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Article: Risk Factors for Non-Adherence to Medication for Liver Transplant Patients: An Umbrella Review.

Colmenero, Jordi / Gastaca, Mikel / Martínez-Alarcón, Laura / Soria, Cristina / Lázaro, Esther / Plasencia, Inmaculada

2024 Volume 13, Issue 8

Abstract: Background/ ... ...

Abstract	Background/Objectives
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13082348
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Article ; Online: The ILTS-SETH Consensus Conference on Extrahepatic Cancer and Liver Transplantation: Paving the Way.

Colmenero, Jordi / Berenguer, Marina / Watt, Kymberly D

Transplantation

2021 Volume 106, Issue 1, Page(s) e1–e2

Abstract: The International Liver Transplantation Society and the Spanish Society of Liver Transplantation consensus conference on extrahepatic cancer and liver transplantation (LT) was held on January 28-30, 2021. Working groups were organized to focus on one ... ...

Abstract	The International Liver Transplantation Society and the Spanish Society of Liver Transplantation consensus conference on extrahepatic cancer and liver transplantation (LT) was held on January 28-30, 2021. Working groups were organized to focus on one topic and develop evidence-based recommendations specifically addressing (a) nonhepatic cancer in LT candidates, (b) de novo malignancies after LT, (c) prevention and management of donor-derived malignancies after LT, and (d) nonhepatic cancer in the pediatric population. All consensus conference attendees voted on the recommendations proposed as well as the quality of evidence according to the Grading of Recommendations, Assessment, Development and Evaluation system.
MeSH term(s)	Child ; Consensus ; Humans ; Liver Transplantation/adverse effects ; Neoplasms ; Tissue Donors
Language	English
Publishing date	2021-12-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003994
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Reply to: "Age and comorbidity are central to the risk of death from COVID-19 in liver transplant recipients".

Rodríguez-Perálvarez, Manuel / Colmenero, Jordi / Salcedo, Magdalena

Journal of hepatology

2021 Volume 75, Issue 1, Page(s) 228–229

MeSH term(s)	COVID-19 ; Calcineurin Inhibitors ; Comorbidity ; Humans ; Immunosuppressive Agents ; Liver Transplantation ; SARS-CoV-2
Chemical Substances	Calcineurin Inhibitors ; Immunosuppressive Agents
Language	English
Publishing date	2021-04-20
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2021.04.005
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Article: Prophylaxis and treatment in liver transplantation. VII Consensus Document of the Spanish Society of Liver Transplantation.

Fernández, Inmaculada / Pascasio, Juan Manuel / Colmenero, Jordi

Gastroenterologia y hepatologia

2020 Volume 43, Issue 3, Page(s) 169–177

Abstract: Whilst prophylaxis of hepatitis B is universally accepted after liver transplantation (LT), national recommendations for the prophylaxis and treatment of hepatitis B virus (HBV) infection after LT are lacking in Spain. The aim of the VII consensus ... ...

Title translation	Profilaxis y tratamiento de la infección por virus de la hepatitis B en el trasplante hepático. VII Documento de consenso de la Sociedad Española de Trasplante Hepático.
Abstract	Whilst prophylaxis of hepatitis B is universally accepted after liver transplantation (LT), national recommendations for the prophylaxis and treatment of hepatitis B virus (HBV) infection after LT are lacking in Spain. The aim of the VII consensus meeting organised by the Spanish Society of Liver Transplantation (SETH) was to set recommendations on the prophylaxis and treatment of hepatitis B after LT. The scientific evidence and strength of recommendations was evaluated by using the "Grading of Recommendations Assessment, Development and Evaluation" (GRADE) system. This document describes the recommendations and their level of evidence for: the definition and risk factors for hepatitis B recurrence after LT, monitoring and prophylaxis of hepatitis B recurrence at different periods after LT, treatment of hepatitis B before and after LT, and the prophylaxis of HBV infection by the recipients of LT with hepatitis B core antigen positive donors.
MeSH term(s)	Alanine Transaminase/blood ; Antiviral Agents/therapeutic use ; Combined Modality Therapy ; DNA, Viral/blood ; Drug Resistance, Multiple, Viral ; Hepatitis B Antibodies/blood ; Hepatitis B Antibodies/therapeutic use ; Hepatitis B Core Antigens/immunology ; Hepatitis B Surface Antigens/blood ; Hepatitis B Vaccines/therapeutic use ; Hepatitis B virus/drug effects ; Hepatitis B virus/isolation & purification ; Hepatitis B, Chronic/blood ; Hepatitis B, Chronic/prevention & control ; Hepatitis B, Chronic/surgery ; Humans ; Liver Transplantation/methods ; Preoperative Care/methods ; Recurrence ; Risk Factors ; Tissue Donors ; Vaccination ; Viral Load ; Viremia/blood
Chemical Substances	Antiviral Agents ; DNA, Viral ; Hepatitis B Antibodies ; Hepatitis B Core Antigens ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines ; Alanine Transaminase (EC 2.6.1.2)
Language	Spanish
Publishing date	2020-02-21
Publishing country	Spain
Document type	Consensus Development Conference ; Journal Article ; Practice Guideline
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2019.11.005
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Article ; Online: Implementation of a quality management system in a liver transplant programme.

López-Púa, Yolanda / Navasa, Miquel / Trilla, Antoni / Colmenero, Jordi / García, Raquel / López, Eva / Durà, Anna / Guash, Ana / Ríos, José

BMJ open quality

2023 Volume 12, Issue 3

Abstract: Background: The management of liver transplantation has become a complex process involving different healthcare professionals. Teamwork, standardisation and definition of the best practices are essential for success, patient satisfaction and society's ... ...

Abstract	Background: The management of liver transplantation has become a complex process involving different healthcare professionals. Teamwork, standardisation and definition of the best practices are essential for success, patient satisfaction and society's favourable perception of transplantation programmes.ISO 9001:2015 certification provides the necessary elements to help implement a quality management system (QMS) to ensure that patient care is performed with the highest guarantees of clinical quality and safety. The aim of this study is to describe the steps, strengths and limitations in the implementation of a QMS in a liver transplant programme (LTP). Project management method: This included analysing the starting point, setting up a working group, training, defining the scope of certification, preparing documentation, and conducting an internal and external audit, which culminated in the ISO 9001 quality certification award. The scope of QMS includes all the processes of LTP, from referral of candidates to long-term follow-up after transplantation. Results: The project was structured in seven phases that took place between 2008 and 2011. The implementation of QMS led to the generation of all the necessary documentation to meet the requirements of the standard, including internal and legal requirements related to the transplant activity. The establishment of indicators to measure the effectiveness of processes, risk management and the identification of incidents allows us to implement measures devoted to avoiding the deficiencies and to meet the established objectives. Conclusion: ISO 9001:2015 certification has contributed to the adaptation of a new quality and safety culture focused on the patient. All activities are protocolised, everything is recorded, measured, and verified, and all steps are taken as planned. Work is carried out in terms of continuous improvement. This has led to less variability in daily clinical practice and a better understanding of work dynamics.
MeSH term(s)	Humans ; Liver Transplantation ; Quality Assurance, Health Care
Language	English
Publishing date	2023-09-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-6641
ISSN (online)	2399-6641
DOI	10.1136/bmjoq-2023-002440
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Article ; Online: A plasmatic score using a miRNA signature and CXCL-10 for accurate prediction and diagnosis of liver allograft rejection.

Millán, Olga / Ruiz, Pablo / Julian, Judit / Lizana, Ana / Fundora, Yiliam / Crespo, Gonzalo / Colmenero, Jordi / Navasa, Miquel / Brunet, Mercè

Frontiers in immunology

2023 Volume 14, Page(s) 1196882

Abstract: Introduction: The use of noninvasive biomarkers may avoid the need for liver biopsy (LB) and could guide immunosuppression adjustment in liver transplantation (LT). The aims of this study were: to confirm the predictive and diagnostic capacity of ... ...

Abstract	Introduction: The use of noninvasive biomarkers may avoid the need for liver biopsy (LB) and could guide immunosuppression adjustment in liver transplantation (LT). The aims of this study were: to confirm the predictive and diagnostic capacity of plasmatic expression of miR-155-5p, miR-181a-5p, miR-122-5p and CXCL-10 for assessing T-cell mediated rejection (TCMR) risk; to develop a score based on a panel of noninvasive biomarkers to predict graft rejection risk and to validate this score in a separate cohort. Methods: A prospective, observational study was conducted with a cohort of 79 patients followed during the first year after LT. Plasma samples were collected at predetermined time points for the analysis of miRNAs and the CXCL-10. Patients with LFTs abnormalities were submitted to a LB to rule out rejection, assessing previous and concurrent expression of the biomarkers to evaluate their predictive and diagnostic ability. Information from 86 patients included in a previous study was collected and used as a validation cohort. Results: Twenty-four rejection episodes were diagnosed in 22 patients. Plasmatic CXCL-10 concentration and the expression of the three miRNAs were significantly elevated prior to and at the moment of the diagnosis of rejection. We developed a logistic model for rejection prediction and diagnosis, which included CXCL-10, miR-155-5p and miR-181a-5p. The area under the ROC curve (AUROC) for rejection prediction was 0.975 (79.6% sensitivity, 99.1% specificity, 90,7% PPV; 97.7% NPV; 97.1% correctly classified) and 0.99 for diagnosis (87.5% sensitivity, 99.5% specificity, 91.3% PPV; 99.3% NPV; 98.9% correctly classified). In the validation cohort (n=86; 14 rejections), the same cut-off points were used obtaining AUROCs for rejection prediction and diagnosis of 0.89 and 0.92 respectively. In patients with graft dysfunction in both cohorts the score could discriminate those with rejection regarding other causes with an AUROC of 0.98 (97.3% sensitivity, 94.1%specificity). Conclusion: These results suggest that the clinical implementation of the monitoring of this noninvasive plasmatic score may allow the prediction and diagnosis of rejection and identify patients with graft dysfunction due to rejection, helping with a more efficient guide for immunosuppressive therapy adjustment. This finding warrants the development of prospective biomarker-guided clinical trials.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Liver ; Transplantation, Homologous ; Biomarkers ; Allografts
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1196882
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Article ; Online: Mesenchymal stromal cells for immunomodulatory cell therapy in liver transplantation: One step at a time.

Colmenero, Jordi / Sancho-Bru, Pau

Journal of hepatology

2017 Volume 67, Issue 1, Page(s) 7–9

MeSH term(s)	Cell- and Tissue-Based Therapy ; Immunomodulation ; Liver Transplantation ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells
Language	English
Publishing date	2017-04-21
Publishing country	Netherlands
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2017.04.004
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Article ; Online: Focusing on Ischemic Reperfusion Injury in the New Era of Dynamic Machine Perfusion in Liver Transplantation.

Chullo, Gabriela / Panisello-Rosello, Arnau / Marquez, Noel / Colmenero, Jordi / Brunet, Merce / Pera, Miguel / Rosello-Catafau, Joan / Bataller, Ramon / García-Valdecasas, Juan Carlos / Fundora, Yiliam

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Liver transplantation is the most effective treatment for end-stage liver disease. Transplant indications have been progressively increasing, with a huge discrepancy between the supply and demand of optimal organs. In this context, the use of extended ... ...

Abstract	Liver transplantation is the most effective treatment for end-stage liver disease. Transplant indications have been progressively increasing, with a huge discrepancy between the supply and demand of optimal organs. In this context, the use of extended criteria donor grafts has gained importance, even though these grafts are more susceptible to ischemic reperfusion injury (IRI). Hepatic IRI is an inherent and inevitable consequence of all liver transplants; it involves ischemia-mediated cellular damage exacerbated upon reperfusion and its severity directly affects graft function and post-transplant complications. Strategies for organ preservation have been constantly improving since they first emerged. The current gold standard for preservation is perfusion solutions and static cold storage. However, novel approaches that allow extended preservation times, organ evaluation, and their treatment, which could increase the number of viable organs for transplantation, are currently under investigation. This review discusses the mechanisms associated with IRI, describes existing strategies for liver preservation, and emphasizes novel developments and challenges for effective organ preservation and optimization.
MeSH term(s)	Humans ; Liver Transplantation ; Perfusion ; Reperfusion ; Cryopreservation ; Reperfusion Injury
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021117
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Article ; Online: Long-Term Outcomes of Incidental Liver Malignancies in Simultaneous Liver-Kidney Transplant Recipients.

Rodríguez-Espinosa, Diana / Morantes, Laura / García, Jenmy / Broseta, José Jesús / Cuadrado-Payán, Elena / Colmenero, Jordi / Torregrosa, Josep Vicens / Diekmann, Fritz / Esforzado, Nuria

Transplantation proceedings

2024 Volume 56, Issue 2, Page(s) 330–334

Abstract: Background: The pretransplant diagnosis of liver malignancies in nodular cirrhotic livers remains a diagnostic challenge despite current advances. Although the prognostic impact of incidental hepatocellular carcinoma (HCC) or intrahepatic ... ...

Abstract	Background: The pretransplant diagnosis of liver malignancies in nodular cirrhotic livers remains a diagnostic challenge despite current advances. Although the prognostic impact of incidental hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (iCC) in liver transplant recipients is well documented, there are no data on the impact in simultaneous liver kidney transplant (LKT) recipients. Methods: This is a single-center observational, retrospective study of all LKT performed from May 1993 to April 2022. Among these patients, demographic data, immunosuppressive therapy, rejection episodes, and prevalence of incidental HCC or iCC were evaluated. Results: One hundred eight LKTs were performed and 6 were excluded. There were 13 patients with incidental carcinomas in the explanted liver: one of them with both an HCC and iCC, one with an iCC, and the remaining with an HCC. One case of iCC died. No other recurrences occurred. There were no cases of incidental HCC nor iCC in patients with a hereditary or metabolic LKT indication. We found no differences in the 5-year patient survival, and death-censored kidney and liver graft survival rates for those LKT with an incidental HCC and those without it (76.9% vs 84.2%, P = .5; 100% vs 91.6%, P = .28; and 100% vs 94.7%, P = 0.39, respectively). Finally, there were no significant associations between explant carcinoma and rejections of the liver (7.7% vs 17.9%, P = .34) or kidney graft (0% vs 16.8%, P = 0.11). Conclusion: Despite a high prevalence of incidental HCC or iCC, patient, kidney, and liver graft 5-year survival were unaffected by incidental HCC.
MeSH term(s)	Humans ; Liver Neoplasms/pathology ; Carcinoma, Hepatocellular/pathology ; Kidney Transplantation/adverse effects ; Retrospective Studies ; Cholangiocarcinoma ; Bile Ducts, Intrahepatic/pathology ; Bile Duct Neoplasms ; Kidney/pathology
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2024.01.004
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Article ; Online: Modulating immunosuppression in liver transplant patients with COVID-19.

Rodriguez-Peralvarez, Manuel / Salcedo, Magdalena / Colmenero, Jordi / Pons, Jose Antonio

Gut

2020 Volume 70, Issue 7, Page(s) 1412–1414

MeSH term(s)	COVID-19 ; Graft Rejection ; Humans ; Immunosuppression Therapy/adverse effects ; Liver Transplantation ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-08-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2020-322620
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