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  1. Book ; Article ; Online: Prevalencia de la infección por el VIH y de Treponema pallidum en mujeres trabajadoras sexuales de Argentina

    Pando, María de los Ángeles / Reynaga, Elena / Coloccini, Romina Soledad / Rodríguez Fermepín, Marcelo / Kochel, Tadeusz / Montano, Silvia Maria / Marone, Rubén / Avila, María Mercedes

    2015  

    Keywords Enfermedades de Transmisión Sexual ; Treponema pallidum ; VIH ; Salud de la mujer ; Argentina ; Sexually transmitted diseases ; HIV ; Women's Health ; Preservativos ; Infecções por HIV ; Profissionais do Sexo ; Doenças Sexualmente Transmissíveis ; Sífilis ; Estudos Transversais ; Educação ; Conhecimentos ; Atitudes e Prática em Saúde ; Prevalência ; Assunção de Riscos ; Fatores Socioeconômicos ; Saúde da Mulher
    Publishing date 2015-08-25T14:55:50Z
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Biomarkers of Progression after HIV Acute/Early Infection: Nothing Compares to CD4⁺ T-cell Count?

    Turk, Gabriela / Ghiglione, Yanina / Hormanstorfer, Macarena / Laufer, Natalia / Coloccini, Romina / Salido, Jimena / Trifone, César / Ruiz, María Julia / Falivene, Juliana / Holgado, María Pía / Caruso, María Paula / Figueroa, María Inés / Salomón, Horacio / Giavedoni, Luis D / Pando, María de Los Ángeles / Gherardi, María Magdalena / Rabinovich, Roberto Daniel / Pury, Pedro A / Sued, Omar

    Viruses

    2018  Volume 10, Issue 1

    Abstract: Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A ... ...

    Abstract Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A total of seventy-five treatment-naïve subjects were enrolled during acute/early HIV infection. CD4⁺ T-cell counts (CD4TC) and viral load (VL) levels were determined at enrollment and for one year. Immune activation, HIV-specific immune response, Human Leukocyte Antigen (HLA) and C-C chemokine receptor type 5 (CCR5) genotypes, and plasma levels of 39 cytokines were determined. Data were analyzed by machine learning and non-parametric methods. Variable hierarchization was performed by Weka correlation-based feature selection and J48 decision tree. Plasma interleukin (IL)-10, interferon gamma-induced protein (IP)-10, soluble IL-2 receptor alpha (sIL-2Rα) and tumor necrosis factor alpha (TNF-α) levels correlated directly with baseline VL, whereas IL-2, TNF-α, fibroblast growth factor (FGF)-2 and macrophage inflammatory protein (MIP)-1β correlated directly with CD4⁺ T-cell activation (
    MeSH term(s) Acute Disease ; Adult ; Biomarkers/blood ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; Chemokine CXCL10/blood ; Cytokines/immunology ; Disease Progression ; Female ; HIV Infections/blood ; HIV Infections/diagnosis ; HIV-1 ; Humans ; Male ; Receptors, CCR5/blood ; Viral Load
    Chemical Substances Biomarkers ; CCR5 protein, human ; CXCL10 protein, human ; Chemokine CXCL10 ; Cytokines ; Receptors, CCR5
    Language English
    Publishing date 2018-01-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v10010034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Host genetic factors associated with symptomatic primary HIV infection and disease progression among Argentinean seroconverters.

    Coloccini, Romina Soledad / Dilernia, Dario / Ghiglione, Yanina / Turk, Gabriela / Laufer, Natalia / Rubio, Andrea / Socías, María Eugenia / Figueroa, María Inés / Sued, Omar / Cahn, Pedro / Salomón, Horacio / Mangano, Andrea / Pando, María Ángeles

    PloS one

    2014  Volume 9, Issue 11, Page(s) e113146

    Abstract: Background: Variants in HIV-coreceptor C-C chemokine receptor type 5 (CCR5) and Human leukocyte antigen (HLA) genes are the most important host genetic factors associated with HIV infection and disease progression. Our aim was to analyze the association ...

    Abstract Background: Variants in HIV-coreceptor C-C chemokine receptor type 5 (CCR5) and Human leukocyte antigen (HLA) genes are the most important host genetic factors associated with HIV infection and disease progression. Our aim was to analyze the association of these genetic factors in the presence of clinical symptoms during Primary HIV Infection (PHI) and disease progression within the first year.
    Methods: Seventy subjects diagnosed during PHI were studied (55 symptomatic and 15 asymptomatic). Viral load (VL) and CD4 T-cell count were evaluated. HIV progression was defined by presence of B or C events and/or CD4 T-cell counts <350 cell/mm3. CCR5 haplotypes were characterized by polymerase chain reaction and SDM-PCR-RFLP. HLA-I characterization was performed by Sequencing.
    Results: Symptoms during PHI were significantly associated with lower frequency of CCR5-CF1 (1.8% vs. 26.7%, p = 0.006). Rapid progression was significantly associated with higher frequency of CCR5-CF2 (16.7% vs. 0%, p = 0.024) and HLA-A*11 (16.7% vs. 1.2%, p = 0.003) and lower frequency of HLA-C*3 (2.8% vs. 17.5%, p = 0.035). Higher baseline VL was significantly associated with presence of HLA-A*11, HLA-A*24, and absence of HLA-A*31 and HLA-B*57. Higher 6-month VL was significantly associated with presence of CCR5-HHE, HLA-A*24, HLA-B*53, and absence of HLA-A*31 and CCR5-CF1. Lower baseline CD4 T-cell count was significantly associated with presence of HLA-A*24/*33, HLA-B*53, CCR5-CF2 and absence of HLA-A*01/*23 and CCR5-HHA. Lower 6-month CD4 T-cell count was associated with presence of HLA-A*24 and HLA-B*53, and absence of HLA-A*01 and HLA-B*07/*39. Moreover, lower 12-month CD4 T-cell count was significantly associated with presence of HLA-A*33, HLA-B*14, HLA-C*08, CCR5-CF2, and absence of HLA-B*07 and HLA-C*07.
    Conclusion: Several host factors were significantly associated with disease progression in PHI subjects. Most results agree with previous studies performed in other groups. However, some genetic factor associations are being described for the first time, highlighting the importance of genetic studies at a local level.
    MeSH term(s) Argentina ; Blotting, Western ; CD4 Lymphocyte Count ; Disease Progression ; HIV Seropositivity/genetics ; HLA Antigens/genetics ; Haplotypes/genetics ; Host-Derived Cellular Factors/metabolism ; Humans ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Receptors, CCR5/genetics ; Viral Load
    Chemical Substances CCR5 protein, human ; HLA Antigens ; Host-Derived Cellular Factors ; Receptors, CCR5
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0113146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Violence as a barrier for HIV prevention among female sex workers in Argentina.

    Pando, María A / Coloccini, Romina S / Reynaga, Elena / Rodriguez Fermepin, Marcelo / Gallo Vaulet, Lucia / Kochel, Tadeusz J / Montano, Silvia M / Avila, María M

    PloS one

    2013  Volume 8, Issue 1, Page(s) e54147

    Abstract: Background: Violence against female sex workers (FSWs) has been increasingly reported as an important determinant of HIV infection risk. This study explores the frequency of different violent experiences (sexual abuse, rejection, beating and ... ...

    Abstract Background: Violence against female sex workers (FSWs) has been increasingly reported as an important determinant of HIV infection risk. This study explores the frequency of different violent experiences (sexual abuse, rejection, beating and imprisonment) among FSWs in Argentina and its association with condom use and HIV and T. pallidum prevalence.
    Methods: A convenience sample of 1255 FSWs was included in a cross-sectional study conducted between October 2006 and November 2009.
    Results: Sexual abuse was reported by 24.1% (219/907) of women. A total of 34.7% (42/1234) reported rejection experiences, 21.9% (267/1215) reported having been beaten and 45.4% (561/1236) stated having been arrested because of their sex work activity. There was a higher frequency of inconsistent condom use with clients among FSWs who had experienced sexual abuse, rejection, and police detention. A higher frequency of HIV and T. pallidum infection was detected among FSWs who reported having been arrested by the police.
    Conclusion: The study shows for the first time the frequency of different violent situations among FSWs in Argentina. The association between violence against sex workers, condom use and STI prevalence demonstrated here calls for measures to reduce stigma and violence against FSWs. Such violent experiences may increase vulnerability to STI through coerced unprotected sex.
    MeSH term(s) Adult ; Argentina/epidemiology ; Female ; HIV Infections/prevention & control ; Humans ; Sex Workers/statistics & numerical data ; Violence ; Young Adult
    Language English
    Publishing date 2013-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0054147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Early Gag immunodominance of the HIV-specific T-cell response during acute/early infection is associated with higher CD8+ T-cell antiviral activity and correlates with preservation of the CD4+ T-cell compartment.

    Turk, Gabriela / Ghiglione, Yanina / Falivene, Juliana / Socias, María Eugenia / Laufer, Natalia / Coloccini, Romina Soledad / Rodriguez, Ana María / Ruiz, María Julia / Pando, María Ángeles / Giavedoni, Luis David / Cahn, Pedro / Sued, Omar / Salomon, Horacio / Gherardi, María Magdalena

    Journal of virology

    2013  Volume 87, Issue 13, Page(s) 7445–7462

    Abstract: The important role of the CD8(+) T-cell response on HIV control is well established. Moreover, the acute phase of infection represents a proper scenario to delineate the antiviral cellular functions that best correlate with control. Here, multiple ... ...

    Abstract The important role of the CD8(+) T-cell response on HIV control is well established. Moreover, the acute phase of infection represents a proper scenario to delineate the antiviral cellular functions that best correlate with control. Here, multiple functional aspects (specificity, ex vivo viral inhibitory activity [VIA] and polyfunctionality) of the HIV-specific CD8(+) T-cell subset arising early after infection, and their association with disease progression markers, were examined. Blood samples from 44 subjects recruited within 6 months from infection (primary HIV infection [PHI] group), 16 chronically infected subjects, 11 elite controllers (EC), and 10 healthy donors were obtained. Results indicated that, although Nef dominated the anti-HIV response during acute/early infection, a higher proportion of early anti-Gag T cells correlated with delayed progression. Polyfunctional HIV-specific CD8(+) T cells were detected at early time points but did not associate with virus control. Conversely, higher CD4(+) T-cell set points were observed in PHI subjects with higher HIV-specific CD8(+) T-cell VIA at baseline. Importantly, VIA levels correlated with the magnitude of the anti-Gag cellular response. The advantage of Gag-specific cells may result from their enhanced ability to mediate lysis of infected cells (evidenced by a higher capacity to degranulate and to mediate VIA) and to simultaneously produce IFN-γ. Finally, Gag immunodominance was associated with elevated plasma levels of interleukin 2 (IL-2) and macrophage inflammatory protein 1β (MIP-1β). All together, this study underscores the importance of CD8(+) T-cell specificity in the improved control of disease progression, which was related to the capacity of Gag-specific cells to mediate both lytic and nonlytic antiviral mechanisms at early time points postinfection.
    MeSH term(s) Acute-Phase Reaction/immunology ; Argentina ; Base Sequence ; Biomarkers/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cytokines/immunology ; Enzyme-Linked Immunospot Assay ; HIV Infections/immunology ; HLA Antigens ; Humans ; Molecular Sequence Data ; Polymerase Chain Reaction ; Sequence Analysis, DNA ; Statistics, Nonparametric ; gag Gene Products, Human Immunodeficiency Virus/immunology ; nef Gene Products, Human Immunodeficiency Virus/immunology
    Chemical Substances Biomarkers ; Cytokines ; HLA Antigens ; gag Gene Products, Human Immunodeficiency Virus ; nef Gene Products, Human Immunodeficiency Virus
    Language English
    Publishing date 2013-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00865-13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 609: Show issues Location:
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  6. Article ; Online: Prevalencia de la infección por el VIH y de Treponema pallidum en mujeres trabajadoras sexuales de Argentina.

    Pando, María de Los Ángeles / Reynaga, Elena / Coloccini, Romina Soledad / Rodríguez Fermepín, Marcelo / Kochel, Tadeusz / Montano, Silvia Maria / Marone, Rubén / Avila, María Mercedes

    Revista panamericana de salud publica = Pan American journal of public health

    2011  Volume 30, Issue 4, Page(s) 303–308

    Abstract: Objective: Estimate the prevalence of human immunodeficiency virus (HIV) infection and Treponema pallidum in Argentine female sex workers (FSW), and describe the sociodemographic characteristics of this population group associated with HIV transmission.! ...

    Title translation Prevalence of HIV infection and Treponema pallidum in Argentine female sex workers.
    Abstract Objective: Estimate the prevalence of human immunodeficiency virus (HIV) infection and Treponema pallidum in Argentine female sex workers (FSW), and describe the sociodemographic characteristics of this population group associated with HIV transmission.
    Methods: A cross-sectional study and convenience sampling were conducted in FSW over 18 years of age in nine Argentine cities from October 2006 to December 2009. A total of 1 255 women participated in this study. A group of FSW was especially trained to invite other women to participate in the workshops and undergo screening for HIV and T. pallidum.
    Results: The most noteworthy socioepidemiological characteristics of the FSW included a high percentage of sexual abuse, limited condom use with noncommercial sex partners, and a high percentage of violence. HIV prevalence was 2% (25/1 255, 95% confidence interval [95% CI]:1.2-2.8) and T. pallidum prevalence was 22.4% (245/1 094; 95% CI: 19.9-24.9). In the city of La Plata, HIV prevalence in FSW was significantly lower compared to that of other regions of the country (0.3% vs. 2.7%, P < 0.05, respectively).
    Conclusions: The lower HIV prevalence and the higher rate of condom use reported by the women from La Plata surveyed suggest that the presence of a health center for FSW has a direct influence on reducing risky behavior and, consequently, HIV infection. The creation of "friendly" health centers like the one already in this city contributes to providing a comprehensive response to the problems faced by these women and encourages use of the health system. It therefore helps reverse their vulnerability and higher risk of contracting HIV and other sexually transmitted infections.
    MeSH term(s) Argentina/epidemiology ; Condoms/statistics & numerical data ; Cross-Sectional Studies ; Education ; Female ; HIV Infections/epidemiology ; Health Knowledge, Attitudes, Practice ; Humans ; Prevalence ; Risk-Taking ; Sex Workers/statistics & numerical data ; Sexually Transmitted Diseases/epidemiology ; Socioeconomic Factors ; Syphilis/epidemiology ; Treponema pallidum/isolation & purification ; Women's Health
    Language Spanish
    Publishing date 2011-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1376934-0
    ISSN 1680-5348 ; 1020-4989
    ISSN (online) 1680-5348
    ISSN 1020-4989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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