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  1. Article: Endoscopic vacuum therapy: management of upper gastrointestinal anastomotic leaks and esophageal perforations.

    de Armas Conde, María / Díaz-López, Carmen / Concepción-Martín, Vanessa / Borque-Barrera, María Del Pilar

    Revista espanola de enfermedades digestivas

    2024  

    Abstract: Background and study aims: Upper gastrointestinal tract (UGT) leaks are associated with severe morbidity and mortality. Endoluminal vacuum (EVAC) therapy is a promising approach for repairing effectively these defects. Our study describes the results ... ...

    Abstract Background and study aims: Upper gastrointestinal tract (UGT) leaks are associated with severe morbidity and mortality. Endoluminal vacuum (EVAC) therapy is a promising approach for repairing effectively these defects. Our study describes the results obtained from a series of cases treated with EVAC for the management of esophageal anastomotic (EA) leak following esophagectomy for cancer, gastroenteric (GE) anastomoses leak after bariatric surgery and esophageal perforation (EP).
    Patients and methods: We retrospectively analyzed ten patients who had an EA and GE anastomoses leaks and EP treated with EVAC. We described the results of the sample in terms of treatment failure, treatment duration, and number of EVAC replacements.
    Results: Five patients underwent esophagectomy with neoadjuvant radio-chemotherapy, one patient underwent gastrojejunal bypass bariatric surgery and there were four EP. The median size of mucosal defects was 6,9 mm. The median duration of treatment was thirteen days with 3,6 interventions performed, every three to four days. Treatment success rate was 70%. Treatment failure was 30%: two patients required surgery and in one case an endoluminal prosthesis.
    Conclusions: EVAC therapy is an appropriate treatment for the management of postoperative fistulas in the UGT. Longer treatments are associated with neoadjuvant chemoradiotherapy and larger fistulas.
    Language English
    Publishing date 2024-04-18
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2024.10424/2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Giant sigmoid diverticulum.

    de Armas-Conde, María / Hernández-Alonso, Ricardo / Concepción-Martín, Vanessa / Abellán-Fernández, Jorge / Padilla-Quintana, Javier / Menéndez-Moreno, Alejandro / Martínez-Blanco, Leynis Isabel / Barrera-Gómez, Manuel Ángel

    Revista espanola de enfermedades digestivas

    2023  Volume 115, Issue 9, Page(s) 536–537

    Abstract: Unlike acute diverticulitis, giant diverticulum larger than 4 cm is a rare entity with few cases described in the literature. We present a case of a 66-year-old male patient diagnosed with colonic diverticulosis. He presented to the emergency department ... ...

    Abstract Unlike acute diverticulitis, giant diverticulum larger than 4 cm is a rare entity with few cases described in the literature. We present a case of a 66-year-old male patient diagnosed with colonic diverticulosis. He presented to the emergency department with symptoms of acute abdomen and was diagnosed by CT scan with a 13x14 cm giant diverticulum showing signs of complication. Given the findings, an urgent surgical intervention was decided, and diverticulectomy at the diverticular neck was performed using an endostapler. The etiology of giant diverticula is related to a mechanism of one-way valve at the diverticular neck. Diagnosis poses a challenge as the clinical presentation is nonspecific. The imaging modality of choice is CT scan, which reveals a large cystic image dependent on the sigmoid colon. Definitive treatment is surgical, either by resecting the affected segment including the lesion or by performing a simple diverticulectomy in uncomplicated cases.
    MeSH term(s) Male ; Humans ; Aged ; Colon, Sigmoid/pathology ; Diverticulum, Colon/complications ; Diverticulum, Colon/diagnostic imaging ; Diverticulum, Colon/surgery ; Diverticulum/diagnostic imaging ; Diverticulum/surgery ; Diverticulum/complications ; Tomography, X-Ray Computed ; Diagnosis, Differential ; Diverticulitis/diagnostic imaging ; Diverticulitis/surgery
    Language English
    Publishing date 2023-08-01
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.9804/2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effective and alternative treatment of anastomotic leak after gastrojejunal bypass: endoluminal vacuum therapy.

    de Armas Conde, María / Rojas Estévez, Marta / Díaz López, Carmen / Concepción Martín, Vanessa / Gianchandani Moorjani, Rajesh / Borque Barrera, María Del Pilar / García Romero, Diana María / Moneva Arce, Modesto Enrique

    Revista espanola de enfermedades digestivas

    2023  Volume 116, Issue 1, Page(s) 52–53

    Abstract: Anastomotic leak (AL) after with Roux-en-Y gastric bypass (RYGB) has a morbidity rate to 53% and it can be potentially lethal (mortality rate from 0.5 to 10%). In these cases, surgery is usually a challenge, so in recent years minimally invasive ... ...

    Abstract Anastomotic leak (AL) after with Roux-en-Y gastric bypass (RYGB) has a morbidity rate to 53% and it can be potentially lethal (mortality rate from 0.5 to 10%). In these cases, surgery is usually a challenge, so in recent years minimally invasive endoscopic treatment is gaining ground. Endoluminal vacuum therapy (EVAC) is a promising treatment that is being used in esophagogastric and rectal surgery for the management of AL. We present the case of a patient on his 5th postoperative day of bariatric surgery (RYGB) with an acute abdomen. He was diagnosed of dehiscence of gastrojejunal anastomosis and he needed urgent surgery twice. Subsequently, in control CT, a new anastomotic leak is evidenced. However, given the clinical stability of the patient, it was decided to start EVAC type ESO-Sponge® placed by endoscopy. A total of 4 changes are made every 3-4 days with a total duration of treatment of 15 days. EVAC was removed when the defect presented a 1 mm sized.
    MeSH term(s) Male ; Humans ; Anastomotic Leak/surgery ; Negative-Pressure Wound Therapy ; Gastric Bypass/adverse effects ; Bariatric Surgery ; Endoscopy, Gastrointestinal ; Obesity, Morbid/surgery ; Retrospective Studies
    Language English
    Publishing date 2023-05-17
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.9675/2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: An uncommon cause of intestinal obstruction: Vanek's tumor.

    Hueso Mor, Alejandro / Díaz López, Carmen / Caballero Rodríguez, Eugenia / Storti, Natalia Carina / Gianchandani Moorjani, Rajesh / Concepción-Martín, Vanessa / Moneva Arce, Modesto Enrique / Barrera Gómez, Manuel

    Revista espanola de enfermedades digestivas

    2023  

    Abstract: Vanek's Tumor, also known as Inflammatory Fibroid Polyp (IFP), is a rare submucosal mesenchymal lesion with spindle cells and eosinophilic infiltration. Its etiology is unknown but linked to chronic cellular damage. IFP can develop in various ... ...

    Abstract Vanek's Tumor, also known as Inflammatory Fibroid Polyp (IFP), is a rare submucosal mesenchymal lesion with spindle cells and eosinophilic infiltration. Its etiology is unknown but linked to chronic cellular damage. IFP can develop in various gastrointestinal segments, most commonly in the gastric antrum (70%), small intestine (18-20%), colon, and rectum (4-7%). IFP are usually symptomless and are often found incidentally during colonoscopies or gastroscopies. Most cases can be treated with simple endoscopic resection. In rare cases where larger lesions over 1 cm are identified through endoscopic ultrasound without deeper layer involvement, submucosal endoscopic dissection can be done with good outcomes and minimal risk. Some polyps may cause dyspeptic, hemorrhagic, or obstructive symptoms based on size and location. We report a case of a 56-year-old patient with a 24-hour history of obstructive symptoms, including bowel cessation and vomiting. The patient also had abdominal pain and gradual weight loss over the past two months. Notably, the patient had a prior diagnosis of Crohn's disease 12 years ago, without treatment or continuous medical monitoring.
    Language English
    Publishing date 2023-11-06
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.9914/2023
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  5. Article ; Online: Efficacy and Safety of Intraoperative Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Colon Cancer: A Phase 3 Randomized Clinical Trial.

    Arjona-Sánchez, Alvaro / Espinosa-Redondo, Esther / Gutiérrez-Calvo, Alberto / Segura-Sampedro, Juan J / Pérez-Viejo, Estibalitz / Concepción-Martín, Vanessa / Sánchez-García, Susana / García-Fadrique, Alfonso / Prieto-Nieto, Isabel / Barrios-Sanchez, Pedro / Torres-Melero, Juan / Ramírez Faraco, Maria / Prada-Villaverde, Arancha / Carrasco-Campos, Joaquin / Artiles-Armas, Manuel / Villarejo-Campos, Pedro / Ortega-Pérez, Gloria / Boldo-Roda, Emrique / Sánchez-Hidalgo, Juan-Manuel /
    Casado-Adam, Angela / Rodríguez-Ortiz, Lidia / Aranda, Enrique / Cano-Osuna, Maria Teresa / Díaz-López, Cesar / Romero-Ruiz, Antonio / Briceño-Delgado, Javier / Rufián-Peña, Sebastian

    JAMA surgery

    2023  Volume 158, Issue 7, Page(s) 683–691

    Abstract: Importance: Peritoneal metastasis in patients with locally advanced colon cancer (T4 stage) is estimated to recur at a rate of approximately 25% at 3 years from surgical resection and is associated with poor prognosis. There is controversy regarding the ...

    Abstract Importance: Peritoneal metastasis in patients with locally advanced colon cancer (T4 stage) is estimated to recur at a rate of approximately 25% at 3 years from surgical resection and is associated with poor prognosis. There is controversy regarding the clinical benefit of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in these patients.
    Objective: To assess the efficacy and safety of intraoperative HIPEC in patients with locally advanced colon cancer.
    Design, setting, and participants: This open-label, phase 3 randomized clinical trial was conducted in 17 Spanish centers from November 15, 2015, to March 9, 2021. Enrolled patients were aged 18 to 75 years with locally advanced primary colon cancer diagnosed preoperatively (cT4N02M0).
    Interventions: Patients were randomly assigned 1:1 to receive cytoreduction plus HIPEC with mitomycin C (30 mg/m2 over 60 minutes; investigational group) or cytoreduction alone (comparator group), both followed by systemic adjuvant chemotherapy. Randomization of the intention-to-treat population was done via a web-based system, with stratification by treatment center and sex.
    Main outcomes and measures: The primary outcome was 3-year locoregional control (LC) rate, defined as the proportion of patients without peritoneal disease recurrence analyzed by intention to treat. Secondary end points were disease-free survival, overall survival, morbidity, and rate of toxic effects.
    Results: A total of 184 patients were recruited and randomized (investigational group, n = 89; comparator group, n = 95). The mean (SD) age was 61.5 (9.2) years, and 111 (60.3%) were male. Median duration of follow-up was 36 months (IQR, 27-36 months). Demographic and clinical characteristics were similar between groups. The 3-year LC rate was higher in the investigational group (97.6%) than in the comparator group (87.6%) (log-rank P = .03; hazard ratio [HR], 0.21; 95% CI, 0.05-0.95). No differences were observed in disease-free survival (investigational, 81.2%; comparator, 78.0%; log-rank P = .22; HR, 0.71; 95% CI, 0.41-1.22) or overall survival (investigational, 91.7%; comparator, 92.9%; log-rank P = .68; HR, 0.79; 95% CI, 0.26-2.37). The definitive subgroup with pT4 disease showed a pronounced benefit in 3-year LC rate after investigational treatment (investigational: 98.3%; comparator: 82.1%; log-rank P = .003; HR, 0.09; 95% CI, 0.01-0.70). No differences in morbidity or toxic effects between groups were observed.
    Conclusions and relevance: In this randomized clinical trial, the addition of HIPEC to complete surgical resection for locally advanced colon cancer improved the 3-year LC rate compared with surgery alone. This approach should be considered for patients with locally advanced colorectal cancer.
    Trial registration: ClinicalTrials.gov Identifier: NCT02614534.
    MeSH term(s) Humans ; Male ; Female ; Hyperthermic Intraperitoneal Chemotherapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Hyperthermia, Induced ; Neoplasm Recurrence, Local/pathology ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/surgery ; Chemotherapy, Adjuvant
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.0662
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  6. Article ; Online: Association between use of enhanced recovery after surgery protocols and postoperative complications after gastric surgery for cancer (POWER 4): a nationwide, prospective multicentre study.

    Ripollés-Melchor, Javier / Abad-Motos, Ane / Bruna-Esteban, Marcos / García-Nebreda, María / Otero-Martínez, Isabel / Abdel-Lah Fernández, Omar / Tormos-Pérez, María P / Paseiro-Crespo, Gloria / García-Álvarez, Raquel / A Mayo-Ossorio, María / Zugasti-Echarte, Orreaga / Nespereira-García, Paula / Gil-Gómez, Lucia / Logroño-Ejea, Margarita / Risco, Raquel / Parreño-Manchado, Felipe C / Gil-Trujillo, Silvia / Benito, Carmen / Jericó, Carlos /
    De-Miguel-Cabrera, María I / Ugarte-Sierra, Bakarne / Barragán-Serrano, Cristina / García-Erce, José A / Muñoz-Hernández, Henar / Río-Fernández, Sabela Del- / Herrero-Bogajo, María L / Espinosa-Moreno, Alma M / Concepción-Martín, Vanessa / Zorrilla-Vaca, Andrés / Vaquero-Pérez, Laura / Mojarro, Irene / Llácer-Pérez, Manuel / Gómez-Viana, Leticia / Fernández-Martín, María T / Abad-Gurumeta, Alfredo / Ferrando-Ortolà, Carlos / Ramírez-Rodríguez, José M / Aldecoa, César

    Cirugia espanola

    2023  Volume 101, Issue 10, Page(s) 665–677

    Abstract: Introduction: The effectiveness of the Enhanced Recovery After Surgery (ERAS) protocols in gastric cancer surgery remains controversial.: Methods: Multicentre prospective cohort study of adult patients undergoing surgery for gastric cancer. Adherence ...

    Abstract Introduction: The effectiveness of the Enhanced Recovery After Surgery (ERAS) protocols in gastric cancer surgery remains controversial.
    Methods: Multicentre prospective cohort study of adult patients undergoing surgery for gastric cancer. Adherence with 22 individual components of ERAS pathways were assessed in all patients, regardless of whether they were treated in a self-designed ERAS centre. Each centre had a three-month recruitment period between October 2019 and September 2020. The primary outcome was moderate-to-severe postoperative complications within 30 days after surgery. Secondary outcomes were overall postoperative complications, adherence to the ERAS pathway, 30 day-mortality and hospital length of stay (LOS).
    Results: A total of 743 patients in 72 Spanish hospitals were included, 211 of them (28.4 %) from self-declared ERAS centres. A total of 245 patients (33 %) experienced postoperative complications, graded as moderate-to-severe complications in 172 patients (23.1 %). There were no differences in the incidence of moderate-to-severe complications (22.3% vs. 23.5%; OR, 0.92 (95% CI, 0.59 to 1.41); P = 0.068), or overall postoperative complications between the self-declared ERAS and non-ERAS groups (33.6% vs. 32.7%; OR, 1.05 (95 % CI, 0.70 to 1.56); P = 0.825). The overall rate of adherence to the ERAS pathway was 52% [IQR 45 to 60]. There were no differences in postoperative outcomes between higher (Q1, > 60 %) and lower (Q4, ≤ 45 %) ERAS adherence quartiles.
    Conclusions: Neither the partial application of perioperative ERAS measures nor treatment in self-designated ERAS centres improved postoperative outcomes in patients undergoing gastric surgery for cancer.
    Trial registration: ClinicalTrials.gov Identifier NCT03865810.
    MeSH term(s) Adult ; Humans ; Enhanced Recovery After Surgery ; Perioperative Care ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prospective Studies ; Stomach Neoplasms/surgery ; Stomach Neoplasms/complications
    Language English
    Publishing date 2023-04-23
    Publishing country Spain
    Document type Journal Article ; Multicenter Study
    ISSN 2173-5077
    ISSN (online) 2173-5077
    DOI 10.1016/j.cireng.2023.04.011
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  7. Article ; Online: HIPECT4: multicentre, randomized clinical trial to evaluate safety and efficacy of Hyperthermic intra-peritoneal chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma.

    Arjona-Sánchez, A / Barrios, P / Boldo-Roda, E / Camps, B / Carrasco-Campos, J / Concepción Martín, V / García-Fadrique, A / Gutiérrez-Calvo, A / Morales, R / Ortega-Pérez, G / Pérez-Viejo, E / Prada-Villaverde, A / Torres-Melero, J / Vicente, E / Villarejo-Campos, P / Sánchez-Hidalgo, J M / Casado-Adam, A / García-Martin, Ruben / Medina, Manuel /
    Caro, T / Villar, C / Aranda, Enrique / Cano-Osuna, M T / Díaz-López, C / Torres-Tordera, E / Briceño-Delgado, F J / Rufián-Peña, S

    BMC cancer

    2018  Volume 18, Issue 1, Page(s) 183

    Abstract: Background: Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6%. There are promising results ... ...

    Abstract Background: Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6%. There are promising results using prophylactic HIPEC in this group of patients, and it is estimated that up to 26% of all T4 colon cancer could benefit from this treatment with a minimal morbidity. Adjuvant HIPEC is effective to avoid the possibility of peritoneal seeding after surgical resection. Taking into account these results and the cumulative experience in HIPEC use, we will lead a randomized controlled trial to determine the effectiveness and safety of adjuvant treatment with HIPEC vs. standard treatment in patients with colon cancer at high risk of peritoneal recurrence (pT4).
    Methods/design: The aim of this study is to determine the effectiveness and safety of adjuvant HIPEC in preventing the development of PC in patients with colon cancer with a high risk of peritoneal recurrence (cT4). This study will be carried out in 15 Spanish HIPEC centres. Eligible for inclusion are patients who underwent curative resection for cT4NxM0 stage colon cancer. After resection of the primary tumour, 200 patients will be randomized to adjuvant HIPEC followed by routine adjuvant systemic chemotherapy in the experimental arm, or to systemic chemotherapy only in the control arm. Adjuvant HIPEC will be performed simultaneously after the primary resection. Mitomycin C will be used as chemotherapeutic agent, for 60 min at 42-43 °C. Primary endpoint is loco-regional control (LC) in months and the rate of loco-regional control (%LC) at 12 months and 36 months after resection.
    Discussion: We assumed that adjuvant HIPEC will reduce the expected absolute risk of peritoneal recurrence from 36% to 18% at 36 months for T4 colon-rectal carcinoma.
    Trial registration: NCT02614534 ( clinicaltrial.gov ) Nov-2015.
    MeSH term(s) Adult ; Aged ; Antibiotics, Antineoplastic/therapeutic use ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/therapy ; Combined Modality Therapy ; Female ; Humans ; Hyperthermia, Induced/methods ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Mitomycin/therapeutic use ; Treatment Outcome ; Young Adult
    Chemical Substances Antibiotics, Antineoplastic ; Mitomycin (50SG953SK6)
    Language English
    Publishing date 2018-02-13
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-018-4096-0
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  8. Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

    Nepogodiev, D / Bhangu, A / Glasbey, JC / Li, E / Omar, OM / Simoes, JFF / Abbott, TEF / Alser, O / Arnaud, AP / Bankhead-Kendall, BK / Breen, KA / Cunha, MF / Davidson, GH / Di Saverio, S / Gallo, G / Griffiths, EA / Gujjuri, RR / Hutchinson, PJ / Kaafarani, HMA /
    Lederhuber, H / Löffler, MW / Mashbari, HN / Minaya-Bravo, A / Morton, DG / Moszkowicz, D / Pata, F / Tsoulfas, G / Venn, ML / Cox, D / Roslani, AC / Alakaloko, F / de Vries, JPPM / Aaraj, MA / Abbott, SJ / Abdalla, MOM / Abdelaal, AS / Ademuyiwa, AO / Aherne, TM / Ali, OM / Alkadeeki, GZ / Almeida, AC / Alrahawy, MM / Ambler, GK / Alameer, E / Andreani, SM / De Andrés-Asenjo, B / Antonanzas, LL / Aoun, SG / Ashoush, FM / Augestad, KM / Avellana, RB / Ayeni, FA / Ayorinde, JOO / Babu, BH / Baig, MMAS / Bajomo, OM / Baker, OJ / Baker, MP / Baldwin, AJ / Ban, VS / Baron, RD / Barranquero, AG / Barry, CP / DI Bartolomeo, A / Bass, GA / Bath, MF / Batjer, HH / Beamish, AJ / Belgaumkar, AP / Bence, MN / Benson, RA / Bernal-Sprekelsen, JC / Bhama, AR / Bhavaraju, AV / Biffl, WL / Blundell, CM / Boddy, AP / Borgstein, ABJ / Bosanquet, DC / Bosch, KD / Bouhuwaish, AEM / Bozkurt, MA / Brathwaite, CEM / Brown, BC / Brown, OD / Brown, AK / Buarque, IL / Bueno-Ca nones, AD / Bulugma, MR / Burke, JR / Byrne, MHV / Cagigal-Ortega, EP / Callcut, RA / DI Candido, F / Canova, ME / Carlos, WJ / Caruana, EJ / Cato, LD / Catton, AB / Ceretti, AP / Chase, TJG / Chiara, FD / Chowdhury, AH / Chung, EA / Cicerchia, PM / Clough, ECS / Coleman, NL / Collins, CG / Collins, ML / Colonna, ET / Comini, LV / Coughlin, PA / Cruzado, LFG / Davidson, BR / Davies, RJ / Davies, EJ / Davis, NF / Dawson, BE / Dean, BJF / Delgado, MGC / Diaz, JJ / Dickson, KE / Diez-Alonso, MM / Dixon, JR / Doe, MJ / Drake, TD / Drake, FT / Duffy, JP / Dunne, DFJ / Dunne, NJM / Durán-Mu noz-Cruzado, VM / Durst, AZE / Eardley, NJ / Edwards, JG / Elfallal, AH / Elfiky, MMA / Elliott, JA / Emile, SH / Emslie, KM / Endorf, FW / Engel, JL / Enjuto, DT / Etchill, EW / Evans, JP / Fahey, BA / Faria, CS / Feo, CV / Ferguson, HJM / Fernandez, BD / Fernandez, AG / Fernández, AJ / Fernández-Pacheco, BC / Fitzgerald, JE / Fonsi, GB / Font, RF / Fowler, AL / Fretwell, KR / Fructuoso, LS / Fusai, GK / Garcia, MH / Garcia-Ure na, MA / Gill, CK / Gisbertz, SS / Del Giudice, R / Giuffrida, MC / Di Giuseppe, M / Gómez, MF / Guariglia, CA / Hainsworth, AJ / Hall, BJ / Hall, JRW / Hammond, JS / Haqqani, MH / Harrison, EM / Hazelton, JP / van Heinsbergen, M / Hill, ADK / Hing, CB / Hirji, SA / Ho, MWS / Holbrook, CM / Holme, TJ / Hopkins, JC / Hopkinson, DN / Hossain, FS / Hudson, VE / Hughes, JL / Hwang, ES / Ibrahim, MAH / Isolani, SM / Jenkinson, MD / Jenny, HE / Jeyaretna, DS / Jones, RP / Jones, AP / Jonker, PKC / Jönsson, ML / Joyce, DP / Kalkwarf, KJ / Kamarajah, SK / El Kassas, M / Kavanagh, DO / Keatley, JM / Khalefa, MA / Khan, JS / Kirmani, BH / Kisiel, AP / Kouris, SM / Kowal, MR / Labib, PL / Larkin, JO / Lauscher, JC / Leclercq, WKG / Ledesma, FSJ / Leite-Moreira, AM / Leung, EYL / Lewis, SE / Lima, MJA / Lin, DJ / Liu, HH / Lowery, AJ / Lozano, SM / Luney, CR / Maia, MMA / Mariani, NM / Marino, MV / Marra, AA / Marsh, CL / Martin, RCG / McCluney, SJ / McIntyre, RC / Mckay, SC / McKevitt, KL / 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    an international cohort study

    2020  

    Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

    Abstract Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
    Keywords covid19
    Language English
    Publisher Elsevier
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

    Nepogodiev D. / Bhangu A. / Glasbey J.C. / Li E. / Omar O.M. / Simoes J.F. / Abbott T.E. / Alser O. / Arnaud A.P. / Bankhead-Kendall B.K. / Breen K.A. / Cunha M.F. / Davidson G.H. / Di Saverio S. / Gallo G. / Griffiths E.A. / Gujjuri R.R. / Hutchinson P.J. / Kaafarani H.M. /
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G.S. / Mateo-Sierra O. / Martinez-Perez C. / Serrano Gonzalez J. / Hernandez Bartolome M.A. / Diaz Perez D. / Gutierrez Samaniego M. / Galindo Jara P. / Sharma N. / Smart N.J. / Keller D.S.

    an international cohort study

    2020  

    Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

    Abstract Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p<0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
    Keywords Adult ; Aged ; Betacoronavirus ; Coronavirus Infections ; Elective Surgical Procedures ; Emergency Medical Services ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia ; Viral ; Postoperative Complications ; Respiratory Tract Diseases ; Retrospective Studies ; Surgical Procedures ; Operative ; Young Adult ; covid19
    Subject code 610 ; 616
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

    Salomone, / Saverio, Di / Griffiths, / Ewen, A / Gujjuri, Rohan R / Hutchinson, Peter J / Kaafarani, Haytham MA / Lederhuber, Hans / Löffler, Markus W / Mashbari, Hassan N / Minaya-Bravo, Ana / Morton, Dion G / Moszkowicz, David / Pata, Francesco / Tsoulfas, George / Venn, Mary L / Cox, Daniel / Roslani, April C / Alakaloko, Felix /
    de Vries, Jean-Paul PM / Aaraj, Mahmoud A / Abbott, Tom EF / Abbott, Sarah J / Abdalla, Mutwakil OM / Abdelaal, Ahmed S / Ademuyiwa, Adesoji O / Aherne, Thomas M / Ali, Osman M / Alkadeeki, Ghadah Z / Almeida, Ana C / Alrahawy, Mahmoud M / Ambler, Graeme K / Alameer, Ehab / Andreani, Stefano M / De Andrés-Asenjo, Beatriz / Antonanzas, Leyre Lopez / Aoun, Salah G / Ashoush, Fouad M / Augestad, Knut Magne / Avellana, Rocio B / Ayeni, Funbi A / Ayorinde, John OO / Babu, Bheemanakone H / Baig, Mirza MAS / Bajomo, Oreoluwa M / Baker, Olivia J / Baker, Markus P / Baldwin, Alexander J / Ban, Vin Shen / Baron, Ryan D / Barranquero, Alberto G / Barry, Conor P / DI Bartolomeo, Alessandro / Bass, Gary A / Bath, Michael F / Batjer, H Hunt / Beamish, Andrew J / Belgaumkar, Ajay P / Bence, Matthew N / Benson, Ruth A / Bernal-Sprekelsen, Juan Carlos / Bhama, Anuradha R / Bhavaraju, Avi V / Biffl, Walter L / Blundell, Chris M / Boddy, Alexander P / Borgstein, Alexander BJ / Bosanquet, David C / Bosch, Karen D / Bouhuwaish, Ahmad EM / Bozkurt, Mehmet A / Brathwaite, Collin EM / Brown, Benjamin C / Brown, Oliver D / Brown, Allison K / Buarque, Igor Lima / Bueno-Cañones, Alejandro D / Bulugma, Mustafa R / Burke, Joshua R / Byrne, Matthew HV / Cagigal-Ortega, Elima P / Callcut, Rachael A / DI Candido, Francesca / Canova, Michaela E / Carlos, William J / Caruana, Edward J / Cato, Liam D / Catton, Andrew B / Ceretti, Andrea Pisani / Chase, Thomas JG / Chiara, Francesco Di / Chowdhury, Abeed H / Chung, Eric A / Cicerchia, Pierfranco M / Clough, Ethan CS / Coleman, Natasha L / Collins, Chris G / Collins, Michelle L / Colonna, Emily T / Comini, Lara V / Coughlin, Patrick A / Cruzado, Laura Fernández-Gomez / Davidson, Brian R / Davies, Richard J / Davies, Emma J / Davis, Niall F / Dawson, Brett E / Dean, Benjamin JF / Delgado, Maria Garcia-Conde / Diaz, Jose J / Dickson, Kathryn E / Diez-Alonso, Manuel M / Dixon, Jan R / Doe, Matthew J / Drake, Thomas D / Drake, Frederick T / Duffy, John P / Dunne, Declan FJ / Dunne, Naomi JM / Durán-Muñoz-Cruzado, Virginia M / Durst, Alexander ZE / Eardley, Nicola J / Edwards, John G / Elfallal, Ahmed H / Elfiky, Mahmoud MA / Elliott, Jessie A / Emile, Sameh H / Emslie, Katy M / Endorf, Frederick W / Engel, Jamie L / Enjuto, Diego T / Etchill, Eric W / Evans, Jonathan P / Fahey, Brian A / Faria, Carlos S / Feo, Carlo V / Ferguson, Henry JM / Fernandez, Beatriz Dieguez / Fernandez, Andres Garcia / Fernández, Antonio J / Fernández-Pacheco, Borja Camacho / Fitzgerald, J Edward / Fonsi, Giovanni B / Font, Roser Farré / Fowler, Amy L / Fretwell, Kenneth R / Fructuoso, Lorena Sanchon / Fusai, Giuseppe K / Garcia, Miguel Hernandez / Garcia-Ureña, Miguel Angel / Gill, Charn K / Gisbertz, Suzanne S / Del Giudice, Roberto / Giuffrida, Maria Carmela / Di Giuseppe, Matteo / Gómez, María Fanjul / Griffiths, Ewen A / Guariglia, Claudio A / Hainsworth, Alison J / Hall, Bria J / Hall, James RW / Hammond, John S / Haqqani, Maha H / Harrison, Ewen M / Hazelton, Joshua P / van Heinsbergen, Maarten / Hill, Arnold DK / Hing, Caroline B / Hirji, Sameer A / Ho, Michael WS / Holbrook, Charlotte M / Holme, Thomas J / Hopkins, James C / Hopkinson, David N / Hossain, Fahad S / Hudson, Victoria E / Hughes, Jane L / Hwang, E. Shelley / Ibrahim, Mohamed AH / Isolani, Simone M / Jenkinson, Michael D / Jenny, Hillary E / Jeyaretna, Deva S / Jones, Robert P / Jones, Andrew P / Jonker, Pascal KC / Jönsson, Maria L / Joyce, Doireann P / Kalkwarf, Kyle J / Kamarajah, Sivesh K / El Kassas, Mohamed / Kavanagh, Dara O / Keatley, James M / Khalefa, Mohamed A / Khan, Jim S / Kirmani, Bilal H / Kisiel, Aaron P / Kouris, Spyros Marinos / Kowal, Mikolaj R / Labib, Peter L / Larkin, John O / Lauscher, Johannes C / Leclercq, Wouter KG / Ledesma, Frances SJ / Leite-Moreira, André M / Leung, Elaine YL / Lewis, Sophia E / Lima, Maria João / Lin, Daniel J / Liu, Helen H / Lowery, Aoife J / Lozano, Saida Martel / Luney, Catriona R / Maia, Mariana Magalhães / Mariani, Nicolò M / Marino, Marco V / Marra, Angelo A / Marsh, Christopher L / Martin, Robert CG / McCluney, Simon J / McIntyre, Robert C / Mckay, Siobhan C / McKevitt, Kevin L / Meagher, Ashley D / Mehdi, Mohammad Q / Mehigan, Brian J / Gonzalez-De Miguel, Melania / De Miguel-Ardevines, Maria-Carmen / Mills, Sarah J / Mohan, Helen M / Moir, John AG / Monson, John RT / Monteiro, Joana M / Montella, Maria T / Montesinos, Cristina Soto / Morgom, Marwa M / Moura, Francisco S / Muguerza, Jose M / Murphy, Suzanne H / De Nardi, Paola / Naumann, David N / Neary, Paul C / Neely, David TA / Ng-Kamstra, Joshua S / Ngu, Albert WT / Nguyen, Truong A / Nita, George E / Nunes, Quentin M / Nygaard, Rachel M / O'Meara, Lindsay B / O'Neill, John R / Okafor, Barbara U / Olson, Steven A / Oo, Aung Y / Ormazabal, Pablo Collera / Osorio, Alexander L / Pachl, Max J / Parry, James T / Patel, Panna K / Pérez-Sánchez, Luis E / Pevidal, Ana Nogues / Pezzuto, Anna P / Philp, Matthew M / Pinkney, Thomas D / Pollok, Joerg M / Povey, Meical G / Poza, Alfredo Alonso / Rajgor, Amarkumar D / Rao, Jagan N / Raptis, Dimitri A / Rice, Henry E / Ridgway, Paul F / Rivas, Ana Munoz / Rodriguez-Sanjuan, Juan C / Rogers, Luke J / Da Roit, Anna / Rollett, Rebecca A / Romera, Jose L / Rooney, Siobhan M / Roxo, Vanessa I / Le Roy, Bertrand / Rubio, Eduardo E / Ruiz, Carolina Castro / Ruiz, Manuel Losada / Ryan, Éanna J / Saad, Abdel Rahman / Saeed, Samerah A / Salama, Hiba A / Salamah, Abdulrauf A / Sampietro, Gianluca M / Sarma, Diwakar R / Schaffer, Kathryn B / Schnitzbauer, Andreas A / Scurrah, Rachel J / Serevina, Olivia L / Serralheiro, Pedro A / Sewards, Joseph M / Shackcloth, Michael J / Shaw, Abigail V / Sheel, Andrea RG / Sica, Giuseppe S / De Simone, Veronica / Singh, Aminder A / Singh, Rabindra P / Skelly, Brendan L / Smith, Henry G / Sohail, Amir H / Spalding, Duncan R / Springford, Laurie R / Ssentongo, Anna E / Steinkamp, Pieter J / Stevens, Kent A / Stewart, Grant D / Stylianides, Nicholas A / Sullivan, Tom BB / Taher, Ahmed SA / Tamimy, Muhammad S / Tang, Alethea M / Tebala, Giovanni D / Tejero-Pintor, Francisco J / Thaha, Mohamed A / Thomas, Amy J / De Toma, Giorgio / La Torre, Filippo / Torres, Antonio J / Townshend, David N / Trout, Isobel M / Tucker, Sarah C / Ubhi, Harmony K / Vega, Viviana A / Velmahos, George C / Velopulos, Catherine G / Viswanath, Yirupaiahgari KS / Vivas, Alfredo A / Wade, Ryckie G / Wadley, Martin S / Wall, Joshua JS / Walters, Andrew M / Warren, Oliver J / Weerasinghe, Chamindri K / Wilkin, Richard JW / Williams, Katherine J / Winter, Stuart C / Wormald, Justin CR / Wright, Franklin L / Xyda, Souzana E / Young, Alastair L / Youssef, Mina MG / Yousuf, Farhat B / El Youzouri, Hanan / Zappa, Marco A / Abate, Emmanuele / Abdalaziz, Hossam / Abdelkarim, Mostafa / Abdou, Hossam / Aboelkassem-Ibrahim, Ahmad / Abuown, Ala / Acebes-Garcia, Fernando / Acharya, Metesh / Adamina, Michel / Addae-Boateng, Emmanuel / Aftab, Raiyyan / Agarwal, Arnav / Aguilar, José / Ahmed, Yousra / Aitken, Emma / Al-Azzawi, Marwa / Al-Embideen, Somya / Al-Masri, Mahmoud / Al-Najjar, Hani / Al-Sukaini, Ahmad / Alam, Ruhina / Alderson, Derek / Aliyeva, Zumrud / Aljanadi, Firas / Almasri, Murad / Alonso-Ortuño, Paula / Altintoprak, Fatih / Amira, Gamal / Amjad, Rabbia / Anania, Gabriele / Andabaka, Tatjana / Angelou, Dimitrios / Annamalai, Seethalakshmi / Annessi, Valerio / Anthoney, James / Anwar, Sibtain / Anwer, Mariyah / Aragon-Chamizo, Juan / Ardito, Antonella / Arigoni, Michele / Armao, Teodora / Arminio, Armando / Armstrong, Lara / Arnaud, Alexis / Asaad, Peter / Ashcroft, James / Ashmore, Christopher / Asqalan, Ahmad / Asti, Emanuele / Aubry, Emmanuelle / Aytac, Erman / Ayuso-Herrera, Esther / Baeza, Melody / Bailon-Cuadrado, Martin / Bakmaz, Bernarda / Baldi, Caterina / Baldini, Edoardo / Baldo, Stefano / Ballabio, Michele / Baloyiannis, Ioannis / Baltazar, Gerard / Bàmbina, Fabrizio / Bandiera, Alessandro / Barlow, Emma / Barmasse, Roberto / Barmpagianni, Christina / Baronio, Gianluca / Barra, Fabio / Bartsch, Anne-Marie / Basgaran, Amedra / Basha, Amr / Bashkirova, Varvara / Bastazza, Marco / Baumber, Rachel / Belcher, Elizabeth / Belvedere, Angela / Benítez-Linero, Inmaculada / Bergeat, Damien / Bernasconi, Matteo / Bhalla, Ashish / Bhutiani, Neal / Bianco, Federica / Bisagni, Pietro / Blake, Iain / Blanco-Colino, Ruth / Blazquez-Martin, Alma / Boal, Matthew / Bonavina, Luigi / Bonavina, Giulia / Bond-Smith, Giles / Booth, Karen / Borges, Filipe / Borghi, Felice / Bouchagier, Konstantinos / Bourke, Grainne / Boyle, Emily / Brachini, Gioia / Brain, Jessie / Brar, Amanpreet / Breckles, Lisa / Bretagnol, Frédéric / Brixton, Genevieve / Bruzzaniti, Placido / Bueser, Teofila / Burnside, Nathan / Caballero, Albert / Calcerrada-Alises, Enrique / Callahan, Miriam / Camarero, Enrique / Campagnaro, Tommaso / Campanelli, Michela / Candiani, Massimo / Cantalejo-Diaz, Miguel / Cao, Han / Capelli, Patrizio / Capizzi, Vita / Carcano, Giulio / Carissimi, Francesca / Carlini, Massimo / Carlucci, Michele / Carmichael, Heather / Carrasco, Milagros / Carrillo, Mariana / Carvello, Michele / Casati, Massimiliano / Castoro, Carlo / Catalan, Vanesa / Cavaleiro, Salomé / Cellerino, Paola / Centinaio, Giovanna / Cernei, Cristina / Cerro, Cristina / Cervellera, Maurizio / Chakrabortee, Sohini / Chamberlain, Stephanie / Chan, Jeffrey / Chang, Grace / Chaudhry, Dauod / Chebaro, Alexandre / Chen, David / Chetty, Govind / Chia, Zoe / Chiappini, Ambra / Chiarugi, Massimo / Chidambaram, Swathikan / Chiozza, Matteo / Cholewa, Hanna / Chong, Clara / Choolani-Bhojwani, Ekta / Christoforidis, Dimitri / Chui, Karen / Chung, Choyin / Cirillo, Bruno / Citterio, Davide / Clermidi, Pauline / Coccolini, Federico / Colletti, Gaia / Compagnoni, Bruno / Concepción-Martín, Vanesa / Confalonieri, Marco / Connolly, Hannah / Conso, Christel / Conti, Luigi / Cooper, Zara / Cordera, Fernando / Corral, Javier / Costa, Marta / Costanzi, Andrea / Cotsoglou, Christian / Cozza, Valerio / Cuming, Tamzin / Curtis, Miles / Cuschieri, Joseph / D'Agruma, Michele / D'Andrea, Giancarlo / Daliya, Prita / Dare, Oliver / Darko, Ebenezer / Day, Andrew / Dehal, Ahmed / Dehart, Dustin / Delgado-Oliver, Eduardo / Denning, Max / Desai, Anant / Desender, Liesbeth / Dester, Sara / Díaz-García, Alberto / Diaz-Peña, Patricia / Dousset, Bertrand / Doussot, Alexandre / Duchateau, Nicolas / Duff, Sarah / Dunning, Joel / Duque-Mallen, Victoria / Dziakova, Jana / Egan, Bridget / Egan, Richard / El-Ali, Abess / Elfeki, Hossam / Elhadi, Muhammed / Eljareh, Mohammed / Elkady, Ramy / Elkhafeefi, Fatimah / Elmore, Ugo / Elmoslemany, Tarek / Emmerson, Oliver / Enemosah, Ibrahim / English, Camilla / English, William / Escartin, Jorge / Estaire-Gomez, Mercedes / Evans, Luke / Evans, Jessica / Exley, Rebecca / Fabbri, Nicoló / Falco, Giuseppe / Familiari, Pietro / Fancellu, Alessandro / Farik, Shebani / Farrell, Tony / Fehervari, Matyas / Fell, Adam / Fernandez-Camuñas, Angel / Fernández-Marín, Reyes / Fernández-Martínez, María / Ferrara, Francesco / Ferrari, Guglielmo / Ferrero, Simone / Findlay, Laura / Fiore, Marco / Fiori, Enrico / Flatman, Michael / Flindall, Ian / Flor, Blas / Fontana, Tommaso / Ford, Samuel / Ford, David / Forlani, Stefano / Francone, Elisa / Frattaruolo, Colomba / Frio, Federico / Gagliano, Annalisa / Gagliardi, Filippo / Gahunia, Sukhpreet / Gaino, Francesca / Gala, Tanzeela / Galfrascoli, Elisa / Galimberti, Luca / Gallagher, Phoebe / Galleano, Raffaele / Galván-Pérez, Armando / Gammeri, Emanuele / Ganau, Mario / Garcés-García, Raúl / Garulli, Gianluca / Gascon-Ferrer, Isabel / Gattolin, Andrea / Gaujoux, Sebastien / Gentilli, Sergio / Georgiades, Fanourios / Ghanbari, Amir / Ghosh, Dhruv / Giacometti, Marco / Giblin, Anna-Victoria / Gilbert, Catherine / Giménez, Clara / Giorgakis, Emmanouil / Gipponi, Manuel / Glen, Paul / Goatly, Giles / Gobatti, Davide / Godbole, Chintamani / Gohil, Kajal / Gómez, Marcos / Gomez-Rosado, Juan-Carlos / Gonullu, Emre / Gonzalez-Gonzalez, Enrique / Gordini, Luca / Gracia, Isabel / Gracia-Roche, Carlos / Granieri, Stefano / Green, Susanna / Grivon, Manuela / Grove, Thomas / Guaglio, Marcello / Guaitoli, Eleonora / Guglielmi, Alfredo / Guha, Soumya / Gustavino, Claudio / Habeeb, Amir / Hagger, Robert / Hakmi, Hazim / Halkias, Constantine / Hall, Claire / Hampton, Matthew / Handa, Siddhartha / Hansen, Laura / Haq, Iram / Harky, Amer / Harries, Rhiannon / Harrison, Joseph / Hasan, Raashad / Hawari, Mohammad / Hawkin, Paul / Hebblethwaite, Bethany / Henriques, Susana / Heritage, Emily / Hernandez-Juara, Pilar / Herrero-Lopez, Maria / Hervieux, Erik / Heyd, Bruno / Higgs, Simon / Hitchman, Louise / Ho, Beatrice / Hogan, Aisling / Hölzle, Frank / Hossain, Tanvir / Hurt, Libor / Hutchinson, Peter / Iacob, Giulio / Iannone, Immacolata / Ibrahim, Sherif / Iovino, Domenico / Isik, Arda / Jafarova, Sevda / Jamil, Tahir / Jayaraju, Ullas / Jenner, Edward / Jimenez-Higuera, Elisa / Jimeno, Jaime / Jones, Mark / Judkins, Nicholas / Kalavrezos, Nicholas / Kalidindi, Venugopala / Kalkat, Maninder / Kamal, Mona / Kamphues, Carsten / Kang, Chong / Kara, Yasin / Karam, Edward / Karim, Ahmed / Kashora, Florence / Kearney, David / Khajuria, Apoorva / Khan, Umul / Khan, Azam / Khatri, Chetan / Kinnaman, Gabriel / Kinross, James / Kler, Aaron / Klimopoulos, Serafeim / Kocataş, Ali / Kolias, Angelos / Königsrainer, Alfred / Konsten, Joop / Kontovounisios, Christos / Kourdouli, Amar / Krishnan, Emily / Kristinsson, Sverrir / Kruijff, Schelto / Kudsk-Iversen, Søren / Kufeji, Dorothy / Kugler, Nadav / Kulkarni, Rugved / Kurihara, Hayato / Laface, Letizia / Lakkis, Zaher / Lami, Mariam / Landaluce-Olavarria, Aitor / Lapolla, Pierfrancesco / Lawani, Ismail / Lawday, Samuel / Lázaro, André / Lecolle, Katia / Leventoglu, Sezai / Li, Zoe / Liew, Ignatius / Lisi, Giorgio / Lizzi, Vincenzo / Lo, Terence / Lomiento, Daniele / Longhi, Marco / Lostis, Emilie / Lostoridis, Eftychios / Loubani, Mahmoud / Lowy-Benoliel, Alejandro / Lucianetti, Alessandro / Luke, Louis / Lunevicius, Raimundas / Luraghi, Marco / Lye, George / Mabrouk, Islam / Macchi, Alberto / MacDonald, Luisa / Machairas, Nikolaos / Madonini, Marco / Magowan, Drew / Maisonneuve, Emeline / Majkowska, Agata / Majkowski, Lawrence / Mak, Jason / Malabarba, Stefano / Malerba, Michele / Mannan, Syed / Manson, Joanna / Mansuri, Ahmer / Mantoglu, Baris / Manu, Nichola / Maqsood, Afnan / Marano, Alessandra / Marchbank, Adrian / Marcos-Santos, Pablo / Marrano, Enrico / Martin, Janet / Martin, Emmeline / Martin, Guy / Martin-Albo, Lorena / Martín-Román, Lorena / Martinelli, Fabio / Martínez-dePaz, Fernando / Martinez-German, Antonio / Martinez-Pinedo, Carlos / Martins, Ricardo / Marwan, Hisham / Marzi, Federica / Mathieu, Pierre / Matute-Najarro, Maria-Soledad / Maw, Andrew / Mazingi, Dennis / Mazzaferro, Vincenzo / McCanny, Andrew / McKenzie, Katherine / McLarty, Nicola / McPherson, Iain / Medina, Esther / Mediratta, Saniya / Medone, Marzia / Mehra, Gautam / Mele, Simone / Melero-Cortés, Lidia / Mendoza-Moreno, Fernando / Meneghini, Simona / Mercante, Giuseppe / Merdrignac, Aude / Merola, Stephen / Metallidis, Symeon / Michel, Martin / Migliore, Marco / Mihanovic, Jakov / Miller, Douglas / Mingoli, Andrea / Minto, Gary / Mirabella, Antonello / Misra, Nikhil / Mitrasinovic, Stefan / Miu, Victor / Moawad, Nader / Mochet, Sylvie / Modabber, Ali / Mohammad, Adam / Mohan, Midhun / Moliner-Sánchez, Carmen / Mongelli, Francesco / Monteleone, Michela / Montuori, Mauro / Moore, Rachel / Mora-Guzmán, Ismael / Morales, Xavier / Morales, Dieter / Morelli, Luca / Morelli, Lucia / Morgan, Richard / Morris, Chris / Mortini, Pietro / Mosca, Angelo / Motter, Dema / Moug, Susan / Mukherjee, Samrat / Najdy, Manhal / Nakas, Apostolos / Namazov, Ilgar / Naredla, Pradyumna / Nasef, Emmhamed / Nassa, Heeam / Nath, Rahul / Navarro-Sánchez, Antonio / Nazarian, Scarlet / Negri, Giampiero / Nehra, Deepika / Neil-Dwyer, Jason / Neri, Jacopo / Newton, Katy / Nikaj, Herald / Niquen, Milagros / Nobile, Sara / Nogueiro, Jorge / Ntirenganya, Faustin / Nugent, Michael / Núñez, Jordi / Ocaña, Juan / Okechukwu, Valentine / Oliva-Mompean, Fernando / Oliveira, Ana / Ollat, Didier / Onos, Lavinia / Osagie-Clouard, Liza / Osman, Khabab / Ottolina, Jessica / Ourieff, Jared / Outani, Oumaima / Oyewole, Bankole / Ozben, Volkan / Pacheco-Sanchez, David / Padilla-Valverde, David / Pai, Madhava / Paiella, Salvatore / Paisley, Samuel / Palini, Gianmarco / Palmeri, Matteo / Panahi, Pedram / Parente, Alessandro / Parlanti, Daniele / Parmar, Chetan / Pascual, Angela / Patel, Mahul / Pathak, Abhijit / Patil, Sangram / Pattyn, Piet / Peckham-Cooper, Adam / Pedrazzani, Corrado / Pellino, Gianluca / Peluso, Chiara / Pereira, André / Pereira-Neves, António / Perez-Diaz, Md / Pérez-González, Marta

    an international cohort study

    2020  

    Keywords covid19
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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