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  1. Article ; Online: Cardiovascular imaging updates and future perspectives.

    Colombo, Giada / Cameli, Matteo / Metra, Marco / Inciardi, Riccardo M

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2023  Volume 24, Issue 8, Page(s) 488–491

    MeSH term(s) Humans ; Cardiovascular System/diagnostic imaging
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Estimation of Right Atrial Pressure by Ultrasound-Assessed Jugular Vein Distensibility in Patients With Heart Failure.

    Ammirati, Enrico / Marchetti, Davide / Colombo, Giada / Pellicori, Pierpaolo / Gentile, Piero / D'Angelo, Luciana / Masciocco, Gabriella / Verde, Alessandro / Macera, Francesca / Brunelli, Dario / Occhi, Lucia / Musca, Francesco / Perna, Enrico / Bernasconi, Davide P / Moreo, Antonella / Camici, Paolo G / Metra, Marco / Oliva, Fabrizio / Garascia, Andrea

    Circulation. Heart failure

    2024  Volume 17, Issue 2, Page(s) e010973

    Abstract: Background: Clinical evaluation of central venous pressure is difficult, depends on experience, and is often inaccurate in patients with chronic advanced heart failure. We assessed the ultrasound-assessed internal jugular vein (JV) distensibility by ... ...

    Abstract Background: Clinical evaluation of central venous pressure is difficult, depends on experience, and is often inaccurate in patients with chronic advanced heart failure. We assessed the ultrasound-assessed internal jugular vein (JV) distensibility by ultrasound as a noninvasive tool to identify patients with normal right atrial pressure (RAP ≤7 mm Hg) in this population.
    Methods: We measured JV distensibility as the Valsalva-to-rest ratio of the vein diameter in a calibration cohort (N=100) and a validation cohort (N=101) of consecutive patients with chronic heart failure with reduced ejection fraction who underwent pulmonary artery catheterization for advanced heart failure therapies workup.
    Results: A JV distensibility threshold of 1.6 was identified as the most accurate to discriminate between patients with RAP ≤7 versus >7 mm Hg (area under the receiver operating characteristic curve, 0.74 [95% CI, 0.64-0.84]) and confirmed in the validation cohort (receiver operating characteristic, 0.82 [95% CI, 0.73-0.92]). A JV distensibility ratio >1.6 had predictive positive values of 0.86 and 0.94, respectively, to identify patients with RAP ≤7 mm Hg in the calibration and validation cohorts. Compared with patients from the calibration cohort with a high JV distensibility ratio (>1.6; n=42; median RAP, 4 mm Hg; pulmonary capillary wedge pressure, 11 mm Hg), those with a low JV distensibility ratio (≤1.6; n=58; median RAP, 8 mm Hg; pulmonary capillary wedge pressure, 22 mm Hg;
    Conclusions: Ultrasound-assessed JV distensibility identifies patients with chronic advanced heart failure with normal RAP and better outcomes.
    Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03874312.
    MeSH term(s) Humans ; Atrial Pressure ; Cardiac Catheterization ; Catheterization, Swan-Ganz ; Heart Failure/diagnostic imaging ; Heart Failure/therapy ; Jugular Veins/diagnostic imaging ; Pulmonary Wedge Pressure ; Stroke Volume
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Clinical Study ; Journal Article
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.123.010973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characteristics and outcomes of patients with tricuspid regurgitation and advanced heart failure.

    Pagnesi, Matteo / Riccardi, Mauro / Chiarito, Mauro / Stolfo, Davide / Baldetti, Luca / Lombardi, Carlo Mario / Colombo, Giada / Inciardi, Riccardo Maria / Tomasoni, Daniela / Loiacono, Ferdinando / Maccallini, Marta / Villaschi, Alessandro / Gasparini, Gaia / Montella, Marco / Contessi, Stefano / Cocianni, Daniele / Perotto, Maria / Barone, Giuseppe / Merlo, Marco /
    Cappelletti, Alberto Maria / Sinagra, Gianfranco / Pini, Daniela / Metra, Marco / Adamo, Marianna

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2024  Volume 25, Issue 3, Page(s) 200–209

    Abstract: Aims: To evaluate the role of tricuspid regurgitation in advanced heart failure.: Methods: The multicenter observational HELP-HF registry enrolled consecutive patients with heart failure and at least one 'I NEED HELP' criterion evaluated at four ... ...

    Abstract Aims: To evaluate the role of tricuspid regurgitation in advanced heart failure.
    Methods: The multicenter observational HELP-HF registry enrolled consecutive patients with heart failure and at least one 'I NEED HELP' criterion evaluated at four Italian centers between January 2020 and November 2021. Patients with no data on tricuspid regurgitation and/or receiving tricuspid valve intervention during follow-up were excluded. The population was stratified by no/mild tricuspid regurgitation vs. moderate tricuspid regurgitation vs. severe tricuspid regurgitation. Variables independently associated with tricuspid regurgitation, as well as the association between tricuspid regurgitation and clinical outcomes were investigated. The primary outcome was all-cause mortality.
    Results: Among the 1085 patients included in this study, 508 (46.8%) had no/mild tricuspid regurgitation, 373 (34.4%) had moderate tricuspid regurgitation and 204 (18.8%) had severe tricuspid regurgitation. History of atrial fibrillation, any prior valve surgery, high dose of furosemide, preserved left ventricular ejection fraction, moderate/severe mitral regurgitation and pulmonary hypertension were found to be independently associated with an increased likelihood of severe tricuspid regurgitation. Estimated rates of 1-year all-cause death were of 21.4, 24.5 and 37.1% in no/mild tricuspid regurgitation, moderate tricuspid regurgitation and severe tricuspid regurgitation, respectively (log-rank P  < 0.001). As compared with nonsevere tricuspid regurgitation, severe tricuspid regurgitation was independently associated with a higher risk of all-cause mortality (adjusted hazard ratio 1.38, 95% confidence interval 1.01-1.88, P  = 0.042), whereas moderate tricuspid regurgitation did not.
    Conclusion: In a contemporary, real-world cohort of patients with advanced heart failure, several clinical and echocardiographic characteristics are associated with an increased likelihood of severe tricuspid regurgitation. Patients with severe tricuspid regurgitation have an increased risk of mortality.
    MeSH term(s) Humans ; Heart Failure ; Mitral Valve Insufficiency ; Retrospective Studies ; Stroke Volume ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Tricuspid Valve Insufficiency/diagnostic imaging ; Ventricular Function, Left ; Multicenter Studies as Topic ; Observational Studies as Topic
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ischemic Etiology in Advanced Heart Failure: Insight from the HELP-HF Registry.

    Villaschi, Alessandro / Pagnesi, Matteo / Stolfo, Davide / Baldetti, Luca / Lombardi, Carlo Mario / Adamo, Marianna / Loiacono, Ferdinando / Sammartino, Antonio Maria / Colombo, Giada / Tomasoni, Daniela / Inciardi, Riccardo Maria / Maccallini, Marta / Gasparini, Gaia / Montella, Marco / Contessi, Stefano / Cocianni, Daniele / Perotto, Maria / Barone, Giuseppe / Merlo, Marco /
    Cappelletti, Alberto Maria / Sinagra, Gianfranco / Pini, Daniela / Metra, Marco / Chiarito, Mauro

    The American journal of cardiology

    2023  Volume 204, Page(s) 268–275

    Abstract: In patients with advanced heart failure (HF), defined according to the presence of at least one I-NEED-HELP criterium, the updated 2018 Heart Failure Association of the European Society of Cardiology (HFA-ESC) criteria for advanced HF identify a subgroup ...

    Abstract In patients with advanced heart failure (HF), defined according to the presence of at least one I-NEED-HELP criterium, the updated 2018 Heart Failure Association of the European Society of Cardiology (HFA-ESC) criteria for advanced HF identify a subgroup of patients with HF with worse prognosis, but whether ischemic etiology has a relevant prognostic impact in this very high-risk cohort is unknown. Patients from the HELP-HF registry were stratified according to ischemic etiology and presence of advanced HF based on 2018 HFA-ESC criteria. The primary end point was a composite of all-cause death and HF hospitalization at 1 year. Secondary end points were all-cause death, HF hospitalization, and cardiovascular death at 1 year. Ischemic etiology was a leading cause of HF, in both patients with advanced and nonadvanced HF (46.1% and 42.4%, respectively, p = 0.337). The risk of the primary end point (hazard ratio [HR] 1.31, 95% confidence interval [CI] 1.09 to 1.58) and all-cause mortality (HR 1.37, 95% CI 1.06 to 1.76) was increased in ischemic as compared with nonischemic patients. The risk of the primary end point was consistently higher in ischemic patients in both patients with advanced and nonadvanced HF (advanced HF, HR 1.50 95% CI 1.04 to 2.16; nonadvanced HF, HR 1.25 95% CI 1.01 to 1.56, p
    MeSH term(s) Humans ; Heart Failure/epidemiology ; Heart Failure/etiology ; Prognosis ; Hospitalization ; Registries ; Stroke Volume
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.07.114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Guideline-directed medical therapy in severe heart failure with reduced ejection fraction: An analysis from the HELP-HF registry.

    Tomasoni, Daniela / Pagnesi, Matteo / Colombo, Giada / Chiarito, Mauro / Stolfo, Davide / Baldetti, Luca / Lombardi, Carlo Mario / Adamo, Marianna / Maggi, Giuseppe / Inciardi, Riccardo Maria / Loiacono, Ferdinando / Maccallini, Marta / Villaschi, Alessandro / Gasparini, Gaia / Montella, Marco / Contessi, Stefano / Cocianni, Daniele / Perotto, Maria / Barone, Giuseppe /
    Merlo, Marco / Cappelletti, Alberto Maria / Rosano, Giuseppe / Sinagra, Gianfranco / Pini, Daniela / Savarese, Gianluigi / Metra, Marco

    European journal of heart failure

    2023  Volume 26, Issue 2, Page(s) 327–337

    Abstract: Aim: Persistent symptoms despite guideline-directed medical therapy (GDMT) and poor tolerance of GDMT are hallmarks of patients with advanced heart failure (HF) with reduced ejection fraction (HFrEF). However, real-world data on GDMT use, dose, and ... ...

    Abstract Aim: Persistent symptoms despite guideline-directed medical therapy (GDMT) and poor tolerance of GDMT are hallmarks of patients with advanced heart failure (HF) with reduced ejection fraction (HFrEF). However, real-world data on GDMT use, dose, and prognostic implications are lacking.
    Methods and results: We included 699 consecutive patients with HFrEF and at least one 'I NEED HELP' marker for advanced HF enrolled in a multicentre registry. Beta-blockers (BB) were administered to 574 (82%) patients, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers or angiotensin receptor-neprilysin inhibitors (ACEi/ARB/ARNI) were administered to 381 (55%) patients and 416 (60%) received mineralocorticoid receptor antagonists (MRA). Overall, ≥50% of target doses were reached in 41%, 22%, and 56% of the patients on BB, ACEi/ARB/ARNI and MRA, respectively. Hypotension, bradycardia, kidney dysfunction and hyperkalaemia were the main causes of underprescription and/or underdosing, but up to a half of the patients did not receive target doses for unknown causes (51%, 41%, and 55% for BB, ACEi/ARB/ARNI and MRA, respectively). The proportions of patients receiving BB and ACEi/ARB/ARNI were lower among those fulfilling the 2018 HFA-ESC criteria for advanced HF. Treatment with BB and ACEi/ARB/ARNI were associated with a lower risk of death or HF hospitalizations (adjusted hazard ratio [HR] 0.63, 95% confidence interval [CI] 0.48-0.84, and HR 0.74, 95% CI 0.58-0.95, respectively).
    Conclusions: In a large, real-world, contemporary cohort of patients with severe HFrEF, with at least one marker for advanced HF, prescription and uptitration of GDMT remained limited. A significant proportion of patients were undertreated due to unknown reasons suggesting a potential role of clinical inertia either by the prescribing healthcare professional or by the patient. Treatment with BB and ACEi/ARB/ARNI was associated with lower mortality/morbidity.
    MeSH term(s) Humans ; Heart Failure/drug therapy ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Stroke Volume/physiology ; Registries ; Adrenergic beta-Antagonists/therapeutic use ; Mineralocorticoid Receptor Antagonists/therapeutic use
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists ; Adrenergic beta-Antagonists ; Mineralocorticoid Receptor Antagonists
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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