamara, Pamela D

    1980  

    Author's details edited by Robert H. Herman, Robert M. Cohn, Pamela D. McNamara
    MeSH term(s) Enzymes ; Mammals/metabolism ; Metabolism
    Language English
    Size xix, 669 p. :, ill.
    Publisher Plenum Press
    Publishing place New York
    Document type Book
    ISBN 9780306402616 ; 0306402610
    Database Catalogue of the US National Library of Medicine (NLM)

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    Kategorien

    Order via subito

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