Article ; Online: Mammalian prions and their wider relevance in neurodegenerative diseases.
2016 Volume 539, Issue 7628, Page(s) 217–226
Abstract: Prions are notorious protein-only infectious agents that cause invariably fatal brain diseases following silent incubation periods that can span a lifetime. These diseases can arise spontaneously, through infection or be inherited. Remarkably, prions are ...
Abstract | Prions are notorious protein-only infectious agents that cause invariably fatal brain diseases following silent incubation periods that can span a lifetime. These diseases can arise spontaneously, through infection or be inherited. Remarkably, prions are composed of self-propagating assemblies of a misfolded cellular protein that encode information, generate neurotoxicity and evolve and adapt in vivo. Although parallels have been drawn with Alzheimer's disease and other neurodegenerative conditions involving the deposition of assemblies of misfolded proteins in the brain, insights are now being provided into the usefulness and limitations of prion analogies and their aetiological and therapeutic relevance. |
---|---|
MeSH term(s) | Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/classification ; Amyloid beta-Peptides/metabolism ; Animals ; Humans ; Kinetics ; Mammals ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/therapy ; Prions/chemistry ; Prions/genetics ; Prions/metabolism ; Prions/toxicity ; Protein Folding |
Chemical Substances | Amyloid beta-Peptides ; Prions |
Language | English |
Publishing date | 2016-11-10 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 120714-3 |
ISSN | 1476-4687 ; 0028-0836 |
ISSN (online) | 1476-4687 |
ISSN | 0028-0836 |
DOI | 10.1038/nature20415 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 26: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
|||
Zs.MG 9: Show issues | ||||
Zs.MO 244: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.