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  1. Article ; Online: Iron deficiency and supplementation therapy in heart failure.

    Moliner, Pedro / Comin-Colet, Josep

    Nature reviews. Cardiology

    2022  Volume 19, Issue 9, Page(s) 571–572

    MeSH term(s) Anemia, Iron-Deficiency/drug therapy ; Dietary Supplements ; Heart Failure/drug therapy ; Humans ; Iron Deficiencies
    Language English
    Publishing date 2022-07-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-022-00747-0
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  2. Article ; Online: Chronotropic incompetence: rediscovering phenotypes in heart failure with preserved ejection fraction.

    Jiménez-Marrero, Santiago / Ramos, Raúl / Comín-Colet, Josep

    Revista espanola de cardiologia (English ed.)

    2023  Volume 76, Issue 7, Page(s) 497–499

    MeSH term(s) Humans ; Stroke Volume ; Heart Failure/diagnosis ; Arrhythmias, Cardiac ; Phenotype ; Heart Rate ; Exercise Test
    Language Spanish
    Publishing date 2023-02-04
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2022.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adjusted morbidity groups and geriatric assessment in older patients with acute coronary syndrome.

    Ariza-Solé, Albert / Formiga, Francesc / Monterde, David / Vela, Emili / Calvo, Elena / Comín-Colet, Josep

    Revista espanola de cardiologia (English ed.)

    2024  

    Language Spanish
    Publishing date 2024-03-12
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2024.03.001
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  4. Article ; Online: Systematic review and meta-analysis of intravenous iron-carbohydrate complexes in HFrEF patients with iron deficiency.

    Sindone, Andrew / Doehner, Wolfram / Comin-Colet, Josep

    ESC heart failure

    2022  Volume 10, Issue 1, Page(s) 44–56

    Abstract: Iron deficiency (ID) is a common co-morbidity in patients with heart failure (HF). The present meta-analysis evaluates the effect of intravenous (IV) iron-carbohydrate complex supplementation in patients with HF with reduced ejection fraction (HFrEF) and ...

    Abstract Iron deficiency (ID) is a common co-morbidity in patients with heart failure (HF). The present meta-analysis evaluates the effect of intravenous (IV) iron-carbohydrate complex supplementation in patients with HF with reduced ejection fraction (HFrEF) and ID/iron deficiency anaemia (IDA). Randomized controlled trials (RCTs) comparing IV iron-carbohydrate complexes with placebo/standard of care in patients with HFrEF with ID/IDA were identified using Embase (from 1957) and PubMed (from 1989) databases through 25 May 2021. Twelve RCTs including 2381 patients were included in this analysis. The majority (90.8%) of patients receiving IV iron-carbohydrate therapy were administered ferric carboxymaltose (FCM); 7.5% received iron sucrose and 1.6% received iron isomaltoside. IV iron-carbohydrate therapy significantly reduced hospitalization for worsening HF [0.53 (0.42-0.65); P < 0.0001] and first hospitalization for worsening HF or death [0.75 (0.59-0.95); P = 0.016], but did not significantly impact all-cause mortality, compared with control. IV iron-carbohydrate therapy significantly improved functional and exercise capacity compared with the control. There was no significant difference in outcome between IV iron-carbohydrate formulations when similar endpoints were measured. No significant difference in adverse events (AE) was observed between the treatment groups. IV iron-carbohydrate therapy resulted in improvements in a range of clinical outcomes and increased functional and exercise capacity, whereas AEs were not significantly different between IV iron-carbohydrate and placebo/standard of care arms. These findings align with the European Society of Cardiology's 2021 HF guidelines, which recommend the consideration of FCM in symptomatic patients with a left ventricular ejection fraction < 45% and ID.
    MeSH term(s) Humans ; Iron Deficiencies ; Hematinics ; Anemia, Iron-Deficiency/drug therapy ; Iron/therapeutic use ; Maltose
    Chemical Substances Hematinics ; ferric carboxymaltose (6897GXD6OE) ; Iron (E1UOL152H7) ; Maltose (69-79-4)
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14177
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  5. Article ; Online: Renin-angiotensin-aldosterone inhibition in chronic heart failure: From theory into practice.

    Ramos, Raúl / Moliner, Pedro / Comin-Colet, Josep

    European journal of internal medicine

    2022  Volume 102, Page(s) 40–42

    MeSH term(s) Aldosterone ; Angiotensins ; Heart Failure/drug therapy ; Humans ; Renin ; Renin-Angiotensin System/physiology
    Chemical Substances Angiotensins ; Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2022-07-02
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.06.019
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  6. Article ; Online: First episode of acute heart failure: Can we already predict the risk of short-term mortality?

    Moliner, Pedro / Comin-Colet, Josep

    European journal of internal medicine

    2020  Volume 77, Page(s) 30–31

    MeSH term(s) Acute Disease ; Heart Failure ; Humans ; Risk Factors
    Language English
    Publishing date 2020-05-15
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2020.04.041
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  7. Article ; Online: Short length of hospitalization in patients with acute heart failure entails a high risk of readmission: True or false? Insights from the LOHRCA study.

    Moliner, Pedro / Comin-Colet, Josep

    European journal of internal medicine

    2019  Volume 70, Page(s) 13–15

    MeSH term(s) Heart Failure ; Hospitalization ; Humans ; Patient Readmission
    Language English
    Publishing date 2019-10-31
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2019.10.009
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  8. Article ; Online: Bloqueo auriculoventricular de tercer grado asociado a la vacuna de ARNm contra el SARS-CoV-2.

    Pons-Riverola, Alexandra / Mañas, Pilar / Claver, Eduard / Meroño, Oona / Comín-Colet, Josep / Anguera, Ignasi

    Revista espanola de cardiologia

    2022  Volume 76, Issue 5, Page(s) 384–386

    Title translation Third-degree atrioventricular block associated with the SARS-CoV-2 mRNA vaccine.
    Language Spanish
    Publishing date 2022-12-19
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 128925-1
    ISSN 1579-2242 ; 0300-8932
    ISSN (online) 1579-2242
    ISSN 0300-8932
    DOI 10.1016/j.recesp.2022.10.006
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  9. Article ; Online: Third-degree atrioventricular block associated with the SARS-CoV-2 mRNA vaccine.

    Pons-Riverola, Alexandra / Mañas, Pilar / Claver, Eduard / Meroño, Oona / Comín-Colet, Josep / Anguera, Ignasi

    Revista espanola de cardiologia (English ed.)

    2022  Volume 76, Issue 5, Page(s) 384–386

    MeSH term(s) Humans ; Atrioventricular Block/etiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language Spanish
    Publishing date 2022-10-24
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2022.10.004
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  10. Article: Influence of the COVID-19 pandemic on patients receiving oral anticoagulants for the treatment of non-valvular atrial fibrillation.

    Comín Colet, Josep / Sicras Mainar, Antoni / Salazar-Mendiguchía, Joel / Isabel Del Campo Alonso, María / Echeto, Ainara / Vilanova Larena, David / Delgado Sánchez, Olga

    International journal of cardiology. Heart & vasculature

    2024  Volume 51, Page(s) 101358

    Abstract: Background: Frequent monitoring of patients declined during the COVID-19 pandemic, harming patients with chronic diseases who critically needed correct monitoring. We evaluated the impact of the COVID-19 pandemic in patients with non-valvular atrial ... ...

    Abstract Background: Frequent monitoring of patients declined during the COVID-19 pandemic, harming patients with chronic diseases who critically needed correct monitoring. We evaluated the impact of the COVID-19 pandemic in patients with non-valvular atrial fibrillation (NVAF) receiving treatment with vitamin K antagonists (VKA) or non-vitamin K antagonist oral anticoagulants (NOAC) in clinical practice in Spain.
    Methods: This observational, retrospective study analyzed prevalent patients treated with NOAC/VKA on 14/03/2019 (pre-COVID-19 period) and 14/03/2020 (COVID-19 period), who were followed up to 12 months. The study also considered incident patients who started treatment with NOAC/VKA between 15/03/2019 and 13/03/2020 (pre-COVID-19 period) and from 15/03/2020 to 13/03/2021 (COVID-19 period). Demographic characteristics, comorbidities, effectiveness, treatment patterns, and healthcare resource utilization were considered.
    Results: Prevalent patients amounted to 12,336 and 13,342 patients, whereas 1,612 and 1,602 incident patients were included in the pre-COVID-19 and COVID-19 periods, respectively. Prevalent patients treated with VKA had more strokes, thromboembolism, and major bleeding compared to those receiving NOAC, particularly during the COVID-19 period. NOAC patients had a 12 % lower risk of death than those on treatment with VKA (Hazard ratio = 0.88 [95 % CI: 0.81 - 0.95], p = 0.033). In addition, VKA patients were less persistent after 12 months than NOAC patients (pre-COVID-19 period: 52.1 % vs. 78.9 %, p < 0.001; COVID-19 period: 49.2 % vs. 80.3 %, p < 0.001), and required more healthcare visits and hospitalizations than those on treatment with NOAC.
    Conclusion: Compared to VKA, NOAC seems to have reduced the incidence of severe events and the use of healthcare resources for NVAF, particularly during the pandemic.
    Language English
    Publishing date 2024-02-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2024.101358
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