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Article ; Online: A Home-Based Older Person Upstreaming Prevention Physical Therapy (HOP-UP-PT) Program Utilizing Community Partnership Referrals.

Wilson, Christopher M / Arena, Sara K / Adcock, Karen / Colling, Debra

2019 Volume 37, Issue 2, Page(s) 88–96

Abstract: Traditional home healthcare reimbursement models emphasize intervention after a medical or functional issue occurs, and there is little evidence of preventative home-based physical therapy services for those at highest risk of becoming homebound due to ... ...

Abstract	Traditional home healthcare reimbursement models emphasize intervention after a medical or functional issue occurs, and there is little evidence of preventative home-based physical therapy services for those at highest risk of becoming homebound due to illness, injury, or functional limitation. The purpose of this study was to describe the development and initial pilot results of the Home-based Older Person Upstreaming Prevention Physical Therapy (HOP-UP-PT) Program. The prospective observational pilot study included five participants referred from a community center. The HOP-UP-PT Program utilized fall risk, functional, environmental, cognitive, and health-related assessments. Two males and three females aged 73 to 92 years were enrolled. Outcomes suggest that health, functional, and environmental benefits may be achieved when an older person participates in the HOP-UP-PT Program. Safety and health benefits gained by two individuals referred to the program, but who did not meet inclusion criteria, are also reported. Evidence emerging from this pilot study suggests trends toward improved functional outcomes associated with reduced fall risk and customized home-based safety recommendations among older adults participating in the HOP-UP-PT Program.
MeSH term(s)	Accidental Falls/prevention & control ; Aged ; Aged, 80 and over ; Community Health Services/organization & administration ; Exercise Therapy/organization & administration ; Female ; Geriatric Assessment ; Home Care Services/organization & administration ; Home Health Nursing/organization & administration ; Homebound Persons/rehabilitation ; Humans ; Male ; Partnership Practice/organization & administration ; Pilot Projects ; Program Development ; Program Evaluation ; Prospective Studies ; Referral and Consultation/statistics & numerical data ; United States ; Wounds and Injuries/prevention & control
Language	English
Publishing date	2019-03-02
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2814267-6
ISSN	2374-4537 ; 2374-4529
ISSN (online)	2374-4537
ISSN	2374-4529
DOI	10.1097/NHH.0000000000000716
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Article ; Online: Inferior Vena Cava Respiratory Variations: A Useful Tool at Bedside to Guide Fluid Therapy in Spontaneously Breathing Patients.

Bortolotti, Perrine / Colling, Delphine / Preau, Sebastien

Shock (Augusta, Ga.)

2017 Volume 49, Issue 2, Page(s) 235–236

MeSH term(s)	Fluid Therapy ; Humans ; Respiration ; Vena Cava, Inferior
Language	English
Publishing date	2017-08-21
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000000950
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Article: The development and implementation of a direct admission system at a tertiary care hospital.

Van Blarcom, Jeffrey R / Srivastava, Rajendu / Colling, Dayvalena / Maloney, Christopher G

Hospital pediatrics

2014 Volume 4, Issue 2, Page(s) 69–77

MeSH term(s)	Cooperative Behavior ; Delivery of Health Care/statistics & numerical data ; Health Personnel/statistics & numerical data ; Humans ; Interdisciplinary Communication ; Patient Admission ; Tertiary Healthcare/methods ; Tertiary Healthcare/organization & administration ; Tertiary Healthcare/statistics & numerical data ; Time Factors
Language	English
Publishing date	2014-03
Publishing country	United States
Document type	Journal Article
ISSN	2154-1663
ISSN	2154-1663
DOI	10.1542/hpeds.2013-0019
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Article ; Online: New tools for optimizing fluid resuscitation in acute pancreatitis.

Bortolotti, Perrine / Saulnier, Fabienne / Colling, Delphine / Redheuil, Alban / Preau, Sebastien

World journal of gastroenterology

2014 Volume 20, Issue 43, Page(s) 16113–16122

Abstract: Acute pancreatitis (AP) is a frequent disease with degrees of increasing severity responsible for high morbidity. Despite continuous improvement in care, mortality remains significant. Because hypovolemia, together with microcirculatory dysfunction lead ... ...

Abstract	Acute pancreatitis (AP) is a frequent disease with degrees of increasing severity responsible for high morbidity. Despite continuous improvement in care, mortality remains significant. Because hypovolemia, together with microcirculatory dysfunction lead to poor outcome, fluid therapy remains a cornerstone of the supportive treatment. However, poor clinical evidence actually support the aggressive fluid therapy recommended in recent guidelines since available data are controversial. Fluid management remains unclear and leads to current heterogeneous practice. Different strategies may help to improve fluid resuscitation in AP. On one hand, integration of fluid therapy in a global hemodynamic resuscitation has been demonstrated to improve outcome in surgical or septic patients. Tailored fluid administration after early identification of patients with high-risk of poor outcome presenting inadequate tissue oxygenation is a major part of this strategy. On the other hand, new decision parameters have been developed recently to improve safety and efficiency of fluid therapy in critically ill patients. In this review, we propose a personalized strategy integrating these new concepts in the early fluid management of AP. This new approach paves the way to a wide range of clinical studies in the field of AP.
MeSH term(s)	Critical Illness ; Fluid Therapy/adverse effects ; Fluid Therapy/methods ; Fluid Therapy/standards ; Guideline Adherence ; Hemodynamics ; Humans ; Pancreatitis/diagnosis ; Pancreatitis/physiopathology ; Pancreatitis/therapy ; Practice Guidelines as Topic ; Resuscitation/adverse effects ; Resuscitation/methods ; Resuscitation/standards ; Risk Factors ; Treatment Outcome ; Water-Electrolyte Balance
Language	English
Publishing date	2014-07-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v20.i43.16113
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Article: Measurement site of inferior vena cava diameter affects the accuracy with which fluid responsiveness can be predicted in spontaneously breathing patients: a post hoc analysis of two prospective cohorts.

Caplan, Morgan / Durand, Arthur / Bortolotti, Perrine / Colling, Delphine / Goutay, Julien / Duburcq, Thibault / Drumez, Elodie / Rouze, Anahita / Nseir, Saad / Howsam, Michael / Onimus, Thierry / Favory, Raphael / Preau, Sebastien

Annals of intensive care

2020 Volume 10, Issue 1, Page(s) 168

Abstract: Background: The collapsibility index of the inferior vena cava (cIVC) has potential for predicting fluid responsiveness in spontaneously breathing patients, but a standardized approach for measuring the inferior vena cava diameter has yet to be ... ...

Abstract	Background: The collapsibility index of the inferior vena cava (cIVC) has potential for predicting fluid responsiveness in spontaneously breathing patients, but a standardized approach for measuring the inferior vena cava diameter has yet to be established. The aim was to test the accuracy of different measurement sites of inferior vena cava diameter to predict fluid responsiveness in spontaneously breathing patients with sepsis-related circulatory failure and examine the influence of a standardized breathing manoeuvre. Results: Among the 81 patients included in the study, the median Simplified Acute Physiologic Score II was 34 (24; 42). Sepsis was of pulmonary origin in 49 patients (60%). Median volume expansion during the 24 h prior to study inclusion was 1000 mL (0; 2000). Patients were not severely ill: none were intubated, only 20% were on vasopressors, and all were apparently able to perform a standardized breathing exercise. Forty-one (51%) patients were responders to volume expansion (i.e. a ≥ 10% stroke volume index increase). The cIVC was calculated during non-standardized (cIVC-ns) and standardized breathing (cIVC-st) conditions. The accuracy with which both cIVC-ns and cIVC-st predicted fluid responsiveness differed significantly by measurement site (interaction p < 0.001 and < 0.0001, respectively). Measuring inferior vena cava diameters 4 cm caudal to the right atrium predicted fluid responsiveness with the best accuracy. At this site, a standardized breathing manoeuvre also significantly improved predictive power: areas under ROC curves [mean and (95% CI)] for cIVC-ns = 0.85 [0.78-0.94] versus cIVC-st = 0.98 [0.97-1.0], p < 0.001. When cIVC-ns is superior or equal to 33%, fluid responsiveness is predicted with a sensitivity of 66% and a specificity of 92%. When cIVC-st is superior or equal to 44%, fluid responsiveness is predicted with a sensitivity of 93% and a specificity of 98%. Conclusion: The accuracy with which cIVC measurements predict fluid responsiveness in spontaneously breathing patients depends on both the measurement site of inferior vena cava diameters and the breathing regime. Measuring inferior vena cava diameters during a standardized inhalation manoeuvre at 4 cm caudal to the right atrium seems to be the method by which to obtain cIVC measurements best-able to predict patients' response to volume expansion.
Language	English
Publishing date	2020-12-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-020-00786-1
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Article: How unclogging a sink can be lethal: case report of an accidental methyl bromide poisoning leading to a multiple organ failure.

Lecailtel, Sylvain / Broucqsault-Dedrie, Céline / Vanbaelinghem, Clément / Nyunga, Martine / Colling, Delphine / Herbecq, Patrick

Journal of intensive care

2015 Volume 3, Page(s) 12

Abstract: Methyl bromide (CH3Br) is a colorless and odorless volatile gas, used as an insecticide, fire extinguisher, fumigant, and refrigerant. Although forbidden since 1987 for domestic use, it is still used in industry, for example, to fumigate agricultural ... ...

Abstract	Methyl bromide (CH3Br) is a colorless and odorless volatile gas, used as an insecticide, fire extinguisher, fumigant, and refrigerant. Although forbidden since 1987 for domestic use, it is still used in industry, for example, to fumigate agricultural fields which are for importation in the United States. Here is the case of a 74-year-old man who was accidentally exposed to methyl bromide after using an old fire extinguisher. Even though he finally survived, he developed a severe multiple organ failure and spent 2 months in intensive care unit. We present in this report all the difficulties we had to diagnose this unusual poisoning.
Keywords	covid19
Language	English
Publishing date	2015-03-12
Publishing country	England
Document type	Case Reports
ZDB-ID	2739853-5
ISSN	2052-0492
ISSN	2052-0492
DOI	10.1186/s40560-015-0079-2
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Article: Respiratory changes of the inferior vena cava diameter predict fluid responsiveness in spontaneously breathing patients with cardiac arrhythmias.

Bortolotti, Perrine / Colling, Delphine / Colas, Vincent / Voisin, Benoit / Dewavrin, Florent / Poissy, Julien / Girardie, Patrick / Kyheng, Maeva / Saulnier, Fabienne / Favory, Raphael / Preau, Sebastien

Annals of intensive care

2018 Volume 8, Issue 1, Page(s) 79

Abstract: Background: Whether the respiratory changes of the inferior vena cava diameter during a deep standardized inspiration can reliably predict fluid responsiveness in spontaneously breathing patients with cardiac arrhythmia is unknown.: Methods: This ... ...

Abstract	Background: Whether the respiratory changes of the inferior vena cava diameter during a deep standardized inspiration can reliably predict fluid responsiveness in spontaneously breathing patients with cardiac arrhythmia is unknown. Methods: This prospective two-center study included nonventilated arrhythmic patients with infection-induced acute circulatory failure. Hemodynamic status was assessed at baseline and after a volume expansion of 500 mL 4% gelatin. The inferior vena cava diameters were measured with transthoracic echocardiography using the bi-dimensional mode on a subcostal long-axis view. Standardized respiratory cycles consisted of a deep inspiration with concomitant control of buccal pressures and passive exhalation. The collapsibility index of the inferior vena cava was calculated as [(expiratory-inspiratory)/expiratory] diameters. Results: Among the 55 patients included in the study, 29 (53%) were responders to volume expansion. The areas under the ROC curve for the collapsibility index and inspiratory diameter of the inferior vena cava were both of 0.93 [95% CI 0.86; 1]. A collapsibility index ≥ 39% predicted fluid responsiveness with a sensitivity of 93% and a specificity of 88%. An inspiratory diameter < 11 mm predicted fluid responsiveness with a sensitivity of 83% and a specificity of 88%. A correlation between the inspiratory effort and the inferior vena cava collapsibility was found in responders but was absent in nonresponder patients. Conclusions: In spontaneously breathing patients with cardiac arrhythmias, the collapsibility index and inspiratory diameter of the inferior vena cava assessed during a deep inspiration may be noninvasive bedside tools to predict fluid responsiveness in acute circulatory failure related to infection. These results, obtained in a small and selected population, need to be confirmed in a larger-scale study before considering any clinical application.
Language	English
Publishing date	2018-08-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-018-0427-1
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Article: Processing LHC data in the UK.

Colling, D / Britton, D / Gordon, J / Lloyd, S / Doyle, A / Gronbech, P / Coles, J / Sansum, A / Patrick, G / Jones, R / Middleton, R / Kelsey, D / Cass, A / Geddes, N / Clark, P / Barnby, L

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

2012 Volume 371, Issue 1983, Page(s) 20120094

Abstract: The Large Hadron Collider (LHC) is one of the greatest scientific endeavours to date. The construction of the collider itself and the experiments that collect data from it represent a huge investment, both financially and in terms of human effort, in our ...

Abstract	The Large Hadron Collider (LHC) is one of the greatest scientific endeavours to date. The construction of the collider itself and the experiments that collect data from it represent a huge investment, both financially and in terms of human effort, in our hope to understand the way the Universe works at a deeper level. Yet the volumes of data produced are so large that they cannot be analysed at any single computing centre. Instead, the experiments have all adopted distributed computing models based on the LHC Computing Grid. Without the correct functioning of this grid infrastructure the experiments would not be able to understand the data that they have collected. Within the UK, the Grid infrastructure needed by the experiments is provided by the GridPP project. We report on the operations, performance and contributions made to the experiments by the GridPP project during the years of 2010 and 2011--the first two significant years of the running of the LHC.
Language	English
Publishing date	2012-12-10
Publishing country	England
Document type	Journal Article
ZDB-ID	208381-4
ISSN	1471-2962 ; 1364-503X ; 0080-4614 ; 0264-3820 ; 0264-3952
ISSN (online)	1471-2962
ISSN	1364-503X ; 0080-4614 ; 0264-3820 ; 0264-3952
DOI	10.1098/rsta.2012.0094
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Article ; Online: Sustaining compliance with pediatric asthma inpatient quality measures.

Nkoy, Flory L / Fassl, Bernhard A / Wolfe, Doug / Colling, Dayvalena / Hales, Joseph W / Maloney, Christopher G

AMIA ... Annual Symposium proceedings. AMIA Symposium

2010 Volume 2010, Page(s) 547–551

Abstract: To reduce readmission risk in children hospitalized with asthma, The Joint Commission (JC) mandated hospitals to initiate preventive measures and provide patients/caregivers with a home management plan of care (HMPC) at discharge. Standard methods for ... ...

Abstract	To reduce readmission risk in children hospitalized with asthma, The Joint Commission (JC) mandated hospitals to initiate preventive measures and provide patients/caregivers with a home management plan of care (HMPC) at discharge. Standard methods for recording HMPC compliance require hospitals to commit considerable resources. We developed an asthma-specific "reminder and decision support" (RADS) system to facilitate patient discharge while supporting many clinical and administrative needs, including: 1) providers' compliance with asthma preventive measures, 2) creation of patient's discharge instructions, 3) recording HMPC components for JC accreditation, and 4) creation of discharge summaries with auto-faxing mechanism to primary care providers for follow-up. RADS resulted in significant increased and sustained HMPC compliance (73% vs. 89%, p<0.01) and reduced labor time (53 vs. 15 hours/week, p=0.02) compared to standard methods. Most quality improvement interventions achieve short-term goals, but long-term improvements require decision support tools that support multiple needs while minimizing resource use.
MeSH term(s)	Asthma ; Child ; Guideline Adherence ; Humans ; Inpatients ; Patient Compliance ; Patient Discharge
Language	English
Publishing date	2010-11-13
Publishing country	United States
Document type	Journal Article
ISSN	1942-597X
ISSN (online)	1942-597X
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Article ; Online: Diagnostic Accuracy of the Inferior Vena Cava Collapsibility to Predict Fluid Responsiveness in Spontaneously Breathing Patients With Sepsis and Acute Circulatory Failure.

Preau, Sebastien / Bortolotti, Perrine / Colling, Delphine / Dewavrin, Florent / Colas, Vincent / Voisin, Benoit / Onimus, Thierry / Drumez, Elodie / Durocher, Alain / Redheuil, Alban / Saulnier, Fabienne

Critical care medicine

2016 Volume 45, Issue 3, Page(s) e290–e297

Abstract: Objective: To investigate whether the collapsibility index of the inferior vena cava recorded during a deep standardized inspiration predicts fluid responsiveness in nonintubated patients.: Design: Prospective, nonrandomized study.: Setting: ICUs ... ...

Abstract	Objective: To investigate whether the collapsibility index of the inferior vena cava recorded during a deep standardized inspiration predicts fluid responsiveness in nonintubated patients. Design: Prospective, nonrandomized study. Setting: ICUs at a general and a university hospital. Patients: Nonintubated patients without mechanical ventilation (n = 90) presenting with sepsis-induced acute circulatory failure and considered for volume expansion. Interventions: We assessed hemodynamic status at baseline and after a volume expansion induced by a 30-minute infusion of 500-mL gelatin 4%. Measurements and main results: We measured stroke volume index and collapsibility index of the inferior vena cava under a deep standardized inspiration using transthoracic echocardiography. Vena cava pertinent diameters were measured 15-20 mm caudal to the hepatic vein junction and recorded by bidimensional imaging on a subcostal long-axis view. Standardized respiratory cycles consisted of a deep standardized inspiration followed by passive exhalation. The collapsibility index expressed in percentage equaled the ratio of the difference between end-expiratory and minimum-inspiratory diameter over the end-expiratory diameter. After volume expansion, a relevant (≥ 10%) stroke volume index increase was recorded in 56% patients. In receiver operating characteristic analysis, the area under curve for that collapsibility index was 0.89 (95% CI, 0.82-0.97). When such index is superior or equal to 48%, fluid responsiveness is predicted with a sensitivity of 84% and a specificity of 90%. Conclusions: The collapsibility index of the inferior vena cava during a deep standardized inspiration is a simple, noninvasive bedside predictor of fluid responsiveness in nonintubated patients with sepsis-related acute circulatory failure.
MeSH term(s)	Adult ; Aged ; Area Under Curve ; Echocardiography ; Female ; Fluid Therapy ; Humans ; Inhalation ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; ROC Curve ; Sepsis/complications ; Sepsis/physiopathology ; Sepsis/therapy ; Shock/etiology ; Shock/physiopathology ; Shock/therapy ; Stroke Volume ; Vena Cava, Inferior/diagnostic imaging ; Vena Cava, Inferior/physiopathology ; Water-Electrolyte Balance
Language	English
Publishing date	2016-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000002090
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