Article ; Online: Non-invasive measurement of cerebral oxygen metabolism in the mouse brain by ultra-high field (17)O MR spectroscopy.
2013 Volume 33, Issue 12, Page(s) 1846–1849
Abstract: To assess cerebral energetics in transgenic mouse models of neurologic disease, a robust, efficient, and practical method for quantification of cerebral oxygen consumption is needed. (17)O magnetic resonance spectroscopy (MRS) has been validated to ... ...
Abstract | To assess cerebral energetics in transgenic mouse models of neurologic disease, a robust, efficient, and practical method for quantification of cerebral oxygen consumption is needed. (17)O magnetic resonance spectroscopy (MRS) has been validated to measure cerebral metabolic rate of oxygen (CMRO2) in the rat brain; however, mice present unique challenges because of their small size. We show that CMRO2 measurements with (17)O MRS in the mouse brain are highly reproducible using 16.4 Tesla and a newly designed oxygen delivery system. The method can be utilized to measure mitochondrial function in mice quickly and repeatedly, without oral intubation, and has numerous potential applications to study cerebral energetics. |
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MeSH term(s) | Animals ; Brain/metabolism ; Magnetic Resonance Imaging/methods ; Male ; Mice ; Mice, Inbred C57BL ; Oxygen/metabolism ; Oxygen Consumption ; Oxygen Isotopes/metabolism |
Chemical Substances | Oxygen Isotopes ; Oxygen (S88TT14065) |
Language | English |
Publishing date | 2013-09-25 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 604628-9 |
ISSN | 1559-7016 ; 0271-678X |
ISSN (online) | 1559-7016 |
ISSN | 0271-678X |
DOI | 10.1038/jcbfm.2013.172 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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