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Article ; Online: Retrograde technique with intra-corporeal tie in difficult laparoscopic appendectomy - a video vignette.

Birindelli, A / Dester, S E / Compagnoni, B / Carrara, B / Taglietti, L

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2020 Volume 22, Issue 7, Page(s) 845–846

MeSH term(s)	Appendectomy ; Appendicitis/surgery ; Humans ; Laparoscopy
Language	English
Publishing date	2020-02-17
Publishing country	England
Document type	Letter ; Video-Audio Media
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.14990
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Article: The hERG1 Potassium Channel Behaves As Prognostic Factor In Gastric Dysplasia Endoscopic Samples.

Lastraioli, Elena / Romoli, Maria Raffaella / Iorio, Jessica / Lottini, Tiziano / Chiudinelli, Mariella / Bencivenga, Maria / Vindigni, Carla / Tomezzoli, Anna / De Manzoni, Giovanni / Compagnoni, Bruno / Manzi, Ilaria / Messerini, Luca / Saragoni, Luca / Arcangeli, Annarosa

OncoTargets and therapy

2019 Volume 12, Page(s) 9377–9384

Abstract: Purpose: Gastric cancer (GC) is still a relevant health issue worldwide. The identification of prognostic factors for progression of gastric dysplasia (GD), the main pre-cancerous lesion of the intestinal-type GC, is hence mandatory.: Patients and ... ...

Abstract	Purpose: Gastric cancer (GC) is still a relevant health issue worldwide. The identification of prognostic factors for progression of gastric dysplasia (GD), the main pre-cancerous lesion of the intestinal-type GC, is hence mandatory. Patients and methods: A cohort of 83 GD endoscopic samples belonging to Italian subjects was collected. hERG1 expression was evaluated by immunohistochemistry and scored 0-3, depending on the percentage of stained cells. Expression data were analysed in conjunction with clinico-pathological and survival data. Results: hERG1 turned out to be expressed in 67.47% (56 out of 83) of the GD samples. hERG1 expression was higher in high-grade GD compared to low-grade GD (29 out of 39, 74.36% vs 27 out of 44, 61.36%), although the statistical significance was not reached (P=0.246). No association emerged between hERG1 expression and clinical features of the patients (age, gender, localization, Conclusion: hERG1 is aberrantly expressed in human GD samples and has an impact on both PFS and OS, hence representing a novel prognostic marker for progression of GD towards GC of the intestinal histotype. Once properly validated, hERG1 detection could be included in the clinical practice, during endoscopic surveillance protocols, for the management of GD at higher risk of progression, as already proposed for Barrett's oesophagus.
Language	English
Publishing date	2019-11-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S226257
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Article: Struma ovari--a rare gynecological tumor.

Raina, A / Stasi, G / Monzio Compagnoni, B / Lodeville, D / Caresano, G / Longhini, E

Acta oncologica (Stockholm, Sweden)

1997 Volume 36, Issue 5, Page(s) 533–534

MeSH term(s)	Carcinoma, Papillary/pathology ; Female ; Follow-Up Studies ; Hair/pathology ; Humans ; Middle Aged ; Ovarian Neoplasms/pathology ; Sebum ; Struma Ovarii/pathology
Language	English
Publishing date	1997
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	0284-186X
ISSN	0284-186X
DOI	10.3109/02841869709001311
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Article: I diverticoli del tenue nell'adulto. Aspetti clinici e terapeutici. Presentazione di 2 casi e revisione della letteratura.

Monzio Compagnoni, B / Rusconi, A / Casagrande, A / Galimberti, A / Sansonetti, G M / Valente, M G / Ferrante, F

Minerva chirurgica

2001 Volume 56, Issue 4, Page(s) 399–403

Abstract: The true diverticula of the small bowell are a very rare observation in clinical practice; they have a malformative origin and, occasionally, are acquired, contrary to what observed in the colon, where they are frequently an acquired pathology. They can ... ...

Title translation	Small bowel diverticula in adults: clinical and therapeutic features. Report of 2 cases and review of the literature.
Abstract	The true diverticula of the small bowell are a very rare observation in clinical practice; they have a malformative origin and, occasionally, are acquired, contrary to what observed in the colon, where they are frequently an acquired pathology. They can involve the small bowel as a single lesion (Meckel's diverticulum), or as a segmentary disease (duodenal diverticula), or as a diffused diverticulosis. Generally they are asymptomatic and rarely they produce a true pathology. The symptomatic disease is primarily found in pediatric age and it requires a surgical procedure. This makes even more rare the diverticular pathology in the adult. The authors report 1 case of intestinal occlusion due to ileoileo-colic invagination arising from a Meckel's diverticulum and 1 case of intestinal occlusion in presence of a severe and acute diffuse diverticulosis of the small bowell, both in adult patients.
MeSH term(s)	Adult ; Aged ; Diverticulum/surgery ; Female ; Humans ; Intestine, Small ; Male
Language	Italian
Publishing date	2001-08
Publishing country	Italy
Document type	Case Reports ; English Abstract ; Journal Article ; Review
ZDB-ID	123603-9
ISSN	1827-1626 ; 0026-4733
ISSN (online)	1827-1626
ISSN	0026-4733
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Article: Contributo allo studio dei tumori dello spazio retroperitoneale.

Monzio Compagnoni, B / Tagliavini, A / Marinoni, P

Minerva chirurgica

1984 Volume 39, Issue 8, Page(s) 639–643

Title translation	Tumors of the retroperitoneal space.
MeSH term(s)	Adult ; Aged ; Child ; Female ; Humans ; Male ; Middle Aged ; Retroperitoneal Neoplasms/diagnosis ; Retroperitoneal Neoplasms/pathology ; Retroperitoneal Neoplasms/surgery
Language	Italian
Publishing date	1984-04-30
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	123603-9
ISSN	1827-1626 ; 0026-4733
ISSN (online)	1827-1626
ISSN	0026-4733
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Article ; Online: hERG1 behaves as biomarker of progression to adenocarcinoma in Barrett's esophagus and can be exploited for a novel endoscopic surveillance.

Lastraioli, Elena / Lottini, Tiziano / Iorio, Jessica / Freschi, Giancarlo / Fazi, Marilena / Duranti, Claudia / Carraresi, Laura / Messerini, Luca / Taddei, Antonio / Ringressi, Maria Novella / Salemme, Marianna / Villanacci, Vincenzo / Vindigni, Carla / Tomezzoli, Anna / La Mendola, Roberta / Bencivenga, Maria / Compagnoni, Bruno / Chiudinelli, Mariella / Saragoni, Luca /

Manzi, Ilaria / De Manzoni, Giovanni / Bechi, Paolo / Boni, Luca / Arcangeli, Annarosa

Oncotarget

2016 Volume 7, Issue 37, Page(s) 59535–59547

Abstract: Barrett's esophagus (BE) is the only well-known precursor lesion of esophageal adenocarcinoma (EA). The exact estimates of the annual progression rate from BE to EA vary from 0.07% to 3.6%. The identification of BE patients at higher risk to progress to ... ...

Abstract	Barrett's esophagus (BE) is the only well-known precursor lesion of esophageal adenocarcinoma (EA). The exact estimates of the annual progression rate from BE to EA vary from 0.07% to 3.6%. The identification of BE patients at higher risk to progress to EA is hence mandatory, although difficult to accomplish. In search of novel BE biomarkers we analyzed the efficacy of hERG1 potassium channels in predicting BE progression to EA. Once tested by immunohistochemistry (IHC) on bioptic samples, hERG1 was expressed in BE, and its expression levels increased during progression from BE to esophageal dysplasia (ED) and EA. hERG1 was also over-expressed in the metaplastic cells arising in BE lesions obtained in different BE mouse models, induced either surgically or chemically. Furthermore, transgenic mice which over express hERG1 in the whole gastrointestinal tract, developed BE lesions after an esophago-jejunal anastomosis more frequently, compared to controls. A case-control study was performed on 104 bioptic samples from newly diagnosed BE patients further followed up for at least 10 years. It emerged a statistically significant association between hERG1 expression status and risk of progression to EA. Finally, a novel fluorophore- conjugated recombinant single chain variable fragment antibody (scFv-hERG1-Alexa488) was tested on freshly collected live BE biopsies: it could recognize hERG1 positive samples, perfectly matching IHC data.Overall, hERG1 can be considered a novel BE biomarker to be exploited for a novel endoscopic surveillance protocol, either in biopsies or through endoscopy, to identify those BE patients with higher risk to progress to EA.
Language	English
Publishing date	2016-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.11149
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Article: Subacute combined degeneration and induction of ornithine decarboxylase in spinal cords of totally gastrectomized rats.

Scalabrino, G / Monzio-Compagnoni, B / Ferioli, M E / Lorenzini, E C / Chiodini, E / Candiani, R

Laboratory investigation; a journal of technical methods and pathology

1990 Volume 62, Issue 3, Page(s) 297–304

Abstract: Totally gastrectomized rats have been used to induce a spongy demyelination in the white matter of the spinal cord (SC) which is strongly reminiscent of that observed in subacute combined degeneration of human SC. Totally gastrectomized rats are deprived ...

Abstract	Totally gastrectomized rats have been used to induce a spongy demyelination in the white matter of the spinal cord (SC) which is strongly reminiscent of that observed in subacute combined degeneration of human SC. Totally gastrectomized rats are deprived of intrinsic factor and thereafter become deficient in cobalamin. Morphologically, the spongy demyelination of the white matter of the rat SC, was evident 2 months after total gastrectomy. Biochemically, we investigated the hypothesis that polyamine biosynthesis might be deranged in the rat SC with experimental subacute combined degeneration, since polyamines are well known to be bound to myelin in the mammalian central nervous system. We measured the levels of both the polyamine biosynthetic decarboxylases, L-ornithine decarboxylase (ODC) and S-adenosyl-L-methionine decarboxylase, the key points in the polyamine biosynthetic pathway, in these SC. There was a sharp increase in ODC activity in SC 2 months after total gastrectomy, without significant changes in S-adenosyl-L-methionine decarboxylase activity. The increase in ODC activity seems to be organ-specific and was not due to a proliferation of neuroglial cells. Interestingly enough, the same morphologic and biochemical features found in SC of 2-month-totally-gastrectomized rats were present also in SC of newborn rats, which indeed showed incomplete myelination, vacuolated appearance, and an ODC activity level higher than that of adult SC. Therefore, total gastrectomy seems to induce a type of regression in the SC of totally gastrectomized rats toward neonatal life, at least in terms of the degree of myelination and of ODC activity level. Biochemically, no changes in ODC activity were observed in SC of rats fed a cobalamin-deficient diet for 3 months. Morphologically, only a proliferation of neuroglial cells with a moderate demyelination was observed in SC of these rats maintained on a cobalamin-deficient diet for 3 months.
MeSH term(s)	Animals ; Carboxy-Lyases/biosynthesis ; Carboxy-Lyases/metabolism ; Enzyme Induction ; Folic Acid/blood ; Gastrectomy ; Male ; Nerve Degeneration ; Ornithine Decarboxylase/metabolism ; Polyamines/metabolism ; Rats ; Rats, Inbred Strains ; Spinal Cord/enzymology ; Spinal Cord/pathology ; Vitamin B 12/blood
Chemical Substances	Polyamines ; Folic Acid (935E97BOY8) ; Carboxy-Lyases (EC 4.1.1.-) ; Ornithine Decarboxylase (EC 4.1.1.17) ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	1990-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80178-1
ISSN	1530-0307 ; 0023-6837
ISSN (online)	1530-0307
ISSN	0023-6837
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Article: Subacute combined degeneration in the spinal cords of totally gastrectomized rats. Ornithine decarboxylase induction, cobalamin status, and astroglial reaction.

Scalabrino, G / Lorenzini, E C / Monzio-Compagnoni, B / Colombi, R P / Chiodini, E / Buccellato, F R

Laboratory investigation; a journal of technical methods and pathology

1995 Volume 72, Issue 1, Page(s) 114–123

Abstract: Background: The totally gastrectomized (TGX) rat is a new experimental model with which to produce widespread spongy vacuolation in spinal cord (SC) white matter, strongly reminiscent of that observed in subacute combined degeneration (SCD) of human SC.! ...

Abstract	Background: The totally gastrectomized (TGX) rat is a new experimental model with which to produce widespread spongy vacuolation in spinal cord (SC) white matter, strongly reminiscent of that observed in subacute combined degeneration (SCD) of human SC. Experimental design: We did in long-term experiments combined biochemical and histologic studies on SCs from both TGX-rats and rats fed a cobalamin-deficient (Cbl-D) diet. We also investigated the effects of single in vivo administration of some neurotrophic growth factors on the activity of L-ornithine decarboxylase (ODC) (the key-point in the polyamine biosynthetic pathway) in rat SC. Results: Biochemically, ODC activity was still induced 3 and 6 months after total gastrectomy (TG), while it did not change significantly even after 9 months of feeding a Cbl-D diet. Both TG and feeding the Cbl-D diet greatly decreased the cobalamin level in both serum and SC, although these decreases occurred more slowly in rats fed a Cbl-D diet. Nerve growth factor did not induce ODC in either Cbl-D myeloneuropathy; epidermal growth factor induced ODC in both Cbl-D myeloneuropathies. Basic fibroblast growth factor induced SC ODC only in TGX-rats. Histologically, spongy vacuolation was still widespread 3 and 6 months after TG, while it was spotty even after 9 months of feeding a Cbl-D diet. There was massively increased staining of astrocytes positive for glial fibrillary acidic protein, mainly in the gray matter, in both Cbl-D myeloneuropathies. Finally, repeated in vivo injections of cobalamin to TGX rats only partially reduced ODC induction, the severity of spongy vacuolation, and the increase in glial fibrillary acidic protein-positive astrocytes. Conclusions: These results suggest: (a) ODC induction is a persistent and inherent feature in the TG-induced SCD of rat SC; (b) an increase in glial fibrillary acidic protein positive astrocytes in rat SC is not mandatorily connected with an increase in polyamine biosynthesis; (c) a mere deficiency of Cbl seems to be not the only key-point in the pathogenesis of the ODC induction and of the SCD-like lesions, both brought about in rat SC by TG.
MeSH term(s)	Animals ; Astrocytes/pathology ; Enzyme Induction/physiology ; Gastrectomy ; Glial Fibrillary Acidic Protein/analysis ; Male ; Nerve Degeneration/drug effects ; Nerve Growth Factors/biosynthesis ; Ornithine Decarboxylase/biosynthesis ; Ornithine Decarboxylase/physiology ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/drug effects ; Spinal Cord/pathology ; Vitamin B 12/pharmacology ; Vitamin B 12 Deficiency/etiology ; Vitamin B 12 Deficiency/pathology
Chemical Substances	Glial Fibrillary Acidic Protein ; Nerve Growth Factors ; Ornithine Decarboxylase (EC 4.1.1.17) ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	1995-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80178-1
ISSN	1530-0307 ; 0023-6837
ISSN (online)	1530-0307
ISSN	0023-6837
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Article: Ernia diaframmatica post-traumatica tardiva: una rara causa di occlusione colica.

Galimberti, A / Casagrande, A / Compagnoni, B M / Sansonetti, G / Rusconi, A / Grassi, M / Ferrante, F

Chirurgia italiana

2001 Volume 53, Issue 4, Page(s) 551–554

Abstract: Traumatic diaphragmatic rupture is not an uncommon problem, particularly in the last few years because of the increasing number of road accidents, improved diagnostic techniques and resuscitation techniques after serious traumas. In a certain number of ... ...

Title translation	Late post-traumatic diaphragmatic hernia: unusual cause of colonic occlusion.
Abstract	Traumatic diaphragmatic rupture is not an uncommon problem, particularly in the last few years because of the increasing number of road accidents, improved diagnostic techniques and resuscitation techniques after serious traumas. In a certain number of cases, post-traumatic diaphragmatic hernias may become clinically manifest only months or years after thoracic or abdominal trauma and are still a challenge to surgeons because of the vague clinical symptoms and the diagnostic difficulties involved. The Authors report a case of acute colon occlusion due to diaphragmatic hernia 24 months after thoraco-abdominal trauma. None of the radiological or endoscopic examinations demonstrated the presence of diaphragmatic hernia. Laparoscopy showed a diaphragmatic rupture with incarceration of the left colonic segment. The laparoscopic procedure was converted for technical reasons and the diaphragmatic defect was closed with a primary suture.
MeSH term(s)	Adult ; Colonic Diseases/etiology ; Female ; Hernia, Diaphragmatic, Traumatic/complications ; Humans ; Intestinal Obstruction/etiology ; Time Factors
Language	Italian
Publishing date	2001-07
Publishing country	Italy
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	603591-7
ISSN	0009-4773
ISSN	0009-4773
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Article ; Online: Adjuvant chemotherapy in completely resected gastric cancer: a randomized phase III trial conducted by GOIRC.

Di Costanzo, Francesco / Gasperoni, Silvia / Manzione, Luigi / Bisagni, Giancarlo / Labianca, Roberto / Bravi, Stefano / Cortesi, Enrico / Carlini, Paolo / Bracci, Raffaella / Tomao, Silverio / Messerini, Luca / Arcangeli, Annarosa / Torri, Valter / Bilancia, Domenico / Floriani, Irene / Tonato, Maurizio / Dinota, Angelo / Strafiuso, Gennaro / Corgna, Enrichetta /

Porrozzi, Stella / Boni, Corrado / Rondini, Ermanno / Giunta, Alessandro / Monzio Compagnoni, Barbara / Biagioni, Franco / Cesari, Maurizio / Fornarini, Giuseppe / Nelli, Fabrizio / Carboni, Manlio / Cognetti, Francesco / Enzo, Maria Ruggeri / Piga, Andrea / Romiti, Adriana / Olivetti, Alessandra / Masoni, Luigi / De Stefanis, Marinella / Dalla Mola, Angelo / Camera, Salvatore / Recchia, Francesco / De Filippis, Sandro / Scipioni, Loreto / Zironi, Sandra / Luppi, Gabriele / Italia, Maurizio / Banducci, Stefano / Pisani Leretti, Andrea / Massidda, Bruno / Ionta, Maria Teresa / Nicolosi, Angelo / Canaletti, Rodolfo / Biscottini, Bruno / Grigniani, Fausto / Di Costanzo, Federica / Rovei, Rossella / Croce, Enrico / Carroccio, Rosalia / Gilli, Germana / Cavalli, Carla / Olgiati, Angelo / Pandolfi, Umberto / Rossetti, Riccardo / Natalini, Giovanni / Foa, Paolo / Oldani, Sabina / Bruno, Lorenzo / Cascinu, Stefano / Catalano, Giuseppina / Catalano, Vincenzo / Lungarotti, Ferdinando / Farris, Antonio / Sarobba, Maria Giuseppina / Trignano, Mario / Muscogiuri, Antonio / Francavilla, Fontana / Figoli, Franco / Leoni, Maurizio / Papiani, Giorgio / Orselli, Gianfranco / Antimi, Mauro / Bellini, Vincenzo / Cabassi, Alessandro / Contu, Antonio / Pazzola, Antonio / Frignano, Mario / Lastraioli, Elena / Saggese, Matilde / Bianchini, Diletta / Antonuzzo, Lorenzo / Mela, Micol / Camisa, Roberta

Journal of the National Cancer Institute

2008 Volume 100, Issue 6, Page(s) 388–398

Abstract: Background: Complete surgical resection of gastric cancer is potentially curative, but long-term survival is poor.: Methods: Patients with histologically proven adenocarcinoma of the stomach of stages IB, II, IIIA and B, or IV (T4N2M0) and treated ... ...

Abstract	Background: Complete surgical resection of gastric cancer is potentially curative, but long-term survival is poor. Methods: Patients with histologically proven adenocarcinoma of the stomach of stages IB, II, IIIA and B, or IV (T4N2M0) and treated with potentially curative surgery were randomly assigned to follow-up alone or to intravenous treatment with four cycles (repeated every 21 days) of PELF (cisplatin [40 mg/m(2), on days 1 and 5], epirubicin [30 mg/m(2), days 1 and 5], L-leucovorin [100 mg/m(2), days 1-4], and 5-fluorouracil [300 mg/m(2), days 1-4] in a hospital setting. Frequencies and severity of adverse events were determined. Overall survival (OS) and disease-free survival (DFS) were compared between the treatment arms using Kaplan-Meier analysis and a Cox proportional hazards regression model. All statistical tests were two-sided. Results: From January 1995 through September 2000, 258 patients were randomly assigned to chemotherapy (n = 130) or surgery alone (n = 128). Patient characteristics were well balanced between the two arms. Among those who received chemotherapy, grade 3 or 4 toxic effects including vomiting, mucositis, and diarrhea were experienced by 21.1%, 8.4%, and 11.8% of patients, respectively. Leucopenia, anemia, and thrombocytopenia of grade 3 or 4 were experienced by 20.3%, 3.3%, and 4.2% of patients, respectively. After a median follow-up of 72.8 months, 128 patients (49.6%) experienced recurrence and 139 (53.9%) deaths were observed, one toxicity-related. Relative to treatment with surgery alone, adjuvant chemotherapy did not increase disease-free survival (hazard ratio [HR] of recurrence = 0.92; 95% confidence interval [CI] = 0.66 to 1.27) or overall survival (HR of death = 0.90; 95% CI = 0.64 to 1.26). Conclusions: Our results failed to provide proof of an effect of adjuvant chemotherapy with PELF on overall survival or disease-free survival. The estimated effect of chemotherapy (10% reduction in the hazard of death or relapse) is modest and consistent with the results of meta-analyses of adjuvant chemotherapy without platinum agents.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/analysis ; Chemotherapy, Adjuvant ; Cisplatin/administration & dosage ; Diarrhea/chemically induced ; Disease-Free Survival ; Epirubicin/administration & dosage ; Female ; Fluorouracil/administration & dosage ; Gastrectomy/methods ; Hematologic Diseases/chemically induced ; Humans ; Immunohistochemistry ; Italy ; Kaplan-Meier Estimate ; Leucovorin/administration & dosage ; Lymph Node Excision ; Lymphatic Metastasis ; Male ; Middle Aged ; Mucositis/chemically induced ; Neoplasm Staging ; Patient Compliance ; Prognosis ; Proportional Hazards Models ; Stomach Neoplasms/chemistry ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Treatment Outcome ; Vomiting/chemically induced
Chemical Substances	Biomarkers, Tumor ; Epirubicin (3Z8479ZZ5X) ; Cisplatin (Q20Q21Q62J) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2008-03-19
Publishing country	United States
Document type	Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djn054
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