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  1. Article ; Online: Use of vasopressors and inotropes in ECMO.

    Levy, Bruno / Lescroart, Mickael / Combes, Alain

    Intensive care medicine

    2024  Volume 50, Issue 3, Page(s) 463–466

    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation ; Vasoconstrictor Agents/therapeutic use ; Shock, Cardiogenic/drug therapy
    Chemical Substances Vasoconstrictor Agents
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07338-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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  2. Article ; Online: ECMO and Prone Position in Patients With Severe ARDS-Reply.

    Schmidt, Matthieu / Hajage, David / Combes, Alain

    JAMA

    2024  Volume 331, Issue 14, Page(s) 1233

    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation ; Patient Positioning ; Prone Position ; Respiratory Distress Syndrome/therapy ; Respiration, Artificial/methods ; Clinical Trials as Topic ; Ventilator Weaning
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2024.1876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: What's new in VA-ECMO for acute myocardial infarction-related cardiogenic shock.

    Combes, Alain / Price, Susanna / Levy, Bruno

    Intensive care medicine

    2024  Volume 50, Issue 4, Page(s) 590–592

    MeSH term(s) Humans ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Extracorporeal Membrane Oxygenation ; Myocardial Infarction/complications ; Myocardial Infarction/therapy ; Hospital Mortality ; Retrospective Studies
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07356-0
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    Zs.A 1089: Show issues Location:
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  4. Article ; Online: Contribution of electrical impedance tomography to personalize positive end-expiratory pressure under ECCO

    Pequignot, Benjamin / Combes, Alain / Lescroart, Mickael / Levy, Bruno / Koszutski, Matthieu

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 124

    Abstract: Extracorporeal Carbon Dioxide Removal ( ... ...

    Abstract Extracorporeal Carbon Dioxide Removal (ECCO
    MeSH term(s) Male ; Humans ; Aged ; Electric Impedance ; Positive-Pressure Respiration/methods ; Lung ; Tomography, X-Ray Computed ; Respiratory Distress Syndrome/therapy ; Tidal Volume ; Tomography/methods
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04908-0
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    Zs.A 5517: Show issues Location:
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  5. Article ; Online: Myocarditis: a primer for intensivists.

    Ammirati, Enrico / Vorovich, Esther / Combes, Alain

    Intensive care medicine

    2023  Volume 49, Issue 9, Page(s) 1123–1126

    MeSH term(s) Humans ; Myocarditis ; Critical Care ; Intensive Care Units
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07143-3
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    Zs.A 1089: Show issues Location:
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  6. Article ; Online: Setting and Monitoring of Mechanical Ventilation During Venovenous ECMO.

    Assouline, Benjamin / Combes, Alain / Schmidt, Matthieu

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 95

    Abstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at  https://www.biomedcentral.com/collections/annualupdate2023 . Further information about the ... ...

    Abstract This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at  https://www.biomedcentral.com/collections/annualupdate2023 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from  https://link.springer.com/bookseries/8901 .
    MeSH term(s) Humans ; Respiration, Artificial ; Intensive Care Units ; Extracorporeal Membrane Oxygenation ; Critical Care ; Emergency Medicine
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04372-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  7. Article ; Online: Mechanical circulatory support for end-stage heart failure.

    Combes, Alain

    Metabolism: clinical and experimental

    2017  Volume 69S, Page(s) S30–S35

    Abstract: Mechanical circulatory assistance has become a frequent therapeutic option for patients with advanced heart failure. For patients with acute cardiogenic shock and impaired organ function, short-term assistance with venoarterial extracorporeal membrane ... ...

    Abstract Mechanical circulatory assistance has become a frequent therapeutic option for patients with advanced heart failure. For patients with acute cardiogenic shock and impaired organ function, short-term assistance with venoarterial extracorporeal membrane oxygenation is the leading therapeutic option. It enables a "bridge to decision-making" i.e. withdrawal of the device after myocardial recovery or after recognition of therapeutic futility, or as a bridge-to-transplantation or to long-term mechanical support. For Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) class 2-6 patients, implantation of a long-term ventricular assist-device (VAD) should be considered before progression to multiple organ failure if heart transplantation is not a first-line option. Most patients receive a miniaturized axial or centrifugal fully implantable left VAD as a bridge-to-transplantation or as "destination therapy" in this setting.
    MeSH term(s) Clinical Decision-Making ; Disease Progression ; Extracorporeal Circulation/adverse effects ; Extracorporeal Circulation/trends ; Extracorporeal Membrane Oxygenation/adverse effects ; Extracorporeal Membrane Oxygenation/trends ; Heart Failure/physiopathology ; Heart Failure/surgery ; Heart-Assist Devices/adverse effects ; Heart-Assist Devices/trends ; Humans ; Multiple Organ Failure/etiology ; Multiple Organ Failure/prevention & control ; Patient Selection ; Practice Guidelines as Topic ; Severity of Illness Index ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/physiopathology ; Shock, Cardiogenic/surgery
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2017.01.009
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    Uc I Zs.316: Show issues Location:
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  8. Article: Histoire de l’assistance circulatoire, une technologie au service du progrès médical. History of circulatory assistance, technology at the service of medical progress

    Ortuno, Sofia / Combes, Alain

    Médecine intensive réanimation

    2023  Volume 32, Issue 1, Page(s) 61

    Language French
    Document type Article
    ZDB-ID 2870987-1
    ISSN 2496-6142
    Database Current Contents Medicine

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    Zs.A 4839: Show issues Location:
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  9. Article ; Online: Antiphospholipid Patients Admitted in the Intensive Care Unit: What Must The Rheumatologist Know?

    Moyon, Quentin / Mathian, Alexis / Papo, Matthias / Combes, Alain / Amoura, Zahir / Pineton de Chambrun, Marc

    Current rheumatology reports

    2024  

    Abstract: Purpose of the review: Antiphospholipid syndrome (APS) is a rare systemic autoimmune disorder that can escalate into a 'thrombotic storm' called the catastrophic antiphospholipid syndrome (CAPS), frequently requiring ICU admission for multiple organ ... ...

    Abstract Purpose of the review: Antiphospholipid syndrome (APS) is a rare systemic autoimmune disorder that can escalate into a 'thrombotic storm' called the catastrophic antiphospholipid syndrome (CAPS), frequently requiring ICU admission for multiple organ failure. This review aims to offer insight and recent evidence on critically-ill APS patients.
    Recent findings: The CAPS classification criteria define this condition as the involvement of at least three organs/systems/tissues within less than a week, caused by small vessel thrombosis, in patients with elevated antiphospholipid antibodies levels. These criteria do not encompass the full spectrum of critically-ill thrombotic APS patients and they need to be cautiously used for the bedside diagnosis of CAPS. Thrombocytopenia is the laboratory hallmark of CAPS, sometimes dropping below 20G/L, but a complete thrombotic microangiopathy pattern is infrequent. Anticoagulation is the pivotal treatment for APS and CAPS, associated with improved outcome. Triple therapy - the combination of anticoagulation, high-dose corticosteroids, and either plasma exchange or intravenous immunoglobulins - remains the standard treatment for CAPS patients. Eculizumab, an anti-C5 monoclonal antibody, may be useful in refractory patients. Despite significant progress, CAPS mortality rate remains high. Its diagnosis and management are complex, requiring a close multidisciplinary cross talk between APS specialists and intensivists.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-024-01148-7
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    Zs.A 5531: Show issues Location:
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  10. Article ; Online: Extracorporeal membrane oxygenation in COVID-19 associated acute respiratory distress syndrome: A narrative review.

    Assouline, Benjamin / Combes, Alain / Schmidt, Matthieu

    Journal of intensive medicine

    2022  Volume 3, Issue 1, Page(s) 4–10

    Abstract: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is an established rescue therapy in the management of refractory acute respiratory distress syndrome (ARDS). Although ECMO played an important role in previous respiratory viral epidemics, concerns ...

    Abstract Venovenous extracorporeal membrane oxygenation (VV-ECMO) is an established rescue therapy in the management of refractory acute respiratory distress syndrome (ARDS). Although ECMO played an important role in previous respiratory viral epidemics, concerns about the benefits and usefulness of this technique were raised during the coronavirus disease 2019 (COVID-19) pandemic. Indeed, the mortality rate initially reported in small case series from China was concerning and exceeded 90%. A few months later, the critical care community published the findings from several observational cohorts on the use of extracorporeal membrane oxygenation (ECMO) in COVID-19-related ARDS. Contrary to the preliminary results, data from the first surge supported the use of ECMO in experienced centers because the mortality rate was comparable to those from the ECMO to Rescue Lung Injury in Severe ARDS (EOLIA) trial or other large prospective studies. However, the mortality rate of the population with severe disease evolved during the pandemic, in conjunction with changes in the management of the disease and the occurrence of new variants. The results from subsequent studies confirmed that the outcomes mainly depend on strict patient selection and center expertise. In comparison with non-COVID-related ARDS, the duration of ECMO for COVID-related ARDS was longer and increased over time. Clinicians and decision-makers must integrate this finding in the ECMO decision-making process to plan their ICU capacity and resource allocation. This narrative review summarizes the current evidence and specific considerations for ECMO use in COVID-19-associated ARDS.
    Language English
    Publishing date 2022-10-04
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2667-100X
    ISSN (online) 2667-100X
    DOI 10.1016/j.jointm.2022.08.003
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