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  1. AU="Condel, Laura"
  2. AU="Biccler, Jorne"
  3. AU="Matthias Harbers"
  4. AU="Yang, Yuantong"
  5. AU="Carstens, Elma"
  6. AU="Wu, Xiaoxing"
  7. AU="Sato, Marika"
  8. AU="Rautiala, Petri"
  9. AU="Lin, Liqin"
  10. AU="Deborah Jean McClelland"
  11. AU="Brar, Ajit"
  12. AU="Aniyan Kumbalaparambil, Yesoda"
  13. AU=Carolan Michael
  14. AU="Pojskić, Mirza"
  15. AU="Tsujimoto, Sakura"
  16. AU=Di Tano Giuseppe
  17. AU="Khan, Sobia"
  18. AU="Kao, Yu-Yin"
  19. AU="Katerina Demnerova"
  20. AU="Sorrentino, I"
  21. AU="Pogge von Strandmann, Elke"
  22. AU="Lenzi, Kerry A"
  23. AU="Sakakura, Akira"
  24. AU="Nowell, Sian"
  25. AU="Mirko Cortese"
  26. AU="Klein, Steffen"
  27. AU="Koike, Toru"
  28. AU="Hung, Chung-Yu"
  29. AU="Muendlein, Hayley I"
  30. AU="Papavramidis, Theodosios"

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  1. Artikel ; Online: Comparison of oral, nebulized and combination antibiotic treatment of Bordetella bronchiseptica in baboons (Papio spp.).

    Clemmons, Elizabeth A / Chavez, Deborah / Condel, Laura / Dutton, John W / Price, Sharon / Lanford, Robert

    Journal of veterinary pharmacology and therapeutics

    2021  Band 44, Heft 5, Seite(n) 836–841

    Abstract: Incidence of Bordetella pertussis, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis ...

    Abstract Incidence of Bordetella pertussis, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis research, but like many mammals, they can be naturally infected with Bordetella bronchiseptica. Because B. bronchiseptica interferes with B. pertussis research, it must be excluded from baboons under consideration for enrollment in pertussis studies. In addition to research-related concerns, B. bronchiseptica can sometimes cause clinical disease in baboons and other nonhuman primates. This study examined the use of antibiotics to clear B. bronchiseptica in naturally infected baboons. Thirty-five juvenile baboons were divided into five treatment groups: oral sulfamethoxazole/trimethoprim (TMS), nebulized gentamicin (gentamicin), combination (TMS + gentamicin) in positive animals, combination (TMS + gentamicin) as a prophylactic in exposed animals and no treatment (control). Combination of oral TMS and nebulized gentamicin given to positive animals was most effective, producing long-term clearance in 11 out of 12 treated animals. To avoid unnecessary use of antibiotics, our primary management strategy is screening and separating to allow natural clearance and limiting exposure to non-infected animals, but this study investigates an antibiotic regimen that could be used in special circumstances.
    Mesh-Begriff(e) Animals ; Anti-Bacterial Agents/therapeutic use ; Bordetella bronchiseptica ; Bordetella pertussis ; Papio
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2021-05-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 435216-6
    ISSN 1365-2885 ; 0140-7783
    ISSN (online) 1365-2885
    ISSN 0140-7783
    DOI 10.1111/jvp.12975
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  2. Artikel: Comparison of oral, nebulized and combination antibiotic treatment of Bordetella bronchiseptica in baboons (Papio spp.)

    Clemmons, Elizabeth A. / Chavez, Deborah / Condel, Laura / Dutton, John W., III / Price, Sharon / Lanford, Robert

    Journal of veterinary pharmacology and therapeutics. 2021 Sept., v. 44, no. 5

    2021  

    Abstract: Incidence of Bordetella pertussis, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis ...

    Abstract Incidence of Bordetella pertussis, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis research, but like many mammals, they can be naturally infected with Bordetella bronchiseptica. Because B. bronchiseptica interferes with B. pertussis research, it must be excluded from baboons under consideration for enrollment in pertussis studies. In addition to research‐related concerns, B. bronchiseptica can sometimes cause clinical disease in baboons and other nonhuman primates. This study examined the use of antibiotics to clear B. bronchiseptica in naturally infected baboons. Thirty‐five juvenile baboons were divided into five treatment groups: oral sulfamethoxazole/trimethoprim (TMS), nebulized gentamicin (gentamicin), combination (TMS + gentamicin) in positive animals, combination (TMS + gentamicin) as a prophylactic in exposed animals and no treatment (control). Combination of oral TMS and nebulized gentamicin given to positive animals was most effective, producing long‐term clearance in 11 out of 12 treated animals. To avoid unnecessary use of antibiotics, our primary management strategy is screening and separating to allow natural clearance and limiting exposure to non‐infected animals, but this study investigates an antibiotic regimen that could be used in special circumstances.
    Schlagwörter Bordetella bronchiseptica ; Bordetella pertussis ; Papio ; atomization ; cough ; etiological agents ; gentamicin ; humans ; juveniles ; models ; pharmacology ; sulfamethoxazole ; trimethoprim ; vaccination
    Sprache Englisch
    Erscheinungsverlauf 2021-09
    Umfang p. 836-841.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 435216-6
    ISSN 1365-2885 ; 0140-7783
    ISSN (online) 1365-2885
    ISSN 0140-7783
    DOI 10.1111/jvp.12975
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

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  3. Artikel: Cellular Senescence in Aging Primates

    Herbig, Utz / Carey, Dee / Condel, Laura / Ferreira, Mark / Sedivy, John M

    Science. 2006 Mar. 3, v. 311, no. 5765

    2006  

    Abstract: The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as ... ...

    Abstract The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching >15% of all cells in very old individuals. In addition, the same cells contain activated ataxia-telangiectasia mutated kinase and heterochromatinized nuclei, confirming their senescent status.
    Schlagwörter biomarkers ; cell cycle checkpoints ; cell senescence ; fibroblasts ; longevity ; mammals ; Papio ; somatic cells ; telomeres
    Sprache Englisch
    Erscheinungsverlauf 2006-0303
    Umfang p. 1257.
    Erscheinungsort American Association for the Advancement of Science
    Dokumenttyp Artikel
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1122446
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Cellular senescence in aging primates.

    Herbig, Utz / Ferreira, Mark / Condel, Laura / Carey, Dee / Sedivy, John M

    Science (New York, N.Y.)

    2006  Band 311, Heft 5765, Seite(n) 1257

    Abstract: The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as ... ...

    Abstract The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching >15% of all cells in very old individuals. In addition, the same cells contain activated ataxia-telangiectasia mutated kinase and heterochromatinized nuclei, confirming their senescent status.
    Mesh-Begriff(e) Aging/physiology ; Animals ; Ataxia Telangiectasia Mutated Proteins ; Biomarkers ; Cell Cycle Proteins/metabolism ; Cellular Senescence/physiology ; DNA Damage ; DNA Replication ; DNA-Binding Proteins/metabolism ; Dermis/cytology ; Female ; Fibroblasts/cytology ; Fibroblasts/physiology ; Heterochromatin/metabolism ; Male ; Oxidative Stress ; Papio/physiology ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Telomere/physiology ; Tumor Suppressor Proteins/metabolism
    Chemische Substanzen Biomarkers ; Cell Cycle Proteins ; DNA-Binding Proteins ; Heterochromatin ; Tumor Suppressor Proteins ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2006-03-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1122446
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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