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  1. Article ; Online: Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors.

    Atsuta, Yuji / Lee, ChangHee / Rodrigues, Alan R / Colle, Charlotte / Tomizawa, Reiko R / Lujan, Ernesto G / Tschopp, Patrick / Galan, Laura / Zhu, Meng / Gorham, Joshua M / Vannier, Jean-Pierre / Seidman, Christine E / Seidman, Jonathan G / Ros, Marian A / Pourquié, Olivier / Tabin, Clifford J

    Developmental cell

    2024  Volume 59, Issue 3, Page(s) 415–430.e8

    Abstract: The early limb bud consists of mesenchymal limb progenitors derived from the lateral plate mesoderm (LPM). The LPM also gives rise to the mesodermal components of the flank and neck. However, the cells at these other levels cannot produce the variety of ... ...

    Abstract The early limb bud consists of mesenchymal limb progenitors derived from the lateral plate mesoderm (LPM). The LPM also gives rise to the mesodermal components of the flank and neck. However, the cells at these other levels cannot produce the variety of cell types found in the limb. Taking advantage of a direct reprogramming approach, we find a set of factors (Prdm16, Zbtb16, and Lin28a) normally expressed in the early limb bud and capable of imparting limb progenitor-like properties to mouse non-limb fibroblasts. The reprogrammed cells show similar gene expression profiles and can differentiate into similar cell types as endogenous limb progenitors. The further addition of Lin41 potentiates the proliferation of the reprogrammed cells. These results suggest that these same four factors may play pivotal roles in the specification of endogenous limb progenitors.
    MeSH term(s) Mice ; Animals ; Extremities ; Proteins/metabolism ; Fibroblasts ; Mesoderm/metabolism ; Limb Buds
    Chemical Substances Proteins
    Language English
    Publishing date 2024-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2023.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In vivo topology converts competition for cell-matrix adhesion into directional migration.

    Bajanca, Fernanda / Gouignard, Nadège / Colle, Charlotte / Parsons, Maddy / Mayor, Roberto / Theveneau, Eric

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 1518

    Abstract: When migrating in vivo, cells are exposed to numerous conflicting signals: chemokines, repellents, extracellular matrix, growth factors. The roles of several of these molecules have been studied individually in vitro or in vivo, but we have yet to ... ...

    Abstract When migrating in vivo, cells are exposed to numerous conflicting signals: chemokines, repellents, extracellular matrix, growth factors. The roles of several of these molecules have been studied individually in vitro or in vivo, but we have yet to understand how cells integrate them. To start addressing this question, we used the cephalic neural crest as a model system and looked at the roles of its best examples of positive and negative signals: stromal-cell derived factor 1 (Sdf1/Cxcl12) and class3-Semaphorins. Here we show that Sdf1 and Sema3A antagonistically control cell-matrix adhesion via opposite effects on Rac1 activity at the single cell level. Directional migration at the population level emerges as a result of global Semaphorin-dependent confinement and broad activation of adhesion by Sdf1 in the context of a biased Fibronectin distribution. These results indicate that uneven in vivo topology renders the need for precise distribution of secreted signals mostly dispensable.
    MeSH term(s) Animals ; Cell Adhesion/drug effects ; Cell Adhesion/physiology ; Cell Communication/physiology ; Cell Line ; Cell Movement/physiology ; Cell Shape/drug effects ; Cell Surface Extensions/drug effects ; Cell-Matrix Junctions/drug effects ; Cell-Matrix Junctions/metabolism ; Cell-Matrix Junctions/physiology ; Chemokine CXCL12/metabolism ; Female ; Fibronectins/metabolism ; Male ; Manganese/metabolism ; Mice ; Nerve Tissue Proteins/physiology ; Neural Crest/cytology ; Neural Crest/drug effects ; Neural Crest/metabolism ; Receptors, CXCR4/metabolism ; Semaphorins/metabolism ; Xenopus laevis/embryology ; rac1 GTP-Binding Protein/metabolism
    Chemical Substances Chemokine CXCL12 ; Fibronectins ; Nerve Tissue Proteins ; Receptors, CXCR4 ; Semaphorins ; Manganese (42Z2K6ZL8P) ; rac1 GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2019-04-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-09548-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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