Article ; Online: Motor, cognitive and behavioural outcomes after neonatal hypoxic-ischaemic encephalopathy.
2024 Volume 100, Issue 2, Page(s) 104–114
Abstract: Introduction: The current neurodevelopmental status of patients with neonatal hypoxic-ischaemic encephalopathy (HIE) in Spain is unknown. Recent European studies highlight a shift of severe pathology towards mild motor disorders and emotional problems. ... ...
| Abstract | Introduction: The current neurodevelopmental status of patients with neonatal hypoxic-ischaemic encephalopathy (HIE) in Spain is unknown. Recent European studies highlight a shift of severe pathology towards mild motor disorders and emotional problems. The aim of this study was to analyse neurodevelopmental outcomes in a cohort of neonates with HIE at age 3 years. Patients and method: Multicentre observational study of neonates born at 35 or more weeks of gestation with moderate to severe HIE in 2011-2013 in 12 hospitals in a large Spanish region (91 217 m Results: Sixty-three patients were recruited, of whom 5 (7.9%) were excluded due to other pathology and 14 (24%) died. Of the 44 survivors, 42 (95.5%) were evaluated. Of these 42, 10 (24%) had adverse outcomes (visual or hearing impairment, epilepsy, cerebral palsy or developmental delay). Other detected problems were minor neurological signs in 6 of the 42 (14%) and a higher incidence of emotional problems compared to controls: introversion (10.5% vs. 1.3%), anxiety (34.2% vs. 11.7%) and depression (28.9% vs. 7.8%) (P < .05). The severity of the lesions on neuroimaging was significantly higher in patients with motor impairment (P = .004) or who died or had an adverse outcome (P = .027). Conclusion: In addition to classical sequelae, the followup of patients with neonatal HIE should include the diagnosis and treatment of minor motor disorders and social and emotional problems. |
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| MeSH term(s) | Child, Preschool ; Humans ; Infant, Newborn ; Asphyxia Neonatorum ; Cognition ; Cognitive Dysfunction ; Hypoxia-Ischemia, Brain/therapy ; Parturition |
| Language | English |
| Publishing date | 2024-02-07 |
| Publishing country | Spain |
| Document type | Journal Article ; Multicenter Study ; Observational Study |
| ZDB-ID | 2830901-7 |
| ISSN | 2341-2879 ; 2341-2879 |
| ISSN (online) | 2341-2879 |
| ISSN | 2341-2879 |
| DOI | 10.1016/j.anpede.2024.01.009 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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