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Article ; Online: Baricitinib restrains the immune dysregulation in severe COVID-19 patients

Bronte, Vincenzo / Ugel, Stefano / Tinazzi, Elisa / Vella, Antonio / De Sanctis, Francesco / Canè, Stefania / Batani, Veronica / Trovato, Rosalinda / Fiore, Alessandra / Petrova, Varvara / Hofer, Francesca / Barouni, Roza Maria / Musiu, Chiara / Caligola, Simone / Pinton, Laura / Torroni, Lorena / Polati, Enrico / Donadello, Katia / Friso, Simonetta /
Pizzolo, Francesca / Iezzi, Manuela / Facciotti, Federica / Pelicci, Pier Giuseppe / Righetti, Daniela / Bazzoni, Paolo / Rampudda, Mariaelisa / Comel, Andrea C / Mosaner, Walter / Lunardi, Claudio / Olivieri, Oliviero

2020  

Abstract: COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by ... ...

Abstract COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by small molecules.
Keywords COVID-19 ; Immunology ; Innate immunity ; covid19
Language English
Publishing country it
Document type Article ; Online
Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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