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Article: B-cell acute lymphoblastic leukemia with +der(1)t(1;19) (p13;p13.1) arising in the setting of CALR exon 9 mutated essential thrombocythemia.

Hilal, Talal / Conley, Christopher R

2017 Volume 218-219, Page(s) 81–83

MeSH term(s)	Acute Disease ; Aged ; B-Lymphocytes/pathology ; Exons ; Female ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Thrombocythemia, Essential/blood ; Thrombocythemia, Essential/genetics ; Translocation, Genetic
Language	English
Publishing date	2017-10-19
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	2599227-2
ISSN	2210-7762
ISSN	2210-7762
DOI	10.1016/j.cancergen.2017.10.001
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Article ; Online: Histopathologic Evaluation of Flexor Tenosynovium in Recurrent Carpal Tunnel Syndrome.

Scott, Kelly L / Conley, Christopher R / Renfree, Kevin J

Plastic and reconstructive surgery

2019 Volume 143, Issue 1, Page(s) 169–175

Abstract: Background: The authors' purpose was to evaluate the histopathology of flexor tenosynovium in true, idiopathic recurrent carpal tunnel syndrome for the presence of abnormal inflammatory or pathologic findings that might explain causation or that differ ... ...

Abstract	Background: The authors' purpose was to evaluate the histopathology of flexor tenosynovium in true, idiopathic recurrent carpal tunnel syndrome for the presence of abnormal inflammatory or pathologic findings that might explain causation or that differ from those previously described for primary, idiopathic carpal tunnel syndrome. Methods: Thirty-five patients (19 women and 16 men; mean age, 72 years) underwent open revision carpal tunnel release a mean 13 years (range, 0.5 to 30 years) after primary carpal tunnel release. Recurrence was confirmed by recurrent symptoms, positive provocative tests, and electrodiagnostic testing. All patients underwent tenosynovial biopsy, including Congo red staining for amyloid. Results: Histopathologic findings demonstrated noninflammatory, fibrous connective tissue in 31 of 35 patients (89 percent); and mild, chronic inflammation (without granulomas) in four of 35 patients (11 percent). Nine of 35 patients (26 percent) had positive results for amyloid, with a statistically higher incidence in men (p = 0.03) and advanced age (p = 0.02). Subtyping performed in eight of nine amyloid-positive specimens confirmed seven cases of transthyretin-type amyloid typically seen in localized (senile) amyloidosis and one case of light-chain amyloid in a patient who was subsequently diagnosed with myeloma. Conclusions: Flexor tenosynovium in patients with recurrent carpal tunnel syndrome does not appear to be substantially different histologically from that previously described in primary idiopathic carpal tunnel syndrome, although a slightly higher prevalence of amyloid was seen in this group (especially older men). No patients have developed systemic amyloidosis. Routine biopsy of tenosynovium in idiopathic, recurrent carpal tunnel syndrome is unnecessary.
MeSH term(s)	Adult ; Age Factors ; Aged ; Biopsy, Needle ; Carpal Tunnel Syndrome/pathology ; Carpal Tunnel Syndrome/surgery ; Cohort Studies ; Databases, Factual ; Decompression, Surgical/methods ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prognosis ; Recurrence ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Synovectomy/methods ; Synovial Membrane/pathology ; Tendons/pathology ; Treatment Outcome
Language	English
Publishing date	2019-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000005090
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Article ; Online: Concurrent Liver and Mesentery Primary Extraosseous Multiple Myeloma on 18F-FDG PET/CT.

Carnahan, Molly B / Larsen, Jeremy T / Conley, Christopher R / Yang, Ming

Clinical nuclear medicine

2020 Volume 46, Issue 2, Page(s) e100–e102

Abstract: Abstract: Extramedullary multiple myeloma (EMM) is a subset of multiple myeloma with a poor prognosis. We report a rare case with biopsy-proven concurrent liver and mesentery primary EMM at the time of initial staging after serologic diagnosis of ... ...

Abstract	Abstract: Extramedullary multiple myeloma (EMM) is a subset of multiple myeloma with a poor prognosis. We report a rare case with biopsy-proven concurrent liver and mesentery primary EMM at the time of initial staging after serologic diagnosis of multiple myeloma. 18F-FDG PET/CT is valuable in detection of EMM when the patient has no osseous lesions and a negative bone marrow biopsy.
MeSH term(s)	Aged ; Biopsy ; Female ; Fluorodeoxyglucose F18 ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Male ; Mesentery ; Middle Aged ; Multiple Myeloma/diagnostic imaging ; Multiple Myeloma/pathology ; Neoplasms, Multiple Primary/diagnostic imaging ; Neoplasms, Multiple Primary/pathology ; Peritoneal Neoplasms/diagnostic imaging ; Peritoneal Neoplasms/pathology ; Positron Emission Tomography Computed Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2020-10-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003343
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Zs.A 1276: Show issues

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Article ; Online: Bladder wall fat on computed tomography with pathologic correlation.

Kriegshauser, J Scott / Conley, Christopher R / Hentz, Joseph G

Clinical imaging

2013 Volume 37, Issue 3, Page(s) 509–513

Abstract: Objectives: To determine the prevalence and significance of fat in the urinary bladder wall detectable by computed tomography (CT).: Methods: Retrospective review of 200 consecutive patients with noncontrast CT. Cystectomy specimen CT/pathologic ... ...

Abstract	Objectives: To determine the prevalence and significance of fat in the urinary bladder wall detectable by computed tomography (CT). Methods: Retrospective review of 200 consecutive patients with noncontrast CT. Cystectomy specimen CT/pathologic correlation. Results: CT-detectable fat in 30 (15%) patients was significantly more predominant in men (P=.003) and in patients with past renal stones (P<.001). Urinary tract infections were significantly less common in patients with bladder wall fat (P=.05). Pathologically, CT-detectable fat was submucosal. Conclusion: CT-detectable bladder wall fat is more common in men than women and in patients with a history of renal stones and urinary tract infections.
MeSH term(s)	Adipose Tissue/diagnostic imaging ; Adiposity ; Adult ; Aged ; Aged, 80 and over ; Arizona/epidemiology ; Comorbidity ; Female ; Humans ; Kidney Calculi/diagnostic imaging ; Kidney Calculi/epidemiology ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Statistics as Topic ; Tomography, X-Ray Computed/methods ; Tomography, X-Ray Computed/statistics & numerical data ; Urinary Bladder/diagnostic imaging ; Urinary Tract Infections/diagnostic imaging ; Urinary Tract Infections/epidemiology
Language	English
Publishing date	2013-05
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2012.10.001
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Article: Secondary Philadelphia chromosome and erythrophagocytosis in a relapsed acute myeloid leukemia after hematopoietic cell transplantation.

Kelemen, Katalin / Galani, Komal / Conley, Christopher R / Greipp, Patricia T

Cancer genetics

2014 Volume 207, Issue 6, Page(s) 268–271

Abstract: The acquisition of the Philadelphia chromosome (Ph) as a secondary change during the course of hematopoietic malignancies is rare and is associated with poor prognosis. Few cases of secondary Ph have been reported after hematopoietic cell transplantation ...

Abstract	The acquisition of the Philadelphia chromosome (Ph) as a secondary change during the course of hematopoietic malignancies is rare and is associated with poor prognosis. Few cases of secondary Ph have been reported after hematopoietic cell transplantation (HCT). A secondary Ph at relapse is of clinical importance because it provides a therapeutic target for tyrosine kinase inhibitors along with or in replacement of chemotherapy. We describe a case of relapsed acute myeloid leukemia (AML) after HCT that developed a BCR-ABL1 translocation along with erythrophagocytosis by blasts as a secondary change at the time of relapse. The progression of this patient's myeloid neoplasm from myelodysplastic syndrome to AML to relapsed AML after HCT was accompanied by a stepwise cytogenetic evolution: A deletion 20q abnormality subsequently acquired a deletion 7q and, finally, at relapse after HCT, a secondary Ph was gained. The relationship between the secondary Ph and the erythrophagocytosis by blasts is not clear. We review the possible pathogenesis and cytogenetic associations of erythrophagocytosis by blasts, a rare feature in acute leukemias.
MeSH term(s)	Aged ; Cytogenetic Analysis ; Erythrocytes/metabolism ; Erythrocytes/pathology ; Female ; Fusion Proteins, bcr-abl/genetics ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; In Situ Hybridization, Fluorescence ; Leukemia, Myeloid, Acute/blood ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Neoplasm Recurrence, Local/blood ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Phagocytosis/physiology ; Philadelphia Chromosome ; Transplantation Conditioning/methods
Chemical Substances	BCR-ABL1 fusion protein, human ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
Language	English
Publishing date	2014-06-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2599227-2
ISSN	2210-7762
ISSN	2210-7762
DOI	10.1016/j.cancergen.2014.05.013
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Article ; Online: An Organization Model to Assist Individual Physicians, Scientists, and Senior Health Care Administrators With Personal and Professional Needs.

Shanafelt, Tait D / Lightner, Deborah J / Conley, Christopher R / Petrou, Steven P / Richardson, Jarrett W / Schroeder, Pamela J / Brown, William A

Mayo Clinic proceedings

2017 Volume 92, Issue 11, Page(s) 1688–1696

Abstract: Working as a physician, scientist, or senior health care administrator is a demanding career. Studies have demonstrated that burnout and other forms of distress are common among individuals in these professions, with potentially substantive personal and ... ...

Abstract	Working as a physician, scientist, or senior health care administrator is a demanding career. Studies have demonstrated that burnout and other forms of distress are common among individuals in these professions, with potentially substantive personal and professional consequences. In addition to system-level interventions to promote well-being globally, health care organizations must provide robust support systems to assist individuals in distress. Here, we describe the 15-year experience of the Mayo Clinic Office of Staff Services (OSS) providing peer support to physicians, scientists, and senior administrators at one center. Resources for financial planning (retirement, tax services, college savings for children) and peer support to assist those experiencing distress are intentionally combined in the OSS to normalize the use of the Office and reduce the stigma associated with accessing peer support. The Office is heavily used, with approximately 75% of physicians, scientists, and senior administrators accessing the financial counseling and 5% to 7% accessing the peer support resources annually. Several critical structural characteristics of the OSS are specifically designed to minimize potential stigma and reduce barriers to seeking help. These aspects are described here with the hope that they may be informative to other medical practices considering how to create low-barrier access to help individuals deal with personal and professional challenges. We also detail the results of a recent pilot study designed to extend the activity of the OSS beyond the reactive provision of peer support to those seeking help by including regular, proactive check-ups for staff covering a range of topics intended to promote personal and professional well-being.
MeSH term(s)	Delivery of Health Care/organization & administration ; Humans ; Models, Organizational ; Outcome and Process Assessment (Health Care) ; Physicians/organization & administration
Language	English
Publishing date	2017-11-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2017.08.020
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Article: An Unusual Suspect: Lymphoepithelial Cyst of the Pancreas.

Adike, Abimbola / Horsley-Silva, Jennifer L / Deval, Neha / Conley, Christopher R / Lam-Himlin, Dora M / Nguyen, Cuong C

Case reports in gastrointestinal medicine

2016 Volume 2016, Page(s) 5492824

Abstract: Lymphoepithelial cysts (LECs) of the pancreas are benign, rare pancreatic cysts that are found predominantly in men. These cysts can present as a diagnostic conundrum given their rarity and difficulty of distinguishing these cysts from those with ... ...

Abstract	Lymphoepithelial cysts (LECs) of the pancreas are benign, rare pancreatic cysts that are found predominantly in men. These cysts can present as a diagnostic conundrum given their rarity and difficulty of distinguishing these cysts from those with malignant potential. We present an incidental case of a LEC in a middle-aged man.
Language	English
Publishing date	2016-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2627636-7
ISSN	2090-6536 ; 2090-6528
ISSN (online)	2090-6536
ISSN	2090-6528
DOI	10.1155/2016/5492824
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Article ; Online: Update on intravenous leiomyomatosis: report of five patients and literature review.

Valdés Devesa, Victoria / Conley, Christopher R / Stone, William M / Collins, Joseph M / Magrina, Javier F

European journal of obstetrics, gynecology, and reproductive biology

2013 Volume 171, Issue 2, Page(s) 209–213

Abstract: The objective of this study was to review management and results of surgical therapy of intravenous leiomyomatosis (IVL). A retrospective review of five patients treated at the Mayo Clinic between 2002 and 2012 and a literature review from 1970 to the ... ...

Abstract	The objective of this study was to review management and results of surgical therapy of intravenous leiomyomatosis (IVL). A retrospective review of five patients treated at the Mayo Clinic between 2002 and 2012 and a literature review from 1970 to the present were performed. IVL is a rare condition, often overlooked, misdiagnosed or inadequately treated. Despite its benign histological features, invasion of large vessels and cardiac extension can occur and be fatal. Appropriate diagnosis and a radical surgical approach to IVL provide optimal outcomes. Incomplete resection and/or microscopic foci of IVL can lead to recurrence. Surgery should always aim for complete tumor excision and include hysterectomy and bilateral salpingoophorectomy. Radical parametrectomy and intravenous tumor resection may be necessary.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Hysterectomy ; Leiomyomatosis/pathology ; Leiomyomatosis/surgery ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Ovariectomy ; Retrospective Studies ; Salpingectomy ; Uterine Neoplasms/pathology ; Uterine Neoplasms/surgery
Language	English
Publishing date	2013-12
Publishing country	Ireland
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2013.09.031
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Article: Sentinel lymph node metastases detected by immunohistochemistry only do not mandate complete axillary lymph node dissection in breast cancer.

Gray, Richard J / Pockaj, Barbara A / Conley, Christopher R

Annals of surgical oncology

2004 Volume 11, Issue 12, Page(s) 1056–1060

Abstract: Background: The significance of breast cancer sentinel lymph node (SLN) metastases detected only by immunohistochemistry staining (IHC) remains poorly understood. This study attempted to quantify the risk of non-SLN metastases.: Methods: A ... ...

Abstract	Background: The significance of breast cancer sentinel lymph node (SLN) metastases detected only by immunohistochemistry staining (IHC) remains poorly understood. This study attempted to quantify the risk of non-SLN metastases. Methods: A prospectively collected database of 750 consecutive SLN biopsy procedures in breast cancer patients was reviewed. Medical records were reviewed to supplement the database. Results: SLNs were identified in 738 (98.4%) of these procedures in 723 patients. Of these, 151 patients (20.5%) had metastases detected by hematoxylin and eosin staining (H&E), and 33 (4.6%) of the 718 with known IHC staining results had metastases detected by IHC only. Twenty-eight (84.8%) of 33 patients with IHC-detected metastases underwent complete axillary lymph node dissection (CALND). The median primary tumor size was 2.0 cm among those undergoing CALND and 0.9 cm among the five patients treated without CALND (P = .10). Two of the 28 patients (7.1%) had additional metastases detected with CALND. These patients had a T3 or T4 invasive lobular primary tumor. Of 24 patients with T1 or T2 primary tumors and IHC-detected metastases who underwent CALND, none had additional metastases detected. Median follow-up was 14.5 months. All patients with IHC-detected SLN metastases were treated with adjuvant systemic therapy. None of the five patients with IHC-detected metastases not undergoing CALND has subsequently manifested clinical axillary disease. Conclusions: CALND could have been or was safely omitted in 29 of 29 patients with T1 or T2 primary tumors and metastases detected by IHC. Such patients should be counseled about this low risk before CALND is recommended.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Databases, Factual ; Female ; Humans ; Immunohistochemistry ; Lymph Node Excision ; Lymphatic Metastasis/diagnosis ; Middle Aged ; Neoplasm Staging ; Prognosis ; Prospective Studies ; Risk Assessment ; Sentinel Lymph Node Biopsy
Language	English
Publishing date	2004-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/ASO.2004.03.037
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Article ; Online: A phase 2 study of rituximab, cyclophosphamide, bortezomib and dexamethasone (R-CyBorD) in relapsed low grade and mantle cell lymphoma.

Sonbol, Mohamad Bassam / Hilal, Talal / Dueck, Amylou C / Rosenthal, Allison C / Conley, Christopher R / Kosiorek, Heidi E / Ginos, Brenda F / Gano, Katherine M / Nichols, Craig S / Leis, Jose F / Johnston, Patrick B / Habermann, Thomas M / Northfelt, Donald W / Bergsagel, Peter Leif / Inwards, David J / Witzig, Thomas E / Ansell, Stephen M / Reeder, Craig B

Leukemia & lymphoma

2018 Volume 59, Issue 9, Page(s) 2128–2134

Abstract: In this phase 2 trial, we sought to evaluate the efficacy and safety of rituximab, cyclophosphamide, bortezomib, and dexamethasone (R-CyBorD) in patients with low-grade NHL. The regimen included rituximab on day 1 with weekly cyclophosphamide, ... ...

Abstract	In this phase 2 trial, we sought to evaluate the efficacy and safety of rituximab, cyclophosphamide, bortezomib, and dexamethasone (R-CyBorD) in patients with low-grade NHL. The regimen included rituximab on day 1 with weekly cyclophosphamide, dexamethasone, and bortezomib 1.3 mg/m
MeSH term(s)	Aged ; Aged, 80 and over ; Anemia/chemically induced ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bortezomib/administration & dosage ; Bortezomib/adverse effects ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/adverse effects ; Dexamethasone/administration & dosage ; Dexamethasone/adverse effects ; Fatigue/chemically induced ; Female ; Humans ; Lymphoma, Mantle-Cell/drug therapy ; Lymphoma, Mantle-Cell/pathology ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local ; Rituximab/administration & dosage ; Rituximab/adverse effects ; Survival Analysis ; Thrombocytopenia/chemically induced
Chemical Substances	Rituximab (4F4X42SYQ6) ; Bortezomib (69G8BD63PP) ; Dexamethasone (7S5I7G3JQL) ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2018-01-10
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2017.1416368
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