Article: Prevalence of non-alcoholic fatty liver disease and liver fibrosis in a general population cohort from Argentina.
2023 Volume 28, Issue 4, Page(s) 101111
Abstract: Introduction and objectives: South America is one of the regions with the highest rates of non-alcoholic fatty liver disease (NAFLD). This study aimed to assess the prevalence and severity of NAFLD in suburban Argentina.: Patients and methods: The ... ...
| Abstract | Introduction and objectives: South America is one of the regions with the highest rates of non-alcoholic fatty liver disease (NAFLD). This study aimed to assess the prevalence and severity of NAFLD in suburban Argentina. Patients and methods: The study involved a general community cohort of 993 subjects evaluated sequentially with a comprehensive lifestyle questionnaire, laboratory testing, abdominal ultrasound (US) and transient elastography with XL probe. NAFLD was diagnosed according to standard criteria. Results: The prevalence of NAFLD by the US was 37.2% (326/875) overall, 50.3% in subjects with overweight/obesity, 58.6% with hypertriglyceridemia, 62.3% with diabetes/hyperglycemia and 72.1% with all three risk factors. Male gender (OR 1.42, 95% CI 1.03-1.47, p = 0.029), age (50-59 years: OR 1.98, 95 CI 1.16-3.39, p = 0.013 and ≥60 years: OR 1.86, 95% CI 1.13-3.09, p = 0.015), BMI (25-29: OR 2.87, 95% CI 1.86-4.51, p<0.001 and ≥30: OR 9.57, 95% CI 6.14-15.20, p<0.001), diabetes/hyperglycemia (OR 1.65, 95% CI 1.05-2.61, p = 0.029) and hypertriglyceridemia (OR 1.73, 95% CI 1.20-2.48, p = 0.002) were independent predictors of NAFLD. Among patients with steatosis, 22.2% (69/311) had ≥F2 fibrosis (overweight 25%, hypertriglyceridemia 32%, diabetes/hyperglycemia 34%). BMI (OR 5.22, 95% CI 2.64-11.74, p<0.001), diabetes/hyperglycemia (OR 2.12, 95% CI 1.05-4.29, p = 0.04) and hypertriglyceridemia (OR 1.94, 95% CI 1.03-3.68, p = 0.040) were independent predictors of liver fibrosis. Conclusions: This general population study from Argentina showed a high prevalence of NAFLD. Significant liver fibrosis was present in 22% of subjects with NAFLD. This information adds to the existing knowledge of NAFLD epidemiology in Latin America. |
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| MeSH term(s) | Humans ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/epidemiology ; Overweight ; Prevalence ; Argentina/epidemiology ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/epidemiology ; Diabetes Mellitus/etiology ; Hyperglycemia/complications ; Hyperglycemia/pathology ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/pathology ; Liver/pathology | |||||
| Language | English | |||||
| Publishing date | 2023-04-25 | |||||
| Publishing country | Mexico | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2188733-0 | |||||
| ISSN | 1665-2681 | |||||
| ISSN | 1665-2681 | |||||
| DOI | 10.1016/j.aohep.2023.101111 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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