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Article ; Online: The 2022 ACR vaccination guideline: a call-to-action.

Colmegna, Inés / Libman, Michael

2023 Volume 19, Issue 5, Page(s) 263–264

Language	English
Publishing date	2023-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2491532-4
ISSN	1759-4804 ; 1759-4790
ISSN (online)	1759-4804
ISSN	1759-4790
DOI	10.1038/s41584-023-00954-0
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Zs.A 6338: Show issues

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Article: From Canadian Living Guidelines to Global Living Guidelines: A Post Pandemic Effort.

Colmegna, Ines / Weinblatt, Michael E

The Journal of rheumatology

2022 Volume 49, Issue 10, Page(s) 1077–1078

MeSH term(s)	Humans ; Pandemics ; Canada/epidemiology
Language	English
Publishing date	2022-09-01
Publishing country	Canada
Document type	Editorial ; Comment
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.220811
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 135: Show issues

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Article ; Online: MSC - targets for atherosclerosis therapy.

Colmegna, Ines / Stochaj, Ursula

Aging

2018 Volume 11, Issue 2, Page(s) 285–286

MeSH term(s)	Aging ; Atherosclerosis/drug therapy ; Humans ; Inflammation ; Mesenchymal Stem Cells/drug effects ; Risk Factors
Language	English
Publishing date	2018-12-27
Publishing country	United States
Document type	Editorial
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.101735
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Article ; Online: Superiority of systemic bleomycin to intradermal HOCl for the study of interstitial lung disease.

Morozan, Arina / Joy, Sydney / Fujii, Utako / Fraser, Richard / Watters, Kevin / Martin, James G / Colmegna, Inés

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20577

Abstract: Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, immune dysregulation, and multi-organ fibrosis. Interstitial lung disease (ILD) is a complication of SSc and a leading cause of SSc-death. The administration of hypochlorous ...

Abstract	Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, immune dysregulation, and multi-organ fibrosis. Interstitial lung disease (ILD) is a complication of SSc and a leading cause of SSc-death. The administration of hypochlorous acid (HOCl) intradermally in the mouse (HOCl-SSc) purportedly shows several features typical of SSc. We studied the model by injecting BALB/c mice daily intradermally with HOCl for 6-weeks, an exposure reported to induce lung fibrosis. On day 42, the skinfold thickness and the dermal thickness were two and three times larger respectively in the HOCl group compared to controls. HOCl treatment did not result in histological features of pulmonary fibrosis nor significant changes in lung compliance. Automated image analysis of HOCl mice lungs stained with picrosirius red did not show increased collagen deposition. HOCl injections did not increase pulmonary mRNA expression of pro-fibrotic genes nor induced the production of serum advanced oxidation protein products and anti-topoisomerase 1 antibodies. Immune cells in bronchoalveolar lavage fluid (BALF) and whole lung digests were not increased in HOCl-treated animals. Since lung fibrosis is proposed to be triggered by oxidative stress, we injected HOCl to Nrf2
MeSH term(s)	Animals ; Mice ; Pulmonary Fibrosis/metabolism ; Hypochlorous Acid/metabolism ; Bleomycin/adverse effects ; Bleomycin/metabolism ; NF-E2-Related Factor 2/metabolism ; Skin/metabolism ; Fibrosis ; Lung Diseases, Interstitial/pathology ; Scleroderma, Systemic/pathology ; Lung/pathology ; Disease Models, Animal
Chemical Substances	Hypochlorous Acid (712K4CDC10) ; Bleomycin (11056-06-7) ; NF-E2-Related Factor 2
Language	English
Publishing date	2023-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47083-y
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Article ; Online: Brodie abscess.

Qi, Ruyu / Colmegna, Inés

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2017 Volume 189, Issue 3, Page(s) E117

MeSH term(s)	Abscess/diagnostic imaging ; Abscess/microbiology ; Abscess/therapy ; Adult ; Humans ; Male ; Osteomyelitis/diagnostic imaging ; Osteomyelitis/microbiology ; Osteomyelitis/therapy ; Staphylococcal Infections/complications ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/therapy
Language	English
Publishing date	2017--23
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.151419
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Ua VI Zs.136: Show issues

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Article ; Online: Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures.

Nadeau, Stéphanie / Cheng, Anastasia / Colmegna, Inés / Rodier, Francis

Methods in molecular biology (Clifton, N.J.)

2019 Volume 2045, Page(s) 93–105

Abstract: Cellular senescence is a tumor suppressor mechanism that removes potentially neoplastic cells from the proliferative pool. Senescent cells naturally accumulate with advancing age; however, excessive/aberrant accumulation of senescent cells can disrupt ... ...

Abstract	Cellular senescence is a tumor suppressor mechanism that removes potentially neoplastic cells from the proliferative pool. Senescent cells naturally accumulate with advancing age; however, excessive/aberrant accumulation of senescent cells can disrupt normal tissue function. Multipotent mesenchymal stromal cells (MSCs), which are actively evaluated as cell-based therapy, can undergo replicative senescence or stress-induced premature senescence. The molecular characterization of MSCs senescence can be useful not only for understanding the clinical correlations between MSCs biology and human age or age-related diseases but also for identifying competent MSCs for therapeutic applications. Because MSCs are involved in regulating the hematopoietic stem cell niche, and MSCs dysfunction has been implicated in age-related diseases, the identification and selective removal of senescent MSC may represent a potential therapeutic target. Cellular senescence is generally defined by senescence-associated (SA) permanent proliferation arrest (SAPA) accompanied by persistent DNA damage response (DDR) signaling emanating from persistent DNA lesions including damaged telomeres. Alongside SA cell cycle arrest and DDR signaling, a plethora of phenotypic hallmarks help define the overall senescent phenotype including a potent SA secretory phenotype (SASP) with many microenvironmental functions. Due to the complexity of the senescence phenotype, no single hallmark is alone capable of identifying senescent MSCs. This protocol highlights strategies to validate MSCs senescence through the measurements of several key SA hallmarks including lysosomal SA Beta-galactosidase activity (SA-βgal), cell cycle arrest, persistent DDR signaling, and the inflammatory SASP.
MeSH term(s)	Cell Cycle Checkpoints/genetics ; Cell Cycle Checkpoints/physiology ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Cell Proliferation/genetics ; Cell Proliferation/physiology ; Cells, Cultured ; Cellular Senescence/genetics ; Cellular Senescence/physiology ; Cytokines/metabolism ; DNA Damage ; Deoxyuridine/analogs & derivatives ; Deoxyuridine/metabolism ; Enzyme-Linked Immunosorbent Assay ; Fluorescent Antibody Technique ; Humans ; Inflammation/metabolism ; Mesenchymal Stem Cells/enzymology ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/physiology ; Mesenchymal Stem Cells/radiation effects ; Multipotent Stem Cells/enzymology ; Multipotent Stem Cells/metabolism ; Multipotent Stem Cells/physiology ; Multipotent Stem Cells/radiation effects ; Phenotype ; Signal Transduction/genetics ; Telomere/genetics ; Telomere/metabolism ; Workflow ; beta-Galactosidase/metabolism
Chemical Substances	Cytokines ; beta-Galactosidase (EC 3.2.1.23) ; 5-ethynyl-2'-deoxyuridine (G373S00W2J) ; Deoxyuridine (W78I7AY22C)
Language	English
Publishing date	2019-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/7651_2019_217
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Article ; Online: Sunlight Exposure, Sun-Protective Behavior, and Anti-Citrullinated Protein Antibody Positivity: A General Population-Based Study in Quebec, Canada.

Zhao, Naizhuo / Smargiassi, Audrey / Colmegna, Ines / Hudson, Marie / Fritzler, Marvin / Bernatsky, Sasha

Arthritis care & research

2021 Volume 74, Issue 2, Page(s) 236–242

Abstract: Objective: To examine associations between sunlight exposure and anti-citrullinated protein antibodies (ACPAs) using general population data in Quebec, Canada.: Methods: A random sample of 7,600 individuals (including 786 subjects who were ACPA ... ...

Abstract	Objective: To examine associations between sunlight exposure and anti-citrullinated protein antibodies (ACPAs) using general population data in Quebec, Canada. Methods: A random sample of 7,600 individuals (including 786 subjects who were ACPA positive and 201 self-reported rheumatoid arthritis [RA] cases) from the CARTaGENE cohort was studied cross-sectionally. All subjects were nested in 4 census metropolitan areas, and mixed-effects logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) for ACPA positivity related to sunlight exposure, adjusting for sun-block use, industrial fine particulate matter (PM Results: The adjusted ORs and 95% CIs did not suggest conclusive associations between ACPA and sunlight exposure or sun-block use, but robust positive relationships were observed between industrial PM Conclusion: We did not see clear links between ACPA and sunlight exposure or sun-block use, but we did note positive associations with industrial PM
MeSH term(s)	Anti-Citrullinated Protein Antibodies ; Arthritis, Rheumatoid/immunology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Quebec ; Sunlight
Chemical Substances	Anti-Citrullinated Protein Antibodies
Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.24448
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Zs.A 2446: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 24: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: More than a 'Hundred Days War': Persistent SARS-CoV-2 infection in a patient with ANCA-associated vasculitis.

Mendel, Arielle / Colmegna, Ines / Bourque, Guillaume / Rajda, Ewa / Lee, Todd C / Gálvez, José Héctor / Vinet, Évelyne / Cheng, Matthew P

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

2022 Volume 7, Issue 2, Page(s) 131–134

Abstract: Background: Few reports exist on the characteristics and outcomes of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised hosts.: Methods: A 49-year-old patient with granulomatosis with polyangiitis ( ... ...

Abstract	Background: Few reports exist on the characteristics and outcomes of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised hosts. Methods: A 49-year-old patient with granulomatosis with polyangiitis (GPA) and a renal transplant experienced multiple hospitalizations for coronavirus disease 2019 (COVID-19) pneumonia and relapses between October 2020 and February 2021. Careful chart review of medical history, hospitalizations, and microbiological testing including SARS-CoV-2 cycle threshold values, therapies, and imaging was undertaken. SARS-CoV-2 genome sequencing was performed in five viral samples to distinguish persistent infection from re-infection with a different strain. Results: Sequencing confirmed that all samples tested were from the same viral lineage, indicating a long-term, persistent infection rather than re-infection with a new strain. The patient ultimately stabilized after two courses of remdesivir plus dexamethasone, replacement intravenous immunoglobulin, and bamlanivimab. Rituximab maintenance therapy for vasculitis remains on hold. Conclusions: SARS-CoV-2 may persist for several months in immunocompromised hosts and may go unrecognized as an ongoing active infection. More studies are needed to determine how to optimize COVID-19 treatment in this vulnerable population.
Language	English
Publishing date	2022-06-03
Publishing country	Canada
Document type	Journal Article
ISSN	2371-0888
ISSN (online)	2371-0888
DOI	10.3138/jammi-2021-0033
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Article ; Online: CD26 is a senescence marker associated with reduced immunopotency of human adipose tissue-derived multipotent mesenchymal stromal cells.

Psaroudis, Rose Triantafillia / Singh, Urvashi / Lora, Maximilien / Jeon, Peter / Boursiquot, Abigail / Stochaj, Ursula / Langlais, David / Colmegna, Inés

Stem cell research & therapy

2022 Volume 13, Issue 1, Page(s) 358

Abstract: Introduction: Human mesenchymal stromal cells (MSCs) have immunomodulatory, anti-inflammatory, and tolerogenic effects. Long-term in vitro expansion of MSCs to generate clinical grade products results in the accumulation of senescent-functionally ... ...

Abstract	Introduction: Human mesenchymal stromal cells (MSCs) have immunomodulatory, anti-inflammatory, and tolerogenic effects. Long-term in vitro expansion of MSCs to generate clinical grade products results in the accumulation of senescent-functionally impaired MSCs. Markers to assess the 'senescent load' of MSC products are needed. Methods: Early and late passage human adipose tissue (AT) MSCs from pediatric and adult donors were characterized using established senescent markers [i.e., MSC size, granularity, and autofluorescence by flow cytometry; β-galactosidase staining (SA-β-gal); CDKN2A and CDKN1A by qRT-PCR]. In gene set enrichment analysis, DPP4 (also known as adenosine deaminase complexing protein 2 or CD26) was found as a prominent dysregulated transcript that was increased in late passage MSC(AT). This was confirmed in a larger number of MSC samples by PCR, flow cytometry, Western blotting, and immunofluorescence. In vitro immunopotency assays compared the function of CD26 Results: Late passage MSC(AT) had a senescence transcriptome signature. DPP4 was the most differentially enriched gene in senescent MSCs. Late passage senescent MSC(AT) had higher CD26 surface levels and total protein abundance. Moreover, CD26 surface levels were higher in early passage MSC(AT) from adults compared to pediatric donors. CD26 abundance correlated with established senescence markers. CD26 Conclusions: DPP4 gene expression and DPP4/CD26 protein abundance are markers of replicative senescence in MSC(AT). Samples enriched in CD26
MeSH term(s)	Adipose Tissue/metabolism ; Adult ; Biomarkers/metabolism ; Cell Proliferation/genetics ; Cells, Cultured ; Cellular Senescence ; Child ; Dipeptidyl Peptidase 4/genetics ; Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl Peptidase 4/pharmacology ; Humans ; Mesenchymal Stem Cells/metabolism
Chemical Substances	Biomarkers ; DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
Language	English
Publishing date	2022-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-022-03026-4
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Article ; Online: Influenza Vaccine Hesitancy and Its Determinants Among Rheumatology Patients.

Valerio, Valeria / Hudson, Marie / Wang, Mianbo / Bernatsky, Sasha / Hazel, Elizabeth M / Ward, Brian / Colmegna, Inés

ACR open rheumatology

2022 Volume 4, Issue 4, Page(s) 352–362

Abstract: Objective: Patients with rheumatic disease (RD) have an increased risk of influenza and its complications. Despite inactivated influenza vaccine (IIV) recommendations, IIV uptake in patients with RD is suboptimal, a problem of increasing importance in ... ...

Abstract	Objective: Patients with rheumatic disease (RD) have an increased risk of influenza and its complications. Despite inactivated influenza vaccine (IIV) recommendations, IIV uptake in patients with RD is suboptimal, a problem of increasing importance in the COVID-19 era. We estimated the frequency of IIV hesitancy and associated factors among Canadian patients with RD. Methods: A cross-sectional vaccine hesitancy survey was completed by rheumatology clinic patients (November 2019 to January 2020). Patients rated their likelihood of receiving the influenza vaccine (scale of 0-10). We categorized these as follows: likely to refuse (scale of 0-2), uncertain (scale of 3-7), or likely to accept (scale of 8-10). Multivariate logistical regression was used to evaluate factors associated with vaccine hesitancy. Results: A total of 282 patients (63.5% of those approached) completed the survey, with 165 (58.5%) being likely to accept, 67 (23.8%) being likely to refuse, and 50 (17.7%) uncertain. Uncertain patients were younger and more likely to be employed than those in the other two groups. No previous influenza vaccination (odds ratio [OR] 36.6, 95% confidence interval [CI] 5.3-252.9), belief that vaccination should not be mandatory (OR 0.1, 95% CI 0.0-0.7), unwillingness to take time off work to be vaccinated (OR 6.8, 95% CI 1.5-30.6), and distrust in pharmaceutical companies (OR 41.0, 95% CI 5.6-301.5) predicted likeliness to refuse. Reluctance to pay for vaccination (OR 2.8, 95% CI 1.1-7.5) and no previous influenza vaccination (OR 18.9, 95% CI 3.3-109.7) predicted uncertainty. Conclusion: More than 40% of rheumatology patients are either likely to refuse or uncertain about receiving IIV. This contributes to suboptimal vaccine coverage in this population. Interventions addressing these concerns are needed, particularly in the COVID-19 era.
Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article
ISSN	2578-5745
ISSN (online)	2578-5745
DOI	10.1002/acr2.11408
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