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  1. Article ; Online: Paediatric acute liver failure: Confirm the outbreak, find the cause and explore the mechanisms.

    Coilly, Audrey / Samuel, Didier

    United European gastroenterology journal

    2022  Volume 10, Issue 8, Page(s) 789–790

    MeSH term(s) Child ; Disease Outbreaks ; Humans ; Liver Failure, Acute/diagnosis ; Liver Failure, Acute/epidemiology ; Liver Failure, Acute/etiology
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Editorial
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12306
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  2. Article ; Online: HLA-DQ Diversity Is Associated With Humoral Response to Vaccines in Patients Awaiting or After Liver Transplantation.

    Féray, Cyrille / Allain, Vincent / Desterke, Christophe / Roche, Bruno / Coilly, Audrey / Caillat-Zucman, Sophie

    Gastroenterology

    2024  Volume 166, Issue 5, Page(s) 915–917.e3

    MeSH term(s) Humans ; Liver Transplantation ; HLA-DQ Antigens/immunology ; HLA-DQ Antigens/genetics ; Immunity, Humoral/drug effects ; Female ; Male ; Middle Aged ; Waiting Lists ; Adult ; Vaccination
    Chemical Substances HLA-DQ Antigens
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.01.009
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  3. Article ; Online: Keep watch for the appearing mushroom!

    Coilly, Audrey

    Clinics and research in hepatology and gastroenterology

    2012  Volume 36, Issue 2, Page(s) 95–96

    MeSH term(s) Humans ; Mushroom Poisoning/diagnosis ; Mushroom Poisoning/therapy
    Language English
    Publishing date 2012-04
    Publishing country France
    Document type Editorial
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2011.12.012
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  4. Article ; Online: Management of patients with liver diseases on the waiting list for transplantation: a major impact to the success of liver transplantation.

    Samuel, Didier / Coilly, Audrey

    BMC medicine

    2018  Volume 16, Issue 1, Page(s) 113

    Abstract: Background: The results of liver transplantation are excellent, with survival rates of over 90 and 80% at 1 and 5 years, respectively. The success of liver transplantation has led to an increase in the indications for liver transplantation. Generally, ... ...

    Abstract Background: The results of liver transplantation are excellent, with survival rates of over 90 and 80% at 1 and 5 years, respectively. The success of liver transplantation has led to an increase in the indications for liver transplantation. Generally, priorities are given to cirrhotic patients with a high Model for End-Stage Liver Disease (MELD) score on the principle of the sickest first and to patients with hepatocellular carcinoma (HCC) on the principle of priority points according to the size and number of nodules of HCC. These criteria can lead to a 'competition' on the waiting list between the above patients and those who are cirrhotic and have an intermediate MELD score or with life-threatening liver diseases not well described by the MELD score. For this latter group of patients, 'MELD exception' points can be arbitrarily given.
    Discussion: The management of patients on the waiting list is of prime importance to avoid death and drop out from the waiting list as well as to improve post-transplant survival rates. For the more severe cases who may swiftly access liver transplantation, it is essential to rapidly determine whether liver transplantation is indeed indicated, and to organise a fast workup ahead of this. It is also essential to identify the ideal timing for liver transplantation in order to minimise mortality rates. For patients with HCC, a bridge therapy is frequently required to avoid progression of HCC and to maintain patients within the criteria of liver transplantation as well as to reduce the risk of post-transplant recurrence of HCC. For patients with cirrhosis and intermediate MELD score, waiting time can exceed 1 year; therefore, regular follow-up and management are essential to maintain the patient alive on the waiting list and to achieve a good survival after liver transplantation.
    Conclusion: There is a diversity of patients on the waiting list for transplantation and equity should be preserved between those with cirrhosis of high and intermediate severity and those with HCC. The management of patients on the waiting list is an essential component of the success of liver transplantation.
    MeSH term(s) Female ; Humans ; Liver Diseases/therapy ; Liver Transplantation/methods ; Liver Transplantation/mortality ; Male ; Middle Aged ; Survival Rate ; Waiting Lists
    Language English
    Publishing date 2018-08-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1741-7015
    ISSN (online) 1741-7015
    DOI 10.1186/s12916-018-1110-y
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  5. Article ; Online: HCV treatment in cirrhotic patients: Should we use a different approach for patients awaiting a liver transplant.

    Meunier, Lucy / Pageaux, Georges-Philippe / Coilly, Audrey

    Journal of hepatology

    2020  Volume 73, Issue 4, Page(s) 984–985

    MeSH term(s) Antiviral Agents/therapeutic use ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Liver Neoplasms/drug therapy ; Liver Transplantation
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2020-07-09
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.05.026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
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  6. Article ; Online: Impact of COVID - 19 in patients awaiting liver transplantation.

    Kounis, Ilias / Duhaut, Lea / Breard, Thomas / Samuel, Didier / Coilly, Audrey

    Liver international : official journal of the International Association for the Study of the Liver

    2021  Volume 42, Issue 1, Page(s) 256–257

    MeSH term(s) COVID-19 ; Humans ; Liver Transplantation ; SARS-CoV-2 ; Tissue and Organ Procurement ; Waiting Lists
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15105
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  7. Article ; Online: Cutting out the roots of acute hepatitis C.

    Coilly, Audrey / Samuel, Didier

    The Lancet. Infectious diseases

    2017  Volume 17, Issue 2, Page(s) 125–127

    MeSH term(s) Acute Disease ; Hepatitis C ; Humans ; Plant Roots
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(16)30406-6
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    Zs.A 5743: Show issues Location:
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  8. Article ; Online: Impact of direct antiviral agents for hepatitis C virus -induced liver diseases on registration, waiting list and liver transplant activity in France.

    Coilly, Audrey / Jasseron, Carine / Legeai, Camille / Conti, Filomena / Duvoux, Christophe / Kamar, Nassim / Dharancy, Sébastien / Antoine, Corinne

    Clinics and research in hepatology and gastroenterology

    2023  Volume 47, Issue 8, Page(s) 102168

    Abstract: Direct-acting antivirals (DAA) has dramatically improved the prognosis of liver transplantation (LT) candidates for HCV end-stage liver disease (ESLD). We aimed to evaluate the impact of DAA on waiting list (WL) registration and LT activity in France. We ...

    Abstract Direct-acting antivirals (DAA) has dramatically improved the prognosis of liver transplantation (LT) candidates for HCV end-stage liver disease (ESLD). We aimed to evaluate the impact of DAA on waiting list (WL) registration and LT activity in France. We evaluated all patients registered to the French WL for HCV ESLD between 2000 and 2018. Timespan was divided into two periods according to DAA availability: 2010-2013 versus 2014-2018. Changes in the indications of LT, outcome on WL were evaluated. Then, we evaluated the activity of LT and outcome for HCV recipients in France. Among 3,173 HCV candidates, registration on WL decreased by 33% between 2013 and 2018. The 1-year waitlist survival increased from 76.9% (95%CI: 74.2%-79.4%) in 2010-2013 to 79.8% (95%CI: 77.2%-82.1%) in 2014-2018 (p < 0.01). Regarding LT activity, the part of HCV ESLD decreased from 26% in 2010 to 16% in 2018. The 1-year graft survival rate in HCV recipients increased from 76.9% (95%CI: 73.7%-79.7%) in 2010-2012 to 84.9% (95%CI: 82.9%-86.7%) in 2013-2018 (p < 0.01). The availability of DAA to treat HCV infection is associated with a significant decrease of registration for LT, death and drop out for worsening condition on the LT. In addition, it has decreased the number of HCV+ LT and improved the 1-year graft survival in France.
    MeSH term(s) Humans ; Liver Transplantation ; Hepacivirus ; Antiviral Agents/therapeutic use ; Waiting Lists ; Hepatitis C, Chronic/complications ; Retrospective Studies ; Hepatitis C/complications ; Hepatitis C/drug therapy ; End Stage Liver Disease/complications ; France/epidemiology
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-06-24
    Publishing country France
    Document type Journal Article
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2023.102168
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  9. Article ; Online: Pros and Cons: Usage of organs from donors infected with hepatitis C virus - Revision in the direct-acting antiviral era.

    Coilly, Audrey / Samuel, Didier

    Journal of hepatology

    2016  Volume 64, Issue 1, Page(s) 226–231

    Abstract: Should organs from hepatitis C antibody positive donors (HCVD+) be used for transplantation? Organ shortage forces transplant teams to use donors with extended criteria. The decision to transplant a HCVD+ graft is a balance between the risk of ... ...

    Abstract Should organs from hepatitis C antibody positive donors (HCVD+) be used for transplantation? Organ shortage forces transplant teams to use donors with extended criteria. The decision to transplant a HCVD+ graft is a balance between the risk of transmission of a virus that could lead to end-stage liver diseases and the benefit of access to transplantation, specifically in patients with life-threatening disease. The other issue is the impact of HCV-related liver fibrosis in the donor graft on the long-term outcome in the recipient. Thus, the use of HCVD+ demonstrated a shorter meantime on the waiting list in kidney transplantation. When a HCVD+ graft is transplanted, the risk of HCV transmission depends on; 1) the quality of screening of the donor; 2) the presence of viral replication in the donor at the time of transplantation and the ability to detect it; and 3) the HCV status of the recipient but also the type of transplanted organ. In liver transplantation, the use of HCVD+ graft is usually restricted to recipients with a chronic HCV infection. Several reports showed some competition between HCV donor and recipient strain without deleterious impact on graft and patient survival. Controversies are still pending regarding the quality of the graft and the progression of fibrosis. The recent approval of direct-acting antiviral agents (DAA) dramatically changes the landscape of HCV infection treatment. After transplantation, combinations of DAA show high efficacy and good safety profile. In the near future, extensive use of DAA should reduce the number of HCVD+ with a positive HCV RNA, limiting the risk of transmission but also the number of patients on waiting lists for a disease related to HCV.
    MeSH term(s) Antiviral Agents/therapeutic use ; Hepatitis C/drug therapy ; Hepatitis C/transmission ; Humans ; Liver Transplantation ; Tissue Donors ; Waiting Lists
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2016-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2015.09.002
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    Zs.A 2027: Show issues Location:
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  10. Article ; Online: FABP4 and MMP9 levels identified as predictive factors for poor prognosis in patients with nonalcoholic fatty liver using data mining approaches and gene expression analysis.

    Coilly, Audrey / Desterke, Christophe / Guettier, Catherine / Samuel, Didier / Chiappini, Franck

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 19785

    Abstract: Nonalcoholic fatty liver (NAFLD) may progress to nonalcoholic steatohepatitis (NASH) and ultimately to cirrhosis and hepatocellular carcinoma (HCC). Prognostic markers for these conditions are poorly defined. The aim of this study was to identify ... ...

    Abstract Nonalcoholic fatty liver (NAFLD) may progress to nonalcoholic steatohepatitis (NASH) and ultimately to cirrhosis and hepatocellular carcinoma (HCC). Prognostic markers for these conditions are poorly defined. The aim of this study was to identify predictive gene markers for the transition from NAFL to NASH and then to poorer conditions. Gene expression omnibus datasets associated with a prediction analysis algorithm were used to create a matrix composed of control subject (n = 52), healthy obese (n = 51), obese with NAFL (n = 42) and NASH patients (n = 37) and 19,085 genes in order to identify specific genes predictive of the transition from steatosis to NASH and from NASH to cirrhosis and HCC and thus patients at high risk of complications. A validation cohort was used to validate these results. We identified two genes, fatty acid binding protein-4 (FABP4) and matrix metalloproteinase-9 (MMP9), which respectively allowed distinguishing patients at risk of progression from NAFL to NASH and from NASH to cirrhosis and HCC. Thus, NAFL patients expressing high hepatic levels of FABP4 and NASH patients expressing high hepatic levels of MMP9 are likely to experience disease progression. Therefore, using FABP4 and MMP9 as blood markers could help to predict poor outcomes and/or progression of NAFL during clinical trial follow-up.
    MeSH term(s) Adult ; Aged ; Data Mining ; Databases, Nucleic Acid ; Fatty Acid-Binding Proteins/biosynthesis ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Male ; Matrix Metalloproteinase 9/biosynthesis ; Middle Aged ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Oligonucleotide Array Sequence Analysis ; Predictive Value of Tests ; Prognosis
    Chemical Substances FABP4 protein, human ; Fatty Acid-Binding Proteins ; MMP9 protein, human (EC 3.4.24.35) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2019-12-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-56235-y
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