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  1. AU="Colby, Kathryn A"
  2. AU=Spiekermann Karsten
  3. AU="Haase, T"
  4. AU="Prieto, Manuel"
  5. AU="Picht, Eckard"
  6. AU="Olvera-Sosa, Miguel"
  7. AU="Kent, N"
  8. AU=Simon Junior Hany AU=Simon Junior Hany
  9. AU="Stevens-Hernandez, Christian J"
  10. AU="Xie, Jingwei"
  11. AU="Odenigbo, Kenechukwu A"
  12. AU="Dana N. Mitzel"
  13. AU="Rothenberg, Steven"
  14. AU="Skilling, Tracey"
  15. AU=Barnett Stephen M
  16. AU="Motuzas, Juliuz"
  17. AU="Chata Quispe, Yulisa"
  18. AU="Hougaard, Anders"
  19. AU="Da Cruz ESilva, C Beir Ao"
  20. AU="Weinberg-Shukron, Ariella"
  21. AU="Frost, Patrice A"
  22. AU="Nielsen, David R"
  23. AU="Natsui, Hiroaki"
  24. AU="Ziv Ben-Ari"
  25. AU="Gönen, Murat"
  26. AU="Soliman, Essam S"
  27. AU="Poenisch, Falk"
  28. AU="Ng C."
  29. AU="Cabaton, Nicolas J"

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  1. Artikel ; Online: Potential Rare Danger of Presumably Benign Artificial Tears.

    Prescott, Christina R / Colby, Kathryn A

    JAMA ophthalmology

    2023  Band 141, Heft 5, Seite(n) 497–498

    Mesh-Begriff(e) Humans ; Lubricant Eye Drops ; Tears ; Dry Eye Syndromes ; Ophthalmic Solutions
    Chemische Substanzen Lubricant Eye Drops ; Ophthalmic Solutions
    Sprache Englisch
    Erscheinungsdatum 2023-03-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.1114
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  2. Artikel: Update on the Surgical Management of Fuchs Endothelial Corneal Dystrophy.

    Blitzer, Andrea L / Colby, Kathryn A

    Ophthalmology and therapy

    2020  Band 9, Heft 4, Seite(n) 757–765

    Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common posterior corneal dystrophy and the leading indication for corneal transplantation in the United States. FECD is slowly progressive, and patients develop gradual corneal endothelial ... ...

    Abstract Fuchs endothelial corneal dystrophy (FECD) is the most common posterior corneal dystrophy and the leading indication for corneal transplantation in the United States. FECD is slowly progressive, and patients develop gradual corneal endothelial decompensation, eventually resulting in failure of the endothelium to maintain corneal deturgescence. Medical management consists of topical hyperosmotic agents to facilitate dehydration of the cornea, but surgical intervention is often required to regain corneal clarity. The surgical management of FECD has evolved over the past two decades as corneal transplantation techniques have allowed for more selective keratoplasty and replacement of only the diseased layers of the cornea. Prior surgical management consisted of penetrating keratoplasty (PK) that carried significant intraoperative risks associated with "open sky" as well as postoperative risks of graft rejection, wound dehiscence, postoperative astigmatism, and prolonged visual rehabilitation. In the past 15 years, endothelial keratoplasty (EK) has become the treatment of choice for endothelial disease, significantly reducing the risks associated with the surgical treatment of FECD. Here we discuss the current surgical management of FECD, including the introduction of Descemet stripping only (DSO), and highlight future investigative efforts.
    Sprache Englisch
    Erscheinungsdatum 2020-08-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ISSN 2193-8245
    ISSN 2193-8245
    DOI 10.1007/s40123-020-00293-3
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  3. Artikel ; Online: A Close Look at the Clinical Efficacy of Rho-Associated Protein Kinase Inhibitor Eye Drops for Fuchs Endothelial Corneal Dystrophy.

    Kinoshita, Shigeru / Colby, Kathryn A / Kruse, Friedrich E

    Cornea

    2021  Band 40, Heft 10, Seite(n) 1225–1228

    Abstract: Abstract: The current understanding on the clinical efficacy of Rho-associated protein kinase (ROCK) inhibitor for treating Fuchs endothelial corneal dystrophy is summarized to clarify whether the "off-label" ROCK-inhibitor eye-drop application are ... ...

    Abstract Abstract: The current understanding on the clinical efficacy of Rho-associated protein kinase (ROCK) inhibitor for treating Fuchs endothelial corneal dystrophy is summarized to clarify whether the "off-label" ROCK-inhibitor eye-drop application are appropriate. ROCK-inhibitor eye drops may eventually be deemed a cutting-edge therapy for Fuchs endothelial corneal dystrophy patients with acute corneal endothelial defect.
    Mesh-Begriff(e) 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/administration & dosage ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives ; Administration, Ophthalmic ; Benzoates/administration & dosage ; Clinical Trials as Topic ; Fuchs' Endothelial Dystrophy/drug therapy ; Humans ; Isoquinolines/administration & dosage ; Ophthalmic Solutions ; Protein Kinase Inhibitors/administration & dosage ; Sulfonamides/administration & dosage ; Treatment Outcome ; beta-Alanine/administration & dosage ; beta-Alanine/analogs & derivatives ; rho-Associated Kinases/antagonists & inhibitors
    Chemische Substanzen Benzoates ; Isoquinolines ; K-115 ; Ophthalmic Solutions ; Protein Kinase Inhibitors ; Sulfonamides ; beta-Alanine (11P2JDE17B) ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine (84477-87-2) ; rho-Associated Kinases (EC 2.7.11.1) ; fasudil (Q0CH43PGXS) ; netarsudil (W6I5QDT7QI)
    Sprache Englisch
    Erscheinungsdatum 2021-09-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0000000000002642
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  4. Artikel ; Online: Variations in Management of Zone 1 Open Globe Injuries Across Corneal Specialists.

    Foley, Lindsay M / Colby, Kathryn A / Rapuano, Christopher J / Woreta, Fasika A / Syed, Zeba A

    Cornea

    2023  Band 43, Heft 6, Seite(n) 710–715

    Abstract: Purpose: The aim of this study was to describe variations in practice patterns for the management of zone 1 open globe injuries among corneal specialists worldwide.: Methods: This cross-sectional study was performed using an online survey distributed ...

    Abstract Purpose: The aim of this study was to describe variations in practice patterns for the management of zone 1 open globe injuries among corneal specialists worldwide.
    Methods: This cross-sectional study was performed using an online survey distributed to members of The Cornea Society. Responses were collected between September 9, 2021, and September 30, 2021.
    Results: Of 94 responses included in analysis, respondents averaged 18.2 ± 14.5 years of postfellowship experience. Among respondents, 53 (56.4%) were affiliated with an academic institution and 41 (43.6%) with private practice. Ophthalmologists practicing in the United States were significantly more likely to use an eye shield preoperatively (98.5% vs. 85.7%, P = 0.03) and less likely to perform primary lensectomy in cases of lens involvement (40.9% vs. 75.0%, P = 0.002) compared with those practicing outside the United States. Ophthalmologists in practice fewer than 10 years were more likely to administer preoperative systemic antibiotics (91.4% vs. 66.1%, P = 0.006) and tetanus prophylaxis (88.6% vs. 67.8%, P = 0.03), and to obtain preoperative computed tomography scans (85.7% vs. 54.2%, P = 0.002) compared with more senior physicians. Ophthalmologists at academic institutions were more likely to perform preoperative B-scan (30.2% vs. 9.8%, P = 0.02), use general anesthesia (90.6% vs. 70.7%, P = 0.03), and admit for postoperative antibiotics (28.3% vs. 9.8%, P = 0.04), and were less likely to perform surgery overnight (45.3% vs. 70.7%, P = 0.02) compared with private practice physicians.
    Conclusions: There is significant variation in the practice patterns for the management of zone 1 open globe injuries among corneal specialists, which presents an opportunity to investigate whether certain treatment options lead to better outcomes in these injuries.
    Mesh-Begriff(e) Humans ; Cross-Sectional Studies ; Practice Patterns, Physicians'/statistics & numerical data ; Eye Injuries, Penetrating/surgery ; Male ; Female ; Ophthalmologists/statistics & numerical data ; Surveys and Questionnaires ; Ophthalmologic Surgical Procedures ; Ophthalmology/statistics & numerical data ; Corneal Injuries/surgery ; Adult
    Sprache Englisch
    Erscheinungsdatum 2023-11-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0000000000003425
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  5. Buch ; Online: Ophthalmologic Drug Guide

    Rhee, Douglas J. / Colby, Kathryn A. / Rapuano, Christopher J. / Sobrin, Lucia

    2007  

    Verfasserangabe by Douglas J. Rhee, Kathryn A. Colby, Christopher J. Rapuano, Lucia Sobrin
    Schlagwörter Ophthalmology
    Sprache Englisch
    Verlag Springer Science+Business Media, LLC
    Erscheinungsort New York, NY
    Dokumenttyp Buch ; Online
    HBZ-ID TT050386876
    ISBN 978-0-387-33251-2 ; 978-0-387-49964-2 ; 0-387-33251-0 ; 0-387-49964-4
    DOI 10.1007/978-0-387-49964-2
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

    Volltext online

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  6. Artikel ; Online: Association of Metformin Use With Age-Related Macular Degeneration: A Case-Control Study.

    Blitzer, Andrea L / Ham, Sandra A / Colby, Kathryn A / Skondra, Dimitra

    JAMA ophthalmology

    2021  Band 139, Heft 3, Seite(n) 302–309

    Abstract: Importance: Age-related macular degeneration (AMD), the leading cause of irreversible blindness in older adults, appears to have no effective preventive measures. The common antidiabetic drug metformin has been shown to have protective outcomes in ... ...

    Abstract Importance: Age-related macular degeneration (AMD), the leading cause of irreversible blindness in older adults, appears to have no effective preventive measures. The common antidiabetic drug metformin has been shown to have protective outcomes in multiple age-associated diseases and may have the potential to protect against the development of AMD.
    Objective: To determine whether metformin use is associated with reduced odds of developing AMD.
    Design, setting, and participants: This case-control study of patients from a nationwide health insurance claims database included a population-based sample of patients. Those aged 55 years and older with newly diagnosed AMD from January 2008 to December 2017 were defined as cases and matched with control participants. Data analyses were completed from June 2019 to February 2020.
    Exposures: Dosage of metformin and exposure to other prescribed medications, as identified from outpatient drug claims.
    Main outcomes and measures: Risk of developing AMD.
    Results: A total of 312 404 affected individuals were included (181 817 women [58.2%]). After matching, 312 376 control participants were included (172 459 women [55.2%]; age range, 55 to 107 years). The case group had a slightly higher percentage of participants with diabetes (81 262 participants [26.0%]) compared with the control group (79 497 participants [25.5%]). Metformin use was associated with reduced odds of developing AMD (odds ratio [OR], 0.94 [95% CI, 0.92-0.96]). This association was dose dependent, with low to moderate doses of metformin showing the greatest potential benefit (dosages over 2 years: 1-270 g, OR, 0.91 [95% CI, 0.88-0.94]; 271-600 g, OR, 0.90 [95% CI, 0.87-0.93]; 601-1080 g, OR, 0.95 [95% CI, 0.92-0.98]). Doses of more than 1080 g of metformin over 2 years did not have reduced odds of developing AMD. Both the reduction in odds ratio and the dose-dependent response were preserved in a cohort consisting only of patients with diabetes. Metformin use was associated with a decreased OR of AMD in patients with diabetes without coexisting diabetic retinopathy (OR, 0.93 [95% CI, 0.91-0.95]) but was a risk factor in patients with diabetic retinopathy (OR, 1.07 [95% CI, 1.01-1.15]).
    Conclusion and relevance: In this study, metformin use was associated with reduced odds of developing AMD. This association was dose dependent, with the greatest benefit at low to moderate doses. When looking only at patients with diabetes, we saw a preservation of the dose-dependent decrease in the odds of patients developing AMD. Metformin does not appear to be protective in patients with diabetes and coexisting diabetic retinopathy. This study suggests that metformin may be useful as a preventive therapy for AMD and provides the basis for potential prospective clinical trials.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Case-Control Studies ; Diabetes Mellitus/drug therapy ; Female ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Incidence ; Macular Degeneration/epidemiology ; Macular Degeneration/etiology ; Male ; Metformin/adverse effects ; Metformin/therapeutic use ; Middle Aged ; Prospective Studies ; Retina/drug effects ; Retina/pathology ; Risk Assessment/methods ; Risk Factors ; United States/epidemiology ; Visual Acuity
    Chemische Substanzen Hypoglycemic Agents ; Metformin (9100L32L2N)
    Sprache Englisch
    Erscheinungsdatum 2021-01-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2020.6331
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  7. Artikel ; Online: Zoster Eye Disease Study: Rationale and Design.

    Cohen, Elisabeth J / Hochman, Judith S / Troxel, Andrea B / Colby, Kathryn A / Jeng, Bennie H

    Cornea

    2022  Band 41, Heft 5, Seite(n) 562–571

    Abstract: Purpose: The purpose of this study was to describe the rationale and design of the Zoster Eye Disease Study (ZEDS).: Methods: ZEDS is a National Eye Institute-supported randomized clinical trial designed to determine whether 1 year of suppressive ... ...

    Abstract Purpose: The purpose of this study was to describe the rationale and design of the Zoster Eye Disease Study (ZEDS).
    Methods: ZEDS is a National Eye Institute-supported randomized clinical trial designed to determine whether 1 year of suppressive valacyclovir in patients with herpes zoster ophthalmicus (HZO) reduces complications because there is currently no high-quality evidence to support its use. Eligible patients are 18 years and older, immunocompetent, have a history of a typical rash at disease onset, and have had a record of active epithelial or stromal keratitis or iritis within 1 year before enrollment. Exclusion criteria include estimated glomerular filtration rate less than 45 or pregnancy. The primary endpoint is the time to first occurrence of new or worsening dendriform epithelial keratitis, stromal keratitis without or with ulceration, endothelial keratitis, or iritis due to HZO during 12 months of study treatment requiring prespecified treatment changes. The study has 80% power to detect a 30% difference between treatment groups, with a 30% rate of endpoints by 1 year assumed among controls. Secondary and exploratory questions include whether there is a persistent treatment benefit during the 6 months after treatment, whether development of postherpetic neuralgia varies by treatment group, and whether vaccinations against herpes zoster affect study outcomes and coronavirus disease 19 status.
    Results: Over approximately 4 years, over 400 study participants have been enrolled.
    Conclusions: ZEDS aims to provide scientific evidence on whether suppressive valacyclovir treatment improves outcomes in HZO and should become the standard of care.
    Mesh-Begriff(e) Antiviral Agents/therapeutic use ; COVID-19 ; Herpes Zoster ; Herpes Zoster Ophthalmicus/complications ; Herpes Zoster Ophthalmicus/diagnosis ; Herpes Zoster Ophthalmicus/drug therapy ; Humans ; Neuralgia, Postherpetic/diagnosis ; Neuralgia, Postherpetic/drug therapy ; Neuralgia, Postherpetic/epidemiology ; Valacyclovir/therapeutic use
    Chemische Substanzen Antiviral Agents ; Valacyclovir (MZ1IW7Q79D)
    Sprache Englisch
    Erscheinungsdatum 2022-02-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0000000000002743
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  8. Artikel ; Online: Design and Biocompatibility of a Novel, Flexible Artificial Cornea.

    Li, Gavin / Aldave, Anthony J / Amescua, Guillermo / Colby, Kathryn A / Cortina, Maria S / de la Cruz, Jose / Parel, Jean-Marie A / Schmiedel, Thomas B / Akpek, Esen Karamursel

    Translational vision science & technology

    2024  Band 13, Heft 5, Seite(n) 19

    Abstract: Purpose: We sought to introduce the materials, design, and biocompatibility of a flexible and suturable artificial corneal device.: Methods: Single-piece, fully synthetic, optic-skirt design devices were made from compact perfluoroalkoxy alkane. The ... ...

    Abstract Purpose: We sought to introduce the materials, design, and biocompatibility of a flexible and suturable artificial corneal device.
    Methods: Single-piece, fully synthetic, optic-skirt design devices were made from compact perfluoroalkoxy alkane. The skirt and the optic wall surfaces were lined with a porous tissue ingrowth material using expanded polytetrafluoroethylene. Full-thickness macroapertures around the skirt perimeter were placed to facilitate nutrition of the recipient cornea. Material properties including the skirt's modulus of elasticity and bending stiffness, optic light transmission, wetting behavior, topical drug penetrance, and degradation profile were evaluated.
    Results: The final prototype suitable for human use has a transparent optic with a diameter of 4.60 mm anteriorly, 4.28 mm posteriorly, and a skirt outer diameter of 6.8 mm. The biomechanical and optical properties of the device closely align with the native human cornea with an average normalized device skirt-bending stiffness of 4.7 kPa·mm4 and light transmission in the visible spectrum ranging between 92% and 96%. No optical damage was seen in the 36 devices tested in fouling experiments. No significant difference was observed in topical drug penetrance into the anterior chamber of the device implanted eye compared with the naïve rabbit eye.
    Conclusions: The flexibility and biocompatibility of our artificial cornea device may offer enhanced tissue integration and decreased inflammation, leading to improved retention compared with rigid keratoprosthesis designs.
    Translational relevance: We have developed a fully synthetic, flexible, suturable, optic-skirt design prototype artificial cornea that is ready to be tested in early human feasibility studies.
    Mesh-Begriff(e) Animals ; Cornea ; Rabbits ; Biocompatible Materials/chemistry ; Materials Testing/methods ; Prosthesis Design ; Humans
    Sprache Englisch
    Erscheinungsdatum 2024-05-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.13.5.19
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Re: Lee et al.: Boston keratoprosthesis: outcomes and complications: a report by the American Academy of Ophthalmology (Ophthalmology 2015;122:1504-11).

    Kaufman, Aaron R / Colby, Kathryn A

    Ophthalmology

    2016  Band 123, Heft 7, Seite(n) e42

    Sprache Englisch
    Erscheinungsdatum 2016-07
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2015.10.070
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Reply.

    Moloney, Gregory / Iovieno, Alfonso / Colby, Kathryn A

    Cornea

    2018  Band 37, Heft 4, Seite(n) e21–e22

    Sprache Englisch
    Erscheinungsdatum 2018-01-29
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0000000000001529
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