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  1. AU="Condie, L.W"
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  1. Article: Ten and ninety-day toxicity studies of 2,4-dimethylphenol in Sprague-Dawley rats

    Condie, L. W.

    Drug and Chemical Toxicology

    1993  Volume 16, Issue 4, Page(s) 351–368

    Abstract: Male and female Sprague-Dawley rats received 2,4-dimethylphenol daily by gavage for 10 or 90 consecutive days. The 10-day acute study doses were 0, 60, 120, 600 and 1200mg/kg; the 90-day subchronic study doses were 0, 60, 180 and 540mg/kg. Corn oil was ... ...

    Institution USA-Cincinnati, OH 45268 Ecological Monitoring Research Division, U.S. Environmental Protection Agency
    Abstract Male and female Sprague-Dawley rats received 2,4-dimethylphenol daily by gavage for 10 or 90 consecutive days. The 10-day acute study doses were 0, 60, 120, 600 and 1200mg/kg; the 90-day subchronic study doses were 0, 60, 180 and 540mg/kg. Corn oil was used as the vehicle. In the 10-day study, all the high dose animals died. At 600mg/kg there was a significant increase in relative liver weight in females and several significant alterations in hematologic and clinical chemistry values in both sexes. Histopathological examination revealed changes associated with the forestomach in all dose groups. The 90-day study had numerous compound-related deaths at the 540mg/kg level. In addition, the final body weight in high dose males and females was significantly less while absolute lung weights and relative liver weights in females, and relative brain, kidney and testes weights in males were also altered. Significant clinical chemistry findings in high dose animals (540mg/kg) included reduced creatinine and increased cholesterol in both sexes, with increased triglycerides and decreased AST in males only. Histopathologic evaluation revealed hyperkeratosis and epithelial hyperplasia of the forestomach in males and females in the middle and high-dose groups.
    Keywords Phenol ; Derivat ; Dosis-Wirkungs-Relation ; Leber ; Magen ; Koerpergewicht ; Geschlecht ; Tierexperiment ; Toxizitaet
    Language English
    Document type Article
    Database Social Medicine (SOMED)

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  2. Article: Target organ toxicology of halocarbons commonly found contaminating drinking water.

    Condie, L W

    The Science of the total environment

    1985  Volume 47, Page(s) 433–442

    Abstract: Some of the most frequent drinking water contaminants are organic halocarbons. This paper will initially summarize the target organ effects of three halocarbons: 1,2-dichloroethane, tetrachloroethylene, and trichloroethylene. Following the brief ... ...

    Abstract Some of the most frequent drinking water contaminants are organic halocarbons. This paper will initially summarize the target organ effects of three halocarbons: 1,2-dichloroethane, tetrachloroethylene, and trichloroethylene. Following the brief summaries, a more detailed description of the oral hepatoxicity of carbon tetrachloride is presented. Data are provided that indicate that the hepatotoxicity of carbon tetrachloride is enhanced when administered by corn oil gavage when compared to aqueous suspension gavage.
    MeSH term(s) Animals ; Carbon Tetrachloride Poisoning/enzymology ; Carbon Tetrachloride Poisoning/etiology ; Carbon Tetrachloride Poisoning/pathology ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/physiopathology ; Chronic Disease ; Ethylene Dichlorides/toxicity ; Female ; Humans ; Hydrocarbons, Halogenated/toxicity ; Liver/pathology ; Male ; Mice ; Rats ; Tetrachloroethylene/toxicity ; Trichloroethylene/toxicity ; Water Pollutants/toxicity ; Water Pollutants, Chemical/toxicity ; Water Supply/adverse effects ; Water Supply/analysis
    Chemical Substances Ethylene Dichlorides ; Hydrocarbons, Halogenated ; Water Pollutants ; Water Pollutants, Chemical ; Trichloroethylene (290YE8AR51) ; ethylene dichloride (55163IJI47) ; Tetrachloroethylene (TJ904HH8SN)
    Language English
    Publishing date 1985-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/0048-9697(85)90348-1
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  3. Article: Review of published studies of orally administered asbestos.

    Condie, L W

    Environmental health perspectives

    1983  Volume 53, Page(s) 3–9

    Abstract: There has been great public concern about the adverse health effects resulting from the presence of asbestos fibers in municipal drinking water supplies. This article reviews and summarizes the experimental findings of 11 published papers that have ... ...

    Abstract There has been great public concern about the adverse health effects resulting from the presence of asbestos fibers in municipal drinking water supplies. This article reviews and summarizes the experimental findings of 11 published papers that have evaluated the carcinogenic potential of asbestos following its ingestion. The long-term, high-level ingestion of various types of asbestos fibers in more than one animal species failed to produce any definite, reproducible, organ-specific carcinogenic effect.
    MeSH term(s) Administration, Oral ; Animals ; Asbestos/administration & dosage ; Asbestos/toxicity ; Asbestosis/etiology ; Cricetinae ; Humans ; Neoplasms, Experimental/etiology ; Rats ; Risk ; Time Factors ; Water Supply
    Chemical Substances Asbestos (1332-21-4)
    Language English
    Publishing date 1983-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/ehp.83533
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  4. Article: Toxicological problems associated with chlorine dioxide

    Condie, L. W.

    American Water Works Association J.

    1986  Volume 78, Issue 6, Page(s) 73–78

    Abstract: The toxicological hazards associated with disinfecting drinking water with either chlorine dioxide or chlorine are reviewed and compared. Adverse health effects shown in animal experiments as well as human poisoning incidents are reported. Toxicological ... ...

    Institution 26 West St. Clair St., USA Cincinnati, OH 45268 Health Effects Research Laboratory of the US Environmental Protection Agency
    Abstract The toxicological hazards associated with disinfecting drinking water with either chlorine dioxide or chlorine are reviewed and compared. Adverse health effects shown in animal experiments as well as human poisoning incidents are reported. Toxicological effects, which are associated with the disinfectants themselves and the products formed when the disinfectants react with organic material present in water, are considered.
    Keywords Chlorsauerstoff ; Trinkwasser ; Chlor ; Toxikologie ; Gesundheitsschaedlich
    Language English
    Document type Article
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  5. Article: Targes organ toxicology of halocarbons commonly found contaminating drinking water

    Condie, L. W.

    Science of the Total Environment

    1985  Volume 47, Page(s) 433–442

    Institution 26 West St. Clair, USA Cincinnati, Ohio 45268 U.S. Environmental Protection Agency
    Keywords Trinkwasser ; Verunreinigung ; Toxikologie ; Kwst. halogeniert ; Tetrachloraethylen ; Trichloraethylen ; Tetrachlormethan ; Leberkrankheit ; Versteckte Bibliographie
    Language English
    Document type Article
    ZDB-ID 121506-1
    ISSN 0048-9697 ; 1879-1026 ; 0048-9697
    ISSN (online) 0048-9697 ; 1879-1026
    ISSN 0048-9697
    Database Social Medicine (SOMED)

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  6. Article: Target organ toxicology of halocarbons commonly found contaminating drinking water

    Condie, L.W

    Science of the total environment. Dec 1985. v. 47

    1985  

    Keywords drinking water ; water pollution ; organic compounds ; toxicity
    Language English
    Dates of publication 1985-12
    Size p. 433-442.
    Document type Article
    Note Paper presented at the International Symposium "Organic Micropollutants in Drinking Water and Health, Amsterdam, The Netherlands, June 11-14, 1985.
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
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  7. Article: Review of published studies of orally administered asbestos

    Condie, L. W.

    Environmental Health Perspectives

    1983  Volume 53, Page(s) 3–9

    Abstract: There has been great public concern about the adverse health effects resulting from the presence of asbestos fibers in municipal drinking water supplies. this article reviews and summarizes the experimental findings of 11 published papers that have ... ...

    Institution USA Cincinnati, OH 45268 Health Effects Research Laboratory, US EPA
    Abstract There has been great public concern about the adverse health effects resulting from the presence of asbestos fibers in municipal drinking water supplies. this article reviews and summarizes the experimental findings of 11 published papers that have evaluated the carcinogenic potential of asbestos following its ingestion. The long-tern, high-level ingestion of various types of asbestos fibers in more than one animal species failed to produce any definite, reproducible, organ-specific carcinogenic effect.
    Keywords Oral ; Asbest ; Gesundheitsschaedlich ; Karzinogen ; Tierexperiment ; Trinkwasser
    Language English
    Document type Article
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    Database Social Medicine (SOMED)

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  8. Article: A test battery for screening behavioral teratogens in mice.

    Kallman, M J / Condie, L W

    Neurobehavioral toxicology and teratology

    1985  Volume 7, Issue 6, Page(s) 727–731

    Abstract: The assessment battery was developed for identifying teratogens in mice (CD-1, outbred strain) since many non-behavioral toxicologists prefer working with the mouse and because the mouse is less costly to house and feed. This approach emphasizes the ... ...

    Abstract The assessment battery was developed for identifying teratogens in mice (CD-1, outbred strain) since many non-behavioral toxicologists prefer working with the mouse and because the mouse is less costly to house and feed. This approach emphasizes the importance of adult toxicity data in the selection of exposure levels for teratologic studies and for interpreting behavioral teratogenic effects. Potential teratogen exposure is both prenatal and postnatal with the goal of identifying the need for more costly and time consuming, cross-fostering and critical period designs. The test battery includes the assessment of multiple behavioral capabilities, including physical landmarks, reflex development, motor capability and passive avoidance learning. We have found the behavioral capabilities of the mouse to be similar to those of the rat in variability and range of response. Our methodology has emphasized drinking water exposure to chemicals since we were involved in the evaluation of drinking water contaminants, but the battery should be amenable to any route of exposure.
    MeSH term(s) Aging ; Animals ; Avoidance Learning/drug effects ; Behavior, Animal/drug effects ; Body Weight/drug effects ; Drug Evaluation, Preclinical ; Female ; Gestational Age ; Mice ; Pregnancy ; Prenatal Exposure Delayed Effects ; Taste/drug effects ; Teratogens/toxicity
    Chemical Substances Teratogens
    Language English
    Publishing date 1985-11
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 604507-8
    ISSN 0275-1380
    ISSN 0275-1380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Cardiopathic effect of 1,2,3-trichloropropane after subacute and subchronic exposure in rats.

    Merrick, B A / Robinson, M / Condie, L W

    Journal of applied toxicology : JAT

    1991  Volume 11, Issue 3, Page(s) 179–187

    Abstract: 1,2,3-Trichloropropane (1,2,3-TCP) is an industrial water contaminant with potential for human exposure by the oral route. The systemic toxicology of 1,2,3-TCP was evaluated after subacute or subchronic exposure in male and female Sprague-Dawley rats. ... ...

    Abstract 1,2,3-Trichloropropane (1,2,3-TCP) is an industrial water contaminant with potential for human exposure by the oral route. The systemic toxicology of 1,2,3-TCP was evaluated after subacute or subchronic exposure in male and female Sprague-Dawley rats. Animals were treated with 0.01, 0.05, 0.20 and 0.80 mmol kg-1 day-1 for 10 days and 0.01, 0.05, 0.10 and 0.40 mmol kg-1 day-1 for 90 days. Chemical exposure was by oral gavage in corn oil. Lethality did not occur in either study. Toxicity was observed primarily in the high dose group of subacute and subchronically treated rats of both sexes. Weight gain suppression occurred at a dose of 0.8 mmol kg-1 (118 mg kg-1) after 10 days. After 90 days of exposure to 0.40 mmol kg-1, the final body weights were 81% and 86% of control values for males and females, respectively. When major organ weights were normalized by body weight, liver and kidney values were generally increased relative to control in the two highest dose groups after 10- and 90-day chemical exposure. Serum chemistries and histopathology indicated a mild hepatotoxic response to 1,2,3-TCP in the high dose group of each study but did not support any renal toxicity. Thymic weight reduction due to atrophy occurred at 10 days of exposure in high dose groups but was normal in all groups after the 90-day treatment. The primary histological finding in this study was an inflammation-associated cardiopathy produced by 1,2,3-TCP. Myocardial necrosis and degeneration occurred in a diffuse pattern with marked eosinophilia of affected cells. Male and female animals showed a cardiopathic response only at a dose of 0.8 mmol kg-1 1,2,3-TCP after the 10-day exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) Administration, Oral ; Animals ; Body Weight ; Dose-Response Relationship, Drug ; Female ; Heart/anatomy & histology ; Heart/drug effects ; Male ; Myocardium/pathology ; Necrosis ; Organ Size/drug effects ; Propane/analogs & derivatives ; Propane/toxicity ; Rats ; Rats, Inbred Strains ; Spleen/anatomy & histology ; Thymus Gland/anatomy & histology ; Time Factors
    Chemical Substances 1,2,3-trichloropropane (3MJ7QCK0Z0) ; Propane (T75W9911L6)
    Language English
    Publishing date 1991-06
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 604625-3
    ISSN 1099-1263 ; 0260-437X
    ISSN (online) 1099-1263
    ISSN 0260-437X
    DOI 10.1002/jat.2550110305
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  10. Article: Differing hepatotoxicity and lethality after subacute trichloroethylene exposure in aqueous or corn oil gavage vehicles in B6C3F1 mice

    Merrick, B.A / Robinson, M / Condie, L.W

    Journal of applied toxicology : JAT. Feb 1989. v. 9 (1)

    1989  

    Keywords corn oil ; liver ; toxicity ; mice
    Language English
    Dates of publication 1989-02
    Size p. 15-21.
    Document type Article
    ZDB-ID 604625-3
    ISSN 1099-1263 ; 0260-437X
    ISSN (online) 1099-1263
    ISSN 0260-437X
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