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  1. Buch ; Konferenzbeitrag: Breakthroughs in oncology: setting new standards in bisphosphonate therapy

    Coleman, Robert E.

    [based in part on a Symposium Entitled Breakthroughs in Oncology: Setting New Standards in Aromatase Inhibitor and Bisphosphonate Therapy, held in London, United Kingdom, in December of 2001]

    (American journal of clinical oncology ; 25,6, Suppl. 1)

    2002  

    Körperschaft Symposium Entitled Breakthroughs in Oncology: Setting New Standards in Aromatase Inhibitor and Bisphosphonate Therapy
    Verfasserangabe guest ed. Robert E. Coleman
    Serientitel American journal of clinical oncology ; 25,6, Suppl. 1
    Überordnung
    Schlagwörter Onkologie ; Diphosphonate
    Schlagwörter Biphosphonate ; Etidronate disodium ; Sodium etidronate ; Bisphosphonate ; Geschwulstforschung ; Geschwulstlehre
    Sprache Englisch
    Umfang S38 S. : Ill., graph. Darst.
    Verlag Lippincott Williams & Wilkins
    Erscheinungsort Philadelphia, Pa
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch ; Konferenzbeitrag
    HBZ-ID HT013571525
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: Chain Reaction of Fenton Autoxidation of Tartaric Acid: Critical Behavior at Low pH.

    Coleman, Robert E / Boulton, Roger B / Stuchebrukhov, Alexei A

    The journal of physical chemistry. B

    2023  Band 127, Heft 19, Seite(n) 4300–4308

    Abstract: Autoxidation of tartaric acid in air-saturated aqueous solutions in the presence of Fe(II) at low pH, 2.5, shows autocatalytic behavior with distinct initiation, propagation, and termination phases. With increasing pH, the initiation phase speeds up, ... ...

    Abstract Autoxidation of tartaric acid in air-saturated aqueous solutions in the presence of Fe(II) at low pH, 2.5, shows autocatalytic behavior with distinct initiation, propagation, and termination phases. With increasing pH, the initiation phase speeds up, while the propagation phase shortens and reduces to none. We show that the propagation phase is a chain reaction that occurs via activation of oxygen in the initiation stage with the production of hydrogen peroxide. The subsequent Fenton oxidation that regenerates hydrogen peroxide with a positive feedback is typical of a self-sustained chain reaction. The conditions for such a chain reaction are shown to be similar to those of a dynamical system with critical behavior; namely, the system becomes unstable when the kinetic matrix of pseudo-first-order reaction becomes negatively defined with a negative eigenvalue giving the rate of exponential (chain) growth of the reactive species.
    Sprache Englisch
    Erscheinungsdatum 2023-05-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c02172
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch: Breast cancer 2000

    Coleman, Robert E.

    [meeting ... in December 1996]

    (Cancer treatment reviews ; 23, Suppl. 1)

    1997  

    Verfasserangabe ed. R. Coleman
    Serientitel Cancer treatment reviews ; 23, Suppl. 1
    Überordnung
    Schlagwörter Breast Neoplasms / therapy
    Sprache Englisch
    Umfang S85 S. : graph. Darst.
    Verlag Saunders
    Erscheinungsort London u.a.
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT007814009
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Buch: Understanding and optimizing bone health in breast cancer

    Guise, Theresa A. / Brufsky, Adam / Coleman, Robert E.

    (Current medical research and opinion ; 26, Suppl. 3)

    2010  

    Verfasserangabe Theresa A. Guise, Adam Brufsky and Robert E. Coleman
    Serientitel Current medical research and opinion ; 26, Suppl. 3
    Überordnung
    Sprache Englisch
    Umfang 20 S. : Ill.
    Verlag Informa UK
    Erscheinungsort S.l.
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT016647402
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Artikel: Impact of Bone-Targeted Treatments on Skeletal Morbidity and Survival in Breast Cancer.

    Coleman, Robert E

    Oncology (Williston Park, N.Y.)

    2016  Band 30, Heft 8, Seite(n) 695–702

    Abstract: Bone health is of increasing clinical importance throughout the clinical course of breast cancer. First, many breast cancer treatments have effects on reproductive hormones that are critical for bone health. This endocrine disturbance results in ... ...

    Abstract Bone health is of increasing clinical importance throughout the clinical course of breast cancer. First, many breast cancer treatments have effects on reproductive hormones that are critical for bone health. This endocrine disturbance results in accelerated bone loss and an increased risk of fractures that can have a significant negative impact on cancer survivors. Second, the bone marrow microenvironment is intimately involved in the metastatic processes required for cancer dissemination, and may be modified by agents that influence bone cell physiology; there is now strong clinical trial evidence that the use of adjuvant bisphosphonates reduces metastasis to bone by one-third and reduces breast cancer mortality by one-sixth in postmenopausal or premenopausal women undergoing ovarian function suppression. Finally, bone metastases are common in advanced breast cancer, and may be associated with serious morbidity, including fractures, pain, nerve compression, and hypercalcemia. Through optimum multidisciplinary management and the use of bone-targeted treatments such as bisphosphonates or denosumab, patients with advanced breast cancer have experienced a major reduction in skeletal complications, less bone pain, and an improved quality of life.
    Mesh-Begriff(e) Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Female ; Humans
    Chemische Substanzen Bone Density Conservation Agents
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch ; Konferenzbeitrag: Treatment of skeletal complications of cancer with zoledronic acid (Zometa)

    Berenson, James R. / Coleman, Robert E.

    [based on a satellite symposium ... held October 21 - 25, 2001, in Lisbon, Portugal

    (Seminars in oncology ; 29,6, Suppl. 21)

    2002  

    Verfasserangabe Robert E. Coleman, guest ed. Contributors James Berenson
    Serientitel Seminars in oncology ; 29,6, Suppl. 21
    Überordnung
    Sprache Englisch
    Umfang 49 S. : Ill., graph. Darst.
    Verlag Saunders
    Erscheinungsort Philadelphia, PA
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch ; Konferenzbeitrag
    HBZ-ID HT013588996
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  7. Buch: Preserving skeletal wellness throughout the continuum of care in patients with cancer

    Aapro, Matti S. / Coleman, Robert E.

    (Seminars in oncology ; 34,6, Suppl. 4)

    2007  

    Verfasserangabe Robert E. Coleman, guest ed. Contributors Matti S. Aapro
    Serientitel Seminars in oncology ; 34,6, Suppl. 4
    Überordnung
    Sprache Englisch
    Umfang S32 S. : graph. Darst.
    Verlag Saunders
    Erscheinungsort Philadelphia, Pa
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT015404132
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

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  8. Artikel ; Online: Kinetics of autoxidation of tartaric acid in presence of iron.

    Coleman, Robert E / Boulton, Roger B / Stuchebrukhov, Alexei A

    The Journal of chemical physics

    2020  Band 153, Heft 6, Seite(n) 64503

    Abstract: The kinetics of the autoxidation reaction of tartaric acid in an air-saturated solution in the presence of Fe(II) show autocatalytic behavior with distinct initiation, propagation, and termination phases. The initiation phase, which involves activation ... ...

    Abstract The kinetics of the autoxidation reaction of tartaric acid in an air-saturated solution in the presence of Fe(II) show autocatalytic behavior with distinct initiation, propagation, and termination phases. The initiation phase, which involves activation of dissolved oxygen, decreases with increasing pH, over the test range of pH of 2.5-4.5, indicating that activation of oxygen is catalyzed by an Fe(II)-tartrate complex. The autocatalytic nature of this reaction indicates the presence of a catalytic intermediate that is produced during the initiation phase and regenerated during the propagation phase. The addition of catalase, as well as direct measurements, provided evidence of the presence and kinetic action of hydrogen peroxide as one of the intermediates. Direct addition of hydrogen peroxide resulted in shortening of the initiation stage and the propagation phase with similar rates as in the autoxidation reaction at low pH. The propagation is approximately a zero order reaction with respect to oxygen and iron. The kinetic analysis suggests that an intermediate catalytic complex(s) involving a ferryl ion (FeO
    Sprache Englisch
    Erscheinungsdatum 2020-08-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0013727
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Adjuvant bone-targeted therapy to prevent metastasis: lessons from the AZURE study.

    Coleman, Robert E

    Current opinion in supportive and palliative care

    2012  Band 6, Heft 3, Seite(n) 322–329

    Abstract: Purpose of review: Bone-targeted treatments with bisphosphonates (e.g., zoledronic acid) and denosumab are known to reduce the risk of skeletal complications and prevent treatment-induced bone loss in patients with malignant bone disease. Additionally, ... ...

    Abstract Purpose of review: Bone-targeted treatments with bisphosphonates (e.g., zoledronic acid) and denosumab are known to reduce the risk of skeletal complications and prevent treatment-induced bone loss in patients with malignant bone disease. Additionally, these drugs may modify the course of bone destruction via inhibitory effects on the 'vicious cycle' of growth factor and cytokine signalling between tumour and bone cells within the bone marrow microenvironment.
    Recent findings: In early stage breast cancer, treatment with zoledronic acid has shown improvements in disease-free and overall survival, notably in women with established menopause at diagnosis and in premenopausal women with endocrine-responsive disease, treated with goserelin to suppress ovarian function. Other bisphosphonates such as clodronate may produce similar benefits. Additionally, in castrate-resistant prostate cancer, treatment with denosumab delays the development of bone metastases.
    Summary: These results strongly support the adjuvant use of bone-targeted treatments, but suggest that reproductive hormones are an important treatment modifier to take into account.
    Mesh-Begriff(e) Antibodies, Monoclonal, Humanized/therapeutic use ; Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/prevention & control ; Bone Neoplasms/secondary ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Denosumab ; Diphosphonates/therapeutic use ; Female ; Humans ; Imidazoles/therapeutic use ; Male ; Neoplasm Metastasis ; Prostatic Neoplasms/pathology ; Women's Health
    Chemische Substanzen Antibodies, Monoclonal, Humanized ; Bone Density Conservation Agents ; Diphosphonates ; Imidazoles ; Denosumab (4EQZ6YO2HI) ; zoledronic acid (6XC1PAD3KF)
    Sprache Englisch
    Erscheinungsdatum 2012-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0b013e32835689cd
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Bone cancer in 2011: Prevention and treatment of bone metastases.

    Coleman, Robert E

    Nature reviews. Clinical oncology

    2011  Band 9, Heft 2, Seite(n) 76–78

    Abstract: Bone-targeting treatments have transformed the quality of life of patients with metastatic bone disease. 2011 saw the emergence of denosumab—a RANK ligand-specific antibody—as a more-effective alternative treatment to bisphosphonates and of data on the ... ...

    Abstract Bone-targeting treatments have transformed the quality of life of patients with metastatic bone disease. 2011 saw the emergence of denosumab—a RANK ligand-specific antibody—as a more-effective alternative treatment to bisphosphonates and of data on the use of bone-targeting treatments to prevent metastasis from breast and prostate cancers.
    Mesh-Begriff(e) Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/prevention & control ; Bone Neoplasms/secondary ; Clinical Trials as Topic ; Diphosphonates/therapeutic use ; History, 21st Century ; Humans
    Chemische Substanzen Bone Density Conservation Agents ; Diphosphonates
    Sprache Englisch
    Erscheinungsdatum 2011-12-20
    Erscheinungsland England
    Dokumenttyp Historical Article ; Journal Article ; Review
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/nrclinonc.2011.198
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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