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  1. Book ; Online ; E-Book: Principles and practice of movement disorders

    Jankovic, Joseph / Hallett, Mark / Okun, Michael S. / Comella, Cynthia / Fahn, Stanley

    2022  

    Author's details Joseph Jankovic, Mark Hallet, Michael S. Okun, Cynthia Comella, Stanley Fahn
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xviii,627 Seiten), Illustrationen
    Edition Third edition
    Publisher Elsevier
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021145883
    ISBN 978-0-323-31598-2 ; 9780323310710 ; 0-323-31598-4 ; 0323310710
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Hyperkinetic movement disorders

    Suchowersky, Oksana / Comella, Cynthia L.

    (Current clinical neurology)

    2012  

    Author's details Oksana Suchowersky ; Cynthia Comella
    Series title Current clinical neurology
    Language English
    Size XIV, 288 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016677581
    ISBN 978-1-58829-805-8 ; 9781603271202 ; 1-58829-805-1 ; 1603271201
    Database Catalogue ZB MED Medicine, Health

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    2012 A 2787 order for loan Magazin

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  3. Book: Botulinum toxin in the clinical management of cervical dystonia

    Comella, Cynthia L.

    (Neurology ; 55,12, Suppl. 5)

    2000  

    Author's details Cynthia L. Comella ..., suppl. ed
    Series title Neurology ; 55,12, Suppl. 5
    Collection
    Language English
    Size S35 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Hagerstown, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT012906853
    Database Catalogue ZB MED Medicine, Health

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    Ui II Zs 153 -55,12,Suppl.5- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Dystonia: Then and now.

    Comella, Cynthia L

    Parkinsonism & related disorders

    2018  Volume 46 Suppl 1, Page(s) S66–S69

    Abstract: Introduction: Dystonia is a rare disorder that has undergone extensive scientific investigation leading to a transformation of understanding over the past century.: Methods: This manuscript was prepared through a review of relevant literature for ... ...

    Abstract Introduction: Dystonia is a rare disorder that has undergone extensive scientific investigation leading to a transformation of understanding over the past century.
    Methods: This manuscript was prepared through a review of relevant literature for each topic.
    Results: Historically dystonia was considered the manifestation of psychiatric disorders. Subsequently, investigations have firmly established this as a neurological disorder. Though electrophysiological and imaging, dystonia is thought to arise from a loss inhibition of motor programs, defective sensorimotor integration and abnormal plasticity. The genetic studies in dystonia have revealed the hereditary nature of many forms of familial dystonia. Treatment of dystonia has focused primarily on botulinum toxin for focal and segmental dystonia and deep brain stimulation of the globus pallidus interna for generalized and medically refractory focal dystonia.
    Conclusion: The progress in dystonia in the past century has revised the concepts of this disorder, increased knowledge of genetics and underlying pathophysiology, and provides new therapeutic targets. To promote future research the development of diagnostic criteria, biomarkers and validated rating scales for each form of dystonia is essential.
    MeSH term(s) Dystonia/history ; Dystonia/pathology ; Dystonia/physiopathology ; Dystonia/therapy ; History, 20th Century ; History, 21st Century ; Humans
    Language English
    Publishing date 2018-01
    Publishing country England
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2017.06.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4553: Show issues Location:
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    Zs.MO 420: Show issues

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  5. Article ; Online: Systematic review of botulinum toxin treatment for oromandibular dystonia.

    Comella, Cynthia L

    Toxicon : official journal of the International Society on Toxinology

    2018  Volume 147, Page(s) 96–99

    Abstract: Oromandibular dystonia (OMD) is an isolated focal dystonia that affects the muscles of the jaw, lower face and tongue. It is a rare disorder but is associated with significant impairment in quality of life. Treatment with oral medications has not been ... ...

    Abstract Oromandibular dystonia (OMD) is an isolated focal dystonia that affects the muscles of the jaw, lower face and tongue. It is a rare disorder but is associated with significant impairment in quality of life. Treatment with oral medications has not been successful. Surgical interventions, such as deep brain stimulation, may be of benefit but have not been adequately evaluated. Currently, botulinum toxin (BoNT) injections are regarded as the treatment of choice for OMD. However, the evidence supporting this is not available. Most studies are open label, observational studies, longitudinal clinical experience, case reports or retrospective analysis. From the available studies, OMD is responsive to appropriately targeted BoNT injections. Jaw closing dystonia responds the most robustly. Jaw opening dystonia is more complex to inject, but clinical experience is consistent with benefit. Lingual dystonia is the most difficult because injections into tongue muscles frequently give rise to dysphagia. More controlled studies are required to establish BoNT as an effective treatment for OMD.
    MeSH term(s) Botulinum Toxins/therapeutic use ; Dystonia/drug therapy ; Humans ; Masticatory Muscles/drug effects ; Masticatory Muscles/physiopathology ; Neuromuscular Agents/therapeutic use
    Chemical Substances Neuromuscular Agents ; Botulinum Toxins (EC 3.4.24.69)
    Language English
    Publishing date 2018-02-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
    DOI 10.1016/j.toxicon.2018.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Therapeutic Benefit of Sensory Trick in Cervical Dystonia.

    Mahajan, Abhimanyu / Gonzalez, David A / Stebbins, Glenn T / Comella, Cynthia

    Movement disorders clinical practice

    2023  Volume 10, Issue 11, Page(s) 1666–1670

    Abstract: Background: Sensory tricks (STs) are voluntary maneuvers that dampen the abnormal movement in cervical dystonia (CD).: Objectives: To investigate the effect of ST on CD severity and treatment.: Methods: Data on 1039 individuals with a modified ... ...

    Abstract Background: Sensory tricks (STs) are voluntary maneuvers that dampen the abnormal movement in cervical dystonia (CD).
    Objectives: To investigate the effect of ST on CD severity and treatment.
    Methods: Data on 1039 individuals with a modified Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) score were extracted from the CD Patient Registry for Observation of OnabotulinumtoxinA (onabotA) Efficacy study. Univariate and multivariate models evaluated the direct and indirect impact of ST on CD severity and treatment, while controlling for confounds.
    Results: Complete ST was associated with a 10% lower mean onabotA dose. Absence of complete ST was associated with a higher onabotA dose after controlling for dystonia severity (OR = 1.37,
    Conclusions: ST is related to lower CD severity and toxin dose. It may have a direct effect on lowering toxin dose, independent of CD severity.
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Systematic review of botulinum toxin treatment for oromandibular dystonia

    Comella, Cynthia L

    Toxicon. 2018 June 01, v. 147

    2018  

    Abstract: Oromandibular dystonia (OMD) is an isolated focal dystonia that affects the muscles of the jaw, lower face and tongue. It is a rare disorder but is associated with significant impairment in quality of life. Treatment with oral medications has not been ... ...

    Abstract Oromandibular dystonia (OMD) is an isolated focal dystonia that affects the muscles of the jaw, lower face and tongue. It is a rare disorder but is associated with significant impairment in quality of life. Treatment with oral medications has not been successful. Surgical interventions, such as deep brain stimulation, may be of benefit but have not been adequately evaluated. Currently, botulinum toxin (BoNT) injections are regarded as the treatment of choice for OMD. However, the evidence supporting this is not available. Most studies are open label, observational studies, longitudinal clinical experience, case reports or retrospective analysis. From the available studies, OMD is responsive to appropriately targeted BoNT injections. Jaw closing dystonia responds the most robustly. Jaw opening dystonia is more complex to inject, but clinical experience is consistent with benefit. Lingual dystonia is the most difficult because injections into tongue muscles frequently give rise to dysphagia. More controlled studies are required to establish BoNT as an effective treatment for OMD.
    Keywords botulinum toxin ; brain ; case studies ; dysphagia ; face ; muscles ; observational studies ; quality of life ; retrospective studies ; systematic review ; tongue
    Language English
    Dates of publication 2018-0601
    Size p. 96-99.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
    DOI 10.1016/j.toxicon.2018.02.006
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Valbenazine in the treatment of tardive dyskinesia.

    Witek, Natalie / Comella, Cynthia

    Neurodegenerative disease management

    2019  Volume 9, Issue 2, Page(s) 73–81

    Abstract: Tardive dyskinesia (TD) is a bothersome and - at times, disabling - movement disorder associated with exposure to dopamine receptor antagonist medications. On 11 April 2017, valbenazine became the first US FDA-approved medication indicated for the ... ...

    Abstract Tardive dyskinesia (TD) is a bothersome and - at times, disabling - movement disorder associated with exposure to dopamine receptor antagonist medications. On 11 April 2017, valbenazine became the first US FDA-approved medication indicated for the treatment of TD. Valbenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor that decreases the abnormal movements of TD. The FDA considered valbenazine a breakthrough therapy in 2014 given its underlying mechanism and its importance in addressing an unmet need, as there were no available FDA-approved medications indicated for TD. The advantages of valbenazine include once-daily dosing and a rapid onset of effect within 2 weeks of treatment initiation.
    MeSH term(s) Adrenergic Uptake Inhibitors/pharmacology ; Dopamine Antagonists/adverse effects ; Humans ; Tardive Dyskinesia/chemically induced ; Tardive Dyskinesia/drug therapy ; Tetrabenazine/analogs & derivatives ; Tetrabenazine/pharmacology ; Valine/analogs & derivatives ; Valine/pharmacology ; Vesicular Monoamine Transport Proteins/antagonists & inhibitors
    Chemical Substances Adrenergic Uptake Inhibitors ; Dopamine Antagonists ; Vesicular Monoamine Transport Proteins ; valbenazine (54K37P50KH) ; Valine (HG18B9YRS7) ; Tetrabenazine (Z9O08YRN8O)
    Language English
    Publishing date 2019-02-06
    Publishing country England
    Document type Journal Article
    ISSN 1758-2032
    ISSN (online) 1758-2032
    DOI 10.2217/nmt-2019-0001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Dystonia: etiology, clinical features and treatment

    Brin, Mitchell F. / Comella, Cynthia L. / Jankovic, Joseph

    2004  

    Title variant Dystonia
    Author's details Mitchell F. Brin ; Cynthia Comella ; Joseph Jankovic
    Keywords Dystonia / etiology ; Dystonia / therapy ; Dystonia / physiopathology
    Language English
    Size VI, 262 S. : Ill.
    Publisher Lippincott, Williams & Wilkins
    Publishing place Philadelphia, Pa. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014144383
    ISBN 0-7817-4114-9 ; 978-0-7817-4114-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 4373 order for loan Magazin

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  10. Article ; Online: On demand therapy for Parkinson's disease patients: Opportunities and choices.

    Hauser, Robert A / LeWitt, Peter A / Comella, Cynthia L

    Postgraduate medicine

    2021  Volume 133, Issue 7, Page(s) 721–727

    Abstract: Levodopa is the most effective symptomatic treatment for Parkinson's disease (PD), but a major treatment challenge is that over time, many patients experience periods of return of PD symptoms intermittently through the day, known as OFF periods. OFF ... ...

    Abstract Levodopa is the most effective symptomatic treatment for Parkinson's disease (PD), but a major treatment challenge is that over time, many patients experience periods of return of PD symptoms intermittently through the day, known as OFF periods. OFF periods typically manifest as a return of motor symptoms but can also involve non-motor symptoms and these periods can disrupt good control despite optimization of the oral levodopa regimen. OFF periods emerge in large measure due to a shortening of the duration of clinical benefit from oral levodopa, thought to be related to a progressive loss of dopamine neurons and their ability to store and release levodopa-derived dopamine over many hours. The problem is further compounded by impaired absorption of oral levodopa due to gastroparesis and other factors limiting its uptake in the small intestine, including competition for uptake by meals and their protein content. On-demand therapies are now available for the treatment of OFF episodes in PD and are administered intermittently, on an as-needed basis, on top of the patient's maintenance medication regimen. To be useful, an on-demand medication should take effect more rapidly and reliably than oral levodopa. Options for on-demand therapy for OFF periods have recently increased with the approval of levodopa inhalation powder and sublingual apomorphine as alternatives to the older option of subcutaneous apomorphine injection, each of which avoids the gastrointestinal tract and its potential for absorption delay. On-demand therapy is now available for patients experiencing episodic or intermittent need for rapid and reliable onset of benefit. On-demand therapy may also provide an alternative to more invasive treatment such as infusion of levodopa/carbidopa intestinal gel and for patients whose OFF episodes are not controlled despite deep brain stimulation.
    MeSH term(s) Antiparkinson Agents/administration & dosage ; Antiparkinson Agents/therapeutic use ; Apomorphine/administration & dosage ; Apomorphine/therapeutic use ; Carbidopa/administration & dosage ; Carbidopa/therapeutic use ; Dopamine Agonists/administration & dosage ; Dopamine Agonists/therapeutic use ; Drug Administration Routes ; Drug Combinations ; Humans ; Levodopa/administration & dosage ; Levodopa/therapeutic use ; Parkinson Disease/drug therapy ; Parkinson Disease/physiopathology
    Chemical Substances Antiparkinson Agents ; Dopamine Agonists ; Drug Combinations ; carbidopa, levodopa drug combination ; Levodopa (46627O600J) ; Carbidopa (MNX7R8C5VO) ; Apomorphine (N21FAR7B4S)
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.1080/00325481.2021.1936087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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